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WO2010018593A3 - Gastric acid resistant benzimidazole multiple unit tablet composition - Google Patents

Gastric acid resistant benzimidazole multiple unit tablet composition Download PDF

Info

Publication number
WO2010018593A3
WO2010018593A3 PCT/IN2009/000379 IN2009000379W WO2010018593A3 WO 2010018593 A3 WO2010018593 A3 WO 2010018593A3 IN 2009000379 W IN2009000379 W IN 2009000379W WO 2010018593 A3 WO2010018593 A3 WO 2010018593A3
Authority
WO
WIPO (PCT)
Prior art keywords
gastric acid
multiple unit
acid resistant
tablet composition
unit tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2009/000379
Other languages
French (fr)
Other versions
WO2010018593A2 (en
Inventor
Pratheep Johnson
Yogesh Patel
Rakesh Sheth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torrent Pharmaceuticals Ltd
Original Assignee
Torrent Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd filed Critical Torrent Pharmaceuticals Ltd
Publication of WO2010018593A2 publication Critical patent/WO2010018593A2/en
Publication of WO2010018593A3 publication Critical patent/WO2010018593A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a stable, gastric acid resistant multiple unit tableted dosage form of benzimidazole compound comprising of a cushioning agent such as polyethylene glycol and at least one pharmaceutically acceptable excipient. The invention also relates to the process involved therein.
PCT/IN2009/000379 2008-07-03 2009-07-03 Gastric acid resistant benzimidazole multiple unit tablet composition Ceased WO2010018593A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1379/MUM/2008 2008-07-03
IN1379MU2008 2008-07-03

Publications (2)

Publication Number Publication Date
WO2010018593A2 WO2010018593A2 (en) 2010-02-18
WO2010018593A3 true WO2010018593A3 (en) 2010-04-15

Family

ID=41630491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000379 Ceased WO2010018593A2 (en) 2008-07-03 2009-07-03 Gastric acid resistant benzimidazole multiple unit tablet composition

Country Status (1)

Country Link
WO (1) WO2010018593A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024375A1 (en) * 1995-02-06 1996-08-15 Astra Aktiebolag New oral pharmaceutical dosage form
WO1997025064A1 (en) * 1996-01-08 1997-07-17 Astra Aktiebolag Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a nsaid
WO2000074654A1 (en) * 1999-06-07 2000-12-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel preparation and administration form comprising an acid-labile active compound
US6228400B1 (en) * 1999-09-28 2001-05-08 Carlsbad Technology, Inc. Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same
WO2004089333A2 (en) * 2003-02-28 2004-10-21 Cadila Healthcare Limited A stable benzimidazole formulation
WO2004098594A2 (en) * 2003-05-08 2004-11-18 Altana Pharma Ag Dosage form containing pantoprazole as active ingredient
EP1552833A1 (en) * 2002-10-16 2005-07-13 Takeda Chemical Industries, Ltd. Stable solid preparations
WO2006026829A1 (en) * 2004-09-09 2006-03-16 Metelli Pty Ltd Stable paste composition of enteric coated acid labile active agent and use thereof
EP1837016A2 (en) * 2006-03-08 2007-09-26 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical multiple-unit composition
US20070224260A1 (en) * 2004-04-15 2007-09-27 Dr. Reddy's Laboratories Limited Dosage Form Having Polymorphic Stability
WO2008006534A2 (en) * 2006-07-11 2008-01-17 Lek Pharmaceuticals D.D. Multiple unit tablets
WO2009017716A2 (en) * 2007-07-27 2009-02-05 Depomed, Inc. Pulsatile gastric retentive dosage forms

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024375A1 (en) * 1995-02-06 1996-08-15 Astra Aktiebolag New oral pharmaceutical dosage form
WO1997025064A1 (en) * 1996-01-08 1997-07-17 Astra Aktiebolag Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a nsaid
WO2000074654A1 (en) * 1999-06-07 2000-12-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel preparation and administration form comprising an acid-labile active compound
US6228400B1 (en) * 1999-09-28 2001-05-08 Carlsbad Technology, Inc. Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same
EP1552833A1 (en) * 2002-10-16 2005-07-13 Takeda Chemical Industries, Ltd. Stable solid preparations
WO2004089333A2 (en) * 2003-02-28 2004-10-21 Cadila Healthcare Limited A stable benzimidazole formulation
WO2004098594A2 (en) * 2003-05-08 2004-11-18 Altana Pharma Ag Dosage form containing pantoprazole as active ingredient
US20070224260A1 (en) * 2004-04-15 2007-09-27 Dr. Reddy's Laboratories Limited Dosage Form Having Polymorphic Stability
WO2006026829A1 (en) * 2004-09-09 2006-03-16 Metelli Pty Ltd Stable paste composition of enteric coated acid labile active agent and use thereof
EP1837016A2 (en) * 2006-03-08 2007-09-26 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical multiple-unit composition
WO2008006534A2 (en) * 2006-07-11 2008-01-17 Lek Pharmaceuticals D.D. Multiple unit tablets
WO2009017716A2 (en) * 2007-07-27 2009-02-05 Depomed, Inc. Pulsatile gastric retentive dosage forms

Also Published As

Publication number Publication date
WO2010018593A2 (en) 2010-02-18

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