WO2011027282A1 - Fibre optic light delivery device with a glass fibre and a plastic fibre at its distal part - Google Patents
Fibre optic light delivery device with a glass fibre and a plastic fibre at its distal part Download PDFInfo
- Publication number
- WO2011027282A1 WO2011027282A1 PCT/IB2010/053880 IB2010053880W WO2011027282A1 WO 2011027282 A1 WO2011027282 A1 WO 2011027282A1 IB 2010053880 W IB2010053880 W IB 2010053880W WO 2011027282 A1 WO2011027282 A1 WO 2011027282A1
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- Prior art keywords
- fibre
- distal part
- plastic
- fiber
- light
- Prior art date
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
- G02B6/0005—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type
- G02B6/0008—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type the light being emitted at the end of the fibre
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/241—Light guide terminations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2205—Characteristics of fibres
- A61B2018/2222—Fibre material or composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2255—Optical elements at the distal end of probe tips
- A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
Definitions
- the present invention relates to apparatuses for transmitting and diffusing light for delivery to a target site to be illuminated, heated, irradiated, or treated by exposure to light.
- the present invention relates to the delivery of light to a body lumen or body cavity for photodynamic therapy of atherosclerosis, 10 malignant or benign tumor tissue, cancerous cells and other medical treatments.
- Photodynamic Therapy is a known method of treating target regions or 5 sites, such as tumors, atheromatous plaques and other tissues, in humans by administering a photosensitizing substance to a patient and allowing it to concentrate preferentially in the target sites. It has been found that certain abnormal growths, such as certain cancerous tissue and atheromatous plaque, have an affinity for these photosensitizing agents.
- Photosensitizing agents are 0 compounds that, when exposed to light, or light of a particular wavelength or wavelengths, create 0 2 radicals which react with the target cells. Examples of such agents include texaphyrins, hematoporphyrin, chlorins, and purpurins.
- an appropriate photosensitizing agent is used to create the 0 2 radicals which kill the target cells.
- an appropriate photosensitizing agent is activated to destroy the plaque by lysis (breaking up) of such plaque.
- Mechanisms other than lysis, e.g. cell apoptosis, may also be involved.
- 0 Photoactivation of the photosensitizer is achieved by locally delivering light to the target region, preferably in a manner which achieves an optimum "dose" and emission configuration which is consistent with the volume and geometry of the target tissue. This may be accomplished through the use of light delivery systems which utilize optical fibers.
- an optical fiber may be equipped with an apparatus at its tip which disperses light propagating along the fiber in a uniform cylindrical pattern with respect to the central axis of the optical fiber. Uniformity is usually desired to ensure delivering a known and optimum dose.
- a number of diffuser tip designs have been developed to produce a controlled and generally uniform profile of illumination.
- One approach ('radial coupling') which is illustrated in Fig.
- a distal segment of the waveguide typically an optical fiber. Such modifications include etching the fiber cladding or creating fiber gratings within the fiber core.
- Another approach ('frontal coupling') which is illustrated in Fig. 1 b, involves launching light from the distal end of a waveguide into a diffuser tip containing scattering medium, wherein the light is launched in a primarily axial direction and is distributed radially outward by the optical scattering medium. Both approaches can be based either on glass optical fiber or plastic optical fiber. When a high flexibility of the catheter is necessary, the first approach, the 'radial coupling', using the plastic optical fiber, is an appropriated practical option.
- plastic makes possible etching the fiber cladding or other material modifications inducing change of the transmission of the fiber at the diffusing tip, without risk of fragility of the modified part.
- plastic optical fiber shows much better flexibility property than glass fiber.
- the product a cylindrical light diffuser, model RD, is used for standard PDT treatment protocol of the cholangiocarcinoma where a high bending of the catheter is required at the entrance of the biliary duct (see Fig. 2) and also all along the hepatic ducts in order to guide the diffusing tip in the specific intrahepatic branches to be treated.
