[go: up one dir, main page]

WO2011117371A3 - Ltbp2 en tant que biomarqueur d'un dysfonctionnement rénal - Google Patents

Ltbp2 en tant que biomarqueur d'un dysfonctionnement rénal Download PDF

Info

Publication number
WO2011117371A3
WO2011117371A3 PCT/EP2011/054577 EP2011054577W WO2011117371A3 WO 2011117371 A3 WO2011117371 A3 WO 2011117371A3 EP 2011054577 W EP2011054577 W EP 2011054577W WO 2011117371 A3 WO2011117371 A3 WO 2011117371A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomarker
ltbp2
preeclampsia
dyspnea
pregnancy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/054577
Other languages
English (en)
Other versions
WO2011117371A2 (fr
Inventor
Koen Kas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pronota NV
Original Assignee
Pronota NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pronota NV filed Critical Pronota NV
Priority to JP2013500518A priority Critical patent/JP6092092B2/ja
Priority to CA2788760A priority patent/CA2788760A1/fr
Priority to AU2011231537A priority patent/AU2011231537B2/en
Priority to EP11714716.5A priority patent/EP2553461B1/fr
Priority to US13/636,646 priority patent/US20130040881A1/en
Publication of WO2011117371A2 publication Critical patent/WO2011117371A2/fr
Publication of WO2011117371A3 publication Critical patent/WO2011117371A3/fr
Anticipated expiration legal-status Critical
Priority to US15/057,834 priority patent/US20160245826A1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)

Abstract

Emploi de LTBP2 en tant que biomarqueur de dysfonctionnement rénal; méthodes de prédiction, de diagnostic, de pronostic et/ou de surveillance dudit dysfonctionnement basées sur la mesure dudit biomarqueur ; et trousses et dispositifs de mesure dudit biomarqueur et/ou d'application des dites méthodes.
PCT/EP2011/054577 2010-03-26 2011-03-25 Ltbp2 en tant que biomarqueur d'un dysfonctionnement rénal Ceased WO2011117371A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2013500518A JP6092092B2 (ja) 2010-03-26 2011-03-25 腎機能障害、糸球体濾過速度、呼吸困難、急性心不全、左心室肥大、心線維症、子癇前症、妊娠関連蛋白尿のバイオマーカーとしてのｌｔｂｐ２
CA2788760A CA2788760A1 (fr) 2010-03-26 2011-03-25 Ltbp2 en tant que biomarqueur d'un dysfonctionnement renal
AU2011231537A AU2011231537B2 (en) 2010-03-26 2011-03-25 LTBP2 as a biomarker for renal dysfunction, glomerular filtration rate, dyspnea, acute heart failure, left ventricular hypertrophy, cardiac fibrosis, preeclampsia, pregnancy-associated proteinuria
EP11714716.5A EP2553461B1 (fr) 2010-03-26 2011-03-25 Ltbp2 en tant que biomarqueur d'un dysfonctionnement rénal et du taux de filtration glomérulaire
US13/636,646 US20130040881A1 (en) 2010-03-26 2011-03-25 Ltbp2 as a biomarker for renal dysfunction
US15/057,834 US20160245826A1 (en) 2010-03-26 2016-03-01 Ltbp2 as a biomarker for renal dysfunction

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31806410P 2010-03-26 2010-03-26
US61/318,064 2010-03-26
EP10158061.1 2010-03-26
EP10158061 2010-03-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/636,646 A-371-Of-International US20130040881A1 (en) 2010-03-26 2011-03-25 Ltbp2 as a biomarker for renal dysfunction
US15/057,834 Continuation US20160245826A1 (en) 2010-03-26 2016-03-01 Ltbp2 as a biomarker for renal dysfunction

Publications (2)

Publication Number Publication Date
WO2011117371A2 WO2011117371A2 (fr) 2011-09-29
WO2011117371A3 true WO2011117371A3 (fr) 2011-11-17

Family

ID=44657130

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/054577 Ceased WO2011117371A2 (fr) 2010-03-26 2011-03-25 Ltbp2 en tant que biomarqueur d'un dysfonctionnement rénal

Country Status (6)

