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WO2010071222A1 - Inhibiteur d'émission de méthane pour ruminants et composition alimentaire - Google Patents

Inhibiteur d'émission de méthane pour ruminants et composition alimentaire Download PDF

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Publication number
WO2010071222A1
WO2010071222A1 PCT/JP2009/071362 JP2009071362W WO2010071222A1 WO 2010071222 A1 WO2010071222 A1 WO 2010071222A1 JP 2009071362 W JP2009071362 W JP 2009071362W WO 2010071222 A1 WO2010071222 A1 WO 2010071222A1
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WIPO (PCT)
Prior art keywords
ruminant
methane
ruminants
rumen
hydrogen peroxide
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Ceased
Application number
PCT/JP2009/071362
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English (en)
Japanese (ja)
Inventor
聖 平川
康博 三原
博昭 良知
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of WO2010071222A1 publication Critical patent/WO2010071222A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements

Definitions

  • the present invention relates to a methane production inhibitor, a feed additive and a feed composition for ruminants, and a method for inhibiting ruminant methane production and a method for improving growth, characterized by using these.
  • Methane generation from ruminant rumen not only results in a loss of feed energy use efficiency, but methane is a powerful greenhouse gas that contributes to global warming, reducing methane production in ruminant rumen Is extremely important. In the lumen, fermentation by a wide variety of microorganisms is performed, and various metabolites are generated. Methane is one of them, and is thought to be produced by methanogenic bacteria.
  • the rumen methane-producing bacteria are hydrogen-utilizing bacteria that use hydrogen to reduce carbon dioxide and produce methane. Therefore, if there is a stronger reduction reaction than this, methane production is inhibited.
  • Patent Document 1 As a method for suppressing methane generation in the rumen, a method of feeding ruminants with an ionophore, which is an antibacterial substance such as monensin or ivelin, is known.
  • methods that pay attention to the regulation of reducing ability in rumen include a method of feeding cysteine (Patent Document 3), a method of feeding fumaric acid (Patent Documents 2 and 3), and the like.
  • Addition of nitrate has also been reported to be effective, but toxic nitrite accumulates in the rumen, which is known to cause ruminant poisoning in ruminants. Studies are also underway on the antibacterial bacteriocin produced by microorganisms.
  • Non-patent Document 4 Although there is a report that uses nisin produced by lactic acid bacteria alone (Patent Document 4), it is reported that nisin has no sustained effect because it is easily degraded in rumen, and nisin-resistant bacteria also appear (Non-patent Document). 1). Moreover, although there exists a method of improving feed efficiency by using the preparation of sorbic acid and bacteriocin together (patent document 5), it is not clarified about suppression of methane generation when added as ruminant feed.
  • the present invention provides a methane production inhibitor that suppresses methane generation in rumen of ruminants and improves feed efficiency, feed additives and feed compositions containing the same, and feeds these to ruminants to produce methane.
  • An object is to provide a method for inhibiting production and thus improving its growth.
  • a ruminant characterized by administering the ruminant feed additive and / or ruminant feed composition according to (2) to the ruminant and / or the ruminant feed additive and / or ruminant feed composition according to (2).
  • a method for suppressing methane generation from animal rumen (4)
  • a ruminant characterized by administering the ruminant feed additive and / or ruminant feed composition according to (2) to the ruminant and / or the ruminant feed additive and / or ruminant feed composition according to (2). Animal growth improvement method.
  • methane production in rumen rumen is significantly suppressed, the energy efficiency of the feed is improved, and the development of the ruminant is improved. It can also contribute to environmental problems such as global warming by reducing the production of methane, a greenhouse gas. Confirmation of the effect of suppressing the methane production in the lumen by the administration of the methane production inhibitor of the present invention was confirmed by an artificial rumen system (T. Hino et al., J. Gen. Appl. Microbiol., 39, 35-45 ( 1993)), but it goes without saying that it may be confirmed by oral administration to ruminants in vivo.
  • FIG. 1 is an explanatory diagram showing the relationship between the concentration of hydrogen peroxide and the methane production inhibitory activity.
  • FIG. 2 is an explanatory diagram showing the relationship between the concentration of hydrogen peroxide and the amount of hydrogen produced.
