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WO2011026202A1 - Procédé d'obtention de produits de tabac contenant des substances antioxydantes et produit ainsi obtenu - Google Patents

Procédé d'obtention de produits de tabac contenant des substances antioxydantes et produit ainsi obtenu Download PDF

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Publication number
WO2011026202A1
WO2011026202A1 PCT/BR2009/000274 BR2009000274W WO2011026202A1 WO 2011026202 A1 WO2011026202 A1 WO 2011026202A1 BR 2009000274 W BR2009000274 W BR 2009000274W WO 2011026202 A1 WO2011026202 A1 WO 2011026202A1
Authority
WO
WIPO (PCT)
Prior art keywords
lyophilisate
cigarillos
tobacco
euterpe oleracea
fruits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR2009/000274
Other languages
English (en)
Portuguese (pt)
Inventor
Roberto Soares De Moura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO - UERJ
Original Assignee
UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO - UERJ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO - UERJ filed Critical UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO - UERJ
Priority to PCT/BR2009/000274 priority Critical patent/WO2011026202A1/fr
Publication of WO2011026202A1 publication Critical patent/WO2011026202A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
    • A24B15/303—Plant extracts other than tobacco

Definitions

  • the present invention relates to a process for producing tobacco products for use in cigarettes, cigarillos, cigars and / or tobacco smoke, containing antioxidants derived from polyphenol-rich plants, more precisely plants such as Euterpe oleracea (aça ⁇ ). More particularly the production of tobacco products containing antioxidants with lower potential for inducing lung injury such as chronic obstructive pulmonary disease (COPD) and other diseases such as malignant, cardiovascular and immune system, for example, diseases caused by cigarette smoke , cigarillos and / or cigars, smoke that is responsible for the production and release of pro-oxidants and / or free radicals derived from oxygen and nitrogen, which play an important role in the pathophysiology of those diseases.
  • COPD chronic obstructive pulmonary disease
  • other diseases such as malignant, cardiovascular and immune system, for example, diseases caused by cigarette smoke , cigarillos and / or cigars, smoke that is responsible for the production and release of pro-oxidants and / or free radicals derived from oxygen and nitrogen, which play an important
  • Literature data show that the smoke of tobacco products currently used in cigarettes contains large amounts of pro-oxidant compounds which are of great importance in the pathophysiological mechanism of pulmonary disease formation, such as chronic obstructive pulmonary disease (COPD) (Kode A, Yang SR & Rahman I. Respiratory Research, 2006, 7: 132), malignant and / or cardiovascular diseases.
  • COPD chronic obstructive pulmonary disease
  • Smoke from such tobacco products, especially those used in cigarettes induces oxidative stress that is responsible for organic complications due to oxidative cell injury, release of proinflammatory cytokines, inactivation and antiproteases, and increased lipid peroxidation (Basygit et al. Human Experimental Toxicology 26: 99-103, 2007).
  • Smoke increases pulmonary oxidative stress not only by the presence of oxidizing compounds such as aldehydes, quinones, benzopyrenes and others, but also by the ability to reduce natural antioxidant activity and by the ability to induce formation and release of oxidizing substances, substances released by the inflammatory, immune and epithelial cells of the respiratory tract (Rahman; Treat Respir Med 2005; 4: 175-200).
  • Oxidative stress induced by smoke causes damage to the alveolar wall, inducing airway dilatation and activation of proinflammatory cytokines, which play an important role in pulmonary pathophysiological changes (Kirkham & Rahman, Pharmacol Ther 2006, 111: 476-494).
  • the manufacture of cigarettes, cigarillos, cigars and / or pipe tobacco, containing tobacco products plus antioxidant compounds, which would be bound together with the smoke at the time of inhalation, may confer this cigarette, cigarillo and / or cigar , less ability to induce lung changes, as antioxidants added to tobacco products used in cigarettes, cigarillos and / or cigarettes may reduce the oxidative stress caused by smoke and thus reduce the damage caused by the inhalation of cigarette smoke, cigarillos and or cigar.
  • the present invention relates to the production of used tobacco products, especially in cigarettes, cigarillos and / or cigars, containing natural antioxidant compounds of plant origin, such as that extracted from the aça ⁇ (Euterpe oleracea).
