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WO2010086030A1 - Contenant pour utilisation pharmaceutique destiné à la libération quantitative d'une dose unique pour administration orale d'hormones thyroïdiennes t3 et t4 en solution - Google Patents

Contenant pour utilisation pharmaceutique destiné à la libération quantitative d'une dose unique pour administration orale d'hormones thyroïdiennes t3 et t4 en solution Download PDF

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Publication number
WO2010086030A1
WO2010086030A1 PCT/EP2009/051984 EP2009051984W WO2010086030A1 WO 2010086030 A1 WO2010086030 A1 WO 2010086030A1 EP 2009051984 W EP2009051984 W EP 2009051984W WO 2010086030 A1 WO2010086030 A1 WO 2010086030A1
Authority
WO
WIPO (PCT)
Prior art keywords
fact
solution
container according
eva
plastic material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/051984
Other languages
English (en)
Inventor
Giorgio Zoppetti
Antonio Fontana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Altergon SA
Original Assignee
Altergon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altergon SA filed Critical Altergon SA
Priority to CN2009801558597A priority Critical patent/CN102300542A/zh
Priority to EP09779078A priority patent/EP2391331A1/fr
Publication of WO2010086030A1 publication Critical patent/WO2010086030A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01H—ELECTRIC SWITCHES; RELAYS; SELECTORS; EMERGENCY PROTECTIVE DEVICES
    • H01H1/00—Contacts
    • H01H1/12—Contacts characterised by the manner in which co-operating contacts engage
    • H01H1/14—Contacts characterised by the manner in which co-operating contacts engage by abutting
    • H01H1/22—Contacts characterised by the manner in which co-operating contacts engage by abutting with rigid pivoted member carrying the moving contact
    • H01H1/221—Contacts characterised by the manner in which co-operating contacts engage by abutting with rigid pivoted member carrying the moving contact and a contact pressure spring acting between the pivoted member and a supporting member
    • H01H1/225—Contacts characterised by the manner in which co-operating contacts engage by abutting with rigid pivoted member carrying the moving contact and a contact pressure spring acting between the pivoted member and a supporting member the supporting member being pivotable
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01H—ELECTRIC SWITCHES; RELAYS; SELECTORS; EMERGENCY PROTECTIVE DEVICES
    • H01H1/00—Contacts
    • H01H1/12—Contacts characterised by the manner in which co-operating contacts engage
    • H01H1/14—Contacts characterised by the manner in which co-operating contacts engage by abutting
    • H01H1/22—Contacts characterised by the manner in which co-operating contacts engage by abutting with rigid pivoted member carrying the moving contact
    • H01H1/221—Contacts characterised by the manner in which co-operating contacts engage by abutting with rigid pivoted member carrying the moving contact and a contact pressure spring acting between the pivoted member and a supporting member
    • H01H2001/223—Contacts characterised by the manner in which co-operating contacts engage by abutting with rigid pivoted member carrying the moving contact and a contact pressure spring acting between the pivoted member and a supporting member using a torsion spring
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01H—ELECTRIC SWITCHES; RELAYS; SELECTORS; EMERGENCY PROTECTIVE DEVICES
    • H01H71/00—Details of the protective switches or relays covered by groups H01H73/00 - H01H83/00
    • H01H71/10—Operating or release mechanisms
    • H01H71/1009—Interconnected mechanisms
    • H01H2071/1036—Interconnected mechanisms having provisions for four or more poles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01H—ELECTRIC SWITCHES; RELAYS; SELECTORS; EMERGENCY PROTECTIVE DEVICES
    • H01H71/00—Details of the protective switches or relays covered by groups H01H73/00 - H01H83/00
    • H01H71/10—Operating or release mechanisms
    • H01H71/1009—Interconnected mechanisms