  • the methane production inhibitor of the present invention is a ruminant methane production inhibitor characterized by containing hydrogen peroxide as an active ingredient.
  • the ruminant in the present invention refers to a mammal belonging to the order of the artiodactylid ruminant, and refers to one in which the stomach is divided into 3 or 4 chambers and ruins food. Examples include cows and sheep.
  • the active substance is hydrogen peroxide, which is highly safe when used at an appropriate concentration, and is preferable from the viewpoint of the health of ruminants. Moreover, since it is rapidly decomposed into water and oxygen, there is no residue in ruminant meat or milk.
  • Hydrogen peroxide used as an active ingredient in the methane inhibitor of the present invention can be easily obtained commercially, for example, purchased from Takasugi Pharmaceutical, Naito Shoten, Nippon Peroxide, Wako Pure Chemical, etc. I can do it.
  • cultures such as microorganisms that produce hydrogen peroxide, such as lactic acid bacteria can also be used as the hydrogen peroxide source. .
  • the timing of administration of the methane production inhibitor is not particularly limited as long as the methane production inhibitory effect of the present invention is exhibited, and can be administered at any time as long as the feed remains in the lumen. However, since it is preferable that a methane formation inhibitor is present in the lumen before and after methane is most actively produced, it is preferable to administer the methane production inhibitor immediately before or simultaneously with the administration of feed.
  • the ruminant methane production inhibitor according to the present invention can be used in various forms, and is not particularly limited as long as the methane production inhibitory effect is exerted. For example, an aqueous solution, a capsule, or a feed addition containing these Various forms such as food and feed composition.
  • the dosage of the methane production inhibitor of the present invention is such that the hydrogen peroxide concentration in the rumen solution immediately after administration is at least 0.001 to 10 mM, more preferably 0.01 to 5 mM. To do. Since hydrogen peroxide as an active ingredient decomposes rapidly after administration, it may be administered multiple times a day as long as the concentration is within the above range. By administering at such a dose, methane bacteria are preferentially sterilized or bacteriostatic without adversely affecting useful rumen microorganisms such as fibrinolytic bacteria.
  • the present invention will be further described by examples. Needless to say, the present invention is not limited to these examples, and can be arbitrarily changed without departing from the gist of the present invention.
  • the methane production inhibitory activity of the methane production inhibitor can be confirmed by an activity measurement method described later. Rumen fermentation simplified evaluation method ⁇ Materials and experimental method> Rumen fluid collected from cattle raised mainly in hay before feeding was used. (In this experiment, Holstein cattle were used. However, the type of cattle, the type of feed, and the method for collecting rumen fluid are commonly used in this field. As long as the law does not limit).
  • Example 1 Hydrogen peroxide concentration-dependent methane production inhibitory effect A 30-35% aqueous hydrogen peroxide solution (Wako Pure Chemical Industries, Ltd.) whose concentration was accurately analyzed was diluted with physiological saline, and the hydrogen peroxide concentration was reduced to 0. 0. 0. Sample series having 1, 0.3, 0.5, 0.7, 0.9, 1.1, 1.3, 1.5, 3.0, 5.0, 10.0 mM were prepared. These samples were subjected to the rumen fermentation simplified evaluation method. In this study, independent tests were performed three times, and the average value and standard error are shown in FIGS.
  • the horizontal axis indicates the hydrogen peroxide sample concentration (mM), and the vertical axis indicates the relative amount of methane generated in each sample administration group when the negative control (hydrogen peroxide sample concentration 0 mM) is 100. Is shown.
  • the bar graph shows the average value of three independent experiments, and the error bar shows the standard error obtained from the three experiments.
  • the horizontal axis indicates the hydrogen peroxide sample concentration (mM), and the vertical axis indicates the amount of hydrogen generated when the H 2 O 2 concentration is 1.1 mM in each sample administration group. The amount of hydrogen generation is shown as a relative value.
  • the bar graph shows the average value of three independent experiments, and the error bar shows the standard error obtained from the three experiments.
  • methane which is a powerful greenhouse gas emitted from ruminants. It is extremely useful because it improves growth.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

