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WO2009150399A1 - Needles - Google Patents

Needles Download PDF

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Publication number
WO2009150399A1
WO2009150399A1 PCT/GB2009/001340 GB2009001340W WO2009150399A1 WO 2009150399 A1 WO2009150399 A1 WO 2009150399A1 GB 2009001340 W GB2009001340 W GB 2009001340W WO 2009150399 A1 WO2009150399 A1 WO 2009150399A1
Authority
WO
WIPO (PCT)
Prior art keywords
shaft
needle
oocyte
diameter
ovary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2009/001340
Other languages
French (fr)
Inventor
Stephen James Lodge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smiths Medical International Ltd
Original Assignee
Smiths Medical International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smiths Medical International Ltd filed Critical Smiths Medical International Ltd
Publication of WO2009150399A1 publication Critical patent/WO2009150399A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic

Definitions

  • This invention relates to oocyte needles of the kind having a shaft with a bore extending along its length.
  • the invention is more especially concerned with needles for use in IVF procedures and particularly for use in collecting eggs or oocytes.
  • Oocytes are usually collected from a woman for use in IVF procedures using a sharp- tipped hollow needle that is inserted to puncture the vaginal wall and enter the ovary from where the oocytes can be aspirated.
  • Improved techniques mean that it is now possible to use smaller, premature oocytes in IVF procedures.
  • These smaller oocytes can be collected using smaller-bore needles, which has the advantage of being less traumatic to the oocyte donor and also causes less trauma to the ovaries and follicles. It is also easier to pierce the follicles with smaller diameter needles.
  • the needles are typically about 330mm long and those with a smaller diameter are quite flexible. This is a disadvantage because it makes it more difficult to use the needle accurately.
  • One way of reducing this problem is to use the needle in an assembly including an outer needle along which the oocyte sampling needle can be slid. Alternatively, the wall thickness of the needle can be increased.
  • an oocyte needle of the above-specified kind characterised in that the shaft has a first portion along a major part of its length of a first substantially constant cross-section and is relatively stiff, and that the shaft has a second portion along a part of the length of the shaft at its patient end having a second substantially constant cross-section less than the first cross-section, the second portion being less stiff than the first portion.
  • the shaft of the needle is preferably of a metal and may be terminated by a hub at its machine end.
  • the second portion of the needle shaft is preferably made by a cold drawing or rolling process.
  • the first portion may have a diameter of approximately 17g.
  • the second portion may have a diameter between approximately 21 g and 19g.
  • the first portion is preferably about ten times the length of the second portion.
  • the second portion may be about 30mm long.
  • a technique of extracting an oocyte from an ovary including the steps of providing a needle having a rear end with a hub, a shaft with a rear end portion having a first substantially constant diameter and being relatively stiff, the forward end of the shaft having a portion with a second substantially constant diameter less than the first and being adapted to penetrate an ovary, gripping and manipulating the rear end of the shaft to allow the forward end to be positioned in an ovary, connecting a source of suction to the hub and applying suction to the shaft to aspirate an oocyte in the ovary along the needle.
  • Figure 1 is a side elevation view of the needle
  • Figure 2 is an enlarged cross-sectional view of the needle along the line II-II of
  • Figure 3 is an enlarged cross-sectional view of the needle along the line III-III of Figure 1.
  • the needle comprises a metal shaft 1 attached at its rear or machine end 2 with a standard female luer hub 3 of a hard plastics material. Any conventional technique can be used to attach the hub to the needle, such as a push fit, bonding or over moulding.
  • the shaft 1 has a circular section and a bore 4 extending along its length opening at its rear end 2 into the hub 3 and at its forward end at the tip or patient end 5.
  • the tip 5 of the shaft 1 is bevelled and sharpened to provide a cutting, penetrating tip.
  • the shaft 1 is divided into two portions namely a first, rear or machine end portion 6 and a second, forward or patient end portion 7.
  • the rear end portion 6 forms the major part of the length of the shaft 1 being about 300mm long, has a relatively large constant diameter, typically about 17g (that is, 1.473mm external diameter) and is relatively stiff and inflexible.
  • the forward end portion 7 forms a minor part of the length of the shaft 1, being about 30mm long, has a relatively small constant diameter, typically about 19g, 2Og or 21g (that is, 1.067mm, 0.902mm or 0.813mm) and is relatively flexible compared with the rear end portion 6. It can be seen that the rear end portion 6 is ten times the length of the forward end portion 7.
  • the forward and rear end portions 7 and 6 merge in a transition region 8, which is smoothly tapered and stepless.
  • the needle shaft 1 is preferably formed from stock metal tubing having the diameter of the major, larger-diameter portion 6 of the shaft.
  • the reduced diameter portion 7 is formed at one end such as by a cold drawing or rolling process. The effect of this technique is that both the inside and outside diameter of the forward portion 7 is reduced.
  • the reduced diameter of the forward portion 7 makes it relatively flexible but this is not a great problem because its forward portion is only relatively short.
  • conventional needles having a small diameter along their entire length can be considerably more difficult to use. It will be appreciated that there are various other ways of providing a shaft with these portions of differing diameters. Some of these alternatives may not alter the internal diameter substantially or at all.
  • the clinician grips the needle by the larger diameter rear portion 6 and inserts it transvaginally so that the tip 5 penetrates the wall of the vagina and enters an ovary. Suction is then applied to the rear of the needle, such as by means of a syringe 10 or other suction collection device connected to the hub 3.
  • the overall characteristic of the needle is of a relatively stiff shaft 1 that can be manipulated accurately.
  • the reduced diameter patient end portion 7, however, gives the needle the advantages of one of smaller diameter in that penetration of patient tissue can be made with less force and with less trauma, thereby producing less pain and reducing healing time, and with less damage to the ovaries and follicles.
  • the smaller diameter tip 5 also enables more precise placement under ultrasound observation and facilitates piercing of the ovaries and follicles. Because most of the length of the needle has the internal diameter of the larger portion 6, the overall flow resistance along the needle can be appreciably less than in a needle having a smaller constant internal diameter equal to that of the tip end portion 7.
  • the needle could be modified in various ways such as by means of a coating applied to the needle, perhaps to increase lubricity or prevent direct contact with the metal surface.
  • the needle, especially the patient end tip, could be treated in some conventional way to increase the echo genie characteristics of the tip, to make it more visible under ultrasound observation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Transplantation (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

