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WO2011114210A3 - Procédés de préparation de linézolide - Google Patents

Procédés de préparation de linézolide Download PDF

Info

Publication number
WO2011114210A3
WO2011114210A3 PCT/IB2011/000527 IB2011000527W WO2011114210A3 WO 2011114210 A3 WO2011114210 A3 WO 2011114210A3 IB 2011000527 W IB2011000527 W IB 2011000527W WO 2011114210 A3 WO2011114210 A3 WO 2011114210A3
Authority
WO
WIPO (PCT)
Prior art keywords
linezolid
preparation
provides
bis
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/000527
Other languages
English (en)
Other versions
WO2011114210A2 (fr
Inventor
Ashish Kumar Gupta
Shishupal Singh
Atulya Kumar Panda
Sujay Biswas
Dharam Vir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jubilant Pharmova Ltd
Original Assignee
Jubilant Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Life Sciences Ltd filed Critical Jubilant Life Sciences Ltd
Publication of WO2011114210A2 publication Critical patent/WO2011114210A2/fr
Publication of WO2011114210A3 publication Critical patent/WO2011114210A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé permettant de préparer la linézolide, la linézolide résultante est dépourvue d'impuretés et implique un procédé facile et économique. L'invention concerne en outre la préparation de la linézolide par utilisation d'un intermédiaire azide et d'un procédé concernant ledit intermédiaire.
PCT/IB2011/000527 2010-03-15 2011-03-14 Procédés de préparation de linézolide Ceased WO2011114210A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN595/DEL/2010 2010-03-15
IN595DE2010 2010-03-15

Publications (2)

Publication Number Publication Date
WO2011114210A2 WO2011114210A2 (fr) 2011-09-22
WO2011114210A3 true WO2011114210A3 (fr) 2011-12-01

Family

ID=44084033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/000527 Ceased WO2011114210A2 (fr) 2010-03-15 2011-03-14 Procédés de préparation de linézolide

Country Status (1)

Country Link
WO (1) WO2011114210A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102491954B (zh) * 2011-12-06 2014-04-23 江苏正大丰海制药有限公司 利奈唑胺的制备方法
EP2852580A1 (fr) 2012-01-24 2015-04-01 Jubilant Life Sciences Ltd. Procédé amélioré de préparation de la forme cristalline stable i du linézolide, pratiquement exempte de solvant résiduel
WO2014045292A1 (fr) * 2012-09-20 2014-03-27 Symed Labs Limited Procédé amélioré pour la préparation d'un intermédiaire de linézolide
CN103601704B (zh) * 2013-11-22 2015-05-06 石家庄智恒医药科技有限公司 无定形卡巴他赛的制备
CN104262280B (zh) * 2014-09-22 2016-07-20 山东华生化学股份有限公司 一种利奈唑酮的制备方法
WO2017182853A1 (fr) * 2016-04-21 2017-10-26 Optimus Drugs Pvt Ltd Procédé perfectionné pour la préparation de linézolide
CN110483431A (zh) * 2019-09-04 2019-11-22 桂林南药股份有限公司 利奈唑胺杂质化合物、其制备方法以及其应用
CN119119019B (zh) * 2024-09-11 2025-11-11 遵义医科大学 一种杂环磺酰胺/磺酸酯衍生物及其制备方法、应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291614B2 (en) 2005-02-24 2007-11-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of linezolid intermediate
US20090093631A1 (en) 2007-09-06 2009-04-09 Ben-Zion Dolitzky Processes for the preparation of a linezolid intermediate, linezolid hydroxide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRICKNER S J ET AL: "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF U-100592 AND U-100766, TWO OXAZOLIDINONE ANTOBACTERIAL AGENTS FOR THE POTERTIAL TREATMENT OF MULTIDRUG-RESISTANT GRAM-POSITIVE BACTERIAL INFECTIONS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 39, no. 3, 2 February 1996 (1996-02-02), pages 673 - 679, XP000574381, ISSN: 0022-2623, DOI: DOI:10.1021/JM9509556 *
D'ANDREA S ET AL: "Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 11, 2 June 2005 (2005-06-02), pages 2834 - 2839, XP025313695, ISSN: 0960-894X, [retrieved on 20050602], DOI: DOI:10.1016/J.BMCL.2005.03.099 *
YU DU ET AL: "Synthesis and antibacterial activity of linezolid analogues", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 12, no. 6, 25 March 2002 (2002-03-25), pages 857 - 859, XP002963251, ISSN: 0960-894X, DOI: DOI:10.1016/S0960-894X(02)00043-4 *

Also Published As

Publication number Publication date
WO2011114210A2 (fr) 2011-09-22

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