  • the present invention is based on scientific data obtained in the international literature, as well as experimental data obtained by us and that give scientific support to the obtaining of the products.
  • the smoke produced by burning the tobacco product used in cigarettes, cigarillos or cigar contains approximately 4000 substances, many of them described as toxic to the respiratory, cardiovascular and immune system.
  • Among the mechanisms of the deleterious effects to the body of the smoker is the presence of a great oxidative stress that damages the cells. This oxidative stress derives from the very pro-oxidant substances in the smoke, such as depression of the antioxidant mechanisms of the smoker (Kode et al., Respiratory Research 7: 132, 2006).
  • cigarettes, cigarillos, cigars and / or pipe tobacco will be manufactured from tobacco products already containing antioxidants in their composition. More precisely, cigarettes, cigarillos, cigars and / or pipe smoke will be made from fumes containing antioxidants obtained from phenol rich plants, such as Euterpe oleracea. Data from the literature show that Euterpe oleracea has an important antioxidant action (Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleracea mart.
  • Pulmonary injury was also assessed by myeloperoxidase activity in the bronchial lavage.
  • the following groups (n ⁇ 5 animals) were studied: Control group (control) atmospheric air; Group submitted to Cigarette smoke (CS) and Group submitted to cigarette smoke containing 100 mg of lyophilized Euterpe oleracea (aça ⁇ ) hydro-alcoholic extract (AOX).
  • Control group control
  • Cigarette smoke CS
  • aça ⁇ lyophilized Euterpe oleracea
  • AOX hydro-alcoholic extract
  • Euterpe oleracea fruits or only the core are placed in neutral or stainless steel containers containing a certain amount of distilled water, boiled and after boiling the powder is thoroughly ground and extracted with an ethanol / decoto mixture ( v: v) and allowed to macerate for a certain period when a filtration is carried out to obtain the liquid phase of the extract which is kept in the refrigerator and the semi-solid phase can be extracted again with an ethanol / water mixture for one more to two times, with the liquid phases being joined at the end of the extractions.
  • an ethanol / decoto mixture v: v
  • the liquid phase is concentrated in a rotary evaporator at low pressure and at a temperature between 40 and 60 ° C, with the removal of all ethanol and subsequently subjected to a lyophilization or spray dryer process and the lyophilisate and / or spray dryer maintained at a temperature of approximately -10 ° C until the day of processing.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Botany (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne un procédé d'obtention d'un produit de tabac contenant des antioxydants à partir de la feuille et des fruits d'Euterpe oleracea (açaï). Ce produit de tabac peut être incorporé au tabac à fumer (Nicotiana tabacum) en vue d'une utilisation dans la fabrication de cigarettes, de cigarillos, de cigares, de tabac pour pipe ou de produits appliqués sur la muqueuse buccale. Ledit produit permet de réduire le stress oxydatif et/ou la réaction inflammatoire causée par le tabac à fumer et, par conséquent, de prévenir les lésions de l'appareil respiratoire, du système cardiovasculaire et du système immunitaire.
PCT/BR2009/000274 2009-09-03 2009-09-03 Procédé d'obtention de produits de tabac contenant des substances antioxydantes et produit ainsi obtenu Ceased WO2011026202A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/BR2009/000274 WO2011026202A1 (fr) 2009-09-03 2009-09-03 Procédé d'obtention de produits de tabac contenant des substances antioxydantes et produit ainsi obtenu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/BR2009/000274 WO2011026202A1 (fr) 2009-09-03 2009-09-03 Procédé d'obtention de produits de tabac contenant des substances antioxydantes et produit ainsi obtenu

Publications (1)

Publication Number Publication Date
WO2011026202A1 true WO2011026202A1 (fr) 2011-03-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2009/000274 Ceased WO2011026202A1 (fr) 2009-09-03 2009-09-03 Procédé d'obtention de produits de tabac contenant des substances antioxydantes et produit ainsi obtenu

Country Status (1)

Country Link
WO (1) WO2011026202A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011103648A1 (fr) * 2010-02-23 2011-09-01 Universidade Do Estado Do Rio De Janeiro - Uerj Procédé de préparation de pommades contenant des antioxydants issus de plantes riches en polyphénols, utiles dans le traitement de plaies de diverses étiologies caractérisées par une augmentation des facteurs pro-oxydants et/ou une importante formation d'espèces réactives dérivées de l'oxygène et/ou une formation d'oxyde nitrique réduite