Definitions

  • the present invention relates to a method of administration of pharmaceutical formulations based on thyroid hormones, and the relative means to implement it.
  • the hormones produced by the thyroid cells are released into the blood stream and act on the body's metabolism by increasing oxygen consumption and heat production with an increase in body temperature, stimulate protein synthesis and make the nitrogen balance more positive, increase gluconeogenesis and glycogenosis, and stimulate the synthesis, mobilization, and catabolism of cholesterol and lipids in general.
  • the thyroid hormones increase the rate of oxidative cellular processes and regulate the metabolism of most tissues. In general, it has a predominantly anabolic effect at low doses, while it has a catabolic action at high doses. This biphasic action is evident in the metabolism of glycogen, proteins, and lipids. In case of physiological deficiency, it is necessary to intervene with a therapy based on the administration of thyroid hormones.
  • T3 lastyronine, or O-(4-hydroxy-3- iodophenyl)-3,5-diiodo-L-tyrosine
  • T4 levothyroxine, or O-(4-hydroxy-3,5-diiodo phenyl)-3,5-diiodo-L-tyroxine are known thyroid hormones used, as such or in the form of sodium or hydrate salts, for various therapeutic applications and are obtained by synthesis or extraction from animal glands.
  • T3 or T4 are used primarily in the treatment of hypothyroidism.
  • the thyroid hormone administration therapy can often last for the patient's entire life.
  • the dosage must be individually determined. Generally, the initial dose is low. The amount is then gradually increased until the clinical evaluation and laboratory tests indicate that an optimal response has been obtained from the treated organism. The dose required to obtain this response is then maintained.
  • the age and general physical condition of the patient and the severity and length of the hypothyroidism symptoms determine the initial dose and the speed with which the dosage can be brought to the definitive level. It is particularly important to only increase the doses very gradually in patients with myxedema or with cardiovascular diseases to prevent the manifestation of angina, myocardial infarction or stroke.
  • T3 and T4 are administered orally, in particular through tablets that allow their administration to be adapted to the patient's individual situation through the control of their ingestion frequency and through the choice of the dosage units.
  • a precise dosage is extremely critical as an underdosage could lead to an insufficient response and therefore to hypothyroidism.
  • an overdosage would lead to toxic manifestations of hyperthyroidism including heart pain, palpitations, or cardiac arrhythmias.
  • a small increase in the dose of levothyroxine could be dangerous. Therefore, due to risks associated with overdosage or underdosage of thyroid hormones in general, it is absolutely critical that patients can rely on formulations that are reliable in terms of titer and bioavailability.
  • Liothyronine (T3) and levothyroxine (T4) are currently on the market as oral drops in addition to a solid oral form primarily including tablets and soft gelatin capsules.
  • the former is a single container of 20 ml equipped with a dropper.
  • this dropper does not guarantee the precise measurement of provided volume that is desired.
  • Calculating a content of approximately 3.5 ⁇ g of T4 for every drop various intermediate dosages between 3.5 and 200 ⁇ g could in theory be obtained.
  • the latter dosage is reached by aliquoting 2 ml with 56 drops (considering the minimum quantity of a drop).
  • dispensing a high number of drops is not easy or safe; further, the drops are never dispensed at an identical volume in a repeatable way.
  • a significant advantage of the liquid formulation is the stability of the active ingredient for both T4 and for T3. Therefore, the ability to accurately deliver the volume of a solution containing the effective dose of liothyronine T3 and levothyroxine
  • T4 to administer while maintaining the ideal stability of the active ingredient is the problem to be resolved by this invention.
  • plastic containers available today for pharmaceutical use primarily polyethylene and polypropylene, are designed to dispense even viscous liquid by guaranteeing a minimum dispensable volume, but they do not permit the precision of the delivery.
  • the bottle does not allow a quantitative release of the contained dose, i.e. complete, but only the release of a minimum dose.
  • a typical example are the soft vials for ophthalmic use, containing eye washes or eye drops.
  • a container for pharmaceutical use is proposed for the quantitative release of a single-dose for oral administration of the T3 and T4 thyroid hormones in solution, characterized by the fact of being formed with a plastic material having a
  • suitable plastic materials are those which can be formed with a Young's modulus that is sufficiently low and within the critical range defined above. It has in fact been found that the selection of this critical parameter allows an almost complete emptying, or extraction, of the T3 and T4 thyroid hormones solution under compression from a container containing them, such as a bottle, made of that material.
  • plastic materials with this Young's modulus can be obtained by injection molding.
  • the injection mold is used, the
  • Young's modulus of the suitable plastic materials is generally between 30 and 80
  • Suitable plastic materials are chosen from mixtures of polyethylene (PE) or polypropylene (PP) with ethylene-vinyl acetate (EVA).
  • PE polyethylene
  • PP polypropylene
  • EVA ethylene-vinyl acetate
  • PE/EVA mixes are preferred choices in the range between PE 15% + EVA 85% and
  • PP polypropylene
  • LDPE low-density polyethylene
  • plastic materials with a suitable Young's modulus include gelatin and mixtures thereof.
  • the Young's modulus is generally between 10 and 50 MPa in this case.
  • Plastic materials with a suitable Young's modulus in this case can be obtained with rotary-die process molding suitable for the production of soft gelatin capsules.
  • the T3 and T4 thyroid hormone solution is injected within the gelatin- based plastic material in the form of a gelatinous semi-finished product in the fusion state, in order to create soft capsules; the formation of a sealable opening for the delivery of the solution will be provided within the said soft capsule.
  • the gelatin for example animal gelatin
  • substances that make the gelatin insoluble in or impermeable to water such as cyclodextrins and dimethicone.
  • Polyvinyl alcohol (PVA), polyacrylates or aluminum glycinate are useful substances for making the gelatin insoluble in water.
  • SEC soft elastic capsules
