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WO2011070577A2 - Système de détection et d'analyse d'ovulation - Google Patents

Système de détection et d'analyse d'ovulation Download PDF

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Publication number
WO2011070577A2
WO2011070577A2 PCT/IL2010/001038 IL2010001038W WO2011070577A2 WO 2011070577 A2 WO2011070577 A2 WO 2011070577A2 IL 2010001038 W IL2010001038 W IL 2010001038W WO 2011070577 A2 WO2011070577 A2 WO 2011070577A2
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WO
WIPO (PCT)
Prior art keywords
female subject
temperature
oral
ovulation
sensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2010/001038
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English (en)
Other versions
WO2011070577A3 (fr
Inventor
Yoav Ben-David
Alfonso Rodriguez
Boaz Mendel
Boaz Beeri
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Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US13/514,469 priority Critical patent/US20120265032A1/en
Priority to EP10835609.8A priority patent/EP2509510A4/fr
Publication of WO2011070577A2 publication Critical patent/WO2011070577A2/fr
Publication of WO2011070577A3 publication Critical patent/WO2011070577A3/fr
Priority to IL220248A priority patent/IL220248A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0012—Ovulation-period determination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0012—Ovulation-period determination
    • A61B2010/0019—Ovulation-period determination based on measurement of temperature

Definitions

  • the present invention relates to a system for measuring an oral temperature of a female subject during an ovulation cycle of the female subject for assisting the female subject in determining the next ovulation cycle for fertility and/or birth- control.
  • US Patent No. 4,148,304 describes a system for determining the time of ovulation in females including two probes one of which is inserted into the female's ear (Fig. 2) and the second probe is inserted on the forehead of the female (Fig. 4).
  • the prior art system measures the voltage potential between the two probes as well as the body temperature.
  • the prior art system is drawn to determining the time of ovulation.
  • thermometer for women.
  • the thermometer has processing functions to determine ovulation days and also a function for memorizing the data for several menstruation periods and to display the data when desired to guide exact diagnosis.
  • EP 0 476 730 Al describes a system for ovulation detection and prediction by implanting a temperature sensor into the cervix of the female and measuring the basal body temperature over a predetermined interval of time. The system is removed from the cervix for processing at the end of the time interval.
  • CN 2586146Y describes a digital thermometer for measuring the basal body temperature.
  • the thermometer is located on a body and connected to a controller unit which interfaces with a microcomputer.
  • the present invention seeks to provide a female subject with a prediction of a commencement of her ovulation cycle by measuring the oral temperature of the female subject with a mobile oral temperature sensing system.
  • the results of the temperature measurements are communicated to a remote computing platform.
  • the remote computing system includes a processor which compares the current oral temperature measurements with previous stored oral temperature measurements thus providing the female subject a mobile pregnancy indicator and/or a mobile contraceptive indicator.
  • the female subject measures her oral temperature during the ovulation period and communicates the measured oral temperature of the female subject to a remote computer device.
  • the measured oral temperature is recorded, stored, analyzed and compared to previous oral temperature measurements to enable the female subject to predetermine and predict the date of a next ovulation cycle.
  • the present invention provides a female subject with a mobile predictor device for assisting the female subject to determine the next ovulation cycle for either fertility and/or for birth-control, thus, indicating to a couple the chances of the female partner becoming pregnant or not becoming pregnant.
  • the female subject measures her oral temperature daily over a predetermined time interval, such as a 12-day time interval with an oral sensor device.
  • the oral sensor device communicates the measured oral temperatures to a remote computing platform for recording, storing and analyzing the measured oral temperature on a display unit.
  • the computing platform also compares the current oral temperature measurement with previous measurements in order to enable the female subject to predetermine and predict the commencement of the next ovulation cycle.
  • the communication of the oral temperature measurements are communicated from the temperature sensing device to the remote computer device by communications means, such as RF transmissions communications systems, for example, via a cellular communications network, a Bluetooth communications system and an IR communications system.