L'invention porte sur un inhibiteur d'émission de méthane qui peut inhiber l'émission de méthane dans le rumen d'un ruminant. L'invention porte plus précisément sur un inhibiteur d'émission de méthane, pour ruminants, qui est caractérisé par le fait qu'il comporte du peroxyde d'hydrogène comme ingrédient actif.
PCT/JP2009/071362 2008-12-20 2009-12-16 Inhibiteur d'émission de méthane pour ruminants et composition alimentaire Ceased WO2010071222A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008-336149 2008-12-20
JP2008336149 2008-12-20

Publications (1)

Publication Number Publication Date
WO2010071222A1 true WO2010071222A1 (fr) 2010-06-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/071362 Ceased WO2010071222A1 (fr) 2008-12-20 2009-12-16 Inhibiteur d'émission de méthane pour ruminants et composition alimentaire

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WO (1) WO2010071222A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012159186A1 (fr) 2011-05-23 2012-11-29 Grasp Indústria E Comércio Ltda. Utilisation de nitrates et de sulfates encapsulés pour réduire l'émission de méthane provenant de la fermentation ruminale
CN113453561A (zh) * 2018-10-10 2021-09-28 斯朗切比奥加有限公司 不含抗生素的抗微生物饲料添加剂和抗微生物组合物
WO2023007008A1 (fr) * 2021-07-30 2023-02-02 GlasPort Bio Limited Compositions et procédés
CN116602358A (zh) * 2023-06-12 2023-08-18 山东省农业科学院畜牧兽医研究所 蛇床子素在减少反刍动物瘤胃甲烷排放中的应用
WO2024008734A1 (fr) * 2022-07-08 2024-01-11 Unibio Tech Science A/S Aliment pour ruminants
US12084610B2 (en) 2022-07-01 2024-09-10 Arkea Bio Corp. Compositions and methods for reducing deleterious atmospheric gas emissions from flooded ecosystems

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5029987B1 (fr) * 1970-10-05 1975-09-27
JPS5547665A (en) * 1978-09-12 1980-04-04 Ici Ltd Heterocyclic trichloromethyl compound*its manufacture and composition for decreasing methane formation in rumen of ruminant and*or for increasing ratio of propionic acid in rumen fluid
JPS6183131A (ja) * 1984-07-25 1986-04-26 オレオフイナ・ソシエテ・アノニム 食料又は餌料組成物
JPH06153809A (ja) * 1992-07-07 1994-06-03 Charles T Sweeney 家畜飼料物質の消化性改善法
JPH1146694A (ja) * 1997-08-06 1999-02-23 Ajinomoto Co Inc 反芻動物用メタン生成抑制飼料組成物
JP2002209529A (ja) * 2001-01-22 2002-07-30 Natl Fedelation Of Agricult Coop Assoc ルーメン発酵調整用飼料添加物及びこれを含有する養牛用飼料
JP2002281912A (ja) * 2001-03-27 2002-10-02 Society For Techno-Innovation Of Agriculture Forestry & Fisheries 反芻動物のメタン生成を抑制する飼料組成物
JP2003088301A (ja) * 2001-09-19 2003-03-25 Yakult Honsha Co Ltd 反芻動物用のメタン生成抑制用組成物及び飼料用組成物
JP2004129658A (ja) * 2002-09-18 2004-04-30 Hoshizaki Electric Co Ltd 反芻動物用の消化促進剤および反芻動物の飼育方法
JP2006061092A (ja) * 2004-08-27 2006-03-09 Mitsuba Boeki Kk 反芻動物の飼料効率向上剤
JP2006063002A (ja) * 2004-08-25 2006-03-09 Ajinomoto Co Inc 反芻動物用のメタン生成抑制剤および飼料用組成物
JP2006166853A (ja) * 2004-12-17 2006-06-29 Ajinomoto Co Inc 反芻動物用のメタン生成抑制剤および飼料組成物
JP2007117079A (ja) * 2005-03-16 2007-05-17 Nippon Paper Chemicals Co Ltd 反芻動物用飼料
JP2008067684A (ja) * 2006-09-14 2008-03-27 Mori Sangyo:Kk 牛飼育用飼料
WO2008149992A1 (fr) * 2007-06-08 2008-12-11 Idemitsu Kosan Co., Ltd. Agent améliorant la fermentation dans la panse

