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WO2011037299A1 - Endoscope à capsule ayant une fonction de biopsie et procédé pour sa commande - Google Patents

Endoscope à capsule ayant une fonction de biopsie et procédé pour sa commande Download PDF

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Publication number
WO2011037299A1
WO2011037299A1 PCT/KR2009/006966 KR2009006966W WO2011037299A1 WO 2011037299 A1 WO2011037299 A1 WO 2011037299A1 KR 2009006966 W KR2009006966 W KR 2009006966W WO 2011037299 A1 WO2011037299 A1 WO 2011037299A1
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WIPO (PCT)
Prior art keywords
capsule endoscope
camera
detector
intestines
scattered light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/006966
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English (en)
Inventor
Yun Hee Ku
Yong Ju Yang
Hyun Ho Oh
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LG Electronics Inc
Original Assignee
LG Electronics Inc
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Filing date
Publication date
Application filed by LG Electronics Inc filed Critical LG Electronics Inc
Publication of WO2011037299A1 publication Critical patent/WO2011037299A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters

Definitions

  • the present disclosure relates to a capsule endoscope having biopsy function and method for controlling the same by which tissue testing can be performed using biopsy test function.
  • an endoscope is medical equipment for diagnosing or treating without surgery diseases inside a body such as an esophagus, a stomach, a small intestine, a colon, a rectum and an anus.
  • the endoscope may be inserted into an oral cavity or an anus to cause a pain of a subject according to a coelom structure, and degree of pain and test time may vary according to a technical dexterity of an endoscope operator.
  • endoscope in a field of treatment using an endoscope, is not welcome to a subject due to pain and discomfort.
  • the pain felt by a patient in using a large intestinal endoscope depends on experience and skill of an operator because the large intestinal is curved at an acute angle.
  • the present disclosure is directed to a capsule endoscope having biopsy function and method for controlling the same that substantially obviates one or more problems due to limitations and disadvantages of the related art.
  • a capsule endoscope having biopsy function comprises: a camera photographing an inside of intestines of a subject; a laser diode irradiating laser beam to a tissue inside the intestines of the subject; and a detector detecting light of particular wavelength band in Raman-scattered light of the irradiated laser beam.
  • a method for controlling a capsule endoscope having biopsy function comprises: irradiating light into intestines of a subject from at least one light source; photographing, by a camera, an inside of the intestines; irradiating, by a laser diode, laser beam to a tissue inside the intestines of the subject; and detecting, by a detector, light of a particular wavelength band in Raman-scattered light from the tissue.
  • a method for controlling a capsule endoscope having biopsy function comprises: irradiating light into intestines of a subject from at least one light source; photographing, by a camera, an inside of the intestines; analyzing an image photographed by the camera to determine whether there is any abnormal region in the intestines; irradiating, by laser, laser beam to the abnormal region in case there is an abnormal region in the intestines; and detecting, by a detector, a Raman-scattered light of particular wavelength band in the Raman-scattered light from the abnormal region.
  • the capsule endoscope according to the present disclosure can perform a tissue test without performing a biopsy for testing a resected region from a living body tissue, whereby a subject does not feel the pain caused by resection of living body, and a medical performance such as anesthesia is no longer needed.
  • FIG.1 is a schematic cross-sectional view illustrating a capsule endoscope having biopsy function according to the present disclosure.
  • FIGS.2a to 2d are schematic cross-sectional views illustrating a method for controlling a capsule endoscope having biopsy function according to the present disclosure.
  • FIG.3 is a schematic cross-sectional view illustrating a detector according to the present disclosure.
  • FIG. 4 is a schematic cross-sectional view illustrating a capsule endoscope having biopsy function according to another exemplary embodiment of the present disclosure.
  • FIGS.5a and 5b are schematic cross-sectional views illustrating a backward function of a capsule endoscope having biopsy function according to the present disclosure.
  • FIG.6 is a schematic cross-sectional view illustrating a capsule endoscope having biopsy function according to another exemplary embodiment of the present disclosure.
  • FIG.7 is a block diagram illustrating a construction of a capsule endoscope having biopsy function according to the present disclosure.
  • FIG.8 is a block diagram illustrating another construction of a capsule endoscope having biopsy function according to the present disclosure.
  • FIG.9 is a block diagram illustrating a position detection sensor disposed at a capsule endoscope having biopsy function according to the present disclosure.