  • a method for predicting a commencement of a new ovulation cycle in a female subject including recording the commencement and termination of a menstruation cycle, measuring on a daily basis, an oral temperature of said female subject during a current ovulation cycle following said termination of said menstruation cycle, calculating a current running average of the daily temperature measurements, comparing each daily measurement with at least one previous average oral temperature calculated from at least one previous ovulation cycle, storing said current daily measured oral temperatures, storing said current daily running average temperatures of current measured oral temperatures, calculating a current average oral temperature from said current daily oral temperature measurements, storing said current average oral temperature, comparing and analyzing said current daily temperature with said at least one previous average temperature, predicting said commencement of said new ovulation cycle in said female subject based on said analysis.
  • It is a further object of this invention to disclose such a method including comprising checking if each daily temperature measurement of said oral temperature measurements is within a predetermined temperature range of said previous average temperature and within said running average temperature.
  • It is a further object of this invention to disclose such a method including cancelling said daily temperature measurement if said daily oral temperature measurement of said oral temperature measurements exceeds said predetermined said previous average temperature and said running average temperature, alerting said female subject that the current daily temperature exceeds said predetermined temperature range, repeating said daily oral temperature measurement to obtain a new daily oral temperature measurement, calculating a further average current oral temperature, analyzing said further set of current oral temperature measurements with previously stored oral temperature measurements, and predicting a commencement of a new ovulation cycle of said female subject based on said analysis.
  • It is a further object of this invention to disclose an ovulation sensing and analyzing system for measuring oral temperatures of a female subject comprising an oral temperature sensing system, said oral temperature sensing system including at least one sensing device, and a remote computing platform.
  • the at least one sensing device includes an oral temperature measuring sensor to measure said oral temperatures and said at least one sensing device communicates said measured temperatures to said remote computing platform and said remote computing platform analyzes said oral temperature measurements to predict and display on an output display device a date of a next ovulation cycle of said female subject.
  • It is a further object of this invention to disclose such a system includes at least one sensing device further comprising a control unit, said control unit includes an A/D device for converting measured oral temperatures analog signals to digital signals, and a first transceiver for modulation and communicating said digital signals to said remote computing device.
  • thermometer is selected from any one of a group consisting of a thermometer, an oral thermocouple device, a saliva-sensitive temperature measuring device, a digital thermometer, a thermometer sensitive to a predetermined range of temperatures or any combination thereof.
  • It is a further object of this invention to disclose such a system includes a transceiver for demodulating said communicated signals, a processor for processing said demodulated signals, and an output device for displaying said processed signals.
  • It is a further object of this invention to disclose such a system includes at least one switch device for activating said at least one sensing device to commence oral temperatures measurements and to communicate said oral temperature measurements to said remote computing platform.
  • It is a further object of this invention to disclose such a system includes the oral temperature sensing system is selected from any one of a group consisting of a smart cellular phone, a laptop, a PDA device or any combination thereof.
  • It is a further object of this invention to disclose such a system includes a remote computing platform analyzes and displays said analyzed data in graphical form.
  • At least one sensing device includes a USB connection interface for coupling said at least one sensing device to an external storage and analysis device.
  • It is a further object of this invention to disclose such a system includes wherein an oral temperature sensing system detects and measures temperature changes in a range of 0.15 - 0.45°C.
  • It is a further object of this invention to disclose such a system includes an audio sensor for sensing audio data for measuring environmental noise.
  • It is a further object of this invention to disclose such a system includes a virus detector for detecting virus data.
  • It is a further object of this invention to disclose such a system includes a a sensor for detecting hormonal changes in a body.
  • It is a further object of this invention to disclose such a system includes a body fat-muscle relation detecting sensor for sensing the body fat-muscle relation data.
  • It is a further object of this invention to disclose such a system includes a sensor for sensing and measuring ambient temperature.
  • It is a further object of this invention to disclose such a system includes a wristwatch including a sensor for detecting and storing body temperatures.
