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WO2012041910A1 - Solution de composés de guanidinium, procédé utilisant ladite solution et utilisation associée - Google Patents

Solution de composés de guanidinium, procédé utilisant ladite solution et utilisation associée Download PDF

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Publication number
WO2012041910A1
WO2012041910A1 PCT/EP2011/066872 EP2011066872W WO2012041910A1 WO 2012041910 A1 WO2012041910 A1 WO 2012041910A1 EP 2011066872 W EP2011066872 W EP 2011066872W WO 2012041910 A1 WO2012041910 A1 WO 2012041910A1
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Prior art keywords
solution
solution according
polymeric
spray
disinfection
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Ceased
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PCT/EP2011/066872
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German (de)
English (en)
Inventor
Sebastian Oberwalder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCHARK CHRISTOPHER
Elektra Management Sro
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SCHARK CHRISTOPHER
Elektra Management Sro
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Priority to EP11767666.8A priority Critical patent/EP2621281A1/fr
Publication of WO2012041910A1 publication Critical patent/WO2012041910A1/fr
Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof

Definitions

  • the invention relates to solutions of guanidinium compounds and to a method using this solution and to the use thereof, in particular solutions for killing microorganisms, for preventing renewed growth of microorganisms and for eliminating odors.
  • the efficient killing of microorganisms and the prevention of microbial growth are of high or growing importance in a number of areas. This starts with normal household hygiene and goes beyond the cleanliness of public facilities such as public buildings and transport facilities to areas with specific hygiene requirements, such as hospitals, medical practices, care facilities, laboratories and military facilities.
  • the type of hygiene requirement ranges from purely preventive measures for preventing or slowing down the relocation of microorganisms after cleaning, to conservation measures, for example in the food sector, to (special) decontamination, for example to remove mold from buildings or from ( highly) pathogenic germs in hospitals and laboratories.
  • US 2004/0191284 describes an ophthalmic solution consisting of a surfactant, an oil and a chlorite, which may also contain a biguanidine as further disinfectant.
  • No. 7,575,673 describes a system for water treatment in which other biocides can be used in addition to polymeric biguanidines as disinfectants.
  • US 2007/0048344 describes the possibility of combining PHMB with another biocide, and optionally an anti-static agent or fluoropolymer.
  • the object of the invention is therefore to provide a solution of a guanidinium compound, which is particularly long-lasting efficacy against microorganisms, and to provide a method using this solution and their use.
  • R 2 HN NH-Ri where R 1 and R 2 independently of one another are H, an organic radical or [-C (NHNH) -NHR 3 ], in which R 3 is a hydrocarbon radical,
  • n> 2 are,
  • the use of acids verzieh et forgiven that are even considered harmful. Avoiding acids avoids massive undesirable effects, such as the corrosion of (metal) surfaces or the skin of persons entrusted with the use of this solution.
  • the present invention already quite generally differs from the prior art in that instead of polymeric biguanidines, in particular PHMB, it is also possible to use polymeric (mono) guanidines, in particular polyhexamethyleneguanidine (chloride) (hereinafter: PHMG).
  • PHMG polyhexamethyleneguanidine
  • polymeric guanidines and polymeric biguanidines are completely different.
  • completely different derivatives of the individual polymers are available: While available on the market biguanidines are as far as visible only in their chloride form, polymeric (mono) guanidines are also available as hydroxide or phosphate form, which brings significant advantages hiriengine their corrosion behavior. Finally, the efficacy of polymeric (mono) guanidines and polymeric biguanidines also varies.
  • the individual components one or more guanidinium compound (s), one or more surfactants, film formers, layer formers, surface-active substances, detergents and / or wetting agents, for simplicity's sake referred to as "film former", unless otherwise stated
  • solvent and optionally one or more disinfectants are sprayed in succession and the mixture directly on eg the surface of the object to be treated (surface, etc.) mixed as a solution, the order without Influence on the intended effect.
  • the successive delivery of the components of the solution according to the invention in the environment (indoor air or in closed systems) and the there mixing is suitable as sufficient for the method steps described later.
  • the radicals R 1, R 2 and R 3 in the formula A are independently of one another aliphatic or aromatic, branched or unbranched hydrocarbon radicals having 1 to 40 carbon atoms and X "is an acid radical
  • 2 and R 3 have been found to be 2- (2-ethoxy) ethoxyethylene, ethylenediamine, triethyleneglycol diamine, hexamethylenediamine and various (poly) oxyalkylenediamines.