An oocyte needle has a metal shaft (1) with a hub (3) attached at its rear end (2). The shaft (1) has a main rear portion 6 about 300mm long with a diameter of about 17g. A shorter portion 7 about 30mm long at the forward end of the shaft (1) is made by cold drawing or rolling with a smaller diameter of between about 21g and 19g. The small diameter forward end (7) facilitates extraction of oocytes whereas the thicker rear portion (6) ensures that the needle shaft (1) has sufficient overall rigidity to enable it to be manipulated effectively.

Description

NEEDLES
This invention relates to oocyte needles of the kind having a shaft with a bore extending along its length.
The invention is more especially concerned with needles for use in IVF procedures and particularly for use in collecting eggs or oocytes.
Oocytes are usually collected from a woman for use in IVF procedures using a sharp- tipped hollow needle that is inserted to puncture the vaginal wall and enter the ovary from where the oocytes can be aspirated. Improved techniques mean that it is now possible to use smaller, premature oocytes in IVF procedures. These smaller oocytes can be collected using smaller-bore needles, which has the advantage of being less traumatic to the oocyte donor and also causes less trauma to the ovaries and follicles. It is also easier to pierce the follicles with smaller diameter needles. The needles are typically about 330mm long and those with a smaller diameter are quite flexible. This is a disadvantage because it makes it more difficult to use the needle accurately. One way of reducing this problem is to use the needle in an assembly including an outer needle along which the oocyte sampling needle can be slid. Alternatively, the wall thickness of the needle can be increased.
It is an object of the present invention to provide an alternative needle.
According to one aspect of the present invention there is provided an oocyte needle of the above-specified kind, characterised in that the shaft has a first portion along a major part of its length of a first substantially constant cross-section and is relatively stiff, and that the shaft has a second portion along a part of the length of the shaft at its patient end having a second substantially constant cross-section less than the first cross-section, the second portion being less stiff than the first portion.
The shaft of the needle is preferably of a metal and may be terminated by a hub at its machine end. The second portion of the needle shaft is preferably made by a cold drawing or rolling process. The first portion may have a diameter of approximately 17g. The second portion may have a diameter between approximately 21 g and 19g. The first portion is preferably about ten times the length of the second portion. The second portion may be about 30mm long.
According to another aspect of the present invention there is provided a method of extracting an oocyte from an ovary using a needle according to the above one aspect of the invention.
According to a third aspect of the present invention there is provided a technique of extracting an oocyte from an ovary including the steps of providing a needle having a rear end with a hub, a shaft with a rear end portion having a first substantially constant diameter and being relatively stiff, the forward end of the shaft having a portion with a second substantially constant diameter less than the first and being adapted to penetrate an ovary, gripping and manipulating the rear end of the shaft to allow the forward end to be positioned in an ovary, connecting a source of suction to the hub and applying suction to the shaft to aspirate an oocyte in the ovary along the needle.
An oocyte sampling needle and its method of use according to the present invention will now be described by way of example, with reference to the accompanying drawing (not to scale), in which:
Figure 1 is a side elevation view of the needle;
Figure 2 is an enlarged cross-sectional view of the needle along the line II-II of
Figure 1 ; and
Figure 3 is an enlarged cross-sectional view of the needle along the line III-III of Figure 1.
The needle comprises a metal shaft 1 attached at its rear or machine end 2 with a standard female luer hub 3 of a hard plastics material. Any conventional technique can be used to attach the hub to the needle, such as a push fit, bonding or over moulding. The shaft 1 has a circular section and a bore 4 extending along its length opening at its rear end 2 into the hub 3 and at its forward end at the tip or patient end 5. The tip 5 of the shaft 1 is bevelled and sharpened to provide a cutting, penetrating tip. The shaft 1 is divided into two portions namely a first, rear or machine end portion 6 and a second, forward or patient end portion 7. The rear end portion 6 forms the major part of the length of the shaft 1 being about 300mm long, has a relatively large constant diameter, typically about 17g (that is, 1.473mm external diameter) and is relatively stiff and inflexible. The forward end portion 7 forms a minor part of the length of the shaft 1, being about 30mm long, has a relatively small constant diameter, typically about 19g, 2Og or 21g (that is, 1.067mm, 0.902mm or 0.813mm) and is relatively flexible compared with the rear end portion 6. It can be seen that the rear end portion 6 is ten times the length of the forward end portion 7. The forward and rear end portions 7 and 6 merge in a transition region 8, which is smoothly tapered and stepless.