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5029987B1 (fr) * 1970-10-05 1975-09-27
JPS5547665A (en) * 1978-09-12 1980-04-04 Ici Ltd Heterocyclic trichloromethyl compound*its manufacture and composition for decreasing methane formation in rumen of ruminant and*or for increasing ratio of propionic acid in rumen fluid
JPS6183131A (ja) * 1984-07-25 1986-04-26 オレオフイナ・ソシエテ・アノニム 食料又は餌料組成物
JPH06153809A (ja) * 1992-07-07 1994-06-03 Charles T Sweeney 家畜飼料物質の消化性改善法
JPH1146694A (ja) * 1997-08-06 1999-02-23 Ajinomoto Co Inc 反芻動物用メタン生成抑制飼料組成物
JP2002209529A (ja) * 2001-01-22 2002-07-30 Natl Fedelation Of Agricult Coop Assoc ルーメン発酵調整用飼料添加物及びこれを含有する養牛用飼料
JP2002281912A (ja) * 2001-03-27 2002-10-02 Society For Techno-Innovation Of Agriculture Forestry & Fisheries 反芻動物のメタン生成を抑制する飼料組成物
JP2003088301A (ja) * 2001-09-19 2003-03-25 Yakult Honsha Co Ltd 反芻動物用のメタン生成抑制用組成物及び飼料用組成物
JP2004129658A (ja) * 2002-09-18 2004-04-30 Hoshizaki Electric Co Ltd 反芻動物用の消化促進剤および反芻動物の飼育方法
JP2006063002A (ja) * 2004-08-25 2006-03-09 Ajinomoto Co Inc 反芻動物用のメタン生成抑制剤および飼料用組成物
JP2006061092A (ja) * 2004-08-27 2006-03-09 Mitsuba Boeki Kk 反芻動物の飼料効率向上剤
JP2006166853A (ja) * 2004-12-17 2006-06-29 Ajinomoto Co Inc 反芻動物用のメタン生成抑制剤および飼料組成物
JP2007117079A (ja) * 2005-03-16 2007-05-17 Nippon Paper Chemicals Co Ltd 反芻動物用飼料
JP2008067684A (ja) * 2006-09-14 2008-03-27 Mori Sangyo:Kk 牛飼育用飼料
WO2008149992A1 (fr) * 2007-06-08 2008-12-11 Idemitsu Kosan Co., Ltd. Agent améliorant la fermentation dans la panse

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETSURO MATSUMOTO ET AL.: "V29-12 Rumen Methane Seisei ni Oyobosu Kasanka Suiso no Eikyo", THE JAPANESE SOCIETY ZOOTECHNICAL SCIENCE 111TH ANNUAL MEETING ABSTRACTS, - 28 September 2009 (2009-09-28), pages 61 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012159186A1 (fr) 2011-05-23 2012-11-29 Grasp Indústria E Comércio Ltda. Utilisation de nitrates et de sulfates encapsulés pour réduire l'émission de méthane provenant de la fermentation ruminale
CN113453561A (zh) * 2018-10-10 2021-09-28 斯朗切比奥加有限公司 不含抗生素的抗微生物饲料添加剂和抗微生物组合物
WO2023007008A1 (fr) * 2021-07-30 2023-02-02 GlasPort Bio Limited Compositions et procédés
GB2609445A (en) * 2021-07-30 2023-02-08 Glasport Bio Ltd Compositions and methods
EP4356750A3 (fr) * 2021-07-30 2024-06-19 Glasport Bio Limited Compositions et procédés
US12084610B2 (en) 2022-07-01 2024-09-10 Arkea Bio Corp. Compositions and methods for reducing deleterious atmospheric gas emissions from flooded ecosystems
WO2024008734A1 (fr) * 2022-07-08 2024-01-11 Unibio Tech Science A/S Aliment pour ruminants
CN116602358A (zh) * 2023-06-12 2023-08-18 山东省农业科学院畜牧兽医研究所 蛇床子素在减少反刍动物瘤胃甲烷排放中的应用

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