  • the solution contains 0.00001 to 15% by weight of the one or more polymeric guanidinium compound (s), 0.0001 to 15% by weight of one or more film formers, 55 to 99.99% by weight. a solvent and optionally 0.00001 to 15% by weight of one or more disinfectants. Solutions have been found to be particularly effective, from 0.001 to 2 parts by weight of one or more polymeric guanidinium compound, 0.01 to 2 wt .-% of one or more film formers, 94 to 99.9% by weight of a solvent and optionally from 0.001 to 2% by weight of one or more disinfectants, in particular of stabilized chlorine dioxide.
  • Preferred radicals X ' are the radicals hydroxide, phosphate, fluoride, bromide, iodide, acetate, diphosphate, sulfate, nitrate, thiocyanate, thiosulfate, carbonate, maleate, fumarate, tartrate, mesylate, gluconate or toluenesulfonate, in particular
  • Hydroxide, phosphate, diphosphate, acetate and carbonate are preferred.
  • the corrosivity in comparison with the economically most prevalent radical, chloride can be considerably reduced, in particular with low additional costs. This improves both the ease of use and the range of applications. Regardless of the lower corrosivity increased by the preferred ions, the environmental compatibility of the product or its degradation products.
  • Particularly useful guanidinium compounds which can be used in the present invention are compounds selected from the group consisting of polyhexamethylene biguanide, polyhexamethylene guanidinium chloride, polytriethylene glycol di-guanuanidinium chloride, oligo- (2- (2-ethoxy) ethoxy-ethylguanidinium chloride), polyoxy; alkylguanidinium hydroxide, polytriethylene glycol diamine guanidinium hydroxide, oligo- (2- (2-ethoxy) ethoxyethylguanidine dinium hydroxide), polyoxyalkylene guanidine diamine phosphate, polytriethylene glycol diamine guanidinium phosphate or oligo (2- (2-ethoxy) ethoxyethyl guanidinium phosphate).
  • polyhexamethylene biguanidine hydroxide polyhexamethylene guanidinium hydroxide
  • polyhexamethylene biguanidine phosphate polyhexamethylene biguanidine phosphate
  • polyhexamethylene guanidinium phosphate are particularly preferred. These compounds are commercially available from Arch Chemical Inc. or Innova Solutions GmbH, Friedrichshafen, Germany.
  • hydroxide or 'phosphate derivatives of the abovementioned compounds can also be obtained by Ibnenley of the chloride derivatives.
  • surfactants surface-active substances, film formers, layer formers, detergents and / or wetting agents used, where the one or more surfactants is a cationic, nonionic and / or amphoteric surfactant.
  • the surfactants according to the invention, surface-active substances, film formers, layer formers, detergents and / or wetting agents are generally added in a molar ratio of surfactant / surfactants, surface-active substances, film formers, layer formers, detergents and / or wetting agents to the guanidinium compounds or compounds used a molar ratio of 0.001: 1 to 10: 1 used.
  • the solution according to the invention may contain one or more disinfectants.
  • Biocides are preferably used or tenside or an oxidizing action preservatives, such as stabilized chlorine dioxide, benzyl-2- Ci-i8 alkyldimethylchlorid, didecyl dimethyl ammonium chloride, N-alkyl (C 1 i 4 2-) -N-ethylbehzyl-N, N-dimethyl ammonium chloride.
  • the addition of these additional disinfectants and / or biocides is usually in from 0.00001 to 15% by weight, preferably from 0.001 to 2% by weight. It has been found to be particularly effective if chlorine dioxide is added to the solution as a disinfectant.
  • stabilized chlorine dioxide which is commercially available from Dow Chemical Michigan, USA.
  • Peroxodisulfates preferably sodium peroxodisulfate, ammonium peroxodisulfate or potassium peroxodisulfate are particularly preferred as stabilizers of the chlorine dioxide.
  • the influence of the stabilizers means that the chlorine dioxide in the solution or in its precursors remains storable for longer, which considerably simplifies the logistics required for distribution or generally increases the economic efficiency of the application.
  • chlorine dioxide is preferred over other disinfectants in that, unlike other disinfectants, it has a very low corrosive effect.
  • chlorine dioxide is highly efficient at destroying spores, bacteria and viruses, requiring very little contact time, in particular.