Country Link
US (3) US20110237513A1 (fr)
EP (2) EP2924439B1 (fr)
JP (2) JP6092092B2 (fr)
AU (1) AU2011231537B2 (fr)
CA (1) CA2788760A1 (fr)
WO (1) WO2011117371A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2788760A1 (fr) * 2010-03-26 2011-09-29 Pronota N.V. Ltbp2 en tant que biomarqueur d'un dysfonctionnement renal
JP5899213B2 (ja) 2010-08-06 2016-04-06 マイカーティス エヌ．ヴェ．ＭｙＣａｒｔｉｓ ＮＶ 腎機能不全のバイオマーカーとしてのパールカン
EP2788771A1 (fr) * 2011-12-09 2014-10-15 Pronota NV Ltbp2 à titre de biomarqueur de lésion pulmonaire
CN104620111B (zh) * 2012-09-12 2017-08-08 霍夫曼-拉罗奇有限公司 鉴定具有异常分数缩短的患者
US20150330989A1 (en) * 2012-11-15 2015-11-19 The Brigham And Women's Hospital, Inc. Method and system for diagnosing and treating preeclampsia
EP3102224B1 (fr) 2013-12-20 2019-02-20 NephroGenesis, LLC. Appareils de dialyse rénale et lipocaline pour utilisation dans la prévention et le traitement de l'urémie par dialyse
WO2019075411A1 (fr) * 2017-10-12 2019-04-18 Cedars-Sinai Medical Center Biomarqueurs de pronostic et de progression d'une néphropathie chronique
CA3094294A1 (fr) * 2018-03-23 2019-09-26 F. Hoffmann-La Roche Ag Procedes de depistage du risque de nephropathie chronique chez un sujet et procede mis en ƒuvre par ordinateur
CN112684048B (zh) * 2020-12-22 2023-03-14 中山大学附属第一医院 一种术前鉴别甲状腺良恶性结节的生物标志物、试剂盒及其应用
CN112683857B (zh) * 2021-01-06 2022-10-14 上海药明生物医药有限公司 一种通过评估分析物的溶剂效应对亲和力实验的影响来指导spr检测前处理的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075835A2 (fr) * 2003-02-21 2004-09-10 Genentech Inc. Procédés de traitement de carcinome
WO2008046509A1 (fr) * 2006-10-16 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Protéine ltbp2 utilisée en tant que biomarqueur, cible thérapeutique et diagnostique
WO2008137586A1 (fr) * 2007-05-01 2008-11-13 University Of Miami Biomarqueurs transcriptomiques pour évaluation de risque individuel de nouvelle survenue d'insuffisance cardiaque
WO2009027339A1 (fr) * 2007-08-30 2009-03-05 F. Hoffmann La-Roche Ag Protéines b et d tensioactives pour une différenciation des causes d'une insuffisance respiratoire
WO2010022210A2 (fr) * 2008-08-21 2010-02-25 Pxbiosciences Llc Diagnostic et surveillance de l’insuffisance rénale au moyen de biomarqueurs peptidiques