  • Other processes known and described in the pharmaceutical literature for the production of soft elastic capsules (SEC) with liquid or semi-liquid content such as the "Plate Process” or the use of the "Norton Capsule Machine” or the “Accogel Capsule Machine” as in “Remington's Pharmaceutical Sciences", 18th edition, edited by Alfonso R.
  • Gennaro, 1990, Mack Publishing Company, Easton Pennsylvania 18042, ISBN 0-912734-04-3, are applicable for the production of containers in the form of soft capsules according to this invention including thyroid hormones and any excipients in a liquid or semi-liquid carrier.
  • the surface energy of the material in addition to the Young's modulus selected in the critical way as described above, should preferably be maintained under 36 mN/m.
  • the total surface energy values y expressed in mN/m, are stated for the mixes of plastic materials of the invention specified in the above table.
  • Low-density polyethylene (LDPE) 50.0 Kg 100 % The product consists of a strip of 5 1.0 ml single-doses with screw cap.
  • the strip of 5 single-doses and the strip of 5 caps are produced by injection molding with two different molds, and are then assembled with semi-automatic equipment.
  • the characterization of the molder products is carried out through determination of the Young's modulus: samples of sizes determined by the UNI-EN-ISO 527-1 reference standard are used, and subjected to traction with a traction velocity of 5 mm/min.
  • the glycerol-ethanol solution obtained according to example 1 is used.
  • c) Filling of the single-use containers
  • the containers obtained in a) are filled with 1.05 ml of glycerol-ethanol solution described in b) by automatic pipette (Gilson P-1000), then sealed with a Pentaseal- lab model bench-top sealer (Lameplast - Rovereto di Modena - Italy).
  • the emptying test of a container according to c) has provided a percentage extractability of the solution with respect to theory equal to 90%.
  • the product consists of a strip of 5 1.0 ml single-doses with screw cap.
  • the strip of 5 single-doses and the strip of 5 caps are produced by injection molding with two different molds, and are then assembled with semi-automatic equipment.
  • the characterization of the molder products is carried out through determination of the Young's modulus: samples of sizes determined by the UNI-EN-ISO 527-1 reference standard are used, and subjected to traction with a traction velocity of 5 mm/min. The following is measured:
  • the total surface energy y of the material, evaluated according to the Owens Wendt method, was also measured: 50 PE / 50 EVA Mix ⁇ 31.3 mN/m b) preparation of the T4 solution
  • the containers obtained in a) are filled with 1.05 ml of glycerol-ethanol solution described in b) by automatic pipette (Gilson P-1000), then sealed with a Pentaseal- lab model bench-top sealer (Lameplast - Rovereto di Modena - Italy).
  • LDPE Low-density polyethylene
  • EVA ethylene-vinyl acetate
  • the product consists of a strip of 5 1.0 ml single-doses with screw cap.
  • the strip of 5 single-doses and the strip of 5 caps are produced by injection molding with two different molds, and are then assembled with semi-automatic equipment.
  • the characterization of the molder products is carried out through determination of the Young's modulus: samples of sizes determined by the UNI-EN-ISO 527-1 reference standard are used, and subjected to traction with a traction velocity of 5 mm/min. The following is measured: 25 LDPE / 75 EVA Mix 42.2 MPa
  • the total surface energy y of the material, evaluated according to the Owens Wendt method, was also measured: 25 PE / 75 EVA Mix ⁇ 34.1 mN/m b) preparation of the T4 solution
  • the containers obtained in a) are filled with 1.05 ml of glycerol-ethanol solution described in b) by automatic pipette (Gilson P-1000), then sealed with a Pentaseal- lab model bench-top sealer (Lameplast - Rovereto di Modena - Italy).
  • the glycerol-ethanol solution obtained according to example 1 is used. c) preparation of the container with solution in the form of soft capsules Soft gelatin capsules with an 8-tube format (or twist-off) were prepared according to the following known Rotary Die type process.
  • the gelatinous mixture prepared according to a) is transferred by nitrogen pressure to two thermostated (50 0 C / 70 0 C) spreader boxes, from which it drips on two rollers cooled to 18°C ⁇ 5°C, allowing the formation of gelatin ribbons of a predetermined thickness.
  • the two gelatin ribbons are accompanied to the sides of the solution injection segment and through two molds.
  • the injection pump operates the filling with the solution according to b) allowing the formation of the capsules.
  • the solution according to b) is injected in the measure of 1 ml, in capsules of an 8- tube format, whose sealing is guaranteed by the combined and simultaneous pressure of the molds, the heating of the injection segment, and the ribbons (partial fusion).
  • the capsules formed are transferred to special tumble driers where they begin the water loss phase, completed after a pause in the desiccation tunnel for the achievement of a moisture content between 5% and 15%.
  • Openable soft gelatin capsules having the following characteristics are thus obtained: average weight per capsule: 745 mg ⁇ 7.5% residual moisture: 1.0%
  • T4 content 0.050 mg/capsule, equal to 100.0% d.d. hardness: 6-10 N
  • Young's modulus between 10 and 50 MPa.
  • the emptying test of a soft capsule container according to this example has provided a percentage extractability of the solution with respect to theory equal to 98%.
  • the invention allows the achievement of a nearly quantitative release of a predetermined dose of thyroid hormones T3 and T4 in solution for oral administration, thus effectively achieving the originally proposed purpose.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention porte sur un contenant pour utilisation pharmaceutique destiné à la libération quantitative d'une dose unique pour administration orale d'hormones thyroïdiennes T3 et T4 en solution, caractérisé en ce qu'il est constitué d'une matière plastique ayant un module de Young compris entre 10 et 80 MPa.
PCT/EP2009/051984 2009-01-30 2009-02-19 Contenant pour utilisation pharmaceutique destiné à la libération quantitative d'une dose unique pour administration orale d'hormones thyroïdiennes t3 et t4 en solution Ceased WO2010086030A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2009801558597A CN102300542A (zh) 2009-01-30 2009-02-19 一种用于定量释放单剂量的用于口服的t3和t4甲状腺激素溶液的药用容器
EP09779078A EP2391331A1 (fr) 2009-01-30 2009-02-19 Contenant pour utilisation pharmaceutique destiné à la libération quantitative d'une dose unique pour administration orale d'hormones thyroïdiennes t3 et t4 en solution