  • chlorine dioxide is biofilm-destructive. This property is advantageous because often only insufficient biofilm destruction and, consequently, rapid repopulation of the infested objects, rooms, etc. with germs occurs due to other disinfectants, as well as by low-concentration polymeric guanidines.
  • the (stabilized) chlorine dioxide is introduced in from 0.01 ppm to 3000 ppm into the ready-to-use solution. Particularly preferred ranges are from 0.1 ppm to 1000 ppm, in particular from 0.01 ppm to 300 ppm, very particularly preferably from 0.1 ppm to 150 ppm.
  • the pH of the solution used is from 4 to 10. Particularly preferred is a pH of from 5 to 9, particularly preferably from 5.5 to 8.5.
  • the pH value according to the invention makes it possible to achieve increased human compatibility, in particular increased skin tolerance, and generally lower corrosiveness.
  • the solution according to the invention may contain corrosion inhibitors as a further constituent.
  • corrosion inhibitors from the group consisting of triazo compounds, triethanolamine and their compounds, aminocarboxylates, neutralized carboxylic acid compounds, bisethanols, (alkyl) phosphoric esters and / or poly / / orthophosphates have been shown.
  • Preferred corrosion inhibitors include triazo compounds such as benzotriazole, tolutriazole, triethanolamines, and the like Compounds such as triethanolamine dinonylnaphthalenesulfonate, amine carboxylates, neutralized carboxylic acid compounds such as amine neutralized alkylsulfonamidocarboxylic acids, bisethanols such as 2,2 '- [[(5-methyl-1H-benzotriazol-1-yl) methyl] imino] bisethanol; 2,2 '- [[(4-Methyl-1H-benzotriazol-1-yl) methyl] imino] - bisethanol, (alkyl) phosphoric acid ester.
  • triazo compounds such as benzotriazole, tolutriazole, triethanolamines, and the like
  • Compounds such as triethanolamine dinonylnaphthalenesulfonate, amine carboxylates, neutralized carboxylic acid compounds such as amine neutralized al
  • poly- / orthophosphates which, in addition to their suitability for inhibiting corrosion when used in water-carrying systems, have the advantage of hardness stabilization, thereby preventing undesirable scale precipitations.
  • the formation of protective films on the treated surfaces is desired.
  • these anti-corrosive agents are used in concentrations of 0.0001 to 5% by weight, preferably in concentrations of 0.01 to 1% by weight.
  • the solution according to the invention has largely surprising advantages over known solutions of guanidine compounds and is usually used for killing bacteria, viruses, fungi and / or other microorganisms for the reduction or elimination of perceptible odors for preservation, as an additive and / or for surface treatment ,
  • the mixture according to the invention is not only suitable for killing microorganisms, but also outstanding for odor neutralization. This is by no means self-evident, since many known disinfection solutions themselves often cause a smell that is often perceived as unpleasant. It is particularly surprising that odors are greatly reduced or; neutralized by bioactivity but by completely independent sources such as burning smell, smoke, tobacco smoke or kitchen fumes. The effect This is done by actual odor reduction, so not by covering the possibly perceived as disturbing smell with the inherent odor of the mixture. Rather, the lyiischung appears to be more or less odor-free for the human sense of smell, depending on the concentration of use, and does not leave any perceptible odor in the long term.
  • polymeric guanidines with oxidative preservatives or biocides generally leads to a better profile of action.
  • combinations of polymeric guanidines and oxidative preservatives or biocides are effective Surprisingly, not only as expected in the short and long term, but also mutually enhancing and synergistic, which is in no way obvious. Enhancement of action is defined here in that the effect of the combination of two or more active ingredients is greater than would be expected by pure addition of their known modes of action, ie, for example, a combination of less than half the known minimum inhibitory concentration (minimum MIC) of two active ingredients is sufficient to achieve an inhibitory effect.
  • Synergetic effect is here defined to the effect that the effect of the combination of two or more active ingredients has a greater spectrum of activity than the respective individual substances.
  • film formers for simplification purposes, unless stated otherwise
  • film formers for simplification purposes, unless stated otherwise
  • polymeric guanidinium compounds have disadvantageous properties for many applications in that, after evaporation of the solvent used, they remain as a sticky residue on the treated surfaces and thereby promote re-fouling of these surfaces
  • film formers used themselves leave residues, which combine in an advantageous manner with the applied polymeric guanidines. So can be formed by the use of fatty alcohols, a waxy film, which is no longer sticky, but effectively counteracts a renewed contamination by dust particles, for example.
