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WO2011118954A3 - Method for differentiating cartilage cells, bone cells, nerve cells or fat cells from human inferior turbinate mesenchymal stromal cells - Google Patents

Method for differentiating cartilage cells, bone cells, nerve cells or fat cells from human inferior turbinate mesenchymal stromal cells Download PDF

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Publication number
WO2011118954A3
WO2011118954A3 PCT/KR2011/001947 KR2011001947W WO2011118954A3 WO 2011118954 A3 WO2011118954 A3 WO 2011118954A3 KR 2011001947 W KR2011001947 W KR 2011001947W WO 2011118954 A3 WO2011118954 A3 WO 2011118954A3
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WO
WIPO (PCT)
Prior art keywords
cells
inferior turbinate
bone
nerve
mesenchymal stromal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2011/001947
Other languages
French (fr)
Korean (ko)
Other versions
WO2011118954A2 (en
WO2011118954A9 (en
Inventor
김성원
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Catholic University of Korea
Original Assignee
Industry Academic Cooperation Foundation of Catholic University of Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry Academic Cooperation Foundation of Catholic University of Korea filed Critical Industry Academic Cooperation Foundation of Catholic University of Korea
Priority to US13/636,660 priority Critical patent/US20130122587A1/en
Priority to EP11759703.9A priority patent/EP2551342B1/en
Publication of WO2011118954A2 publication Critical patent/WO2011118954A2/en
Publication of WO2011118954A9 publication Critical patent/WO2011118954A9/en
Publication of WO2011118954A3 publication Critical patent/WO2011118954A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a method for inducing differentiation of human inferior turbinate mesenchymal stromal cells to bone cells, cartilage cells or nerve cells. More particularly, the present invention relates to a method for inducing differentiation of human inferior turbinate mesenchymal stromal cells to bone cells, cartilage cells, nerve cells or fat cells, wherein the method comprises the step of culturing the mesenchymal stromal cells that are isolated from human inferior turbinate tissues in a medium containing growth factors. The present invention also relates to a composition for prevention or treatment of cartilage injury or disease, bone injury or osseous metabolic disease, or nerve injury or disease that contain cells differentiated by said method as active ingredients. The bone cells, cartilage cells, nerve cells or fat cells differentiated from human inferior turbinate mesenchymal stromal cells according to the present invention can be used in the fields of cell replacement therapy and regenerative medicine for treating diseases caused by the damage of said cells, and the human inferior turbinate tissues used in the present invention can be easily obtained as the source of the cells from the discarded tissues during inferior turbinate surgery.
PCT/KR2011/001947 2010-03-22 2011-03-22 Method for differentiating cartilage cells, bone cells, nerve cells or fat cells from human inferior turbinate mesenchymal stromal cells Ceased WO2011118954A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/636,660 US20130122587A1 (en) 2010-03-22 2011-03-22 Method for differentiating cartilage cells, bone cells, nerve cells or fat cells from human inferior turbinate mesenchymal stromal cells
EP11759703.9A EP2551342B1 (en) 2010-03-22 2011-03-22 Method for differentiating cartilage cells, bone cells, nerve cells or fat cells from human inferior turbinate mesenchymal stromal cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2010-0025207 2010-03-22
KR20100025207 2010-03-22
KR10-2011-0019208 2011-03-04
KR1020110019208A KR101327076B1 (en) 2010-03-22 2011-03-04 Method of inducing chondrogenic, osteogenic, neurogenic or adipocytic differentiation of human turbinate mesenchymal stromal cells

Publications (3)

Publication Number Publication Date
WO2011118954A2 WO2011118954A2 (en) 2011-09-29
WO2011118954A9 WO2011118954A9 (en) 2011-11-17
WO2011118954A3 true WO2011118954A3 (en) 2012-03-15

Family

ID=44956255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/001947 Ceased WO2011118954A2 (en) 2010-03-22 2011-03-22 Method for differentiating cartilage cells, bone cells, nerve cells or fat cells from human inferior turbinate mesenchymal stromal cells