  • thermometer selected from any one of a group consisting of a thermometer, an oral thermocouple device, a saliva-sensitive temperature measuring device, a digital thermometer, a thermometer sensitive to a predetermined range of temperatures or any combination thereof.
  • It is a further object of this invention to disclose such a method including providing a ristwatch including a sensor for detecting and storing body temperature.
  • It is a further object of this invention to disclose such a method including at least one sensing device is selected from any one of a group consisting of a temperature sensor, a microbiological sensor, a gas analysis sensor, a pH sensor, an electroconductivity sensor, a physiological sensor, a biometric sensor, a miniature stills camera or video imaging device with or without illumination means such as but not limited to an LED, a fiber optic device, or any combination thereof.
  • a method for predicting a commencement of a new ovulation cycle in a female subject including recording the commencement and termination of a menstruation cycle, measuring on a daily basis, an oral temperature of said female subject during a current ovulation cycle following said termination of said menstruation cycle, calculating a current running average of the daily temperature measurements, comparing each daily measurement with at least one previous average oral temperature calculated from at least one previous ovulation cycle, storing said current daily measured oral temperatures, storing said current daily running average temperatures of current measured oral temperatures, calculating a current average oral temperature from said current daily oral temperature measurements, storing said current average oral temperature, comparing and analyzing said current daily temperature with said at least one -previous average temperature and predicting said commencement of said new ovulation cycle in said female subject based on said analysis.
  • each daily temperature measurement of said oral temperature measurements is within a predetermined temperature range of said previous average temperature and within said running average temperature.
  • the predetermined temperature range is 0.15 - 0.45°C. Additionally in accordance with a preferred embodiment of the present invention said oral temperature measurements are measured over a 12-day time interval.
  • an ovulation sensing and analyzing system for measuring oral temperatures of a female subject comprising an oral temperature sensing system, said oral temperature sensing system including at least one sensing device and a remote computing platform.
  • the at least one sensing device includes an oral temperature measuring sensor to measure said oral temperatures and said at least one sensing device communicates said measured temperatures to said remote computing platform and said remote computing platform analyzes said oral temperature measurements to predict and display on an output display device a date of a next ovulation cycle of said female subject.
  • In accordance with another preferred embodiment of the present invention includes a method for measuring an oral temperature of a female subject during an ovulation cycle of a female subject and includes providing an oral temperature sensor, measuring said oral temperature with said oral temperature sensor, comparing and analyzing said measured oral temperatures and previously stored oral temperatures of said female subject and predicting a date of a next ovulation cycle of said female subject.
  • the system and method is noninvasive.
  • the step of comparing and analyzing includes an iterative method for predicting said commencement of an ovulation cycle in said female subject.
  • the step of comparing and analyzing includes a learning method for predicting said commencement of an ovulation cycle in said female subject.
  • the step of comparing and analyzing includes a feedback method for predicting said commencement of an ovulation cycle in said female subject.
  • the at least one sensing device further comprising a control unit, said control unit includes an AID device for converting measured oral temperatures analog signals to digital signals and a first transceiver for modulation and communicating said digital signals to said remote computing device.
  • the oral temperature sensor is selected from any one of a group consisting of a thermometer, an oral thermocouple device, a saliva-sensitive temperature measuring device, a digital thermometer, a thermometer sensitive to a predetermined range of temperatures or any combination thereof.
  • the computing platform includes a transceiver for demodulating said communicated signals, a processor for processing said demodulated signals and an output device for displaying said processed signals.
  • the present invention further includes at least one switch device for activating said at least one sensing device to commence oral temperatures measurements and to communicate said oral temperature measurements to said remote computing platform.
  • the oral temperature sensing system is selected from any one of a group consisting of a smart cellular phone, a laptop, a PDA device or any combination thereof.
  • the remote computing platform analyzes and displays said analyzed data in graphical form.
  • the at least one sensing device includes a USB connection interface for coupling said at least one sensing device to an external storage and analysis device.
  • the oral temperature sensing system detects and measures temperature changes in a range of 0.15 - 0.45°C.
