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WO2011012369A3 - Beschichtungsmittel zum tauchbeschichten von kapselhälften - Google Patents

Beschichtungsmittel zum tauchbeschichten von kapselhälften Download PDF

Info

Publication number
WO2011012369A3
WO2011012369A3 PCT/EP2010/058370 EP2010058370W WO2011012369A3 WO 2011012369 A3 WO2011012369 A3 WO 2011012369A3 EP 2010058370 W EP2010058370 W EP 2010058370W WO 2011012369 A3 WO2011012369 A3 WO 2011012369A3
Authority
WO
WIPO (PCT)
Prior art keywords
dispersion
solution
capsule halves
coating
dip coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/058370
Other languages
English (en)
French (fr)
Other versions
WO2011012369A2 (de
Inventor
Brigitte Skalsky
Manfred Assmus
Odette Hensel
Hans-Ulrich Petereit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roehm GmbH Darmstadt
Original Assignee
Evonik Roehm GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm GmbH filed Critical Evonik Roehm GmbH
Priority to CA2769046A priority Critical patent/CA2769046A1/en
Priority to CN201080022662.9A priority patent/CN102448446B/zh
Priority to EP10724857A priority patent/EP2459178A2/de
Priority to JP2012522057A priority patent/JP5686802B2/ja
Priority to HK12105568.7A priority patent/HK1164726B/xx
Publication of WO2011012369A2 publication Critical patent/WO2011012369A2/de
Publication of WO2011012369A3 publication Critical patent/WO2011012369A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Beschichtungsmittel zum magensaftresistenten Beschichten von Kapselhälften aus wasserlöslichem oder in Wasser quellbaren Polymermaterial im Tauchverfahren, in Form einer wässrigen Dispersion oder Lösung, enthaltend eine Polymermischung aus mindestens einem ersten (Meth)acrylat Copolymer, welches magensaftresistent ist, und mindestens einem weiteren (Meth)acrylat Copolymer, welches magensaftresistent oder wasserunlöslich ist, sowie Hilfsstoffen,die die Viskosität der Dispersion und die Elastizität des getrockneten Polymerfilms beeinflussen, dadurch gekennzeichnet, dass der Feststoffgehalt der Dispersion oder Lösung mehr als 25 Gew.-% und die Viskosität 150 bis 1500 mPa s beträgt, wobei ein aus der Dispersion oder Lösung erzeugter, getrockneter Film eine Reißdehnung von mindestens 200 % aufweist und sich eine aus zwei mit der Dispersion oder Lösung im Tauchverfahren beschichteten Kapselhälften zusammengesetzte Kapsel in 0,1 N HCl bei p H 1,2 nach zwei Stunden nicht auflöst, sich aber anschließend in Puffer bei pH 6,8 in weniger als 30 Minuten vollständig auflöst.
PCT/EP2010/058370 2009-07-29 2010-06-15 Beschichtungsmittel zum tauchbeschichten von kapselhälften Ceased WO2011012369A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2769046A CA2769046A1 (en) 2009-07-29 2010-06-15 Coating agent for the dip coating of capsule halves
CN201080022662.9A CN102448446B (zh) 2009-07-29 2010-06-15 用于浸渍涂覆胶囊半分体的涂覆剂
EP10724857A EP2459178A2 (de) 2009-07-29 2010-06-15 Beschichtungsmittel zum tauchbeschichten von kapselhälften
JP2012522057A JP5686802B2 (ja) 2009-07-29 2010-06-15 カプセル片の浸漬被覆用被覆剤
HK12105568.7A HK1164726B (en) 2009-07-29 2010-06-15 Coating agent for the dip coating of capsule halves

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009028076A DE102009028076A1 (de) 2009-07-29 2009-07-29 Beschichtungsmittel zum Tauchbeschichten von Kapselhälften
DE102009028076.6 2009-07-29

Publications (2)

Publication Number Publication Date
WO2011012369A2 WO2011012369A2 (de) 2011-02-03
WO2011012369A3 true WO2011012369A3 (de) 2011-09-15

Family

ID=42635497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/058370 Ceased WO2011012369A2 (de) 2009-07-29 2010-06-15 Beschichtungsmittel zum tauchbeschichten von kapselhälften

Country Status (6)

Country Link
EP (1) EP2459178A2 (de)
JP (1) JP5686802B2 (de)
CN (1) CN102448446B (de)
CA (1) CA2769046A1 (de)
DE (1) DE102009028076A1 (de)
WO (1) WO2011012369A2 (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11576866B2 (en) 2016-09-30 2023-02-14 Lyndra Therapeutics, Inc. Gastric residence systems for sustained delivery of adamantane-class drugs
US11576859B2 (en) 2015-10-23 2023-02-14 Lyndra Therapeutics, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
US11992552B2 (en) 2015-12-08 2024-05-28 Lyndra Therapeutics, Inc. Geometric configurations for gastric residence systems
US12023406B2 (en) 2017-06-09 2024-07-02 Lyndra Therapeutics, Inc. Gastric residence systems with release rate-modulating films
US12109305B2 (en) 2016-05-27 2024-10-08 Lyndra Therapeutics, Inc. Materials architecture for gastric residence systems

