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WO2010036086A2 - Tomographie par émission de positons se couplant à la tomographie assistée par ordinateur - Google Patents

Tomographie par émission de positons se couplant à la tomographie assistée par ordinateur Download PDF

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Publication number
WO2010036086A2
WO2010036086A2 PCT/KR2009/005579 KR2009005579W WO2010036086A2 WO 2010036086 A2 WO2010036086 A2 WO 2010036086A2 KR 2009005579 W KR2009005579 W KR 2009005579W WO 2010036086 A2 WO2010036086 A2 WO 2010036086A2
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WO
WIPO (PCT)
Prior art keywords
pet
attached
image
scanner
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/005579
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English (en)
Korean (ko)
Other versions
WO2010036086A3 (fr
Inventor
최용
민병준
최준영
최연성
이경한
김병태
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samsung Life Public Welfare Foundation
Original Assignee
Samsung Life Public Welfare Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020090091734A external-priority patent/KR101136609B1/ko
Application filed by Samsung Life Public Welfare Foundation filed Critical Samsung Life Public Welfare Foundation
Publication of WO2010036086A2 publication Critical patent/WO2010036086A2/fr
Publication of WO2010036086A3 publication Critical patent/WO2010036086A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5235—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation

Definitions

  • the present invention relates to a CT attached PET and a method for providing a CT-PET fusion image using the same.
  • Computed Tomography is a device that uses a computer to image a certain cross-section of the human body, and it is widely used today by using X-ray developed by G. Housefield and J. Abrose of England in 1972.
  • the principle is to divide a cross section of the human body into a small matrix, transmit a thin X-ray beam in various directions, and measure X-ray absorption values of each matrix and reconstruct them into images.
  • the reconstruction method uses Fourier transform method and superposition integral method.
  • PET Positron emission tomography
  • PET has the affinity of certain neuro-receptors for metabolism and neurotransmitter ligands of certain substrates such as glucose and ganciclovir. It has the ability to measure gene phenomena as well as affinity / distribution.
  • PET can provide molecular and functional information of human tissue with very high contrast.
  • CT can provide detailed anatomical information about human tissue, but it cannot provide molecular and functional information as opposed to PET.
  • CT and PET have been developed as an integrated device.
  • an expensive integrated PET / CT fusion image device needs to be introduced, which causes a high cost.
  • Another object of the present invention to provide a method for providing a CT-PET fusion image using the CT attached PET.
  • the present invention includes a PET detector 30 located at 0 cm to 150 cm depth 35 from one side of the PET attached to the CT scanner 20, the anatomical image of the CT scanner And CT attached PET 33 for providing a fusion image of the functional image of the PET detector.
  • the PET detector is located at a depth of 0 cm from one side of the PET attached to the CT scanner when the PET detector is located on one side of the PET.
  • the inner diameter 34 of the PET detector is 2 cm to 130 cm.
  • the elliptical short radius 35 of one side of the PET attached to the CT scanner is 0 cm to 200 cm.
  • the oval short radius 35 of one side of the PET attached to the CT scanner is 0 cm, which corresponds to the case where one side of the PET is vertical.
  • the support further comprises a support 32 for maintaining the CT attached PET attachment.
  • the support 32 is inclined at 0 to 45 degrees with respect to the vertical plane. The inclination of the support to 0 ° with respect to the vertical plane corresponds to the case where the support is perpendicular to the floor.
  • the bed is inserted into the CT port 21 and the PET port 31 and photographed with the CT scanner 20 and the PET detector 33 to move the pointers 41a, 42a, 43a provided on the marker. Recognizing;
  • the markers are X-axis 41, Y-axis 42 and Z-axis 43 and pointers 41a, 42a, 43a provided on each axis as reference points on the coordinates. Is done.
  • CT attached PET of the present invention can be detachably mounted on the existing CT without the use of expensive equipment in which the CT and PET used in the hospital is integrally integrated, and it is possible to fuse anatomical and functional images Done Therefore, it is very economical by increasing the utilization of the existing CT device through the CT-attached PET of the present invention without purchasing an expensive PET / CT integrated device, and at the same time, it is highly reliable in the diagnosis of various tumors, brain neurological diseases, heart diseases, etc. There is an effect to be improved.
  • Figure 1 is a schematic diagram of a PET / CT system attached CT attached PET which is a preferred embodiment of the present invention.
  • Figure 2 is a side view (b) and cross-sectional view (a, c) showing a CT-attached PET which is a preferred embodiment of the present invention.
  • Figure 3 is a side view showing a CT attached PET is another preferred embodiment of the present invention.
  • FIG. 4 is a cross-sectional view showing that the CT attached PET 33, which is a preferred embodiment of the present invention, is attached to the CT scanner 20. As shown in FIG.
