[go: up one dir, main page]

WO2010048633A3 - Method and apparatus for feedback control of hifu treatments - Google Patents

Method and apparatus for feedback control of hifu treatments Download PDF

Info

Publication number
WO2010048633A3
WO2010048633A3 PCT/US2009/062127 US2009062127W WO2010048633A3 WO 2010048633 A3 WO2010048633 A3 WO 2010048633A3 US 2009062127 W US2009062127 W US 2009062127W WO 2010048633 A3 WO2010048633 A3 WO 2010048633A3
Authority
WO
WIPO (PCT)
Prior art keywords
hifu
changes
signals
backscatter
backscatter signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/062127
Other languages
French (fr)
Other versions
WO2010048633A2 (en
Inventor
Barry Friemel
Jessica E. Parsons
Charles D. Emery
Gregory P. Darlington
Justin A. Reed
Tim Etchells
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mirabilis Medica Inc
Original Assignee
Mirabilis Medica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirabilis Medica Inc filed Critical Mirabilis Medica Inc
Priority to HK12100453.6A priority Critical patent/HK1160048B/en
Priority to JP2011533418A priority patent/JP2012506736A/en
Priority to EP09822853.9A priority patent/EP2349482B1/en
Priority to CA2741723A priority patent/CA2741723A1/en
Publication of WO2010048633A2 publication Critical patent/WO2010048633A2/en
Publication of WO2010048633A3 publication Critical patent/WO2010048633A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00115—Electrical control of surgical instruments with audible or visual output
    • A61B2017/00119—Electrical control of surgical instruments with audible or visual output alarm; indicating an abnormal situation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Surgical Instruments (AREA)
  • Electrotherapy Devices (AREA)

Abstract

HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.
PCT/US2009/062127 2008-10-24 2009-10-26 Method and apparatus for feedback control of hifu treatments Ceased WO2010048633A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
HK12100453.6A HK1160048B (en) 2008-10-24 2009-10-26 Apparatus for feedback control of hifu treatments
JP2011533418A JP2012506736A (en) 2008-10-24 2009-10-26 Method and apparatus for feedback control of HIFU therapy
EP09822853.9A EP2349482B1 (en) 2008-10-24 2009-10-26 Apparatus for feedback control of hifu treatments
CA2741723A CA2741723A1 (en) 2008-10-24 2009-10-26 Method and apparatus for feedback control of hifu treatments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10843508P 2008-10-24 2008-10-24
US61/108,435 2008-10-24

Publications (2)

Publication Number Publication Date
WO2010048633A2 WO2010048633A2 (en) 2010-04-29
WO2010048633A3 true WO2010048633A3 (en) 2010-08-05

Family

ID=42118150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/062127 Ceased WO2010048633A2 (en) 2008-10-24 2009-10-26 Method and apparatus for feedback control of hifu treatments

Country Status (5)