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2968186A4 (de) * 2013-03-15 2016-10-19 Banner Life Sciences Llc Kapseln auf seidenbasis
CA2951909C (en) * 2014-06-11 2022-08-16 Massachusetts Institute Of Technology Self-assembled residence devices and related methods
TWI793141B (zh) 2017-07-11 2023-02-21 日商快力膠囊股份有限公司 腸溶性硬質膠囊
MX2020005012A (es) 2017-11-17 2020-08-27 Evonik Operations Gmbh Procedimiento de preparacion de una capsula de envoltura dura revestida.
JP7366893B2 (ja) 2018-06-22 2023-10-23 クオリカプス株式会社 腸溶性硬質カプセル
CA3130184A1 (en) 2019-03-14 2020-09-17 Bettina Holzer Capsule shell comprising a core-shell polymer and a cellulose
WO2020229192A1 (en) 2019-05-15 2020-11-19 Evonik Operations Gmbh Process for preparing filled hard-shell capsules with cellulose or starch-based coatings with a capsule-filling machine
CN120420296A (zh) * 2019-05-15 2025-08-05 赢创运营有限公司 用胶囊填充机制备具有基于(甲基)丙烯酸酯共聚物的包衣的填充硬壳胶囊的方法
IL308701A (en) * 2021-05-25 2024-01-01 Evonik Operations Gmbh Hard shell capsules with modified release coating
EP4559458A1 (de) 2022-07-22 2025-05-28 Qualicaps Co., Ltd. Mehrschichtige enterale steife kapsel

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0393747A2 (de) * 1989-04-20 1990-10-24 The Procter & Gamble Company Mebeverine Dosierungsform
US20040142035A1 (en) * 2003-01-03 2004-07-22 Rong-Kun Chang Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics
WO2009036812A1 (en) * 2007-09-21 2009-03-26 Evonik Röhm Gmbh Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol
WO2009074811A2 (en) * 2007-12-12 2009-06-18 Photocure Asa Use of 5-aminolevulinic acid and derivatives in a solid form for photodynamic treatment and diagnosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59155325A (ja) * 1983-02-25 1984-09-04 Kohjin Co Ltd 水系の腸溶性コ−テイング剤の製法
ES2130056B1 (es) * 1997-01-16 2000-02-01 Lipotec Sa Un nuevo preparado farmaceutico para mejorar la biodisponibilidad oral de drogas de dificil absorcion.
US6287594B1 (en) * 1998-01-20 2001-09-11 Edward S. Wilson Oral liquid compositions
DE10208335A1 (de) 2002-02-27 2003-09-04 Roehm Gmbh Arzneiform und Verfahren zu ihrer Herstellung
MXPA04010956A (es) * 2003-01-30 2005-01-25 Roehm Gmbh Forma de dosis farmaceutica y metodo para la produccion de la misma.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0393747A2 (de) * 1989-04-20 1990-10-24 The Procter & Gamble Company Mebeverine Dosierungsform
US20040142035A1 (en) * 2003-01-03 2004-07-22 Rong-Kun Chang Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics
WO2009036812A1 (en) * 2007-09-21 2009-03-26 Evonik Röhm Gmbh Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol
WO2009074811A2 (en) * 2007-12-12 2009-06-18 Photocure Asa Use of 5-aminolevulinic acid and derivatives in a solid form for photodynamic treatment and diagnosis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ASSMUS M ET AL: "Accurate GI Targeting with Eudragit FS 30 D/ L 30 D-55 Mixtures", INTERNET CITATION, 2008, pages 1, XP002560459, Retrieved from the Internet <URL:http://www.pharma-polymers.com/pharmapolymers/MCMSbase/Pages/ProvideR esource.aspx?respath=/NR/rdonlyres/32DDD09C-18F5-47A0-AFFA-0030E84F9C 57/0/CRS2008_AccurateGITargetingwithEUDRAGITFS30DandL30D55mixtures.pdf> [retrieved on 20091214] *
EVONIK INDUSTRIES: "Guidelines for Formulation Development and Process Technology for Enteric Coatings", INTERNET CITATION, 1 March 2009 (2009-03-01), pages 1 - 3, XP002560458, Retrieved from the Internet <URL:http://www.pharma-polymers.com/NR/rdonlyres/1EA56E7C-0D38-4084-8DF9-5 3F9B484FD5D/0/31eGuidelinesforFormulationDevelopmentandProcessTechnologyforEntericCoatings.pdf> [retrieved on 20091214] *
HUYGHEBAERT N ET AL: "In vitro evaluation of coating polymers for enteric coating and human ileal targeting", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 298, no. 1, 14 July 2005 (2005-07-14), pages 26 - 37, XP004943736, ISSN: 0378-5173, DOI: DOI:10.1016/J.IJPHARM.2005.03.032 *
See also references of EP2459178A2 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11576859B2 (en) 2015-10-23 2023-02-14 Lyndra Therapeutics, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
US11992552B2 (en) 2015-12-08 2024-05-28 Lyndra Therapeutics, Inc. Geometric configurations for gastric residence systems
US12109305B2 (en) 2016-05-27 2024-10-08 Lyndra Therapeutics, Inc. Materials architecture for gastric residence systems
US11576866B2 (en) 2016-09-30 2023-02-14 Lyndra Therapeutics, Inc. Gastric residence systems for sustained delivery of adamantane-class drugs
US12023406B2 (en) 2017-06-09 2024-07-02 Lyndra Therapeutics, Inc. Gastric residence systems with release rate-modulating films

Also Published As

Publication number Publication date
CN102448446B (zh) 2015-04-01
CA2769046A1 (en) 2011-02-03
JP2013500293A (ja) 2013-01-07
CN102448446A (zh) 2012-05-09
JP5686802B2 (ja) 2015-03-18
WO2011012369A2 (de) 2011-02-03
HK1164726A1 (en) 2012-09-28
EP2459178A2 (de) 2012-06-06
DE102009028076A1 (de) 2011-02-03

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