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WO2010043408A3 - Microencapsulated fesoterodine - Google Patents

Microencapsulated fesoterodine Download PDF

Info

Publication number
WO2010043408A3
WO2010043408A3 PCT/EP2009/007445 EP2009007445W WO2010043408A3 WO 2010043408 A3 WO2010043408 A3 WO 2010043408A3 EP 2009007445 W EP2009007445 W EP 2009007445W WO 2010043408 A3 WO2010043408 A3 WO 2010043408A3
Authority
WO
WIPO (PCT)
Prior art keywords
fesoterodine
microencapsulated
relates
pharmaceutical
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/007445
Other languages
German (de)
French (fr)
Other versions
WO2010043408A2 (en
Inventor
Katrin Rimkus
Frank Muskulus
Sandra Brueck
Jana Paetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ratiopharm GmbH
Original Assignee
Ratiopharm GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm GmbH filed Critical Ratiopharm GmbH
Publication of WO2010043408A2 publication Critical patent/WO2010043408A2/en
Publication of WO2010043408A3 publication Critical patent/WO2010043408A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to microencapsulated fesoterodine. In particular, the invention relates to a pharmaceutical intermediate, composed of a core (a) and a shell (b), wherein (a) the core contains fesoterodine and/or metabolites as the active ingredient, and (b) the shell contains one or more pharmaceutical adjuvants, which modify the release of the active ingredient, and to a method for producing the intermediate. Furthermore, the invention relates to a pharmaceutical composition containing the intermediate according to the invention, specifically in the form of tablets.
PCT/EP2009/007445 2008-10-17 2009-10-16 Microencapsulated fesoterodine Ceased WO2010043408A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08018241 2008-10-17
EP08018241.3 2008-10-17

Publications (2)

Publication Number Publication Date
WO2010043408A2 WO2010043408A2 (en) 2010-04-22
WO2010043408A3 true WO2010043408A3 (en) 2010-07-01

Family

ID=40260837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/007445 Ceased WO2010043408A2 (en) 2008-10-17 2009-10-16 Microencapsulated fesoterodine

Country Status (1)

Country Link
WO (1) WO2010043408A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2549985A1 (en) * 2010-03-22 2013-01-30 Cadila Healthcare Limited Stable pharmaceutical compositions comprising fesoterodine
TWI590821B (en) 2011-01-18 2017-07-11 輝瑞有限公司 Solid molecular dispersion
EP2508173A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Stabilized pharmaceutical composition comprising fesoterodine
EP2508175A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Pharmaceutical composition comprising fesoterodine or a salt or a solvate thereof
US20140199401A1 (en) * 2011-07-04 2014-07-17 Cadila Healthcare Limited Extended release pharmaceutical compositions of fesoterodine
WO2013160909A1 (en) * 2012-03-19 2013-10-31 Astron Research Limited Stable composition of fesoterodine
CZ2014400A3 (en) 2014-06-09 2015-12-16 Zentiva, K.S. Fesoterodine stabilized formulation
TR201721437A2 (en) 2017-12-25 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi FORMULATIONS OF FESOTHERODY PROVIDING MODIFIED EMISSION
WO2019132832A1 (en) 2017-12-25 2019-07-04 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Tablet compositions of fesoterodine fumarate
CN110151720B (en) * 2019-05-09 2019-12-17 合肥信风科技开发有限公司 Pharmaceutical composition containing fesoterodine and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008006506A1 (en) * 2006-07-10 2008-01-17 Dr. R. Pfleger Chemische Fabrik Gmbh Pharmaceutical preparation for oral administration with controlled active ingredient release in the small intestine and methods for its production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008006506A1 (en) * 2006-07-10 2008-01-17 Dr. R. Pfleger Chemische Fabrik Gmbh Pharmaceutical preparation for oral administration with controlled active ingredient release in the small intestine and methods for its production

Also Published As

Publication number Publication date
WO2010043408A2 (en) 2010-04-22

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