  • an audio sensor for sensing audio data for measuring environmental noise.
  • Still further in accordance with a preferred embodiment of the present invention includes a virus detector for detecting virus data. Additionally in accordance with a preferred embodiment of the present invention includes a sensor for detecting hormonal changes in a body.
  • a body fat-muscle relation detecting sensor for sensing the body fat-muscle relation data.
  • a sensor for sensing and measuring ambient temperature.
  • Still further in accordance with a preferred embodiment of the present invention includes a wristwatch including a sensor for detecting and storing body temperatures.
  • a key ring for carrying said temperature sensing device.
  • the at least one sensing device is selected from any one of a group consisting of a temperature sensor, a microbiological sensor, a gas analysis sensor, a pH sensor, an electroconductivity sensor, a physiological sensor, a biometric sensor or any combination thereof.
  • Fig. 1 shows a general view of a female subject measuring her oral temperature and communicating the measurement to a computing platform, in accordance with a preferred embodiment of the present invention
  • Fig. 2 shows the components included in a mobile oral temperature sensing system including a sensing apparatus and the computing platform, in accordance with a preferred embodiment of the present invention
  • Fig. 3 shows a method of measuring the oral temperature including the steps of oral temperature measurements, communicating the measurements to the computing platform and displaying the results on an output device, in accordance with a preferred embodiment of the present invention
  • Fig. 4 shows a method of recording, storing and analyzing the oral temperature measurements over an ovulation cycle of the female subject in order to predict a next ovulation cycle and the sex of a conceived child, in accordance with a preferred embodiment of the present invention
  • Fig. 5 shows a method of obtaining a monthly summary of the measured oral temperatures in order to obtain an infertility report, in accordance with a preferred embodiment of the present invention
  • Fig. 6 shows typical results for an oral temperature measurement for determining the sex of a child, in accordance with a preferred embodiment of the present invention.
  • FIGs. 1 and 2 show an ovulation sensing and analyzing system 5 including a mobile oral temperature sensing system 100 for sensing, measuring and communicating with a remote computing platform, oral temperature measurements of a female subject 12 during ovulation, in accordance with a preferred embodiment of the present invention.
  • the mobile oral temperature sensing system 100 includes a sensing apparatus 110 and computing platform 120.
  • the sensing apparatus 1 10 includes at least one oral temperature measuring sensor 112, such as an oral thermometer, which is inserted into the mouth of the female subject 12 and a control unit 16 associated with the oral temperature measuring sensor 112.
  • the sensing apparatus 110 communicates the measured oral temperatures to the computer platform 120.
  • the control unit 16 includes an A/D device 114 for converting the analog temperature measurements received from the temperature measuring sensor 112 to digital signals, a controller 1 16 for collating and formatting the digital signals into the required format for communications and a first transceiver 1 18 for typically modulating and wirelessly communicating the digital signals to a computing platform 120, via an antenna 119.
  • the control unit 16 typically also includes a first switch device 113 for activating the ovulation sensing and analyzing device 5 on commencement of the temperature measurements and for communicating the temperature measurements in the form of modulated digital signals to the computing platform 120.
  • the digital temperature measurements are wirelessly communicated to the computing platform 120 by means of an RF transceiver, Bluetooth, IR transceiver and an audio transceiver. It is appreciated that a wired device, such as a wire connection may also transfer the digital temperature measurements to the computing platform 120.
  • the temperature sensing apparatus 110 may include an interface unit, such as a USB connection, for coupling the temperature sensing apparatus 110 to an external non-remote storage and analysis device.
  • an interface unit such as a USB connection
  • the computing platform 120 includes a second antenna 129 and a second transceiver 126 for receiving the digital signals communicated from the sensing apparatus 110.
  • the second transceiver 126 demodulates the communicated signals and forwards the demodulated signals to a processor 124 for recording, storing and analyzing the measured temperatures.