- the other cylindrical light diffuser presently on the market are based on glass optical fiber and 'frontal coupling' approach. There are stiff and show high probability of breakage especially at the interface between the glass optical fiber and the diffusing scattering tip as it is shown by Todd H. Baron in Editorial of Clinical Gastroenterology and Hepatology, 2008, 6, 266-267. Such a breakage occurs during the introduction of the catheter in the patient and can induce, during the treatment, a serious change of the light intensity and distribution along the diffusing tip. Such a breakage and change are usually not detectable by simple visual inspection by the physician during or after the treatment. Consequently their medical outcomes are difficult to avoid. Moreover, because of their stiffness, treatment is generally limited to the main hepatic ducts since the fiber does not bend around corners to reach intrahepatic branches.
- Plastic fibers may therefore appear to be the best candidates. Unfortunately they show a high variation in light transmission property, this parameter is a function of the wavelength (see Fig. 3). For light delivery between 630 nm and 710 nm, corresponding to the excitation wavelengths of PDT photosensitizing agents presently commercialized, the transmission is acceptable (typ. > 70%) for appropriated catheter length (2-3 meters long). However, for new photosensitizing agents, with the excitation wavelengths between 710 and 800 nm, the design based on the plastic optical fiber does not appear applicable, the transmission of the plastic fiber being too low at these wavelengths.
- cylindrical light diffuser with an acceptable light transmission property (typ. > 70%) at all of the wavelengths of interest and which can be used in organs where high bending capability is required during the positioning of the diffuser tip and this without risk of breakage.
- the present invention aims, in particular, to alleviate the aforementioned problems.
- a medical cylindrical light delivery device for the irradiation of biological tissues within the context of photodynamic treatment, this device comprising a proximal part made of a glass fiber and a distal part made of a plastic fiber, said distal part comprising a diffusing tip which is adapted to provide a radial emission of the light and both fibers being connected by frontal coupling.
- FIG. 1a illustrates the radial coupling approach as known from the prior art.
- FIG. 1 b illustrates the frontal coupling approach as known from the prior art.
- FIG. 2 is a radioscopic view of a biliary duct showing a cylindrical light diffuser according to the prior art.
- the angle ⁇ is perennial to 50 degrees.
- FIG. 3 shows the transmission of a plastic optical fiber according to the prior art as a function of the wavelength for different fiber lengths.
- FIG.4 illustrates a light delivery device according to the present invention.
- List of numerical reference used in the figures :
- Waveguide optical fiber
- the present invention combines the 2 design approaches, radial and frontal coupling, and the 2 optical fiber technologies, glass and plastic fiber.
- the first part of the device is based on a glass optical fiber, with its good transmission properties but low flexibility. It transmits the light from the light source to the proximity of the treatment site.
- the light is launched in a plastic optical fiber section whose the extremity, the diffusing tip, is modified, including etching the fiber cladding or creating fiber gratings within the fiber core, in order to obtain controlled radial emission along the diffusing tip.
- the length of the plastic fiber section, corresponding to the high flexible part of the device is selected as short as possible (typ.
- the cylindrical light diffuser shows suitable flexibility property where is required and the interface between the glass and the plastic fiber is never submitted to mechanical strain.
- the length of the flexible section can be optimized as a function of the application (treatment site geometry and protocol).
- the length of the proximal part of the device according to the invention is comprised between 25 cm and 4 meters.
- the length of the distal part of the device according to the invention is comprised between 2 cm and 2 meters.
- the length of the distal part is preferably comprised between 25 cm and 50 cm.
- the length ratio between said proximal part and said distal part is comprised between 0.125 and 200.
- Example of design Cylindrical light diffuser for illumination of the hepatic ducts.
- the extremity of a standard gastroscope is positioned at the entrance of the biliary duct (see Fig. 2).
- a standard ERCP catheter catheter of opacification
- the cylindrical light diffuser is positioned in the ERCP catheter with the diffusing tip in front of the lesion to be treated.
- the illumination is performed through the wall of the ERCP catheter.
- a 25-50 cm length for the flexible section based on plastic fiber is suitable.
- the transmission of the device is higher than 70% for the wavelength range of interest in PDT, 630-800 nm, and the flexible part is long enough to cover all of the section of the ERCP catheter where stiffness and fragility are critical (from the entrance of the biliary duct).
- the interface between the glass and plastic optical fiber is, all over the treatment, protected in the working channel of the scope, with low bending risk.
- the length of the flexible part based on plastic fiber could be longer or shorter. In some applications, it could be as short as the diffusing tip.