  • film formers or the residues caused by these often protects against certain forms of surface damage, especially corrosion.
  • the often desired long-term effect is promoted by the use of film formers.
  • the long-term effect on wall surfaces has already been fundamentally improved, since the uniform distribution better prevents the formation of inactive areas or offers better protection against accidental removal by stripping or similar mechanical impairments.
  • the residues of the film formers result in the formation of a mixed layer of the polymeric guanidines and the film formers (and possibly the other constituents of the solution), as already described above.
  • This mixed layer now represents a more or less permanent biocidal or preservative protective layer depending on the selected film former (s).
  • the solution according to the invention is suitable for application in the spray process and thus leads to a spray disinfection, in particular in the compressed air / cold mist process.
  • a device under positive pressure with at least one spray nozzle is used, wherein the solution in the form of a mixture or aerosol from the solution and a gas is applied.
  • mist life - Another surprising application advantage of the solution according to the invention in comparison with the subsequent atomization of polymeric guanidines is the residence time of the cold mist - also referred to as mist life - in a treated container or room. While this mist life with the use of pure polymeric guanidines depending on the concentration relatively long can be surprisingly significantly shortened in the inventive solution, ⁇
  • This lower fog life is advantageous because this shortened cleaning cycle times and thus a lower time and personnel costs for cleaning personnel is possible.
  • the ratio between film formers and polymeric guanidines, such as PHMB has to be determined separately, with no appreciable changes in the application behavior at a MoH ratio of less than 0.001 mol of film former per 1 mol of PHMB is expected.
  • a molar ratio of more than 5 moles of film-forming agent per one (1) mole of polymeric guanidine no longer leads to a significant increase in the application advantages such as (re) cleaning options, surface protection or fog lives.
  • the surprising possibility of influencing the mist life by the change in the film former content opens up the potentially extremely advantageous possibility of faster elimination of an already built fog. If, for example, a cold mist with a rather long residence time is introduced into a room, and if this room unexpectedly becomes fog-free again before the (calculated) end of the fog period - for example because of a surprising need for another use or because of an accident during the execution of the disinfection measure the in itself relatively stable Fog - in addition to other removal measures such as airing - be eliminated much faster by the additional nebulization of a pure film-forming solution.
  • Disinfectant for performing a spray disinfection In addition to a lower environmental impact, this is expressed above all in further shortened periods of use, which have a significant cost-saving effect, in particular due to the likewise saved working hours and faster reusability.
  • the same or a better disinfecting effect as with about 1, 35 l of a 0.2% PHMG solution can be achieved with one liter of the solution 4 according to preparation example 1 described below, whereby u.a. shorten the application times by approx. 25%. This is particularly important in the disinfection of large objects, such as
  • conditional inability to use can be reduced by several hours.
  • conditional inability to use can be reduced by several hours.
  • the particularly broad effectiveness, the combination of immediate with long-term effect, the reduced corrosivity and the surprising ability to remove odor are particularly advantageous when used for spray disinfection.
  • the solution for spray disinfection the following method is particularly preferred:
  • pre-cleaning For pre-cleaning, standard cleaning measures such as wiping cleaning will generally suffice.
  • closed systems rinsing with compressed air and / or water are also preferred for pre-cleaning.
  • a pre-cleaning by compressed air / water mixtures is preferred, in piping and hose systems in particular by the use of diiirch compressed air accelerated water units, which is also referred to as "Druckpulsmaschine'l.
  • Druckpulsvon'l For larger water-bearing or water-resistant containers and for outdoor use on vehicles, buildings, etc., the use of high pressure washers is also preferred.
  • the spray disinfection can in principle be carried out with all suitable devices.
  • the use is with at least one spray nozzle and at least one compressed air or propellant gas source, e.g. the use of hand pump spray bottles, pump spray containers, compressed air spray cans, propellant spray cans, compressed air nozzle spray systems, compressor nozzle spray systems, vacuum turbine nozzle spray systems, or ultrasonic nozzle spray systems.
  • cold mist spray devices through which in a single device, an aerosol of compressed air and the inventive solution with droplet sizes of preferably ⁇ 50 microns, more preferably ⁇ 1 0 microns, generated and sprayed.
  • inventive solution with droplet sizes of preferably ⁇ 50 microns, more preferably ⁇ 1 0 microns, generated and sprayed.