The needle shaft 1 is preferably formed from stock metal tubing having the diameter of the major, larger-diameter portion 6 of the shaft. The reduced diameter portion 7 is formed at one end such as by a cold drawing or rolling process. The effect of this technique is that both the inside and outside diameter of the forward portion 7 is reduced. The reduced diameter of the forward portion 7 makes it relatively flexible but this is not a great problem because its forward portion is only relatively short. By comparison, conventional needles having a small diameter along their entire length can be considerably more difficult to use. It will be appreciated that there are various other ways of providing a shaft with these portions of differing diameters. Some of these alternatives may not alter the internal diameter substantially or at all.
In use, the clinician grips the needle by the larger diameter rear portion 6 and inserts it transvaginally so that the tip 5 penetrates the wall of the vagina and enters an ovary. Suction is then applied to the rear of the needle, such as by means of a syringe 10 or other suction collection device connected to the hub 3. The overall characteristic of the needle is of a relatively stiff shaft 1 that can be manipulated accurately. The reduced diameter patient end portion 7, however, gives the needle the advantages of one of smaller diameter in that penetration of patient tissue can be made with less force and with less trauma, thereby producing less pain and reducing healing time, and with less damage to the ovaries and follicles. The smaller diameter tip 5 also enables more precise placement under ultrasound observation and facilitates piercing of the ovaries and follicles. Because most of the length of the needle has the internal diameter of the larger portion 6, the overall flow resistance along the needle can be appreciably less than in a needle having a smaller constant internal diameter equal to that of the tip end portion 7.
The needle could be modified in various ways such as by means of a coating applied to the needle, perhaps to increase lubricity or prevent direct contact with the metal surface. The needle, especially the patient end tip, could be treated in some conventional way to increase the echo genie characteristics of the tip, to make it more visible under ultrasound observation.

Claims

1. An oocyte needle having a shaft (1) with a bore (4) extending along its length, characterised in that the shaft (1) has a first portion (6) along a major part of its length of a first substantially constant cross-section and is relatively stiff, and that the shaft (1) has a second portion (7) along a part of the length of the shaft at its patient end having a second substantially constant cross-section less than the first cross-section, the second portion (7) being less stiff than the first portion (6).
2. An oocyte needle according to Claim 1 , characterised in that the shaft (1) of the needle is of a metal and is terminated by a hub (3) at its machine end (2).
3. An oocyte needle according to Claim 2, characterised in that the second portion (7) of the needle shaft is made by a cold drawing or rolling process.
4. An oocyte needle according to any one of the preceding claims, characterised in that the first portion (6) has a diameter of approximately 17g.
5. An oocyte needle according to any one of the preceding claims, characterised in that the second portion (7) has a diameter between approximately 21 g and 19g.
6. An oocyte needle according to any one of the preceding claims, characterised in that the first portion (6) is about ten times the length of the second portion (7).
7. An oocyte needle according to any one of the preceding claims, characterised in that the second portion (7) is about 30mm long.
8. A method of extracting an oocyte from an ovary using a needle according to any one of the preceding claims.
9 A technique of extracting an oocyte from an ovary including the steps of providing a needle having a rear end (2) with a hub (3), a shaft (1) with a rear end portion (6) having a first substantially constant diameter and being relatively stiff, the forward end of the shaft having a portion (7) with a second substantially constant diameter less than the first and being adapted to penetrate an ovary, gripping and manipulating the rear end (6) of the shaft (1) to allow the forward end (5) to be positioned in an ovary, connecting a source of suction (10) to the hub (3) and applying suction to the shaft (1) to aspirate an oocyte in the ovary along the needle.
PCT/GB2009/001340 2008-06-13 2009-05-28 Needles Ceased WO2009150399A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0810836.7 2008-06-13
GBGB0810836.7A GB0810836D0 (en) 2008-06-13 2008-06-13 Needles