  • FIG.10 is a block diagram illustrating a position detection sensor disposed at an outside device according to the present disclosure.
  • FIG.11 is a block diagram illustrating a state where radio frequency reception antennas are attached to skin of a subject according to the present disclosure.
  • FIGS.12a and 12b are pulse waveforms applied to a light source and a laser diode according to the present disclosure.
  • FIG.13 is a graph illustrating a method for diagnosing diseases using Raman-scattered light detected by a single detector according to the present disclosure.
  • FIG.14 is a schematic view illustrating a capsule endoscope having a plurality of detectors according to the present disclosure.
  • FIG.15 is a graph illustrating a method for diagnosing diseases using Raman-scattered light detected by a plurality of detectors according to the present disclosure.
  • FIG.16 is a flowchart illustrating a method for controlling a capsule endoscope having biopsy function according to the present disclosure.
  • FIG.17 is another flowchart illustrating a method for controlling a capsule endoscope having biopsy function according to the present disclosure.
  • FIG.1 is a schematic cross-sectional view illustrating a capsule endoscope having biopsy function according to the present disclosure.
  • a capsule endoscope 300 may include a camera 100 photographing an inside of intestines of a subject, a laser diode 130 irradiating laser beam to a tissue inside the intestines of the subject, and a detector 150 detecting light of particular wavelength band in Raman-scattered light of the irradiated laser beam.
  • the capsule endoscope 300 proximity-photographs a narrow-spaced inside of intestines of a subject such as an esophagus, a large intestine and a small intestine, and irradiates laser beam to a tissue inside the intestines, whereby the detector can detect light of particular wavelength band in Raman-scattered light from the tissue, and the tissue can be tested using Raman spectroscopy to diagnose diseases such as a cancer and the like.
  • the capsule endoscope according to the present disclosure can perform a tissue test without performing a biopsy for testing a resected region from a living body tissue, whereby a subject does not feel the pain caused by resection of living body, and a medical performance such as anesthesia is no longer needed.
  • the capsule endoscope may further need at least one light source for irradiating light into an inside of intestines whereby it is easier to photograph the inside of the intestines.
  • the capsule endoscope 300 uses a first light source 111 and a second light source 112 to irradiate light (a1, a2) inside the intestines, and the camera 100 to photograph the inside of the intestines.
  • the laser diode 130 irradiates laser beam (b1) to a tissue inside the intestines, and the detector 150 detects a light (b2) of a particular wavelength band in the Raman-scattered light from the tissue.
  • the camera 100, the laser diode 130, the detector 150 and the light source may be disposed at a distal end of the capsule endoscope positioned at an advancing direction of the capsule endoscope 300.
  • the capsule endoscope 300 may be mounted with a driver capable of moving forward or backward along the intestines of the subject.
  • FIGS.2a to 2d are schematic cross-sectional views illustrating a method for controlling a capsule endoscope having biopsy function according to the present disclosure.
  • the first and second light sources 111, 112 irradiate light into the intestine 200 (FIG.2a).
  • the camera 100 photographs the inside of the intestine 200 of the subject (FIG.2b).
  • the laser diode 130 irradiates laser beam to an inside tissue of the intestine 200 (FIG.2c).
  • the detector 150 detects a light of a particular wavelength band from Raman-scattered light from the tissue (FIG.2d).
  • the capsule endoscope lights up a light source to irradiate light, lights off the light source after the camera photographs the inside of the tissue, drives the laser diode to irradiate laser beam, and detects a light of a particular wavelength band from Raman scattered light using the detector to stop driving the laser beam, whereby the power consumption of the capsule endoscope can be reduced.
  • FIG.3 is a schematic cross-sectional view illustrating a detector according to the present disclosure.
  • the detector 150 detects a light of a particular wavelength band from Raman scattered light of the irradiated laser beam.
  • the detector 150 may be mounted with a photo diode 151 and a wavelength filter 152 installed at the photo diode 151 for transmitting a particular wavelength band.
  • the light Raman-scattered from laser beam-irradiated tissue is incident on the detector 150 to reach the wavelength filter 152.
  • the wavelength filter 152 At this time, only a light of allowable wavelength band (A2) out of the Raman-scattered light (A1, A2, A3) that has reached the wavelength filter 152 succeeds to transmit to reach the photo diode 151, whereby the photo diode 151 can detect only the light (A2) of a particular wavelength band.
  • the capsule endoscope according to the present disclosure dispenses with a grating for spectrum by applying a wavelength filter capable of detecting a light of a particular wavelength band.