Country Status (4)

Country Link
US (1) US20130122587A1 (en)
EP (1) EP2551342B1 (en)
KR (1) KR101327076B1 (en)
WO (1) WO2011118954A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102175468B1 (en) * 2014-01-20 2020-11-06 (주)아모레퍼시픽 Cosmetic composition for promoting a differentiation of adipocyte comprising hydroxy pyranone derivative
KR102104120B1 (en) 2017-05-02 2020-04-23 가톨릭대학교 산학협력단 3D bioprinting construct using human nasal inferior turbinate derived mesenchymal stem cell and uses thereof
WO2018203651A2 (en) 2017-05-02 2018-11-08 가톨릭대학교 산학협력단 Human nose inferior nasal concha-derived mesenchymal stem cell-based, 3d bioprinted construct, and use thereof
KR102348696B1 (en) * 2017-05-17 2022-01-07 주식회사 엘지생활건강 Cosmetic composition comprising teprenone
KR102167819B1 (en) * 2017-07-28 2020-10-20 가톨릭대학교 산학협력단 Pharmaceutical composition for preventing or treating rheumatoid arthritis, comprising nasal inferior turbinate derived mesenchymal stem cell as an active ingredient
KR102053868B1 (en) * 2018-01-31 2020-01-22 가톨릭대학교 산학협력단 Pharmaceutical composition for preventing or treating neurodegenerative disease, comprising turbinate mesenchymal stem cell as an active ingredient
CN109082407A (en) * 2018-06-14 2018-12-25 广州思晋生物科技有限公司 A kind of mescenchymal stem cell is at chondrocyte induction differential medium
KR102181526B1 (en) 2019-04-24 2020-11-20 가톨릭대학교 산학협력단 Method for preparing induced pluripotent stem cells from human turbinate mesenchymal stem cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050016396A (en) * 2002-05-13 2005-02-21 도시바 세라믹스 가부시키가이샤 Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation
JP5546760B2 (en) * 2008-01-21 2014-07-09 株式会社ジーシー Method for producing porous cell support
EP3514229A1 (en) * 2008-05-28 2019-07-24 Ramot at Tel-Aviv University Ltd. Mesenchymal stem cells for the treatment of cns diseases
WO2010077294A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Olfactory stem cells and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COLLEONI ET AL.: "Establishment, differentiation, electroporation, viral transduction, and nuclear transfer of bovine and porcine mesenchymal stem cells", CLONING AND STEM CELLS, vol. 7, no. 3, 2005, pages 154 - 166 *
KIM ET AL.: "Induction of chondrogenic differentiation in cultured fibroblasts isolated from the inferior turbinate", OTOLARYNGOLOGY-HEAD AND NECK SURGERY, vol. 139, July 2008 (2008-07-01), pages 143 - 148, XP022849544, DOI: doi:10.1016/j.otohns.2008.04.015 *
KIM ET AL.: "Inferior turbinate: new source of mesechymal stromal cells", OTOLARYNGOLOGY-HEAD AND NECK SURGERY, vol. 143, 10 August 2010 (2010-08-10), pages P151, XP027168035 *
SUNG WON KIM: "Current trends in tissue regeneration using fibroblasts", KOREAN JOURNAL OF OTORHINOLARYNGOLOGY-HEAD AND NECK SURGERY, vol. 5, no. 1, 2008, pages 114 - 119 *

Also Published As

Publication number Publication date
EP2551342B1 (en) 2018-05-02
KR20110106235A (en) 2011-09-28
EP2551342A2 (en) 2013-01-30
KR101327076B1 (en) 2013-11-08
US20130122587A1 (en) 2013-05-16
WO2011118954A2 (en) 2011-09-29
WO2011118954A9 (en) 2011-11-17
EP2551342A4 (en) 2013-08-28

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