Country Link
US (1) US8480600B2 (en)
EP (1) EP2349482B1 (en)
JP (1) JP2012506736A (en)
CA (1) CA2741723A1 (en)
WO (1) WO2010048633A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028434B2 (en) * 2009-05-18 2015-05-12 Olympus Medical Systems Corp. Ultrasound operation apparatus, cavitation control method, and ultrasound transducer control method
US8845537B2 (en) * 2009-06-03 2014-09-30 Olympus Medical Systems Corp. Ultrasound operation apparatus, ultrasound operation system, and cavitation utilization method
US8858439B2 (en) * 2009-06-03 2014-10-14 Olympus Medical Systems Corp. Ultrasound operation apparatus, ultrasound operation system, and cavitation suppression method
KR20130020054A (en) * 2011-08-18 2013-02-27 삼성전자주식회사 Method for generating ultrasound image and ultrasound system
EP3689250B1 (en) 2011-10-17 2022-12-07 BFLY Operations, Inc. Transmissive imaging and related apparatus and methods
RU2654616C2 (en) * 2012-04-03 2018-05-21 Конинклейке Филипс Н.В. Energy density map calculation using thermoacoustic mode
US20130281877A1 (en) * 2012-04-19 2013-10-24 Siemens Medical Solutions Usa, Inc Skin Temperature Control in Therapeutic Medical Ultrasound
CN103479403B (en) * 2012-06-08 2016-06-22 长庚大学 System and method for guiding focused ultrasonic energy release by surgical navigation system
US20140073907A1 (en) 2012-09-12 2014-03-13 Convergent Life Sciences, Inc. System and method for image guided medical procedures
US20140297044A1 (en) * 2013-03-15 2014-10-02 Mirabilis Medica, Inc. Acoustic-Pulser Feedback and Power Factor Control of a HIFU Device
US9060709B2 (en) * 2013-03-15 2015-06-23 Wisconsin Alumni Research Foundation Method and apparatus for quantifying organization in collagenous tissue
US9667889B2 (en) 2013-04-03 2017-05-30 Butterfly Network, Inc. Portable electronic devices with integrated imaging capabilities
JP2015204894A (en) * 2014-04-17 2015-11-19 オリンパス株式会社 Medical ultrasound device
CN104622504A (en) * 2015-02-12 2015-05-20 黄晶 Phased array high-intensity focused ultrasonic detection and therapy system
WO2018036912A1 (en) * 2016-08-26 2018-03-01 Koninklijke Philips N.V. Detection of treatment failure for mild hyperthermia
EP3525883A4 (en) 2016-10-16 2020-12-02 Vibrato Medical, Inc. EXTRACORPORAL THERAPEUTIC ULTRASOUND TO PROMOTE ANGIOGENESIS
EP3412342B1 (en) 2017-06-09 2025-08-20 Theraclion SA Devices for therapeutic treatment and a computer program product
WO2019204639A1 (en) * 2018-04-18 2019-10-24 Vibrato Medical, Inc. Extracorporeal therapeutic ultrasound for promoting angiogenesis
EP3801762A2 (en) * 2018-06-06 2021-04-14 Insightec Ltd. Improved reflection autofocusing
WO2020039257A1 (en) * 2018-08-24 2020-02-27 Insightec, Ltd. Ultrasound-mediated neurostimulation
CN113117265B (en) * 2019-12-30 2023-03-28 重庆融海超声医学工程研究中心有限公司 Detection device
CN113117267B (en) * 2019-12-30 2022-11-11 重庆融海超声医学工程研究中心有限公司 Treatment plan making device
JP7728015B2 (en) * 2020-03-31 2025-08-22 エアーウエイブ メディカル， エルエルシー Bronchial denervation method using integrated A-mode signals

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006129099A1 (en) * 2005-06-02 2006-12-07 Cancercure Technology As Ultrasound treatment system
US20070083120A1 (en) * 2005-09-22 2007-04-12 Cain Charles A Pulsed cavitational ultrasound therapy
US20070255267A1 (en) * 2006-04-20 2007-11-01 The Regents Of The University Of California Method of thermal treatment of myolysis and destruction of benign uterine tumors
US20070270792A1 (en) * 2006-05-08 2007-11-22 Willard Hennemann Interferometric characterization of ablated tissue
US20080154131A1 (en) * 2006-12-20 2008-06-26 General Electric Company Methods for enhancement of visibility of ablation regions