  • FIG. 4 is a schematic cross-sectional view illustrating a capsule endoscope having biopsy function according to another exemplary embodiment of the present disclosure.
  • the capsule endoscope 300 uses the camera 100 to photograph an inside of the intestine 200 by moving along the intestine 200. Outside equipment analyzes images photographed by the camera 100, and in case there is any abnormal region 210 inside the intestine 200 as a result of the analysis by the outside equipment, the capsule endoscope 300 can test the tissue of the abnormal region.
  • the tissue test can diagnose diseases such as a cancer and the like by irradiating, by the laser diode 130, laser beam to a tissue of abnormal region 210, detecting, by the detector, a light of a particular wavelength band from Raman-scattered light from the tissue and testing the tissue using a signal based on the Raman scattered light detected by the detector 150.
  • the capsule endoscope 300 continuously moves along the intestine 200 ('B' direction), where, in case the laser diode 130 and the detector 150 are positioned at the distal end of the capsule endoscope 300, there may be cases where the laser beam cannot be irradiated on the tissue of abnormal region and cannot detect the Raman scattered light either.
  • the movement of the capsule endoscope 300 may cause the abnormal region 210 of the tissue to deviate from a laser beam irradiation region of the laser diode 130 and a detection region of the detector 150.
  • the laser diode 130 and the detector 150 of the capsule endoscope according to the present disclosure are installed at a lateral surface of the capsule endoscope 300, whereby the Raman scattered light can be detected from the tissue of abnormal region even in case the capsule endoscope 300 moves.
  • FIGS.5a and 5b are schematic cross-sectional views illustrating a backward function of a capsule endoscope having biopsy function according to the present disclosure.
  • an active locomotion control such as a driver capable of moving the capsule endoscope backward be mounted on the capsule endoscope.
  • the driving of the driver capable of moving the capsule endoscope 300 forward is stopped, and the driver capable of moving the capsule endoscope 300 backward is activated to move the capsule endoscope 300 backward in order to position the abnormal region 210 at the laser beam irradiation region of the laser diode 130 and the detection region of the detector 150, as shown in FIG.5b.
  • the position of the capsule endoscope 300 is adjusted by being moved backward from a position (L) in FIG.5a to a position in FIG.5b.
  • the operation of performing a detection of light of a particular wavelength band in the Raman scattered light from the tissue of abnormal region can be smoothly conducted by the laser diode 130 and the detector 150.
  • FIG.6 is a schematic cross-sectional view illustrating a capsule endoscope having biopsy function according to another exemplary embodiment of the present disclosure.
  • the capsule endoscope according to the exemplary embodiment of the present disclosure may further include light sources 121, 122 and a camera 101 at a lateral surface thereof.
  • the capsule endoscope finds out an abnormal region using the photographed images while moving along inside the intestines
  • the light sources 121, 122 and the camera 101 can be utilized to photograph the abnormal region again before irradiating laser on the abnormal region of the tissue, and capsule endoscope analyzes the photographed images and reconfirm whether the re-photographed images are the abnormal region or a normal region of the tissue.
  • the laser installed at the lateral surface of the capsule endoscope irradiates laser beam, and the detector 150 detects the Raman scattered light to test the tissue.
  • the existence of abnormal region can be initially determined by an image (C1) photographed by the camera 100 installed at the distal end of the forwardly-moving capsule endoscope. Thereafter, the existence of abnormal region can be secondly determined by an image (C2) photographed by the camera 101 installed at the lateral surface of the capsule endoscope.
  • FIG.7 is a block diagram illustrating a construction of a capsule endoscope having biopsy function according to the present disclosure.
  • a capsule endoscope 300 may include at least one light source 310 irradiating light to an inside of intestines of a subject, a camera 100 photographing the inside of intestines of the subject; a laser diode 130 irradiating laser beam to a tissue inside the intestines of the subject; and a detector 150 detecting light of particular wavelength band in Raman-scattered light of the irradiated laser beam.
  • the light source 310, the camera 100, the laser diode 130 and the detector 150 are all controlled and driven by a controller 350. That is, the controller 350 controllably drives the capsule endoscope 300 in a smooth manner inside the intestines of the subject.
  • the capsule endoscope according to the exemplary embodiment of the present invention may include an embedded power source such as a battery for driving the capsule endoscope, or may be driven by an external magnetic field.
  • FIG.8 is a block diagram illustrating another construction of a capsule endoscope having biopsy function according to the present disclosure.
