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WO2011114071A3 - Cyclopeptide synthetique, procede de preparation et utilisations - Google Patents

Cyclopeptide synthetique, procede de preparation et utilisations Download PDF

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Publication number
WO2011114071A3
WO2011114071A3 PCT/FR2011/050552 FR2011050552W WO2011114071A3 WO 2011114071 A3 WO2011114071 A3 WO 2011114071A3 FR 2011050552 W FR2011050552 W FR 2011050552W WO 2011114071 A3 WO2011114071 A3 WO 2011114071A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclopeptide
synthetic
preparation process
relates
angiogenesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2011/050552
Other languages
English (en)
Other versions
WO2011114071A2 (fr
Inventor
Pascal Sonnet
Sophie Da Nascimento
Carole Amant
Roger Ourouda
Jacques Rochette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTRE HOSPITALIER UNIVERSITAIRE
Universite de Picardie Jules Verne
Original Assignee
CENTRE HOSPITALIER UNIVERSITAIRE
Universite de Picardie Jules Verne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CENTRE HOSPITALIER UNIVERSITAIRE, Universite de Picardie Jules Verne filed Critical CENTRE HOSPITALIER UNIVERSITAIRE
Publication of WO2011114071A2 publication Critical patent/WO2011114071A2/fr
Publication of WO2011114071A3 publication Critical patent/WO2011114071A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un cyclopeptide synthétique, son procédé de préparation et ses utilisations dans la prévention ou le traitement d'une maladie associée à l' angiogenèse. L'invention concerne également une composition pharmaceutique comprenant un cyclopeptide selon l'invention.
PCT/FR2011/050552 2010-03-17 2011-03-17 Cyclopeptide synthetique, procede de preparation et utilisations Ceased WO2011114071A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1051899 2010-03-17
FR1051899A FR2957597A1 (fr) 2010-03-17 2010-03-17 Cyclopeptides synthetiques, procede de preparation et utilisations

Publications (2)

Publication Number Publication Date
WO2011114071A2 WO2011114071A2 (fr) 2011-09-22
WO2011114071A3 true WO2011114071A3 (fr) 2011-12-29

Family

ID=42753436

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2011/050552 Ceased WO2011114071A2 (fr) 2010-03-17 2011-03-17 Cyclopeptide synthetique, procede de preparation et utilisations

Country Status (2)

Country Link
FR (1) FR2957597A1 (fr)
WO (1) WO2011114071A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111662363A (zh) * 2020-06-22 2020-09-15 上海大学 环肽类抗肿瘤活性化合物及其制备方法与应用
CN111777668B (zh) * 2020-07-28 2022-02-25 安徽工程大学 一种基于海洋环肽Samoamide A的改造多肽、合成方法及应用
CN116617359B (zh) * 2023-05-05 2024-01-30 天津中医药大学第一附属医院 王不留行环肽b在制备治疗前列腺肿瘤药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004015392A2 (fr) * 2002-08-08 2004-02-19 Targeted Molecules Corporation Procede ameliore d'identification de molecules de ciblage

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004015392A2 (fr) * 2002-08-08 2004-02-19 Targeted Molecules Corporation Procede ameliore d'identification de molecules de ciblage

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
HIROSHI MORITA, YOUNG SOOK YUN, KOICHI TAKEYA, HIDEJA ITOKAWA, KENJI YAMADA: "Segetalins B, C and D, Three New Cyclic Peptides from Vaccaria segetalis", TETRAHEDRON, vol. 51, no. 21, 22 May 1995 (1995-05-22), pages 6003 - 6014, XP002602883 *
HIROYUKI MIYAKE, YOSHITANE KOJIMA, TETSUSHI YAMASHITA, AKIO OHSUKA: "Two Conformers and Aggregation of Cyclic Octapeptide, cyclo(G-eLL-G)2 in Chloroform", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 65, no. 3, March 1992 (1992-03-01), pages 917 - 919, XP002602886 *
MORITA H ET AL: "Dichotomins J and K, vasodilator cyclic peptides from Stellaria dichotoma", JOURNAL OF NATURAL PRODUCTS, vol. 68, 2 November 2005 (2005-11-02), pages 1686 - 1688, XP002603006, ISSN: 0250-4367 *
MORITA H ET AL: "Segetalin A, a new cyclic hexapeptide from vaccaria segetalis", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/0040-4039(94)88519-2, vol. 35, no. 51, 19 December 1994 (1994-12-19), pages 9593 - 9596, XP026620279, ISSN: 0040-4039, [retrieved on 19941219] *
PASCAL SONNET, LAURENT PETIT, DANIELLE MARTY, JEAN GUILLON, JACQUES ROCHETTE, JEAN-DANIEL BRION: "First synthesis of segetalin A and analogous cyclohexapeptides", TETRAHEDRON LETTERS, vol. 42, no. 9, 26 February 2001 (2001-02-26), pages 1681 - 1683, XP002602882 *
ROGER OUROUDA, CAROLE AMANT, SOPHIE NADASCIMENTO, SABRINA KELLOUCHE, AGNES BOULLIER, JEAN-PIERRE MAROLLEAU, PASCAL SONNET ET AL.: "Antiangiogenic Properties of a New VEGF Inhibitor Family: The Segetalins", BLOOD, vol. 114, no. 22, 3038, 20 November 2009 (2009-11-20), XP002602884 *
SCOTT T. PHILLIPS, LANDY K. BLASDEL, PAUL A. BARTLETT: "@-Tides as Reporters for Molecular Associations", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, no. 12, 30 March 2005 (2005-03-30), pages 4193 - 4198, XP002602885 *
SONNET P ET AL: "First synthesis of segetalins B and G: two cyclopentapeptides with estrogen-like activity", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/S0040-4039(03)00583-5, vol. 44, no. 16, 14 April 2003 (2003-04-14), pages 3293 - 3296, XP004417090, ISSN: 0040-4039 *
WELE A ET AL: "Glaucacyclopeptide A from the seeds of Annona glauca", PHYTOCHEMISTRY, PERGAMON PRESS, GB LNKD- DOI:10.1016/J.PHYTOCHEM.2005.04.028, vol. 66, no. 10, 1 May 2005 (2005-05-01), pages 1154 - 1157, XP004967665, ISSN: 0031-9422 *

Also Published As

Publication number Publication date
FR2957597A1 (fr) 2011-09-23
WO2011114071A2 (fr) 2011-09-22

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