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1289617B (en) 1964-06-06 1969-02-20 Siemens Ag Ultrasound diagnostic device
US3480002A (en) 1967-01-24 1969-11-25 Magnaflux Corp Medical ultrasonic scanning system
US3676584A (en) 1970-07-13 1972-07-11 Chris J Plakas Echo coincidence ultrasonic scanning
US4097835A (en) 1976-09-20 1978-06-27 Sri International Dual transducer arrangement for ultrasonic imaging system
US4185502A (en) 1977-10-11 1980-01-29 Ralph Frank Transducer coupling apparatus
US4282755A (en) 1979-12-05 1981-08-11 Technicare Corporation Transducer drive and control
US4347850A (en) 1980-03-19 1982-09-07 Indianapolis Center For Advanced Research, Inc. Direct water coupling device for ultrasound breast scanning in a supine position
US4484569A (en) 1981-03-13 1984-11-27 Riverside Research Institute Ultrasonic diagnostic and therapeutic transducer assembly and method for using
US5143073A (en) 1983-12-14 1992-09-01 Edap International, S.A. Wave apparatus system
DE3607949A1 (en) 1986-03-11 1987-09-17 Wolf Gmbh Richard METHOD FOR DETECTING POSSIBLE TISSUE DAMAGE IN THE MEDICAL APPLICATION OF HIGH-ENERGY SOUND
US4742829A (en) 1986-08-11 1988-05-10 General Electric Company Intracavitary ultrasound and biopsy probe for transvaginal imaging
DE3704909A1 (en) 1987-02-17 1988-08-25 Wolf Gmbh Richard DEVICE FOR SPACIOUS LOCATION AND DESTRUCTION OF INTERIOR OBJECTS WITH ULTRASOUND
US4835689A (en) 1987-09-21 1989-05-30 General Electric Company Adaptive coherent energy beam formation using phase conjugation
US4932414A (en) 1987-11-02 1990-06-12 Cornell Research Foundation, Inc. System of therapeutic ultrasound and real-time ultrasonic scanning
US4855911A (en) 1987-11-16 1989-08-08 Massachusetts Institute Of Technology Ultrasonic tissue characterization
US4858613A (en) 1988-03-02 1989-08-22 Laboratory Equipment, Corp. Localization and therapy system for treatment of spatially oriented focal disease
US5036855A (en) 1988-03-02 1991-08-06 Laboratory Equipment, Corp. Localization and therapy system for treatment of spatially oriented focal disease
US4893624A (en) 1988-06-21 1990-01-16 Massachusetts Institute Of Technology Diffuse focus ultrasound hyperthermia system
US5070879A (en) 1989-11-30 1991-12-10 Acoustic Imaging Technologies Corp. Ultrasound imaging method and apparatus
DE4207463C2 (en) 1992-03-10 1996-03-28 Siemens Ag Arrangement for the therapy of tissue with ultrasound
DE4302537C1 (en) 1993-01-29 1994-04-28 Siemens Ag Ultrasound imaging and therapy device - generates imaging waves and focussed treatment waves having two differing frequencies for location and treatment of e.g tumours
JP3860227B2 (en) 1993-03-10 2006-12-20 株式会社東芝 Ultrasonic therapy device used under MRI guide
GB2279742A (en) * 1993-06-29 1995-01-11 Cancer Res Inst Royal Apparatus for monitoring ultrasonic surgical ablation
US5471988A (en) 1993-12-24 1995-12-05 Olympus Optical Co., Ltd. Ultrasonic diagnosis and therapy system in which focusing point of therapeutic ultrasonic wave is locked at predetermined position within observation ultrasonic scanning range
FR2715313B1 (en) 1994-01-27 1996-05-31 Edap Int Method for controlling a hyperthermia treatment device using ultrasound.
US5984881A (en) 1995-03-31 1999-11-16 Kabushiki Kaisha Toshiba Ultrasound therapeutic apparatus using a therapeutic ultrasonic wave source and an ultrasonic probe
US5810007A (en) 1995-07-26 1998-09-22 Associates Of The Joint Center For Radiation Therapy, Inc. Ultrasound localization and image fusion for the treatment of prostate cancer
US6840936B2 (en) 1996-10-22 2005-01-11 Epicor Medical, Inc. Methods and devices for ablation
US5769790A (en) 1996-10-25 1998-06-23 General Electric Company Focused ultrasound surgery system guided by ultrasound imaging
JP2002505596A (en) 1997-05-23 2002-02-19 トランサージカル，インコーポレイテッド MRI guided therapy device and method
US6071239A (en) 1997-10-27 2000-06-06 Cribbs; Robert W. Method and apparatus for lipolytic therapy using ultrasound energy
US6126607A (en) 1997-11-03 2000-10-03 Barzell-Whitmore Maroon Bells, Inc. Ultrasound interface control system
