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WO2010079253A3 - Bio-markers for diagnosing fibrosis - Google Patents

Bio-markers for diagnosing fibrosis Download PDF

Info

Publication number
WO2010079253A3
WO2010079253A3 PCT/ES2010/070007 ES2010070007W WO2010079253A3 WO 2010079253 A3 WO2010079253 A3 WO 2010079253A3 ES 2010070007 W ES2010070007 W ES 2010070007W WO 2010079253 A3 WO2010079253 A3 WO 2010079253A3
Authority
WO
WIPO (PCT)
Prior art keywords
markers
bio
fibrosis
methods
diagnosing fibrosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2010/070007
Other languages
Spanish (es)
French (fr)
Other versions
WO2010079253A2 (en
Inventor
Fernando José CORRALES IZQUIERDO
Joaquín FERNÁNDEZ IRIGOYEN
Leticia Odriozola Moncayola
Jesús María PRIETO VALTUEÑA
Enrique SANTAMARÍA MARTÍNEZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proyecto de Biomedicina CIMA SL
Original Assignee
Proyecto de Biomedicina CIMA SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proyecto de Biomedicina CIMA SL filed Critical Proyecto de Biomedicina CIMA SL
Publication of WO2010079253A2 publication Critical patent/WO2010079253A2/en
Publication of WO2010079253A3 publication Critical patent/WO2010079253A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to methods for detecting and diagnosing fibrosis and diseases associated with fibrosis, and to methods for determining the effectiveness of a therapy against fibrosis by determining the expression levels of bio-markers, where the one or more bio-markers are selected from the group formed by SLURP1, HAMP, GSN and APOD. The invention also relates to kits comprising reagents suitable for carrying out the methods according to the invention.
PCT/ES2010/070007 2009-01-09 2010-01-07 Bio-markers for diagnosing fibrosis Ceased WO2010079253A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200900056 2009-01-09
ES200900056 2009-01-09

Publications (2)

Publication Number Publication Date
WO2010079253A2 WO2010079253A2 (en) 2010-07-15
WO2010079253A3 true WO2010079253A3 (en) 2010-10-14

Family

ID=42232658

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2010/070007 Ceased WO2010079253A2 (en) 2009-01-09 2010-01-07 Bio-markers for diagnosing fibrosis

Country Status (1)

Country Link
WO (1) WO2010079253A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012162B2 (en) 2006-09-08 2015-04-21 The Chancellor, Masters And Scholars Of The University Of Oxford Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers
ES2897692T3 (en) * 2009-05-14 2022-03-02 Shox Science Ltd Clinical diagnosis of liver fibrosis using a new set of low-abundant human plasma protein biomarkers
GB201614455D0 (en) 2016-08-24 2016-10-05 Univ Oxford Innovation Ltd Biomarkers
CN114527275A (en) * 2022-02-22 2022-05-24 深圳市亚辉龙生物科技股份有限公司 Diagnostic kit for hepatic fibrosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016949A1 (en) * 2000-08-21 2002-02-28 Assistance Publique - Hopitaux De Paris Diagnosis method of fibrotic disease using biochemical markers
WO2003073822A2 (en) * 2002-02-28 2003-09-12 Prometheus Laboratories, Inc. Methods of diagnosing liver fibrosis
WO2008123948A1 (en) * 2007-03-27 2008-10-16 Vermillion, Inc. Biomarkers for ovarian cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
ES2201077T3 (en) 1993-05-28 2004-03-16 Baylor College Of Medicine METHOD AND SPECTROMETER OF MASSES FOR DESORTION AND IONIZATION OF ANALYTS.
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
WO2002086168A1 (en) 2001-04-19 2002-10-31 Ciphergen Biosystems, Inc. Biomolecule characterization using mass spectrometry and affinity tags
US8068987B2 (en) 2001-08-13 2011-11-29 Bg Medicine, Inc. Method and system for profiling biological systems
AU2003239152A1 (en) 2002-04-23 2003-11-10 Millipore Corporation Sample preparation of biological fluids for proteomic applications
FR2870348B1 (en) 2004-05-14 2010-08-27 Univ Angers METHOD FOR DIAGNOSING THE PRESENCE AND / OR SEVERITY OF A HEPATHIC PATHOLOGY IN A SUBJECT
ES2288358B1 (en) 2005-07-01 2008-11-16 Proyecto De Biomedicina Cima, S.L. FIBROSIS MARKERS.
US7972785B2 (en) 2006-01-24 2011-07-05 Industrial Technology Research Institute (Itri) Biomarkers for liver fibrotic injury
US9012162B2 (en) 2006-09-08 2015-04-21 The Chancellor, Masters And Scholars Of The University Of Oxford Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016949A1 (en) * 2000-08-21 2002-02-28 Assistance Publique - Hopitaux De Paris Diagnosis method of fibrotic disease using biochemical markers
WO2003073822A2 (en) * 2002-02-28 2003-09-12 Prometheus Laboratories, Inc. Methods of diagnosing liver fibrosis
WO2008123948A1 (en) * 2007-03-27 2008-10-16 Vermillion, Inc. Biomarkers for ovarian cancer

Also Published As

Publication number Publication date
WO2010079253A2 (en) 2010-07-15

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