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- Physics & Mathematics (AREA)
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
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Abstract
A medical cylindrical light delivery device for the irradiation of biological tissues within the context of photodynamic treatment, this device comprising a proximal part made of a glass fiber (10) and a distal part made of a plastic fiber (12), said distal part comprising a diffusing tip (13) which is adapted to provide a radial emission of the light and both fibers being connected by frontal coupling (11).
Description
FIBRE OPTIC LIGHT DELIVERY DEVICE WITH A GLASS FIBRE AND A PLASTIC FIBRE AT ITS DISTAL PART
Field of the invention
5
The present invention relates to apparatuses for transmitting and diffusing light for delivery to a target site to be illuminated, heated, irradiated, or treated by exposure to light. Particularly, the present invention relates to the delivery of light to a body lumen or body cavity for photodynamic therapy of atherosclerosis, 10 malignant or benign tumor tissue, cancerous cells and other medical treatments.
State of the art
Photodynamic Therapy (PDT) is a known method of treating target regions or 5 sites, such as tumors, atheromatous plaques and other tissues, in humans by administering a photosensitizing substance to a patient and allowing it to concentrate preferentially in the target sites. It has been found that certain abnormal growths, such as certain cancerous tissue and atheromatous plaque, have an affinity for these photosensitizing agents. Photosensitizing agents are 0 compounds that, when exposed to light, or light of a particular wavelength or wavelengths, create 02 radicals which react with the target cells. Examples of such agents include texaphyrins, hematoporphyrin, chlorins, and purpurins. In the case of living cells, such as cancer tumors, an appropriate photosensitizing agent is used to create the 02 radicals which kill the target cells. In other situations, 5 such as when it is desired to destroy atheromatous plaque tissue, an appropriate photosensitizing agent is activated to destroy the plaque by lysis (breaking up) of such plaque. Mechanisms other than lysis, e.g. cell apoptosis, may also be involved. 0 Photoactivation of the photosensitizer is achieved by locally delivering light to the target region, preferably in a manner which achieves an optimum "dose" and emission configuration which is consistent with the volume and geometry of the
target tissue. This may be accomplished through the use of light delivery systems which utilize optical fibers. For example, for tubular body areas and lumens, such as a bronchus, esophagus or biliary duct, it is common to use a fiber optic diffuser which distributes the light in a cylindrical pattern. Thus, for PDT treatment of esophageal cancer, an optical fiber may be equipped with an apparatus at its tip which disperses light propagating along the fiber in a uniform cylindrical pattern with respect to the central axis of the optical fiber. Uniformity is usually desired to ensure delivering a known and optimum dose. A number of diffuser tip designs have been developed to produce a controlled and generally uniform profile of illumination. One approach ('radial coupling') which is illustrated in Fig. 1a, involves modifying a distal segment of the waveguide, typically an optical fiber. Such modifications include etching the fiber cladding or creating fiber gratings within the fiber core. Another approach ('frontal coupling') which is illustrated in Fig. 1 b, involves launching light from the distal end of a waveguide into a diffuser tip containing scattering medium, wherein the light is launched in a primarily axial direction and is distributed radially outward by the optical scattering medium. Both approaches can be based either on glass optical fiber or plastic optical fiber. When a high flexibility of the catheter is necessary, the first approach, the 'radial coupling', using the plastic optical fiber, is an appropriated practical option. Indeed, plastic makes possible etching the fiber cladding or other material modifications inducing change of the transmission of the fiber at the diffusing tip, without risk of fragility of the modified part. Moreover, plastic optical fiber shows much better flexibility property than glass fiber. Finally, in the radial coupling approach, there is no discontinuity between the waveguide and the diffusing tip itself where strain could concentrate when bending is requested and where coupling properties could be consequently changed under this bending condition, with for instance strong decrease of the light coupling efficiency between the waveguide and the diffusing tip (unwanted lost of light at the interface).
A cylindrical light diffuser based on the radial coupling approach and plastic fiber is proposed by Medlight SA (Switzerland) and is described in the patent EP 0935485. The product, a cylindrical light diffuser, model RD, is used for standard PDT treatment protocol of the cholangiocarcinoma where a high bending of the catheter is required at the entrance of the biliary duct (see Fig. 2) and also all along the hepatic ducts in order to guide the diffusing tip in the specific intrahepatic branches to be treated.