US6275478B1 (en) 1998-07-10 2001-08-14 Qualcomm Incorporated Methods and apparatuses for fast power control of signals transmitted on a multiple access channel
US6042556A (en) 1998-09-04 2000-03-28 University Of Washington Method for determining phase advancement of transducer elements in high intensity focused ultrasound
US6425867B1 (en) 1998-09-18 2002-07-30 University Of Washington Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
US6540700B1 (en) 1998-10-26 2003-04-01 Kabushiki Kaisha Toshiba Ultrasound treatment apparatus
US6196972B1 (en) 1998-11-11 2001-03-06 Spentech, Inc. Doppler ultrasound method and apparatus for monitoring blood flow
US6508774B1 (en) * 1999-03-09 2003-01-21 Transurgical, Inc. Hifu applications with feedback control
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
WO2001045550A2 (en) 1999-12-23 2001-06-28 Therus Corporation Ultrasound transducers for imaging and therapy
AU2001255724A1 (en) 2000-04-29 2001-11-12 Focus Surgery, Inc. Non-invasive tissue characterization
US6645162B2 (en) 2000-12-27 2003-11-11 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
JP2002301070A (en) 2001-04-04 2002-10-15 Fuji Photo Film Co Ltd Ultrasonic imaging method and apparatus
US20040153126A1 (en) 2001-06-07 2004-08-05 Takashi Okai Method and apparatus for treating uterine myoma
US7175596B2 (en) 2001-10-29 2007-02-13 Insightec-Txsonics Ltd System and method for sensing and locating disturbances in an energy path of a focused ultrasound system
CN1169588C (en) 2001-11-05 2004-10-06 北京源德生物医学工程股份有限公司 Extenal high-energy focusing ultrasonic treating apparatus
EP1476080A4 (en) 2002-02-20 2010-06-02 Medicis Technologies Corp Ultrasonic treatment and imaging of adipose tissue
US7061381B2 (en) 2002-04-05 2006-06-13 Beezerbug Incorporated Ultrasonic transmitter and receiver systems and products using the same
US6632177B1 (en) 2002-05-01 2003-10-14 Acuson Corporation Dual process ultrasound contrast agent imaging
US7285092B2 (en) * 2002-12-18 2007-10-23 Barbara Ann Karmanos Cancer Institute Computerized ultrasound risk evaluation system
US7311701B2 (en) 2003-06-10 2007-12-25 Cierra, Inc. Methods and apparatus for non-invasively treating atrial fibrillation using high intensity focused ultrasound
US7993289B2 (en) 2003-12-30 2011-08-09 Medicis Technologies Corporation Systems and methods for the destruction of adipose tissue
JP2007537013A (en) * 2004-05-14 2007-12-20 メドトロニック・インコーポレーテッド Method for forming an ablated tissue region using high intensity focused ultrasound
JP4722039B2 (en) * 2004-06-11 2011-07-13 株式会社日立メディコ Ultrasonic therapy device
US20050281444A1 (en) 2004-06-22 2005-12-22 Vidar Lundberg Methods and apparatus for defining a protocol for ultrasound imaging
US7492666B2 (en) 2004-09-14 2009-02-17 Lockheed Martin Corporation Sonar system having multiple pulse sequences
SE528313C2 (en) 2004-09-24 2006-10-17 Spectronic Ab Method and apparatus for separating particles using ultrasonic waves
US7452357B2 (en) 2004-10-22 2008-11-18 Ethicon Endo-Surgery, Inc. System and method for planning treatment of tissue
JP4630127B2 (en) 2005-05-17 2011-02-09 株式会社日立製作所 Ultrasound diagnostic treatment device
US8016757B2 (en) * 2005-09-30 2011-09-13 University Of Washington Non-invasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound
US20070239007A1 (en) * 2006-03-03 2007-10-11 Silverman Ronald H Ultrasound method for enhanced visualization of thermal lesions and other features of biological tissues
US20080253525A1 (en) 2007-04-11 2008-10-16 Boyden Edward S Compton scattered x-ray visualizing, imaging, or information providing of at least some dissimilar matter
US9248318B2 (en) 2008-08-06 2016-02-02 Mirabilis Medica Inc. Optimization and feedback control of HIFU power deposition through the analysis of detected signal characteristics
JP5766604B2 (en) * 2008-08-06 2015-08-19 ミラビリス・メディカ・インコーポレイテッドＭｉｒａｂｉｌｉｓ Ｍｅｄｉｃａ， Ｉｎｃ． HIFU output deposition optimization and feedback control by analysis of inspection signal characteristics