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3760809A (en) 1971-10-22 1973-09-25 Damon Corp Surgical lancet having casing
US4360016A (en) 1980-07-01 1982-11-23 Transidyne General Corp. Blood collecting device
US4553541A (en) 1981-03-23 1985-11-19 Becton, Dickinson And Co. Automatic retractable lancet assembly
FR2515339A1 (fr) 1981-10-28 1983-04-29 Marteau D Autry Eric Pipette de precision a deplacement positif
US4802493A (en) 1981-12-14 1989-02-07 Maganias Nicholas H Device and method for allergy testing
DE3274422D1 (en) 1981-12-14 1987-01-15 Nicholas H Maganias Device and method for allergy testing
US4966159A (en) 1981-12-14 1990-10-30 Maganias Nicholas H Allergy test strip
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8331514D0 (en) 1983-11-25 1984-01-04 Janssen Pharmaceutica Nv Visualization method
US4653513A (en) 1985-08-09 1987-03-31 Dombrowski Mitchell P Blood sampler
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
EP0292928A3 (fr) 1987-05-25 1990-09-12 Eftag Entstaubungs- Und Fördertechnik Ag Moyens pour la détermination d'une réaction allergique et son utilisation comme diagnostique et un dispositif pour ce but
DE3887145T2 (de) 1987-05-29 1994-04-28 North Sydney Area Health Serv Medizinische Testvorrichtung.
US5120643A (en) 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US4853335A (en) 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US4859612A (en) 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
GB8800702D0 (en) 1988-01-13 1988-02-10 Nycomed As Test method & reagent kit therefor
US5202267A (en) 1988-04-04 1993-04-13 Hygeia Sciences, Inc. Sol capture immunoassay kit and procedure
US5108889A (en) 1988-10-12 1992-04-28 Thorne, Smith, Astill Technologies, Inc. Assay for determining analyte using mercury release followed by detection via interaction with aluminum
ES2035210T3 (es) 1988-10-21 1993-04-16 Eppendorf-Netheler-Hinz Gmbh Dispositivo para accionar pipetas.
US5079172A (en) 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US5141850A (en) 1990-02-07 1992-08-25 Hygeia Sciences, Inc. Porous strip form assay device method
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US6027944A (en) 1990-11-22 2000-02-22 Applied Research Systems Ars Holding Nv Capillary-fill biosensor device comprising a calibration zone
US5133730A (en) 1991-05-15 1992-07-28 International Technidyne Corporation Disposable-retractable finger stick device
US5726010A (en) 1991-07-31 1998-03-10 Idexx Laboratories, Inc. Reversible flow chromatographic binding assay
FR2696110B1 (fr) 1992-09-28 1994-12-09 Gilson Medical Electronics Sa Perfectionnement à une piquette de prélèvement et de distribution de volumes réglables de liquides.
JP2630197B2 (ja) 1993-04-28 1997-07-16 株式会社ニッショー 血液吸出器具
US5871452A (en) 1993-07-02 1999-02-16 Rachman Scientific, Inc. Skin test applicator
US5395388A (en) 1993-11-15 1995-03-07 Schraga; Steven Single unit lancet device
JP3393920B2 (ja) 1993-12-09 2003-04-07 富士写真フイルム株式会社 微量定容採血点着用具
US6206829B1 (en) 1996-07-12 2001-03-27 First Opinion Corporation Computerized medical diagnostic and treatment advice system including network access
US6107045A (en) 1994-06-30 2000-08-22 Oklahoma Medical Research Foundation Antibodies to lipoproteins and apolipoproteins and methods of use thereof
AU6248796A (en) 1995-05-19 1996-11-29 Universal Health-Watch, Inc. Rapid self-contained assay format
US5681775A (en) 1995-11-15 1997-10-28 International Business Machines Corporation Soi fabrication process
US5630828A (en) 1996-04-17 1997-05-20 International Techndyne Corporation Low cost disposable lancet
US5613978A (en) 1996-06-04 1997-03-25 Palco Laboratories Adjustable tip for lancet device
US6001658A (en) 1996-09-13 1999-12-14 Diagnostic Chemicals Limited Test strip apparatus and method for determining presence of analyte in a fluid sample
US6086545A (en) 1998-04-28 2000-07-11 Amira Medical Methods and apparatus for suctioning and pumping body fluid from an incision
US6095988A (en) 1998-09-04 2000-08-01 Greer Laboratories, Inc. Autoloader and skin testing system
US6511814B1 (en) 1999-03-26 2003-01-28 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
JP4700245B2 (ja) 1999-08-17 2011-06-15 ティーティーピー ラブテック リミテッド プランジャおよびプランジャ上で硬化されたハウジングを備えたサンプリング／ディスペンシング器具
US6974706B1 (en) 2003-01-16 2005-12-13 University Of Florida Research Foundation, Inc. Application of biosensors for diagnosis and treatment of disease
GB0030929D0 (en) 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
KR20030079958A (ko) 2001-01-22 2003-10-10 에프. 호프만-라 로슈 아게 모세작용을 갖는 란셋장치
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
AU2002315179A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Blood sampling device with diaphragm actuated lancet
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
EP1432466B1 (fr) 2001-09-12 2012-08-15 Becton, Dickinson and Company Stylo a micro-aiguille pour l'administration de medicaments et procede d'utilisation associe
CA2463492A1 (fr) * 2001-10-18 2003-04-24 Genentech, Inc. Methodes de traitement du carcinome
US20030109067A1 (en) 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
DE60335488D1 (de) 2002-10-29 2011-02-03 Ambi Inc Lanzettenvorrichtung zur einmaligen anwendung
DE60332043D1 (de) 2002-12-30 2010-05-20 Roche Diagnostics Gmbh Kapillarrohr-spitzen-design zur unterstützung des blutflusses
US7374546B2 (en) 2003-01-29 2008-05-20 Roche Diagnostics Operations, Inc. Integrated lancing test strip
EP1616181B1 (fr) 2003-04-17 2009-08-12 Vermillion, Inc. Polypeptides lies aux peptides natriuretiques, procedes d'identification et d'utilisation de ces derniers
WO2005000382A2 (fr) 2003-06-04 2005-01-06 Georgia Tech Research Corporation Dispositif a micro-aiguille de forage
JP2007511318A (ja) 2003-11-18 2007-05-10 ナノ パス テクノロジーズ リミテッド 改良された挿入システム及びマイクロニードルを摺動させるための方法
EP1815007A4 (fr) 2004-11-15 2011-10-19 Univ North Dakota Procédé pour incorporer un seul atome d'oxygène dans des peptides digérés au moyen des peptidases
US20070037232A1 (en) * 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
EP2012814B1 (fr) * 2006-04-12 2013-05-22 Genzyme Corporation Procédés de traitement des maladies auto-immunes
PL2386860T4 (pl) * 2006-04-24 2015-09-30 Critical Care Diagnostics Inc Przewidywanie śmiertelności i wykrywanie poważnej choroby
US7749773B2 (en) 2006-10-11 2010-07-06 Day Alan R Device for detection of molecules in biological fluids
US7977110B2 (en) * 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions
CA2788760A1 (fr) * 2010-03-26 2011-09-29 Pronota N.V. Ltbp2 en tant que biomarqueur d'un dysfonctionnement renal
US20130150282A1 (en) * 2010-03-26 2013-06-13 Pronota N.V. Ltbp2 as a biomarker for evaluating the risk of death in a diseased subject