The other cylindrical light diffuser presently on the market are based on glass optical fiber and 'frontal coupling' approach. There are stiff and show high probability of breakage especially at the interface between the glass optical fiber and the diffusing scattering tip as it is shown by Todd H. Baron in Editorial of Clinical Gastroenterology and Hepatology, 2008, 6, 266-267. Such a breakage occurs during the introduction of the catheter in the patient and can induce, during the treatment, a serious change of the light intensity and distribution along the diffusing tip. Such a breakage and change are usually not detectable by simple visual inspection by the physician during or after the treatment. Consequently their medical outcomes are difficult to avoid. Moreover, because of their stiffness, treatment is generally limited to the main hepatic ducts since the fiber does not bend around corners to reach intrahepatic branches.
Plastic fibers may therefore appear to be the best candidates. Unfortunately they show a high variation in light transmission property, this parameter is a function of the wavelength (see Fig. 3). For light delivery between 630 nm and 710 nm, corresponding to the excitation wavelengths of PDT photosensitizing agents presently commercialized, the transmission is acceptable (typ. > 70%) for appropriated catheter length (2-3 meters long). However, for new photosensitizing agents, with the excitation wavelengths between 710 and 800 nm, the design based on the plastic optical fiber does not appear applicable, the transmission of the plastic fiber being too low at these wavelengths.
For these reasons it would be desirable to provide a cylindrical light diffuser with an acceptable light transmission property (typ. > 70%) at all of the wavelengths of
interest and which can be used in organs where high bending capability is required during the positioning of the diffuser tip and this without risk of breakage.
General description of the invention
The present invention aims, in particular, to alleviate the aforementioned problems.
It relates to a medical cylindrical light delivery device for the irradiation of biological tissues within the context of photodynamic treatment, this device comprising a proximal part made of a glass fiber and a distal part made of a plastic fiber, said distal part comprising a diffusing tip which is adapted to provide a radial emission of the light and both fibers being connected by frontal coupling. Detailed description of the invention
The invention will be better understood hereinafter by means of a detailed description and of non-limiting examples illustrated by figures. Brief description of the Figures
FIG. 1a illustrates the radial coupling approach as known from the prior art.
FIG. 1 b illustrates the frontal coupling approach as known from the prior art. FIG. 2 is a radioscopic view of a biliary duct showing a cylindrical light diffuser according to the prior art. The angle Θ is egal to 50 degrees.
FIG. 3 shows the transmission of a plastic optical fiber according to the prior art as a function of the wavelength for different fiber lengths.
FIG.4 illustrates a light delivery device according to the present invention.
List of numerical reference used in the figures :
1. Waveguide (optical fiber)
2. Diffuser tip
3. Light beam
4. Scattering medium
5. Gastroscope
6. Entrance of the biliary duct
7. Biliary duct
8. Distal illumination length of the cylindrical light diffuser defined by 2
radiomarker bands
9. Optical connector
10. Glass fiber
11. Frontal coupling between glass fiber and plastic fiber
12. Plastic fiber
13. Diffusing tip
The present invention combines the 2 design approaches, radial and frontal coupling, and the 2 optical fiber technologies, glass and plastic fiber. As showing by Fig. 4, the first part of the device is based on a glass optical fiber, with its good transmission properties but low flexibility. It transmits the light from the light source to the proximity of the treatment site. At the distal end of this first part, the light is launched in a plastic optical fiber section whose the extremity, the diffusing tip, is modified, including etching the fiber cladding or creating fiber gratings within the fiber core, in order to obtain controlled radial emission along the diffusing tip. The length of the plastic fiber section, corresponding to the high flexible part of the device, is selected as short as possible (typ. < 2 meters), in order to optimize the overall transmission of the device, but must be long enough to cover all of the sites to be gone through and to be illuminated and which require high flexibility of the device. Under this condition, the cylindrical light diffuser shows suitable flexibility property where is required and the interface between the glass and the plastic fiber is never submitted to mechanical strain. The length of the flexible
section can be optimized as a function of the application (treatment site geometry and protocol).
The length of the proximal part of the device according to the invention is comprised between 25 cm and 4 meters.
