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WO2011110683A3 - Glce as a target for anti-tumour therapy - Google Patents

Glce as a target for anti-tumour therapy Download PDF

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Publication number
WO2011110683A3
WO2011110683A3 PCT/EP2011/053743 EP2011053743W WO2011110683A3 WO 2011110683 A3 WO2011110683 A3 WO 2011110683A3 EP 2011053743 W EP2011053743 W EP 2011053743W WO 2011110683 A3 WO2011110683 A3 WO 2011110683A3
Authority
WO
WIPO (PCT)
Prior art keywords
glce
target
tumour therapy
tumour
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/053743
Other languages
French (fr)
Other versions
WO2011110683A2 (en
Inventor
Giancarlo Ghiselli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GLYCONOVA Srl
Original Assignee
GLYCONOVA Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GLYCONOVA Srl filed Critical GLYCONOVA Srl
Publication of WO2011110683A2 publication Critical patent/WO2011110683A2/en
Publication of WO2011110683A3 publication Critical patent/WO2011110683A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/99—Isomerases (5.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The present invention refers to the inhibition of GLCE (D-gIucuronyl-C5- epimerase) for the treatment of diseases, particularly hyperproliferative and/or infectious diseases.
PCT/EP2011/053743 2010-03-12 2011-03-11 Glce as a target for anti-tumour therapy Ceased WO2011110683A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31328410P 2010-03-12 2010-03-12
US61/313284 2010-03-12

Publications (2)

Publication Number Publication Date
WO2011110683A2 WO2011110683A2 (en) 2011-09-15
WO2011110683A3 true WO2011110683A3 (en) 2011-11-24

Family

ID=43971683

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/053743 Ceased WO2011110683A2 (en) 2010-03-12 2011-03-11 Glce as a target for anti-tumour therapy

Country Status (1)

Country Link
WO (1) WO2011110683A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046379A2 (en) * 2000-12-08 2002-06-13 Biotie Therapies Corp. Glucuronyl c5-epimerase, dna encoding the same and uses thereof
WO2010003023A2 (en) * 2008-07-01 2010-01-07 Zacharon Pharmaceuticals, Inc. Heparan sulfate inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046379A2 (en) * 2000-12-08 2002-06-13 Biotie Therapies Corp. Glucuronyl c5-epimerase, dna encoding the same and uses thereof
WO2010003023A2 (en) * 2008-07-01 2010-01-07 Zacharon Pharmaceuticals, Inc. Heparan sulfate inhibitors

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "GLCE siRNA (h): sc-90153. Datasheet", INTERNET ARTICLE, 7 February 2008 (2008-02-07), Santa Cruz, CA, USA, XP002638699, Retrieved from the Internet <URL:http://datasheets.scbt.com/sc-90153.pdf> [retrieved on 20110525] *
GHISELLI G ET AL: "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the [beta]-catenin-TCF4 pathway", BIOCHEMICAL JOURNAL 20050901 PORTLAND PRESS LTD GB, vol. 390, no. 2, 1 September 2005 (2005-09-01), pages 493 - 499, XP002638698, DOI: DOI:10.1042/BJ20050152 *
GHISELLI GIANCARLO ET AL: "D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish", BMC DEVELOPMENTAL BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 5, no. 1, 12 September 2005 (2005-09-12), pages 19, XP021001355, ISSN: 1471-213X, DOI: DOI:10.1186/1471-213X-5-19 *
GRIGORIEVA ELVIRA ET AL: "Decreased expression of human D-glucuronyl C5-epimerase in breast cancer", INTERNATIONAL JOURNAL OF CANCER, vol. 122, no. 5, March 2008 (2008-03-01), pages 1172 - 1176, XP002638703, ISSN: 0020-7136 *
LI JIN-PING ET AL: "Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 31, 1 August 2003 (2003-08-01), pages 28363 - 28366, XP002638702, ISSN: 0021-9258 *
LI J-P ET AL: "CHARACTERIZATION OF THE D-GLUCURONYL C5-EPIMERASE INVOLVED IN THE BIOSYNTHESIS OF HEPARIN AND HEPARAN SULFATE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 276, no. 23, 8 June 2001 (2001-06-08), pages 20069 - 20077, XP002902544, ISSN: 0021-9258, DOI: DOI:10.1074/JBC.M011783200 *
LOPES C C ET AL: "EJ-ras oncogene transfection of endothelial cells upregulates the expression of syndecan-4 and downregulates heparan sulfate sulfotransferases and epimerase", BIOCHIMIE, MASSON, PARIS, FR, vol. 88, no. 10, 1 October 2006 (2006-10-01), pages 1493 - 1504, XP025066414, ISSN: 0300-9084, [retrieved on 20061001], DOI: DOI:10.1016/J.BIOCHI.2006.04.009 *
PRUDNIKOVA TATIANA Y ET AL: "Antiproliferative effect of D-glucuronyl C5-epimerase in human breast cancer cells", CANCER CELL INTERNATIONAL, vol. 10, August 2010 (2010-08-01), XP002638704, ISSN: 1475-2867 *
SUGAHARA K ET AL: "Heparin and heparan sulfate biosynthesis", IUBMB LIFE, TAYLOR AND FRANCIS, LONDON, GB, vol. 54, no. 4, 1 January 2002 (2002-01-01), pages 163 - 175, XP002977758, ISSN: 1521-6543, DOI: DOI:10.1080/15216540214928 *

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Publication number Publication date
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