  • FIG. 5 is a schematic diagram showing before (a, b) and after (c) the CT attached PET is attached to the CT scanner.
  • FIG. 6 is a perspective view schematically showing the marker 40.
  • PET detector 31 PET shooting port
  • CT attached PET which is an embodiment of the present invention in more detail as follows.
  • Figure 1 is a schematic diagram of a PET / CT system attached CT attached PET which is a preferred embodiment of the present invention.
  • PET / CT system according to an embodiment of the present invention as shown is a bed 11 made of a flat plate shape so that the patient can lie down and transportably mounted along the longitudinal direction at the upper end of the support means (10);
  • a CT scanner 20 which is paired with the support means 10 and has a CT port 21 into which the bed 11 can be introduced, and takes an anatomical image of the patient;
  • PET detector 30 is formed in communication with the CT imaging port 21 and the PET detector 30 is mounted on one side of the CT scanner 20;
  • a marker 40 detachably mounted at one end of the bed 11.
  • FIG. 2 is a side view (b) and cross-sectional views (a, c) showing a CT-attached PET 33, which is a preferred embodiment of the present invention.
  • CT-attached PET 33 includes a PET detector 30 attached to the CT scanner 20.
  • the position of the PET detector 30 may vary depending on the usage of the PET / CT system, but is located at a depth of 0 cm to 50 cm from one side of the PET attached to the CT scanner 20.
  • the inner diameter 34 of the PET detector 30 may vary depending on the usage of the PET / CT system, but preferably 2 cm to 130 cm.
  • the elliptical short radius 35 of one side of the PET attached to the CT scanner 20 may vary depending on the usage of the PET / CT system, but is preferably 0 cm to 200 cm.
  • the CT-attached PET may further include a support 32 for maintaining the attachment.
  • the support 32 is preferably inclined at 0 to 45 degrees with respect to the vertical plane so that the PET detector 30 is attached to the CT scanner 20 well.
  • FIG. 3 is a side view showing a CT attached PET 33 according to another preferred embodiment of the present invention.
  • One side opposite to the one side of the PET attached to the CT scanner 20 may be concave as shown in FIG.
  • FIG. 4 is a cross-sectional view showing that the CT attached PET 33, which is a preferred embodiment of the present invention, is attached to the CT scanner 20. As shown in FIG.
  • FIG. 5 is a schematic view showing the CT attached PET 33 before (a, b) and after (c) being attached to the CT scanner 20.
  • PET detector 30 is preferably detachably mounted on one side of the CT scanner 20 to enable additional installation to the existing CT scanner 20 equipment, PET detector 30 is fastened with a bolt Any structure that can be detachably mounted, such as a method or a fixed clamp or a socket structure to be inserted and fixed, can be used, and the CT imaging port 21 and the PET imaging port 31 can communicate with each other through the bed 11. Has a structure.
  • FIG. 6 is a perspective view schematically showing the marker 40.
  • the marker 40 mounted on one end of the CT 11 of the bed 11 has a predetermined frame shape, and the X axis 41, the Y axis 42, and the Z axis 43 are formed in a wire shape. Pointers 41a, 42a, 43a are formed on the axis line, respectively.
  • the method for providing CT-PET fusion images by attaching the CT-attached PET 33 of the present invention to the CT scanner 20 includes the following steps:
  • the bed is inserted into the CT port 21 and the PET port 31 and photographed with the CT scanner 20 and the PET detector 33 to move the pointers 41a, 42a, 43a provided on the marker. Recognizing;
  • the marker 40 is installed on the bed 11 prior to imaging the affected area, and then inserted into the CT imaging tool 21 and the PET imaging tool 31.
  • the CT scanner 20 and the PET detector 30 take a picture to recognize the pointers 41a, 42a, and 43a provided in the marker 40.
  • the reference point of coordinates is found through the positions of the pointers 41a, 42a and 43a captured by the CT scanner 20 and the pointers 41a, 42a and 43a captured by the PET detector 30, and the reference points are fused to two images. When adjusted to the center point.
  • the marker 40 is used when the PET detector 30 is first attached to the CT scanner 20 and installed.
  • the marker 40 is separated when the patient image is taken after installation.
  • the marker 40 can be mounted and used as necessary for equipment defect check and quality control.
  • the patient lies on the bed 11 and moves the bed 11 to allow the affected part to be taken into the CT scanner 20.
  • the lesion to be taken passes the CT imaging port 21 and simultaneously captures the anatomical image of the affected part, and passes the PET port 31 and simultaneously captures the functional image of the affected part.
  • the photographed output signal is transferred to CT image processor and PET image processor, respectively, and is converted into anatomical image and functional image, and each converted image is transferred to fusion image processor and fused into one image. That is, it is possible to obtain an image in which the anatomical image and the functional image are fused.
  • the center point at which the anatomical image and the functional image are fused is already set in three dimensions through the pointers 41a, 42a, and 43a of the marker 40, and thus can be easily fused.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pulmonology (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Nuclear Medicine (AREA)