  • the capsule endoscope according to another construction of the present disclosure may further include a radio frequency (RF) transmitter 360 capable of performing a wireless communication with an RF receiver of an external device 500 located outside of a subject.
  • RF radio frequency
  • the controller 350 may output to the RF transmitter 360 an image signal photographed by a camera 320 and a signal based on the Raman scattered light of a particular wavelength band detected by the detector 150.
  • the RF transmitter 360 may transmit to an RF receiver 510 of the external device 500 an RF of an image signal photographed by the camera 320 and an RF based on the Raman-scattered light of a particular wavelength band detected by the detector 150.
  • the external device 500 may determine using the RF of image signal photographed by the camera 320 received from the RF transmitter 360 whether there is any abnormal region in the intestines of a subject, and determine using an RF based on Raman scattered light of a particular wavelength band detected by the detector 150 whether there is any disease such as a cancer on a tissue.
  • the external device 500 may perform functions such as image signal and Raman scattered light analyzing function and memory storage function.
  • FIG.9 is a block diagram illustrating a position detection sensor disposed at a capsule endoscope having biopsy function according to the present disclosure.
  • the capsule endoscope moves along the inside of intestines of a subject to continuously photograph the inside of the intestines, and detects the Raman scattered light of laser beam from a tissue of an abnormal region.
  • the present disclosure be disposed with a position detection sensor 370 capable of detecting a position when the capsule endoscope moves along.
  • the position detection sensor 370 serves to detect position changes as the capsule endoscope moves along, where it is preferable that a gyro sensor and/or an acceleration speed sensor be mounted.
  • the position detection sensor 370 mounted on the capsule endoscope 300 serves to detect a position of the capsule endoscope 300, output a signal of the position of the capsule endoscope 300 to the controller 350, where the controller 350 outputs to the RF transmitter 360 a signal about the position of the capsule endoscope 300.
  • the RF transmitter 360 to the RF receiver 510 of the external device 500 an RF (S1) of an image signal photographed by the camera 320, an RF (S2) of a signal relative to the Raman scattered light of a particular wavelength band detected by the detector 150, and an RF (S3) of a signal about the position of the capsule endoscope 300.
  • the external device 500 can identify the position of the capsule endoscope 300 using the RF (S3) of a signal about the position of the capsule endoscope 300 received from the RF receiver 510.
  • FIG.10 is a block diagram illustrating a position detection sensor disposed at an outside device according to the present disclosure.
  • the external device 500 may be mounted with a sensor capable of sensing the position of the capsule endoscope 300, where in a case the capsule endoscope 300 is not available therein with a position detection sensor, the RF transmitter 360 transmits to the RF receiver 510 of the external device 500 only the RF (S1) of an image signal photographed by the camera 320 and the RF (S2) of a signal about the Raman scattered light of a particular wavelength band detected by the detector 150. Thereafter, the position detection of the capsule endoscope 300 is taken care of the external device 500.
  • configuration and method for detecting the position of the capsule endoscope 300 by the external device 500 may vary.
  • the position detection may be effected by triangulation.
  • FIG.11 is a block diagram illustrating a state where radio frequency reception antennas are attached to skin of a subject according to the present disclosure.
  • a plurality of RF reception antennas (511 ⁇ 519) is attached to a skin of a subject 600. At this time, a triangle should be formed by three antennas.
  • the plurality of antennas (511 ⁇ 519) may be included in the RF receiver mounted on the external device.
  • FIG. 11 illustrates a state where nine antennas are attached to a skin of a subject 600, where three antennas of the first to ninth RF reception antennas (511 ⁇ 519) attached to the skin of the subject form a triangle.
  • each of the plurality of RF reception antennas (511 ⁇ 519) senses the RF of the image signal that has photographed the inside of the intestines and the RF of the signal that has detected the Raman scattered light from the tissue.
  • the capsule endoscope 300 exists in a triangle formed by the second RF reception antenna 512, the third RF reception antenna 513 and the fifth RF reception antenna 515.
  • parameters ⁇ i.e., each distance to the capsule endoscope in each antenna (512, 513, 515) ⁇ relative to reception strength of each RF of the antennas (512, 513, 515) and equivalent position detection parameters may be used to determine the position of the capsule endoscope.
  • FIGS.12a and 12b are pulse waveforms applied to a light source and a laser diode according to the present disclosure, where FIG.12a illustrates a pulse waveform applied to a light emitting diode (LED) light source in which the diode is lit up at a sine wave pulse (K1), and FIG.12b illustrates a pulse waveform applied to a laser diode, in which 'K2' sine waveform pulse is located in the 'K1' sine waveform to light up the laser diode.