  • the processor 124 preferably also records the date and time of the temperature measurements as a function of time and date over a predetermined time interval, such as the typical 12-day ovulation time interval of the female subject.
  • the processor 124 processes and analyzes the signals in order to allow the female subject to observe the measured oral temperature.
  • the ovulation sensing and analyzing device 5 is activated by a further switch device 125 located on the computing platform 120 thereby allowing the computer platform 120 to communicate a command signal to the sensing apparatus 110 to commence the temperature measurements.
  • the oral temperature sensor 1 12 includes a saliva-sensitive tip so that measurement of the oral temperature commences on insertion of the thermometer into the mouth.
  • the ovulation sensing and analyzing device 5 is activated by the oral temperature sensor 112 sensing an oral temperature within a predetermined oral temperature range.
  • the currently measured oral temperatures are compared with previously measured, recorded and stored oral temperatures, allowing the female subject 10 to observe and note the changes in the oral temperature over a predetermined time.
  • the current and previous oral temperature measurements are displayed on an output display unit 122 for immediate observation and study. These measurements may also be forwarded to an output unit, such as a printer for off-line study thereof, for example, in graphical form.
  • a typical statistical method for predetermining and predicting the next date of ovulation includes a time-dependent regression method, such as Cox's Proportional Hazard Regression or a Time Series Analysis.
  • the oral temperature sensing device 110 includes communication devices such as a smart cellular phone, a laptop and a PDA device.
  • the ovulation sensing and analyzing device 5 is included in a communication device such as a smart cellular phone, a laptop and a PDA device.
  • the temperature measuring sensor 110 may also include a display, such as a color display, for displaying the current temperature measurements.
  • the temperature sensing apparatus 110 may also include a processor for analyzing the temperature measurements and displaying, for example, the temperature measurements in graphical form. It is further appreciated that the temperature sensing device 110 device is preferably of sufficient sensitivity so as to measure a change in the oral temperature of approximately 0.15 - 0.45°C over the oral temperature.
  • Fig. 3 shows a method for measuring the oral temperature and communicating the temperature measurement to the computing platform 120 for storage and analysis, in accordance with the preferred embodiment of the present invention.
  • step 210 the temperature sensor 112 is activated by the switch 113 located in the control unit 16 or by the switch 125 located in the computing platform 120. In the latter case, the computing platform 120 communicates a command signal to the sensing apparatus 110 to commence the temperature measurements, via the antenna 129.
  • step 220 the oral temperature is sensed and measured.
  • step 230 the A/D device 1 14 converts the measured temperature data into digital signals and in step 240, the digital signals are modulated in preparation for transmission by the transceiver 1 18 to the computing platform 120.
  • step 250 the modulated data is transmitted to the computing platform 120 and in step 260, the data is received at the computing platform 120.
  • steps 270 and 280 the data is analyzed and displayed, respectively, as discussed hereinbelow, in accordance with the requirements of the female subject 10.
  • Fig. 4 shows a flow chart 300 of a typical iterative and learning procedure carried by the processor 124 for providing the female subject with an analysis of the oral temperature measurements.
  • the measurements are performed over a predetermined time interval and typically, for example, a 12-day time interval, during the female subject's ovulation cycle.
  • the female subject On comparison of the current temperature measurements with previously stored oral temperature measurements, the female subject is able to predict the date of commencement of the next ovulation period as well as predicting the sex of a conceived child.
  • the processor 124 receives from the temperature sensing apparatus 1 10, the oral temperature measurements typically taken over a 12- day time interval by the mobile oral temperature sensing system 100.
  • the processor 124 records, stores and analyzes the 12-daily oral temperature measurements of the female subject.
  • the oral measurements are conducted in the morning shortly after the female subject has awoken from her nightly sleep.
  • the female subject loads her menstruation cycle data, including the date and length of her previous menstruation cycles into the processor 124.
  • the female subject performs typically, for example, 12-daily oral temperature measurements. After each daily measurement, the measurement is communicated to the computing platform 120 where the processor 124 records, stores and analyzes the temperature data (step 304).
