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WO2009118338A3 - Use of a polyphenolic type compound for preventing or treating a polyglutamine expansion neurodegenerative disease - Google Patents

Use of a polyphenolic type compound for preventing or treating a polyglutamine expansion neurodegenerative disease Download PDF

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Publication number
WO2009118338A3
WO2009118338A3 PCT/EP2009/053519 EP2009053519W WO2009118338A3 WO 2009118338 A3 WO2009118338 A3 WO 2009118338A3 EP 2009053519 W EP2009053519 W EP 2009053519W WO 2009118338 A3 WO2009118338 A3 WO 2009118338A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating
preventing
neurodegenerative disease
type compound
polyglutamine expansion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/053519
Other languages
French (fr)
Other versions
WO2009118338A2 (en
Inventor
Christian Neri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of WO2009118338A2 publication Critical patent/WO2009118338A2/en
Publication of WO2009118338A3 publication Critical patent/WO2009118338A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to the use of polyphenolic type compounds as disclosed in the specification for preventing or treating a polyglutamine expansion neurodegenerative disease.
PCT/EP2009/053519 2008-03-27 2009-03-25 Use of a polyphenolic type compound for preventing or treating a polyglutamine expansion neurodegenerative disease Ceased WO2009118338A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08300163.6 2008-03-27
EP08300163 2008-03-27

Publications (2)

Publication Number Publication Date
WO2009118338A2 WO2009118338A2 (en) 2009-10-01
WO2009118338A3 true WO2009118338A3 (en) 2009-11-26

Family

ID=39671466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/053519 Ceased WO2009118338A2 (en) 2008-03-27 2009-03-25 Use of a polyphenolic type compound for preventing or treating a polyglutamine expansion neurodegenerative disease

Country Status (1)

Country Link
WO (1) WO2009118338A2 (en)

Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031206A2 (en) * 1995-04-07 1996-10-10 Warner-Lambert Company Flavones and coumarins as agents for the treatment of atherosclerosis
WO2001003681A2 (en) * 1999-07-08 2001-01-18 Prendergast Patrick T Use of flavones, coumarins and related compounds to treat infections
CN1403080A (en) * 2002-10-21 2003-03-19 中国人民解放军第二军医大学 Application of kaempferol and its derivative in preparing medicine for cardiac and cerebral vascular diseases
US20030162231A1 (en) * 2002-02-22 2003-08-28 Ronald Wetzel Polyglutamine repeat sequences
WO2003103583A2 (en) * 2002-06-10 2003-12-18 Oklahoma Medical Research Foundation A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
EP1418164A1 (en) * 2002-11-07 2004-05-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) New stilbene derivatives and their use as aryl hydrocarbon receptor ligand antagonists
WO2005092324A1 (en) * 2004-03-19 2005-10-06 The Trustees Of Columbia University In The City Of New York Ginkgolide compounds, compositions, extracts, and uses thereof
EP1607098A1 (en) * 2004-05-28 2005-12-21 Cognis France, S.A.S. Cosmetic use of an active ingredient that increases Gadd45 gene expression
WO2006029371A2 (en) * 2004-09-08 2006-03-16 Yinghe Hu Neuromedin u 2 receptor agonists and uses thereof
US20060105967A1 (en) * 2004-11-18 2006-05-18 Advanced Gene Technology, Corp. Flavone derivatives as TNFalpha inhibitors or antagonists
US20060110481A1 (en) * 2004-11-22 2006-05-25 Sami Labs Limited Compositions containing vitex agnus-castus berry oil for cosmeceutical applications and method of isolation of the active component
WO2006076681A2 (en) * 2005-01-13 2006-07-20 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
WO2006119148A2 (en) * 2005-04-29 2006-11-09 The Ohio State University Research Foundation Keratinocyte growth factor receptor - tyrosine specific inhibitors for the prevention of cancer metastatis
US20060257337A1 (en) * 2005-04-28 2006-11-16 David Sherris Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
WO2007004952A1 (en) * 2005-07-01 2007-01-11 Denovastella Ab Antimicrobial and antiinflammatory composition
WO2007020673A1 (en) * 2005-08-19 2007-02-22 Tubilux Pharma S.P.A. Use of glucosylated hydroxystilbenes for the prevention and treatment of eye pathologies
WO2007045876A1 (en) * 2005-10-21 2007-04-26 Merz Pharma Gmbh & Co. Kgaa Chromenones and their use as modulators of metabotropic glutamate receptors
EP1782802A1 (en) * 2004-07-20 2007-05-09 Universidad de Valencia Combined use of pterostilbene and quercetin for the production of cancer treatment medicaments
US20070249647A1 (en) * 2006-04-25 2007-10-25 Vander Jagt David L Substituted CIS- and trans-stilbenes as therapeutic agents
WO2008011083A2 (en) * 2006-07-18 2008-01-24 Cornell Research Foundation, Inc. Compounds for enhancing arginase activity and methods of use thereof
WO2008021210A2 (en) * 2006-08-11 2008-02-21 Combinatorx, Incorporated Methods and compositions for the treatment of neurodegenerative disorders