  • water When used for spray disinfection, preference is given to the use of water as solvent or carrier medium, in particular water purified by nanofiltration or distillation and demineralized water. This is due to the fact that other solvents often used, such as alcohols, have considerable disadvantages for use, such as an increased flammability, which, for example, in cold fogging; ranging from industrial halls to the risk of explosion could.
  • the demineralization of the water proves to be advantageous in terms of any application residues (limescale, etc.).
  • the mixing of the individual components of the solution can also be done by several leads or a two-chamber cartridge only directly in the nebulization.
  • the solution can be prepared by simultaneous or timely successive nebulization of the individual components only on the treated surface.
  • the mixing can also be done in front of the nozzle before nebulization or by two nozzles, but also by applying one after the other.
  • a spray disinfection under vacuum ventilation is particularly preferred in the disinfection or decontamination of (potentially) with biological
  • Spray over-pressure spray disinfection is preferred in at least partially flexible closed systems, such as systems containing tubing.
  • the overpressure in the system ensures better wetting of all surfaces inside the system.
  • the pressure of the spray system in combination with one or more counterpressure countervalves (s) at the one or more outlet points of the closed system is generally sufficient.
  • An application example may be the disinfection of fiber hoses as air conditioning exhaust systems.
  • the hose itself represents the overpressure counter-valve, whereby; In the case of spray disinfection with positive pressure ventilation, optimum disinfection of the entire outlet system can be achieved. Basically, no post-cleaning is required after spray disinfection.
  • the solution used for post-purification is composed of water and / or surfactants and / or further film formers, with particular amphoteric surfactants such as benzyl-Ci2-i 8-alkyldimethylchlorid, Didecyldimethylammoniumchlorid, N-alkyl (ci2-i4) - N-ethylbenzyl-N, N-dimethylammonium chloride, benzyl-C-i2-i8-alkyldimethyl- hydroxide, Didecyldimethylammoniumhydroxid and N-alkyl (Ci 2- i 4 ) -N-ethylbenzyl- ⁇ , ⁇ -dimethylammonium hydroxide are advantageous.
  • water and surfactants are used in a ratio of from 90 to 99.9999% by weight of water and from 0.0001 to 10% by weight of surfactants. Particularly preferred is the
  • the solution according to the invention is particularly suitable for use as a preservative due to the induction immediate disinfection with subsequent long-term effect.
  • the mixture according to the invention is also particularly suitable for use as a means for dip-disinfecting or dip-preserving.
  • the body to be preserved in a bath with the is neutralized by the solution of any odor residues of the
  • odor removal or odor reduction is also preferred, be it in combination within the scope of a simultaneous (spray) disinfection, or independently of other hygiene measures.
  • Preferred applications are in the human and veterinary field, as well as in personal hygiene, for example odor removal and disinfection in hospital kitchens, odor removal and disinfection on farms, pet odor removal, odor removal and personal care disinfection, e.g. as a shoe spray, mouthwash or deodorant.
  • the invention is based on the following manufacturing
  • Example 1 General example for the preparation of the solution according to the invention
  • the mixture of the solution according to the invention is carried out according to the general manufacturing or laboratory standards, e.g. by mixing in suitable glass laboratory vessels using magnetic stirrers at atmospheric pressure and room temperature (about 20 ° C), wherein the chemicals used are preferably j already used as solutions in the solvent used.
  • the mixture can also be carried out in a further temperature range, with water at approximately from 1 to 40 ° C., with temperatures close to or just below 20 ° C. being preferred. Temperatures higher than 40 ° G should be avoided, in particular when using chlorine dioxide as a further disinfectant, but can only be used with the exclusive use of polymeric guanidines and film formers in the
  • the mixture under lower or Overpressure is basically possible, but usually brings no benefits.
  • certain other disinfectants such as in particular chlorine dioxide
  • the mixture under negative pressure is disadvantageous or to be avoided.
  • didecyldimethylammonium chloride CAS: 7173-51 -5, Akzo Nobel Surface Chemistry AB, Sweden
  • butanediol produced.
  • a distillation process for the separation of the water contained in the solution may be required if I is to be added to the PHMB used in aqueous solution.
  • the mixture with a 20% aqueous solution with subsequent vacuum drying in a suitable device eg Rotavapor
  • this step can be dispensed with.
  • the mixing of the feed chemicals from original materials so is a prolonged Stirring over a period of at least 240 min required, preferably at a temperature between 20 and 40 ° C.
  • the fog has time to settle overnight.