  • step 306 the processor 124, based on the received current daily oral temperature measurements, compares each current daily oral temperature measurement with at least one average oral temperature which has been previously calculated from a previous set of oral temperature measurements measured during a previous complete ovulation cycle and calculates a first daily variation. In addition, the processor 124 compares the daily temperature with a running average of the current daily temperature measurements and calculates a second daily variation.
  • the daily oral temperature measurements and/or average oral temperatures are also available on external databases and may be used for comparing and checking the current temperature measurements.
  • step 308 during the 12-day ovulation period, the processor 124 checks if either or both the first and second daily variations of the current daily measurement is within a temperature range of between approximately 0.15 - 0.45°C of the average temperature and the average running temperature, respectively. If on a particular day, the processor 124 determines that either the first variation and/or the second variation exceeds the temperature range of 0.15 - 0.45°C of the previous average and/or the running average temperature, respectively, the processor 124 decides that this daily measurement is anomalous (step 310) and the current daily measurement is cancelled (step 312). The female subject is alerted to the anomalous measurement by receiving a relevant warning message which is displayed on the output display unit 122 (step 314) and she is requested to repeat this daily oral temperature measurement (step 316).
  • the processor 124 compares the current oral temperature measurements against previously stored oral temperatures and basal body temperatures (step 318) and based on a statistical analysis, provides the female subject with a prediction of the date of commencement of the next ovulation cycle (step 320). It is appreciated that if the new daily measurement also exceeds the temperature range of 0.15 - 0.45°C, the oral temperature measurement is repeated.
  • a typical statistical analysis for predetermining and predicting the next date of ovulation includes a time-dependent regression method, such as Cox's Proportional Hazard Regression or a Time Series Analysis.
  • the processor provides the female subject with prediction as to the sex of the conceived child (steps 322 and 324).
  • Fig. 5 shows that the processor 124 also stores the average daily temperature and provides a monthly oral temperature report. Furthermore, based on a six-day average oral temperature, the processor 124 provides an infertility report to assist the female subject in birth-control.
  • Fig. 6 shows typical results for an oral temperature measurement for determining the sex of a child, in accordance with a preferred embodiment of the present invention.
  • the female subject also obtains pH and 0 2 measurements and deduces the sex of a conceived child.

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Abstract

La présente invention porte sur un système de mesure de la température orale d'un sujet féminin durant un cycle d'ovulation de celui-ci afin d'aider le sujet féminin à déterminer le prochaine cycle d'ovulation pour la fertilité et/ou le contrôle des naissances, comprenant un procédé et un appareil de prédiction du début d'un nouveau cycle d'ovulation chez un sujet féminin comprenant la mesure et la communication des données à une plateforme de calcul à distance par mesure quotidienne des températures orales et par calcul d'une température orale moyenne pour un cycle d'ovulation. Les mesures quotidiennes de la température orale et/ou les températures orales moyennes sont également disponibles dans des bases de données extérieures et peuvent être utilisées pour comparer et vérifier les mesures réelles de température. Différents capteurs sont disponibles à d'autres fins.
PCT/IL2010/001038 2009-12-09 2010-12-09 Système de détection et d'analyse d'ovulation Ceased WO2011070577A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/514,469 US20120265032A1 (en) 2009-12-09 2010-12-09 Ovulating sensing and analyzing system
EP10835609.8A EP2509510A4 (fr) 2009-12-09 2010-12-09 Système de détection et d'analyse d'ovulation
IL220248A IL220248A0 (en) 2009-12-09 2012-06-07 An ovulation sensing and analyzing system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26797109P 2009-12-09 2009-12-09
US61/267,971 2009-12-09

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WO2011070577A2 true WO2011070577A2 (fr) 2011-06-16
WO2011070577A3 WO2011070577A3 (fr) 2011-08-04

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EP2509510A2 (fr) 2012-10-17
WO2011070577A3 (fr) 2011-08-04
EP2509510A4 (fr) 2014-07-09

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