The length of the distal part of the device according to the invention is comprised between 2 cm and 2 meters. The length of the distal part is preferably comprised between 25 cm and 50 cm.
The length ratio between said proximal part and said distal part is comprised between 0.125 and 200.
Example of design: Cylindrical light diffuser for illumination of the hepatic ducts.
In presently validated PDT protocols of the biliary duct, the extremity of a standard gastroscope is positioned at the entrance of the biliary duct (see Fig. 2). Passing through the working channel of the scope, a standard ERCP catheter (catheter of opacification) is introduced in the biliary duct under guide wire guidance. After removing of the guide wire, the cylindrical light diffuser is positioned in the ERCP catheter with the diffusing tip in front of the lesion to be treated. The illumination is performed through the wall of the ERCP catheter. In this medical application, a 25-50 cm length for the flexible section based on plastic fiber is suitable. With this length, the transmission of the device is higher than 70% for the wavelength range of interest in PDT, 630-800 nm, and the flexible part is long enough to cover all of the section of the ERCP catheter where stiffness and fragility are critical (from the entrance of the biliary duct). With this length, the interface between the glass and plastic optical fiber, is, all over the treatment, protected in the working channel of the scope, with low bending risk.
For another application, the length of the flexible part based on plastic fiber could be longer or shorter. In some applications, it could be as short as the diffusing tip.
It goes without saying that the invention is not limited to the illustrated examples disclosed above.
Claims
1. A medical cylindrical light delivery device for the irradiation of biological tissues within the context of photodynamic treatment, this device comprising a proximal part made of a glass fiber (10) and a distal part made of a plastic fiber (12), said distal part comprising a diffusing tip (13) which is adapted to provide a radial emission of the light and both fibers being connected by frontal coupling (11).
2. The device according to claim 1 characterized in that the length of said proximal part is comprised between 25 cm and 4 meters.
3. The device according to one of the previous claims characterized in that the length of said distal part is comprised between 2 cm and 2 meters.
4. The device according to claim 3 characterized in that the length of said distal part is comprised between 25 cm and 50 cm.
5. The device according to one of the previous claims characterized in that the length ratio between said proximal part and said distal part is comprised between 0.125 and 200.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2009053876 | 2009-09-04 | ||
| IBPCT/IB2009/053876 | 2009-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2011027282A1 true WO2011027282A1 (en) | 2011-03-10 |
Family
ID=43500331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2010/053880 Ceased WO2011027282A1 (en) | 2009-09-04 | 2010-08-30 | Fibre optic light delivery device with a glass fibre and a plastic fibre at its distal part |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2011027282A1 (en) |
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|---|---|---|---|---|
| WO2015142623A1 (en) * | 2014-03-18 | 2015-09-24 | Boston Scientific Scimed, Inc. | Pressure sensing guidewires |
| US9429713B2 (en) | 2014-04-17 | 2016-08-30 | Boston Scientific Scimed, Inc. | Self-cleaning optical connector |
| US9775523B2 (en) | 2013-10-14 | 2017-10-03 | Boston Scientific Scimed, Inc. | Pressure sensing guidewire and methods for calculating fractional flow reserve |
| US9782129B2 (en) | 2014-08-01 | 2017-10-10 | Boston Scientific Scimed, Inc. | Pressure sensing guidewires |
| US9795307B2 (en) | 2014-12-05 | 2017-10-24 | Boston Scientific Scimed, Inc. | Pressure sensing guidewires |
| US10028666B2 (en) | 2013-03-15 | 2018-07-24 | Boston Scientific Scimed, Inc. | Pressure sensing guidewire |