  • the light source and the laser diode are designed to sequentially lit up, whereby the power consumption can be reduced.
  • FIG.13 is a graph illustrating a method for diagnosing diseases using Raman-scattered light detected by a single detector according to the present disclosure.
  • the laser beam irradiated from the laser diode is Raman scattered on a tissue of intestines of a subject, and only a particular wavelength band in the Raman scattered light is detected by the detector.
  • the detector may be formed in a singular manner or in a plural manner, where a single detector detects only a peak of a single wavelength band.
  • the detector is preferred to be formed with a wavelength filter and a photo diode.
  • an allowable wavelength band penetrable by the wavelength filter is the one having a peak of 'D1' in FIG.13, whether there is a disease or not is determined by comparison between a wavelength band of a detected Raman scattered light having a 'D3' peak and a wavelength band of a detected Raman scattered light having a 'D2' peak of normal tissue
  • the capsule endoscope having biopsy function may select as a wavelength filter of the detector a wavelength filter corresponding to a wavelength band where there is a big spectrum difference between Raman scattered light of a healthy tissue and that of a cancer tissue.
  • the wavelength bands where there is a big spectrum difference between Raman scattered light of a healthy tissue and that of a cancer tissue are 843nm, 867nm, 886nm and 902nm, such that the wavelength filter of the detector may select as its wavelength filter a wavelength filter capable of transmitting Raman scattered light of any one wavelength of 843nm, 867nm, 886nm and 902nm.
  • FIG.14 is a schematic view illustrating a capsule endoscope having a plurality of detectors according to the present disclosure.
  • the tissue of abnormal region 210 is irradiated by laser beam where the detector detects a Raman scattered light from the tissue.
  • the detector may be configured in the plural form, and as shown in FIG.14, 4 detectors (151a, 152a) (151b, 152b) (151c, 152c) (151d, 152d) may be arranged about the laser diode 130.
  • Each of the 4 detectors (151a, 152a) (151b, 152b) (151c, 152c) (151d, 152d) is disposed with a wavelength filter (151a, 151b, 151c, 151d), where each of the wavelength filters (151a, 151b, 151c, 151d) has a different allowable wavelength band through which the Raman scattered light can transmit. That is, each of the wavelength filters (151a, 151b, 151c, 151d) allows Raman scattered light of mutually different wavelength bands to transmit.
  • FIG.15 is a graph illustrating a method for diagnosing diseases using Raman-scattered light detected by a plurality of detectors according to the present disclosure.
  • the plurality of detectors is so configured as to allow Raman scattered light of mutually different wavelength bands to transmit.
  • a first detector can detect a first wavelength band( ⁇ 1) having a 'D1a' peak
  • a second detector can detect a first wavelength band( ⁇ 2) having a 'D1b' peak
  • a third detector can detect a first wavelength band( ⁇ 3) having a 'D1c' peak.
  • the first detector has detected a Raman scattered light having 'D3a' peak
  • the detected Raman scattered light of 'D3a' peak and a Raman scattered light of 'D2a' peak in normal tissue are compared
  • the second detector has detected a Raman scattered light having 'D3b' peak
  • the detected Raman scattered light of 'D3b' peak and a Raman scattered light of 'D2b' peak in normal tissue are compared
  • the third detector has detected a Raman scattered light having 'D3c' peak
  • the detected Raman scattered light of 'D3c' peak and a Raman scattered light of 'D2c' peak in normal tissue are compared.
  • the capsule endoscope according to the present disclosure can diagnose a disease by way of the detected scatter intensity or scatter intensity ratio.
  • FIG.16 is a flowchart illustrating a method for controlling a capsule endoscope having biopsy function according to the present disclosure.
  • a light source is turned on (S110), and a camera photographs the inside of the intestine (S120).
  • a further step is performed in which the RF of an image signal photographed by the camera and the RF of a signal based on Raman scattered light of a particular wavelength band detected by the detector are transmitted from the external device of the RF transmitter to the RF receiver.
  • the capsule endoscope can test a tissue of an abnormal region inside the intestine. That is, in case the capsule endoscope reaches the intestine of a subject, the light source is turned on (S210) and the camera photographs the inside of the intestine (S220).
  • the images photographed by the camera are analyzed to determine whether there is any region of abnormal state (S230), where the determination of whether there is any abnormalcy in the intestine may be taken care of by the controller of the capsule endoscope, or by the external device.
  • the laser irradiates laser beam to the abnormal tissue (S240). Then, the detector detects a Raman scattered light of a particular wavelength band in the Raman scattered light from the tissue of the abnormal region.
  • This present disclosure may be applied to the capsule endoscope.

