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WO2010115612A3 - Pregabalin compositions - Google Patents

Pregabalin compositions Download PDF

Info

Publication number
WO2010115612A3
WO2010115612A3 PCT/EP2010/002172 EP2010002172W WO2010115612A3 WO 2010115612 A3 WO2010115612 A3 WO 2010115612A3 EP 2010002172 W EP2010002172 W EP 2010002172W WO 2010115612 A3 WO2010115612 A3 WO 2010115612A3
Authority
WO
WIPO (PCT)
Prior art keywords
pregabalin
parts
blend
pregelatinized starch
lactose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/002172
Other languages
French (fr)
Other versions
WO2010115612A2 (en
Inventor
Lisardo ÁLVAREZ FERNÁNDEZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthon BV
Original Assignee
Synthon BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon BV filed Critical Synthon BV
Publication of WO2010115612A2 publication Critical patent/WO2010115612A2/en
Publication of WO2010115612A3 publication Critical patent/WO2010115612A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a solid pharmaceutical blend which comprises 100 parts of a pregabalin compound and at least 15 parts of a pregelatinized starch, wherein said blend is substantially free of lactose, and to a pharmaceutical capsule filling composition, which comprises a pregabalin compound, pregelatinized starch, and a lubricant; wherein said composition does not contain lactose, mannitol, or microcrystalline cellulose.
PCT/EP2010/002172 2009-04-10 2010-04-01 Pregabalin compositions Ceased WO2010115612A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16836309P 2009-04-10 2009-04-10
US61/168,363 2009-04-10

Publications (2)

Publication Number Publication Date
WO2010115612A2 WO2010115612A2 (en) 2010-10-14
WO2010115612A3 true WO2010115612A3 (en) 2011-02-03

Family

ID=42691170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/002172 Ceased WO2010115612A2 (en) 2009-04-10 2010-04-01 Pregabalin compositions

Country Status (1)

Country Link
WO (1) WO2010115612A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102793685B (en) * 2012-08-14 2017-09-22 浙江华海药业股份有限公司 Oral capsule containing Pregabalin and preparation method thereof
EP3038465B1 (en) 2013-08-30 2021-10-06 Merck Sharp & Dohme Corp. Oral pharmaceutical formulation of omarigliptin
JP2019142834A (en) * 2017-07-31 2019-08-29 大原薬品工業株式会社 Solid formulations containing pregabalin and suitable excipients
CN110613694A (en) * 2019-10-18 2019-12-27 杭州百诚医药科技股份有限公司 Pregabalin capsule and preparation method thereof
GB2624861A (en) 2022-11-28 2024-06-05 Orbit Pharma Ltd Sustained release pharmaceutical compositions comprising pregabalin or pharmaceutically acceptable salts thereof
GB2639602A (en) 2024-03-19 2025-10-01 Novumgen Ltd An orodispersible tablet of pregabalin and its process of preparation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001983A1 (en) * 1999-07-02 2001-01-11 Warner-Lambert Company A synergistic combination: gabapentin and pregabalin
WO2002078747A2 (en) * 2001-03-30 2002-10-10 Warner-Lambert Company Llc Pregabalin lactose conjugates
EP1591107A1 (en) * 2004-04-28 2005-11-02 Pfizer GmbH Arzneimittelwerk Gödecke Process for the selective increase of a release rate of an active material from a pharmaceutical composition
WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2008128775A2 (en) * 2007-04-23 2008-10-30 Ratiopharm Gmbh Stabilised pharmaceutical composition containing pregabaline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US20080014280A1 (en) 2006-07-17 2008-01-17 Glenmark Pharmaceuticals Limited Amorphous pregabalin and process for the preparation thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001983A1 (en) * 1999-07-02 2001-01-11 Warner-Lambert Company A synergistic combination: gabapentin and pregabalin
WO2002078747A2 (en) * 2001-03-30 2002-10-10 Warner-Lambert Company Llc Pregabalin lactose conjugates
EP1591107A1 (en) * 2004-04-28 2005-11-02 Pfizer GmbH Arzneimittelwerk Gödecke Process for the selective increase of a release rate of an active material from a pharmaceutical composition
WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2008128775A2 (en) * 2007-04-23 2008-10-30 Ratiopharm Gmbh Stabilised pharmaceutical composition containing pregabaline

Also Published As

Publication number Publication date
WO2010115612A2 (en) 2010-10-14

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