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WO2010039778A3 - Mammalian genes involved in infection - Google Patents

Mammalian genes involved in infection Download PDF

Info

Publication number
WO2010039778A3
WO2010039778A3 PCT/US2009/058947 US2009058947W WO2010039778A3 WO 2010039778 A3 WO2010039778 A3 WO 2010039778A3 US 2009058947 W US2009058947 W US 2009058947W WO 2010039778 A3 WO2010039778 A3 WO 2010039778A3
Authority
WO
WIPO (PCT)
Prior art keywords
infection
genes involved
mammalian genes
involved
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/058947
Other languages
French (fr)
Other versions
WO2010039778A2 (en
Inventor
Donald Rubin
Thomas Hodge
James Murray
Natalie Mcdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zirus Inc
Vanderbilt University
Original Assignee
Zirus Inc
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zirus Inc, Vanderbilt University filed Critical Zirus Inc
Priority to EP09818408A priority Critical patent/EP2362909A4/en
Publication of WO2010039778A2 publication Critical patent/WO2010039778A2/en
Publication of WO2010039778A3 publication Critical patent/WO2010039778A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01005—Isoleucine-tRNA ligase (6.1.1.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
    • C12N2330/31—Libraries, arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.
PCT/US2009/058947 2008-09-30 2009-09-30 Mammalian genes involved in infection Ceased WO2010039778A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09818408A EP2362909A4 (en) 2008-09-30 2009-09-30 INFECTIONS INVOLVED MIRACLE GENES

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19477408P 2008-09-30 2008-09-30
US61/194,774 2008-09-30
US19577008P 2008-10-09 2008-10-09
US61/195,770 2008-10-09

Publications (2)

Publication Number Publication Date
WO2010039778A2 WO2010039778A2 (en) 2010-04-08
WO2010039778A3 true WO2010039778A3 (en) 2010-09-16

Family

ID=42074170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/058947 Ceased WO2010039778A2 (en) 2008-09-30 2009-09-30 Mammalian genes involved in infection

Country Status (2)

Country Link
EP (1) EP2362909A4 (en)
WO (1) WO2010039778A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103201387B (en) * 2010-10-27 2018-02-02 库尔纳公司 Treatment of IFRD 1-related diseases by inhibition of natural antisense transcript to Interferon-related developmental regulator 1(IFRD1)
EP2807180B1 (en) 2012-01-24 2018-03-28 InterK Peptide Therapeutics Limited Peptide agents for cancer therapy
FR2987627B1 (en) * 2012-03-05 2016-03-18 Splicos USE OF RBM39 AS A BIOMARKER
US20150191702A1 (en) * 2012-07-02 2015-07-09 Commonwealth Scientific And Industrial Research Organization Paramyxovirus and Methods of Use
US9732345B2 (en) 2013-12-09 2017-08-15 Baylor College Of Medicine Hippo and dystrophin complex signaling in cardiomyocyte renewal
WO2019119036A1 (en) * 2017-12-19 2019-06-27 Benitec Biopharma Limited Cd70 deficient cells, and methods and reagents for producing same
CN108707607A (en) * 2018-06-08 2018-10-26 邵玉芹 A kind of aptamers and kit of energy specific detection EV71 viruses
KR102637287B1 (en) * 2019-05-29 2024-02-15 상뜨르 나쇼날 드 라 러쉐르쉬 샹띠피끄 Methods for identifying ubiquitin and ubiquitin-like enzyme activity
CN113274510B (en) * 2021-04-29 2022-05-13 山东农业大学 Composition for inhibiting J subgroup avian leukosis virus replication and application thereof
JP2025540101A (en) * 2022-12-01 2025-12-11 キャンプ４ セラピューティクス コーポレイション Modulation of SYNGAP1 gene transcription using antisense oligonucleotides targeting regulatory RNAs
CN118576714B (en) * 2024-05-27 2025-08-26 中国农业科学院兰州兽医研究所(中国动物卫生与流行病学中心兰州分中心) Application of HERC4 gene or protein as a target in screening drugs that inhibit foot-and-mouth disease virus replication

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018505A1 (en) * 2001-06-29 2004-01-29 Lee Ernestine A. Aminoacyl trna synthetases
US20060079474A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Analogs of tRNA synthetase fragments and uses thereof
WO2007084488A2 (en) * 2006-01-13 2007-07-26 Vanderbilt University Adam10 and its uses related to infection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018505A1 (en) * 2001-06-29 2004-01-29 Lee Ernestine A. Aminoacyl trna synthetases
US20060079474A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Analogs of tRNA synthetase fragments and uses thereof
WO2007084488A2 (en) * 2006-01-13 2007-07-26 Vanderbilt University Adam10 and its uses related to infection

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANDREW J. POPE ET AL.: "Characterization of Isoleucyl-tRNA Synthetase from Staphylococcus aureus", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 48, 27 November 1998 (1998-11-27), pages 31691 - 31701, XP008147617 *
CURTIS F. CRASTO ET AL.: "Synthesis and Activity of Analogues of the Isoleucyl tRNA Synthetase Inhibitor SB-203207", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 2687 - 2694, XP008147616 *
DEZHONG YIN ET AL.: "Identification of antimicrobial targets using a comprehensive genomic approach", PHARMACOGENOMICS, vol. 5, no. 1, 2004, pages 101 - 113, XP009055699 *
PAUL SCHIMMEL ET AL.: "Aminoacyl tRNA synthetases as targets for new anti-infectives", FASEB J, vol. 12, 1998, pages 1599 - 1609, XP002191843 *
See also references of EP2362909A4 *

Also Published As

Publication number Publication date
WO2010039778A2 (en) 2010-04-08
EP2362909A2 (en) 2011-09-07
EP2362909A4 (en) 2012-10-10

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