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9907793A (pt) * 1998-02-09 2000-10-17 Rousseau Research Inc " produtos de tabaco com vitamina e "
WO2004084833A2 (fr) * 2003-03-21 2004-10-07 K2A Incorporated Supplements alimentaires a base des fruits du juçara et de l'açai
BRPI0604281A (pt) * 2006-07-18 2008-03-04 Roberto Soares De Moura processo para obtenção de decotos de frutos e caroços de euterpe oleracea (açaì) processo de obtenção de extratos hidro-alcoólicos a partir dos decotos; processo obtenção de liofilizado e/ou spray dryer do extrato hidro-alcoólico; composições farmacêuticas contendo os liofilizados e/ou spray dryer dos ditos extratos e uso terapêutico das composições como vasodilatador no tratamento das sìndromes isquêmicas, vaso-espásticas e da hipertenção arterial
BRPI0418614A2 (pt) * 2004-10-05 2008-11-25 Univ Do Estado Do Rio De Janeiro processo para obtenÇço de decotos de frutos e de caroÇos de euterpe oleracea (aÇai); processo de obtenÇço de extratos hidro-alcoàlicos a partir dos decotos; processo de obtenÇço de liofilizado e/ou spray dryer do extrato hidro-alcoàlico; processo de obtenÇço de um liofilizado e/ou spray dryer; composiÇÕes farmacÊuticas contendo os liofilizados e/ou spray dryer dos ditos extratos e uso terapÊutico das composiÇÕes no tratamento da dor de um modo geral
BRPI0705003A2 (pt) * 2007-12-27 2009-08-25 Univ Do Estado Do Rio De Janei processo para obtenção de creme dental (dentifìcio) e/ou enxaguatórios bucais (anti-sépticos bucais), contendo antioxidantes naturais ou sintéticos e antioxidantes obtidos de plantas ricas em polifenois utilizados na prenvençao e tratamento de doenças bucais nas quais existem um aumento de fatores pró-oxidantes e/ou grande formação de espécies reativas derivadas do oxigênio

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9907793A (pt) * 1998-02-09 2000-10-17 Rousseau Research Inc " produtos de tabaco com vitamina e "
WO2004084833A2 (fr) * 2003-03-21 2004-10-07 K2A Incorporated Supplements alimentaires a base des fruits du juçara et de l'açai
BRPI0418614A2 (pt) * 2004-10-05 2008-11-25 Univ Do Estado Do Rio De Janeiro processo para obtenÇço de decotos de frutos e de caroÇos de euterpe oleracea (aÇai); processo de obtenÇço de extratos hidro-alcoàlicos a partir dos decotos; processo de obtenÇço de liofilizado e/ou spray dryer do extrato hidro-alcoàlico; processo de obtenÇço de um liofilizado e/ou spray dryer; composiÇÕes farmacÊuticas contendo os liofilizados e/ou spray dryer dos ditos extratos e uso terapÊutico das composiÇÕes no tratamento da dor de um modo geral
BRPI0604281A (pt) * 2006-07-18 2008-03-04 Roberto Soares De Moura processo para obtenção de decotos de frutos e caroços de euterpe oleracea (açaì) processo de obtenção de extratos hidro-alcoólicos a partir dos decotos; processo obtenção de liofilizado e/ou spray dryer do extrato hidro-alcoólico; composições farmacêuticas contendo os liofilizados e/ou spray dryer dos ditos extratos e uso terapêutico das composições como vasodilatador no tratamento das sìndromes isquêmicas, vaso-espásticas e da hipertenção arterial
BRPI0705003A2 (pt) * 2007-12-27 2009-08-25 Univ Do Estado Do Rio De Janei processo para obtenção de creme dental (dentifìcio) e/ou enxaguatórios bucais (anti-sépticos bucais), contendo antioxidantes naturais ou sintéticos e antioxidantes obtidos de plantas ricas em polifenois utilizados na prenvençao e tratamento de doenças bucais nas quais existem um aumento de fatores pró-oxidantes e/ou grande formação de espécies reativas derivadas do oxigênio

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011103648A1 (fr) * 2010-02-23 2011-09-01 Universidade Do Estado Do Rio De Janeiro - Uerj Procédé de préparation de pommades contenant des antioxydants issus de plantes riches en polyphénols, utiles dans le traitement de plaies de diverses étiologies caractérisées par une augmentation des facteurs pro-oxydants et/ou une importante formation d'espèces réactives dérivées de l'oxygène et/ou une formation d'oxyde nitrique réduite

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