  • the windows and doors remain closed, additional ventilation or other additional measures do not take place.
  • One hour (1 h) after switching off the ventilation system and closing the windows the same 5 test persons take the car: again. 5 out of 5 people notice a significant reduction in odor. 4 out of 5 people perceive the car as virtually odor-free, without being able to identify a specific residual odor.
  • Example 3 Use of the solution according to the invention for the removal of burning smell
  • an extension of the detectable mist life in accordance with example 4 is achieved from about 150 minutes to about 300 minutes.
  • Example 6 Cold fogging of the solution according to the invention (subsequent shortening of the idle time)
  • Example 7 Reduction of the agents used in the solution according to the invention and shortening of the application times
  • Example 8 Cleaning of hose lines
  • hose lines For the disinfection of hose lines, such.
  • hose lines As fire hoses, about 25 m C-Sehlauchauch connected to a mist-generating device with a suitable outlet, such as a hose disinfecting the company Innova Solutions.
  • a mist-generating device with a suitable outlet
  • hose disinfecting the company Innova Solutions all aerosol or mist generators that are able to be connected to a hose opening in a targeted manner and to generate a slight overpressure in the hose are suitable.
  • an overpressure control valve is attached, with which an overpressure of at least 0.1 bar, preferably over 0.3 bar, is generated in the hose in order to preclude sticking of individual hose parts / hose walls.
  • an overpressure control valve is attached, with which an overpressure of at least 0.1 bar, preferably over 0.3 bar, is generated in the hose in order to preclude sticking of individual hose parts / hose walls. Now a gem with a solution 4.
  • the samples of the sausage submerged in the solution have an average concentration of 2 cfu.
  • Example 11 Preservation of food by spraying
  • concentration corresponds in this case preferably to the undiluted solution used for dip disinfection, although in individual cases deviating concentrations may be expedient.
  • the sausage was treated not by immersion but by spraying with the undiluted solution 1 according to General Production Example 1, thus showing that the treated sausage average of 0 cfu the untreated sausage: on average 1x10 2 cfu had.
  • Example 12 Dilution of the solution as an additive
  • a thin layer of the solution of the invention is applied by misting 50 ml of a solution 2 according to General Preparation Example 1 in a 1000 liter container in which the fabric is suspended.
  • the tissue treated in this way is evenly coated with 1 ml of a bacteria mixture containing 10 6 CFU of bacteria per ml by means of a teflon spoon. After a reaction time of 5 [10 or 30 min, the samples were rinsed with 100 ml of a saline solution! and immediately determines the bacteria in the rinse solution.

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  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
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Abstract

L'invention concerne une solution contenant (a) un ou plusieurs composés polymères de guanidinium de formule (A), dans laquelle R1 et R2 sont indépendamment l'un de l'autre H, un reste organique ou [-C(=NH)-NHR3], où R3 est un reste hydrocarbure, X- est un anion et n est ≥ 2, (b) un ou plusieurs surfactants, substances tensio-actives, agents filmogènes, agents de formation de couches, détergents et/ou agents mouillants, (c) un ou plusieurs solvants, et le cas échéant (d) un ou plusieurs agents désinfectants. L'invention concerne également l'utilisation de cette solution.
PCT/EP2011/066872 2010-10-01 2011-09-28 Solution de composés de guanidinium, procédé utilisant ladite solution et utilisation associée Ceased WO2012041910A1 (fr)

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EP11767666.8A EP2621281A1 (fr) 2010-10-01 2011-09-28 Solution de composés de guanidinium, procédé utilisant ladite solution et utilisation associée

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014094019A1 (fr) * 2012-12-18 2014-06-26 Rauchenschwandtner Harald Procédé et dispositif pour former un brouillard de biocides à teneur en polymère, aqueux, au moyen d'une technologie à ultrasons dans une pièce
EP3034099A1 (fr) * 2014-12-18 2016-06-22 Siefer, Stephan Méthode et système de sterilisation d'habitations avec du peroxyde d'hydrogène et un tensioactif
WO2019178632A1 (fr) * 2018-03-23 2019-09-26 Bcsk Biocid Gmbh Composition liquide contenant une guanidine polymère

Citations (10)

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Publication number Priority date Publication date Assignee Title
EP0031109A2 (fr) * 1979-12-22 1981-07-01 Hoechst Aktiengesellschaft Dérivés de la guanidine, procédé pour leur préparation et leur utilisation comme microbicides
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