Patent Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031206A2 (en) * 1995-04-07 1996-10-10 Warner-Lambert Company Flavones and coumarins as agents for the treatment of atherosclerosis
WO2001003681A2 (en) * 1999-07-08 2001-01-18 Prendergast Patrick T Use of flavones, coumarins and related compounds to treat infections
US20030162231A1 (en) * 2002-02-22 2003-08-28 Ronald Wetzel Polyglutamine repeat sequences
WO2003103583A2 (en) * 2002-06-10 2003-12-18 Oklahoma Medical Research Foundation A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
CN1403080A (en) * 2002-10-21 2003-03-19 中国人民解放军第二军医大学 Application of kaempferol and its derivative in preparing medicine for cardiac and cerebral vascular diseases
EP1418164A1 (en) * 2002-11-07 2004-05-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) New stilbene derivatives and their use as aryl hydrocarbon receptor ligand antagonists
WO2005092324A1 (en) * 2004-03-19 2005-10-06 The Trustees Of Columbia University In The City Of New York Ginkgolide compounds, compositions, extracts, and uses thereof
EP1607098A1 (en) * 2004-05-28 2005-12-21 Cognis France, S.A.S. Cosmetic use of an active ingredient that increases Gadd45 gene expression
EP1782802A1 (en) * 2004-07-20 2007-05-09 Universidad de Valencia Combined use of pterostilbene and quercetin for the production of cancer treatment medicaments
WO2006029371A2 (en) * 2004-09-08 2006-03-16 Yinghe Hu Neuromedin u 2 receptor agonists and uses thereof
US20060105967A1 (en) * 2004-11-18 2006-05-18 Advanced Gene Technology, Corp. Flavone derivatives as TNFalpha inhibitors or antagonists
US20060110481A1 (en) * 2004-11-22 2006-05-25 Sami Labs Limited Compositions containing vitex agnus-castus berry oil for cosmeceutical applications and method of isolation of the active component
WO2006076681A2 (en) * 2005-01-13 2006-07-20 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
US20060257337A1 (en) * 2005-04-28 2006-11-16 David Sherris Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
WO2006119148A2 (en) * 2005-04-29 2006-11-09 The Ohio State University Research Foundation Keratinocyte growth factor receptor - tyrosine specific inhibitors for the prevention of cancer metastatis
WO2007004952A1 (en) * 2005-07-01 2007-01-11 Denovastella Ab Antimicrobial and antiinflammatory composition
WO2007020673A1 (en) * 2005-08-19 2007-02-22 Tubilux Pharma S.P.A. Use of glucosylated hydroxystilbenes for the prevention and treatment of eye pathologies
WO2007045876A1 (en) * 2005-10-21 2007-04-26 Merz Pharma Gmbh & Co. Kgaa Chromenones and their use as modulators of metabotropic glutamate receptors
US20070249647A1 (en) * 2006-04-25 2007-10-25 Vander Jagt David L Substituted CIS- and trans-stilbenes as therapeutic agents
WO2008011083A2 (en) * 2006-07-18 2008-01-24 Cornell Research Foundation, Inc. Compounds for enhancing arginase activity and methods of use thereof
WO2008021210A2 (en) * 2006-08-11 2008-02-21 Combinatorx, Incorporated Methods and compositions for the treatment of neurodegenerative disorders

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Title
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AQUINO, RITA ET AL: "Antioxidant and photoprotective activity of a crude extract of Culcitium reflexum H.B.K. leaves and their major flavonoids", JOURNAL OF ETHNOPHARMACOLOGY , 79(2), 183-191 CODEN: JOETD7; ISSN: 0378-8741, 2002, XP007905400 *
BAJSA JOANNA ET AL: "A survey of synthetic and natural phytotoxic compounds and phytoalexins as potential antimalarial compounds.", BIOLOGICAL & PHARMACEUTICAL BULLETIN SEP 2007, vol. 30, no. 9, September 2007 (2007-09-01), pages 1740 - 1744, XP007905387, ISSN: 0918-6158 *
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