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006129099A1 (en) * 2005-06-02 2006-12-07 Cancercure Technology As Ultrasound treatment system
US20070083120A1 (en) * 2005-09-22 2007-04-12 Cain Charles A Pulsed cavitational ultrasound therapy
US20070255267A1 (en) * 2006-04-20 2007-11-01 The Regents Of The University Of California Method of thermal treatment of myolysis and destruction of benign uterine tumors
US20070270792A1 (en) * 2006-05-08 2007-11-22 Willard Hennemann Interferometric characterization of ablated tissue
US20080154131A1 (en) * 2006-12-20 2008-06-26 General Electric Company Methods for enhancement of visibility of ablation regions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2349482A4 *

Also Published As

Publication number Publication date
EP2349482B1 (en) 2016-07-27
WO2010048633A2 (en) 2010-04-29
HK1160048A1 (en) 2012-08-10
US8480600B2 (en) 2013-07-09
EP2349482A2 (en) 2011-08-03
US20100106019A1 (en) 2010-04-29
CA2741723A1 (en) 2010-04-29
JP2012506736A (en) 2012-03-22
EP2349482A4 (en) 2013-01-16

Similar Documents

Publication Publication Date Title
WO2010048633A3 (en) Method and apparatus for feedback control of hifu treatments
WO2012061713A3 (en) High intensity focused ultrasound apparatuses, systems, and methods for renal neuromodulation
WO2011141918A3 (en) Reflectance-facilitated ultrasound treatment and monitoring
WO2006116198A3 (en) Control methods and devices for energy delivery
WO2009083919A3 (en) Combination therapy
WO2008019051A3 (en) Devices and bandages for the treatment or prevention of scars and/or keloids and methods and kits therefor
WO2009108933A3 (en) System for emr treatment of soft tissue
WO2011112248A3 (en) Methods and devices for real time monitoring of collagen and for altering collagen status
WO2009075879A8 (en) Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
WO2007124074A3 (en) Systems, devices, and methods employing therapeutic ultrasound of living tissues
WO2007147022A3 (en) Method and apparatus for treating vascular obstructions
WO2009121009A3 (en) Irreversible electroporation device for use in attenuating neointimal
GB2592806A (en) Tissue treatment device
WO2009035627A3 (en) System and method for tissue change monitoring during hifu treatment
WO2008127373A3 (en) Methods and devices for treating tissue
WO2011028603A3 (en) Micromanipulator control arm for therapeutic and imaging ultrasound transducers
WO2006044800A3 (en) Structure for applying sprayable wound treatment material
WO2010003130A3 (en) Power parameters for ultrasonic catheter
WO2004091722A8 (en) Ultrasonic mehod and device for wound treatment
WO2010078209A3 (en) Bioresorbable foaming tissue dressing
WO2007012933A3 (en) Method and apparatus for modulating a radiation beam
WO2005123179A3 (en) Adaptive control of optical pulses for laser medicine
WO2009045885A3 (en) Real-time ultrasound monitoring of heat-induced tissue interactions
WO2008024894A3 (en) Apparatus and method for wound care with ultrasound and pressure therapy device
WO2008013598A3 (en) Real-time, on-line and offline treatment dose tracking and feedback process for volumetric image guided adaptive radiotherapy

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09822853

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2741723

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2011533418

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2009822853

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2009822853

Country of ref document: EP