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2009A000118 2009-01-30
ITMI2009A000118A IT1393524B1 (it) 2009-01-30 2009-01-30 Contenitore per uso farmaceutico atto al rilascio quantitativo di una monodose per somministrazione orale di ormoni tiroidei t3 e t4 in soluzione

Publications (1)

Publication Number Publication Date
WO2010086030A1 true WO2010086030A1 (fr) 2010-08-05

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ID=41139334

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/051984 Ceased WO2010086030A1 (fr) 2009-01-30 2009-02-19 Contenant pour utilisation pharmaceutique destiné à la libération quantitative d'une dose unique pour administration orale d'hormones thyroïdiennes t3 et t4 en solution

Country Status (5)

Country Link
US (1) US20100197790A1 (fr)
EP (1) EP2391331A1 (fr)
CN (1) CN102300542A (fr)
IT (1) IT1393524B1 (fr)
WO (1) WO2010086030A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20112066A1 (it) * 2011-11-14 2013-05-15 Altergon Sa Preparazione farmaceutica orale monodose di ormoni tiroidei t3 e t4
ITMI20131008A1 (it) * 2013-06-18 2014-12-19 Altergon Sa Dispositivo monodose spray per applicazioni topiche e sistemiche
EP3311844A1 (fr) 2016-10-18 2018-04-25 Altergon S.A. Solutions emballées à stabilité élevée d'hormone thyroïdienne t4
US11241382B2 (en) 2019-03-01 2022-02-08 Altergon Sa Administration regimen of compositions of T4 thyroid hormone with high oral absorption

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10266228B2 (en) 2016-06-24 2019-04-23 Easy2.Company B.V. Drive train for a treadle scooter
IT201900003013A1 (it) * 2019-03-01 2020-09-01 Altergon Sa Regime di somministrazione di composizioni di ormone tiroideo T4 con elevato assorbimento orale

Citations (6)

