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WO2010056914A8 - Bacterial helicase inhibitor compounds and uses thereof - Google Patents

Bacterial helicase inhibitor compounds and uses thereof Download PDF

Info

Publication number
WO2010056914A8
WO2010056914A8 PCT/US2009/064270 US2009064270W WO2010056914A8 WO 2010056914 A8 WO2010056914 A8 WO 2010056914A8 US 2009064270 W US2009064270 W US 2009064270W WO 2010056914 A8 WO2010056914 A8 WO 2010056914A8
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitor compounds
helicase inhibitor
bacterial
bacterial helicase
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/064270
Other languages
French (fr)
Other versions
WO2010056914A1 (en
Inventor
Donald T. Moir
Daniel Aiello
Marjorie H. Barnes
John D. Williams
Subhasis B. Biswas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Microbiotix Inc
Rutgers Health
Original Assignee
University of Medicine and Dentistry of New Jersey
Rutgers State University of New Jersey
Microbiotix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Medicine and Dentistry of New Jersey, Rutgers State University of New Jersey, Microbiotix Inc filed Critical University of Medicine and Dentistry of New Jersey
Publication of WO2010056914A1 publication Critical patent/WO2010056914A1/en
Publication of WO2010056914A8 publication Critical patent/WO2010056914A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A01N43/52—1,3-Diazoles; Hydrogenated 1,3-diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/707—1,2,3- or 1,2,4-triazines; Hydrogenated 1,2,3- or 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Organic compounds are described that inhibit bacterial helicase activity and growth of bacterial cells on surfaces.
PCT/US2009/064270 2008-11-12 2009-11-12 Bacterial helicase inhibitor compounds and uses thereof Ceased WO2010056914A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19903308P 2008-11-12 2008-11-12
US61/199,033 2008-11-12

Publications (2)

Publication Number Publication Date
WO2010056914A1 WO2010056914A1 (en) 2010-05-20
WO2010056914A8 true WO2010056914A8 (en) 2010-07-15

Family

ID=42170343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/064270 Ceased WO2010056914A1 (en) 2008-11-12 2009-11-12 Bacterial helicase inhibitor compounds and uses thereof

Country Status (1)

Country Link
WO (1) WO2010056914A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109320483A (en) * 2017-08-01 2019-02-12 南京大学 Coumarin derivatives, methods for their preparation and uses as medicines
CA3098293A1 (en) * 2018-04-25 2019-10-31 The Regents Of The University Of California Slc26a3 inhibitors and use thereof
WO2020115009A1 (en) * 2018-12-03 2020-06-11 Universität Bern LPAAT-β INHIBITORS FOR TREATMENT OF CANCER
WO2020205683A1 (en) * 2019-03-29 2020-10-08 The Scripps Research Institute Benzopyrane and imidazole derivatives useful for the stabilization of amyloidogenic immunoglobulin light chains

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318911A (en) * 1980-12-29 1982-03-09 Eli Lilly And Company 5,6-Diaryl-1,2,4-triazines as topical antithrombotic agents
DE60225434T2 (en) * 2001-04-24 2009-03-12 Aryx Therapeutics, Fremont CUMARINE DERIVATIVES AND ITS USE AS ANTICOAGULANTS
US20030176494A1 (en) * 2001-11-16 2003-09-18 Ze-Qi Xu Novel coumarin and chromene compounds and methods of preparation and use thereof for treating or preventing viral infections
AU2003202488A1 (en) * 2002-01-11 2003-07-30 Takeda Pharmaceutical Company Limited Coumarin derivatives, process for their production and use thereof
GB0202187D0 (en) * 2002-01-31 2002-03-20 Rowett Res Inst "Inhibitors"
FR2869906B1 (en) * 2004-05-05 2006-08-11 Fabre Pierre Dermo Cosmetique MONOMERIC DERIVATIVES OF 5,6-DIPHENYL-1,2,4-TRIAZINE AND USES THEREOF

Also Published As

Publication number Publication date
WO2010056914A1 (en) 2010-05-20

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