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075835A2 (fr) * 2003-02-21 2004-09-10 Genentech Inc. Procédés de traitement de carcinome
WO2008046509A1 (fr) * 2006-10-16 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Protéine ltbp2 utilisée en tant que biomarqueur, cible thérapeutique et diagnostique
WO2008137586A1 (fr) * 2007-05-01 2008-11-13 University Of Miami Biomarqueurs transcriptomiques pour évaluation de risque individuel de nouvelle survenue d'insuffisance cardiaque
WO2009027339A1 (fr) * 2007-08-30 2009-03-05 F. Hoffmann La-Roche Ag Protéines b et d tensioactives pour une différenciation des causes d'une insuffisance respiratoire
WO2010022210A2 (fr) * 2008-08-21 2010-02-25 Pxbiosciences Llc Diagnostic et surveillance de l’insuffisance rénale au moyen de biomarqueurs peptidiques

Also Published As

Publication number Publication date
US20130040881A1 (en) 2013-02-14
AU2011231537B2 (en) 2016-05-12
US20110237513A1 (en) 2011-09-29
EP2924439A1 (fr) 2015-09-30
EP2553461A2 (fr) 2013-02-06
JP2013527431A (ja) 2013-06-27
AU2011231537A1 (en) 2012-08-23
CA2788760A1 (fr) 2011-09-29
EP2553461B1 (fr) 2016-01-20
US20160245826A1 (en) 2016-08-25
WO2011117371A2 (fr) 2011-09-29
JP6009595B2 (ja) 2016-10-19
JP6092092B2 (ja) 2017-03-08
JP2015092199A (ja) 2015-05-14
EP2924439B1 (fr) 2017-02-01

Similar Documents

Publication Publication Date Title
WO2011117371A3 (fr) Ltbp2 en tant que biomarqueur d'un dysfonctionnement rénal
WO2012076553A3 (fr) Biomarqueurs et paramètres des troubles d'hypertension de la grossesse
WO2013087887A3 (fr) Biomarqueurs et paramètres pour troubles hypertensifs de grossesse
WO2011095600A3 (fr) Procédé de conduite de travaux dans un puits de forage
WO2011017413A3 (fr) Utilisation de fibres optiques pour la surveillance de la qualité du ciment
EP2304835A4 (fr) Electrolyte pour batteries au lithium, batteries au lithium et procédé de production associé
EP2659371A4 (fr) Prédiction, diagnostic et récupération après défaillances d'une application, basés sur des motifs d'accès à des ressources
GB2500834A (en) Managing compressed memory using tiered interrupts
FR2930605B1 (fr) Procede de controle de l'etat d'un accumulateur a reserve d'energie, notamment pour aeronef.
WO2012065018A3 (fr) Estimation d'usure de mémoire à semi-conducteurs non volatile
WO2006113529A3 (fr) Diagnostic d'une sepsie
EP2581754A3 (fr) Système de gestion d'apprentissage adaptatif de batterie
WO2009028629A1 (fr) Composé hétérocyclique et son utilisation
WO2011047260A3 (fr) Déclenchement d'actions basé sur des modifications d'une connexion de réseau
WO2011017419A3 (fr) Systèmes et procédés de contrôle de corrosion dans un puits
WO2013159872A8 (fr) Biomarqueurs pour le diagnostic, le pronostic, l'évaluation et la stratification thérapeutique d'une syncope
WO2011100016A3 (fr) Procédé d'entretien de pipeline
WO2015013677A3 (fr) Système d'optimisation de la totalité d'une propriété pour améliorer l'efficacité énergétique et obtenir des bâtiments intelligents
EP2418349A4 (fr) Procédé de surveillance de l'exploitation de gisements pétrolifères
EP2124312A3 (fr) Procédé de rajeunissement de batterie et appareil
EP2456260A3 (fr) Récupération d'erreurs de pico cellules dans HetNet
ATE505469T1 (de) 7-alkynyl-1,8-naphthyridon-derivate, verfahren zu ihrer herstellung und ihre verwendung für therapeutika
WO2015057486A3 (fr) Procédé et appareil d'optimisation de la zone de couverture d'une petite cellule
WO2008129296A3 (fr) Marqueurs de maladies
WO2011100439A3 (fr) Procédé et système destinés à estimer des indemnisations impayées

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11714716

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2011231537

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2788760

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2011231537

Country of ref document: AU

Date of ref document: 20110325

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 13636646

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2013500518

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2011714716

Country of ref document: EP