* Cited by examiner, † Cited by third party
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US5271881A (en) * 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
WO1997037629A1 (fr) * 1996-04-05 1997-10-16 Warner-Lambert Company Procede pour encapsuler des caplets dans une gelule et formes galeniques solides obtenues par ledit procede
WO1997040820A1 (fr) * 1996-04-29 1997-11-06 Fuisz Technologies Ltd. Systeme d'administration de doses de medicament a un receveur
EP1291021A2 (fr) * 2001-07-02 2003-03-12 Altergon S.A. Formulations pharmaceutiques comprenant des hormones thyroidiennes
US20030166763A1 (en) * 2000-08-29 2003-09-04 Noboru Hoshi Hard capsule
WO2004085483A2 (fr) * 2003-03-28 2004-10-07 Innogel Ag Materiau resilient

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US5843540A (en) * 1996-11-15 1998-12-01 Tetra Laval Holdings & Finance, S.A. Multi-layer flexible container for flowable materials
US6730735B2 (en) * 1997-07-03 2004-05-04 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Conjugate of polyethylene glycol and chitosan
DE20019365U1 (de) * 2000-11-15 2001-01-18 Dr. Gerhard Mann Chem.-pharm. Fabrik GmbH, 13581 Berlin Eindosis-Kunststoffbehältnis zur Aufnahme von einem flüssigen oder gelartigen pharmazeutischen Präparat
ATE329956T1 (de) * 2001-02-01 2006-07-15 Solvay Draka Inc Flexible, seps enthaltende, elastomerfilme und medizinische behälter
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JP4412463B2 (ja) * 2003-12-11 2010-02-10 藤森工業株式会社 複室容器

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271881A (en) * 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
WO1997037629A1 (fr) * 1996-04-05 1997-10-16 Warner-Lambert Company Procede pour encapsuler des caplets dans une gelule et formes galeniques solides obtenues par ledit procede
WO1997040820A1 (fr) * 1996-04-29 1997-11-06 Fuisz Technologies Ltd. Systeme d'administration de doses de medicament a un receveur
US20030166763A1 (en) * 2000-08-29 2003-09-04 Noboru Hoshi Hard capsule
EP1291021A2 (fr) * 2001-07-02 2003-03-12 Altergon S.A. Formulations pharmaceutiques comprenant des hormones thyroidiennes
WO2004085483A2 (fr) * 2003-03-28 2004-10-07 Innogel Ag Materiau resilient

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20112066A1 (it) * 2011-11-14 2013-05-15 Altergon Sa Preparazione farmaceutica orale monodose di ormoni tiroidei t3 e t4
WO2013072304A1 (fr) 2011-11-14 2013-05-23 Altergon S.A. Préparation pharmaceutique monodose d'hormones thyroïdiennes t3 et/ou t4
EP3056187A1 (fr) 2011-11-14 2016-08-17 Altergon S.a. Préparation pharmaceutique à dose unique d'hormones thyroïdiennes t3 et/ou t4
EP3056187B1 (fr) 2011-11-14 2018-08-22 Altergon S.a. Préparation pharmaceutique à dose unique d'hormones thyroïdiennes t3 et/ou t4
RU2688430C2 (ru) * 2011-11-14 2019-05-21 Альтергон С.А. Однодозовый фармацевтический препарат тиреоидных гормонов т3 и/или т4
ITMI20131008A1 (it) * 2013-06-18 2014-12-19 Altergon Sa Dispositivo monodose spray per applicazioni topiche e sistemiche
EP3311844A1 (fr) 2016-10-18 2018-04-25 Altergon S.A. Solutions emballées à stabilité élevée d'hormone thyroïdienne t4
WO2018073209A1 (fr) 2016-10-18 2018-04-26 Altergon Sa Solutions conditionnées à stabilité élevée d'hormone thyroïdienne t4
US10537538B2 (en) 2016-10-18 2020-01-21 Altergon Sa High-stability packaged solutions of T4 thyroid hormone
US11096913B2 (en) 2016-10-18 2021-08-24 Altergon Sa High-stability packaged solutions of T4 thyroid hormone
US11241382B2 (en) 2019-03-01 2022-02-08 Altergon Sa Administration regimen of compositions of T4 thyroid hormone with high oral absorption

Also Published As

Publication number Publication date
IT1393524B1 (it) 2012-04-27
US20100197790A1 (en) 2010-08-05
EP2391331A1 (fr) 2011-12-07
CN102300542A (zh) 2011-12-28
ITMI20090118A1 (it) 2010-07-31

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