Publications (1)

Publication Number Publication Date
WO2009150399A1 true WO2009150399A1 (en) 2009-12-17

Family

ID=39672223

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/001340 Ceased WO2009150399A1 (en) 2008-06-13 2009-05-28 Needles

Country Status (2)

Country Link
GB (1) GB0810836D0 (en)
WO (1) WO2009150399A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013004578A1 (en) * 2011-07-04 2013-01-10 Hans-Peter Steiner Puncturing device for removing organic samples
WO2017081431A1 (en) * 2015-11-13 2017-05-18 Smiths Medical International Limited Needle assemblies and methods of manufacture
CN107174400A (en) * 2017-06-14 2017-09-19 南京医科大学第附属医院 Human retina cavity of resorption needle for injection and its application
US9907571B2 (en) 2007-09-28 2018-03-06 Vitrolife Sweden Ab Sampling needle

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3540447A (en) * 1967-09-29 1970-11-17 Becton Dickinson Co Spinal needle
DE2554333A1 (en) * 1974-12-14 1976-06-16 De Gaztanondo Carlos Henriquez DEVICE CAN BE USED AS A CATHETER, FOR INJECTION AND DRAINAGE PURPOSES AND FOR PERCUTICAL PARACENTESIS
US4909800A (en) * 1987-07-17 1990-03-20 The Kendall Company Stepped needle
US5843023A (en) * 1995-10-04 1998-12-01 Cecchi; Michael Aspiration needle with side port
WO2004089229A1 (en) * 2003-04-01 2004-10-21 William A. Cook Australia Pty. Ltd. Aspiration and flushing needle
US20060183973A1 (en) * 2001-01-12 2006-08-17 Kamrava Michael M Endoscopic devices and method of use
US20060206055A1 (en) * 2005-03-08 2006-09-14 Ice Dennis A Short-tapered epidural injection needle (ice needle)
EP1795127A2 (en) * 2005-12-09 2007-06-13 Fujifilm Corporation Blood collection needle
WO2009040493A1 (en) * 2007-09-28 2009-04-02 Vitrolife Sweden Ab Sampling needle

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3540447A (en) * 1967-09-29 1970-11-17 Becton Dickinson Co Spinal needle
DE2554333A1 (en) * 1974-12-14 1976-06-16 De Gaztanondo Carlos Henriquez DEVICE CAN BE USED AS A CATHETER, FOR INJECTION AND DRAINAGE PURPOSES AND FOR PERCUTICAL PARACENTESIS
US4909800A (en) * 1987-07-17 1990-03-20 The Kendall Company Stepped needle
US5843023A (en) * 1995-10-04 1998-12-01 Cecchi; Michael Aspiration needle with side port
US20060183973A1 (en) * 2001-01-12 2006-08-17 Kamrava Michael M Endoscopic devices and method of use
WO2004089229A1 (en) * 2003-04-01 2004-10-21 William A. Cook Australia Pty. Ltd. Aspiration and flushing needle
US20060206055A1 (en) * 2005-03-08 2006-09-14 Ice Dennis A Short-tapered epidural injection needle (ice needle)
EP1795127A2 (en) * 2005-12-09 2007-06-13 Fujifilm Corporation Blood collection needle
WO2009040493A1 (en) * 2007-09-28 2009-04-02 Vitrolife Sweden Ab Sampling needle

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9907571B2 (en) 2007-09-28 2018-03-06 Vitrolife Sweden Ab Sampling needle
US10765454B2 (en) 2007-09-28 2020-09-08 Vitrolife Sweden Ab Sampling needle
WO2013004578A1 (en) * 2011-07-04 2013-01-10 Hans-Peter Steiner Puncturing device for removing organic samples
WO2017081431A1 (en) * 2015-11-13 2017-05-18 Smiths Medical International Limited Needle assemblies and methods of manufacture
CN107174400A (en) * 2017-06-14 2017-09-19 南京医科大学第附属医院 Human retina cavity of resorption needle for injection and its application

Also Published As

Publication number Publication date
GB0810836D0 (en) 2008-07-23

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