Abstract

La présente invention concerne une tomographie par émission de positrons (33) ou "PET" (Positron Emission Tomography) se couplant à une tomographie assistée par ordinateur ou "CT" (Computed Tomography) de façon à fournir une image de fusion combinant l'image anatomique provenant d'un scanographe de CT à une image fonctionnelle provenant d'un détecteur de PET. La PET se couplant à la CT met en œuvre le détecteur de PET (30) qui est disposé à une profondeur allant de 0 cm à 150 cm mesurée à partir d'un côté de la PET couplée au scanographe de CT (20). En L'invention concerne également un procédé permettant de réaliser une image de fusion CT-PET par couplage au scanographe de CT de la PET se couplant au scanographe CT. La PET se couplant à la CT de la présente invention est capable de se découpler d'une CT conventionnelle, et permet la fusion d'images anatomiques et d'images fonctionnelles sans qu'il y ait besoin du coûteux équipement intégrant CT et PET utilisé jusqu'à présent dans les hôpitaux. Il en résulte que la PET se couplant à la CT selon la présente invention est très économique dans la mesure où elle augmente la disponibilité d'un dispositif de CT conventionnelle sans qu'on ait à acheter un coûteux dispositif intégrant CT et PET. Simultanément, la PET se couplant à la CT améliore la fiabilité du diagnostic de diverses tumeurs, de divers troubles neurologiques, et de diverses pathologies cardiaques.
PCT/KR2009/005579 2008-09-29 2009-09-29 Tomographie par émission de positons se couplant à la tomographie assistée par ordinateur Ceased WO2010036086A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20080095611 2008-09-29
KR10-2008-0095611 2008-09-29
KR1020090091734A KR101136609B1 (ko) 2008-09-29 2009-09-28 Ｃｔ 부착형 ｐｅｔ
KR10-2009-0091734 2009-09-28

Publications (2)

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WO2010036086A2 true WO2010036086A2 (fr) 2010-04-01
WO2010036086A3 WO2010036086A3 (fr) 2010-07-15

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104490415A (zh) * 2015-01-12 2015-04-08 天津医科大学第二医院 用于腹盆部pet、ct及mr图像融合的立体定向框架
CN106890000A (zh) * 2016-12-28 2017-06-27 赛诺联合医疗科技（北京）有限公司 多模态探测系统的坐标配准模体
CN107374656A (zh) * 2017-05-26 2017-11-24 赛诺联合医疗科技（北京）有限公司 多模态探测系统的坐标配准模体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6917666B2 (en) * 2002-12-19 2005-07-12 General Electric Company System and method for table/gantry alignment in imaging systems
US7374337B2 (en) * 2005-06-17 2008-05-20 Siemens Medical Solutions Usa, Inc. Releasably interconnected CT and SPECT scanners
US7652256B2 (en) * 2006-07-03 2010-01-26 Siemens Medical Solutions Usa, Inc. Solid state based PET retrofit for a CT scanner

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104490415A (zh) * 2015-01-12 2015-04-08 天津医科大学第二医院 用于腹盆部pet、ct及mr图像融合的立体定向框架
CN106890000A (zh) * 2016-12-28 2017-06-27 赛诺联合医疗科技（北京）有限公司 多模态探测系统的坐标配准模体
CN106890000B (zh) * 2016-12-28 2020-04-28 赛诺联合医疗科技（北京）有限公司 多模态探测系统的坐标配准模体
CN107374656A (zh) * 2017-05-26 2017-11-24 赛诺联合医疗科技（北京）有限公司 多模态探测系统的坐标配准模体
CN107374656B (zh) * 2017-05-26 2019-12-03 赛诺联合医疗科技（北京）有限公司 多模态探测系统的坐标配准模体

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