| US10278594B2 (en) | 2014-06-04 | 2019-05-07 | Boston Scientific Scimed, Inc. | Pressure sensing guidewire systems with reduced pressure offsets |
| US10499820B2 (en) | 2013-05-22 | 2019-12-10 | Boston Scientific Scimed, Inc. | Pressure sensing guidewire systems including an optical connector cable |
| US10582860B2 (en) | 2012-08-27 | 2020-03-10 | Boston Scientific Scimed, Inc. | Pressure-sensing medical devices and medical device systems |
| US10702162B2 (en) | 2010-11-09 | 2020-07-07 | Opsens Inc. | Guidewire with internal pressure sensor |
| US10835182B2 (en) | 2013-08-14 | 2020-11-17 | Boston Scientific Scimed, Inc. | Medical device systems including an optical fiber with a tapered core |
| US11058307B2 (en) | 2016-02-23 | 2021-07-13 | Boston Scientific Scimed, Inc. | Pressure sensing guidewire systems including an optical connector cable |
| US11076765B2 (en) | 2013-07-26 | 2021-08-03 | Boston Scientific Scimed, Inc. | FFR sensor head design that minimizes stress induced pressure offsets |
| US11311196B2 (en) | 2018-02-23 | 2022-04-26 | Boston Scientific Scimed, Inc. | Methods for assessing a vessel with sequential physiological measurements |
| US11559213B2 (en) | 2018-04-06 | 2023-01-24 | Boston Scientific Scimed, Inc. | Medical device with pressure sensor |
| US11564581B2 (en) | 2017-08-03 | 2023-01-31 | Boston Scientific Scimed, Inc. | Methods for assessing fractional flow reserve |
| US11666232B2 (en) | 2018-04-18 | 2023-06-06 | Boston Scientific Scimed, Inc. | Methods for assessing a vessel with sequential physiological measurements |
| US11850073B2 (en) | 2018-03-23 | 2023-12-26 | Boston Scientific Scimed, Inc. | Medical device with pressure sensor |
| US12087000B2 (en) | 2021-03-05 | 2024-09-10 | Boston Scientific Scimed, Inc. | Systems and methods for vascular image co-registration |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018715A1 (en) * | 1992-03-20 | 1993-09-30 | The General Hospital Corporation | Laser illuminator |
| EP0935485A1 (en) | 1997-09-04 | 1999-08-18 | Medlight S.A. | Light diffusing device for photodynamic treatment of organs |
| WO2007127894A2 (en) * | 2006-04-28 | 2007-11-08 | Ondine International Ltd. | Photodisinfection delivery devices & methods |
| EP1949877A1 (en) * | 2007-01-23 | 2008-07-30 | Alcon, Inc. | Thermally robust illuminator probe |
| US20080269845A1 (en) * | 2007-04-27 | 2008-10-30 | Ondine International, Ltd. | Waveguide connection device |
-
2010
- 2010-08-30 WO PCT/IB2010/053880 patent/WO2011027282A1/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018715A1 (en) * | 1992-03-20 | 1993-09-30 | The General Hospital Corporation | Laser illuminator |
| EP0935485A1 (en) | 1997-09-04 | 1999-08-18 | Medlight S.A. | Light diffusing device for photodynamic treatment of organs |
| EP0935485B1 (en) * | 1997-09-04 | 2005-08-17 | Medlight S.A. | Light diffusing device for photodynamic treatment of organs |
| WO2007127894A2 (en) * | 2006-04-28 | 2007-11-08 | Ondine International Ltd. | Photodisinfection delivery devices & methods |
| EP1949877A1 (en) * | 2007-01-23 | 2008-07-30 | Alcon, Inc. | Thermally robust illuminator probe |
| US20080269845A1 (en) * | 2007-04-27 | 2008-10-30 | Ondine International, Ltd. | Waveguide connection device |
Non-Patent Citations (3)
| Title |
|---|
| HUDSON E J ET AL: "The development of radio-opaque, isotropic, fibre-optic probes for light dosimetry studies in photodynamic therapy", PHYSICS IN MEDICINE AND BIOLOGY, TAYLOR AND FRANCIS LTD. LONDON, GB, vol. 38, no. 10, 1 October 1993 (1993-10-01), pages 1529 - 1536, XP002285621, ISSN: 0031-9155, DOI: DOI:10.1088/0031-9155/38/10/013 * |
| TODD H. BARON ET AL: "Photodynamic Therapy: Standard of Care for Palliation of Cholangiocarcinoma?", CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, AMERICAN GASTROENTEROLOGICAL ASSOCIATION, US, vol. 6, no. 3, 5 March 2008 (2008-03-05), pages 266 - 267, XP022549201, ISSN: 1542-3565 * |
| TODD H. BARON, EDITORIAL OF CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, vol. 6, 2008, pages 266 - 267 |
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