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Abstract

La présente invention porte sur un endoscope à capsule ayant une fonction de biopsie et sur un procédé pour sa commande, le endoscope à capsule comprenant : une caméra photographiant un intérieur d'intestins d'un sujet ; une diode de laser rayonnant un faisceau de laser vers un tissu à l'intérieur des intestins du sujet ; et un détecteur détectant de la lumière à une bande de longueur d'onde particulière dans une lumière à dispersion de Raman du faisceau de laser rayonné.
PCT/KR2009/006966 2009-09-28 2009-11-25 Endoscope à capsule ayant une fonction de biopsie et procédé pour sa commande Ceased WO2011037299A1 (fr)

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KR1020090091738A KR20110034265A (ko) 2009-09-28 2009-09-28 생체 검사 기능을 갖는 캡슐 내시경 및 그 제어방법
KR10-2009-0091738 2009-09-28

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Cited By (6)

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WO2015086629A1 (fr) * 2013-12-11 2015-06-18 Leoni Kabel Holding Gmbh Sonde à laser médicale
CN105208914A (zh) * 2012-12-20 2015-12-30 通用医疗公司 用至少一个胶囊来提供图像导引的体内活检的设备、系统和方法
US10130802B2 (en) 2012-11-01 2018-11-20 Catholic University Industry Academic Cooperation Foundation Capsule endoscope for photodynamic and sonodynamic therapy
CN112472008A (zh) * 2020-11-02 2021-03-12 重庆金山医疗器械有限公司 一种ph胶囊定位装置、方法、设备及可读存储介质
CN117958730A (zh) * 2024-02-04 2024-05-03 上海交通大学 一种基于白光辅助拉曼信号检测的胶囊内窥镜系统
US12053271B2 (en) 2014-09-25 2024-08-06 Biora Therapeutics, Inc. Electromechanical pill device with localization capabilities

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KR20250068803A (ko) 2023-11-09 2025-05-19 장종환 광치료용 바이오 캡슐, 이를 위한 의료 시스템과 처방 유통 시스템, 및 이를 이용한 비-인간 동물의 치료방법

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