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WO2009038008A1 - 微粒子の製造方法及びその微粒子 - Google Patents

微粒子の製造方法及びその微粒子 Download PDF

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Publication number
WO2009038008A1
WO2009038008A1 PCT/JP2008/066386 JP2008066386W WO2009038008A1 WO 2009038008 A1 WO2009038008 A1 WO 2009038008A1 JP 2008066386 W JP2008066386 W JP 2008066386W WO 2009038008 A1 WO2009038008 A1 WO 2009038008A1
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WO
WIPO (PCT)
Prior art keywords
fine particles
thin
producing
film fluid
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/066386
Other languages
English (en)
French (fr)
Inventor
Masakazu Enomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
M Technique Co Ltd
Original Assignee
M Technique Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by M Technique Co Ltd filed Critical M Technique Co Ltd
Priority to JP2009533117A priority Critical patent/JPWO2009038008A1/ja
Priority to CN2008801079121A priority patent/CN101801520B/zh
Priority to EP08832357.1A priority patent/EP2191890B1/en
Priority to US12/679,172 priority patent/US8992981B2/en
Publication of WO2009038008A1 publication Critical patent/WO2009038008A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0031—Evaporation of components of the mixture to be separated by heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
    • B01J19/122—Incoherent waves
    • B01J19/123—Ultraviolet light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B01J19/1887—Stationary reactors having moving elements inside forming a thin film
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00094—Jackets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00132—Controlling the temperature using electric heating or cooling elements
    • B01J2219/00137—Peltier cooling elements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Electromagnetism (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

　単分散の微粒子が作成出来、さらに自己排出性により生成物の詰まりも無く、大きな圧力を必要とせず、また生産性も高い、微粒子の製造方法を提供することを課題とするものであって、微粒子原料を少なくとも１種類溶解した流体を、近接・離反可能に互いに対向して配設され、少なくとも一方が他方に対して回転する処理用面の間に導入して薄膜流体とするものであり、当該薄膜流体を冷却あるいは加熱（加温）して飽和溶解度を変化させる事により、微粒子を析出させる。
PCT/JP2008/066386 2007-09-21 2008-09-11 微粒子の製造方法及びその微粒子 Ceased WO2009038008A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009533117A JPWO2009038008A1 (ja) 2007-09-21 2008-09-11 微粒子の製造方法及びその微粒子
CN2008801079121A CN101801520B (zh) 2007-09-21 2008-09-11 微粒的制造方法
EP08832357.1A EP2191890B1 (en) 2007-09-21 2008-09-11 Process for producing fine particles
US12/679,172 US8992981B2 (en) 2007-09-21 2008-09-11 Method for producing microparticles and the microparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007244568 2007-09-21
JP2007-244568 2007-09-21

Publications (1)

Publication Number Publication Date
WO2009038008A1 true WO2009038008A1 (ja) 2009-03-26

Family

ID=40467825

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066386 Ceased WO2009038008A1 (ja) 2007-09-21 2008-09-11 微粒子の製造方法及びその微粒子

Country Status (5)

Country Link
US (1) US8992981B2 (ja)
EP (1) EP2191890B1 (ja)
JP (1) JPWO2009038008A1 (ja)
CN (1) CN101801520B (ja)
WO (1) WO2009038008A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011096401A1 (ja) * 2010-02-03 2011-08-11 エム・テクニック株式会社 ナノ微粒子の製造方法
WO2012137628A1 (ja) * 2011-04-01 2012-10-11 エム・テクニック株式会社 バリウムチタニル塩及びチタン酸バリウムの製造方法
CN102905783A (zh) * 2010-05-25 2013-01-30 M技术株式会社 控制了掺杂元素量的析出物质的制造方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2184109B1 (en) * 2007-07-06 2017-08-23 M Technique Co., Ltd. Method for producing nanoparticles by forced ultra-thin film rotary processing
JP5382738B2 (ja) * 2008-11-25 2014-01-08 エム・テクニック株式会社 流体処理装置及び処理方法
FR2939423B1 (fr) * 2008-12-09 2011-12-09 Yves Lecoffre Procede et dispositif de traitement d'au moins un compose transporte dans un liquide
CN103282145A (zh) * 2011-03-14 2013-09-04 M技术株式会社 金属微粒的制造方法
WO2012127669A1 (ja) 2011-03-23 2012-09-27 エム・テクニック株式会社 高効率なセラミックス微粒子の製造方法
WO2012147538A1 (ja) * 2011-04-26 2012-11-01 エム・テクニック株式会社 微粒子の製造方法
JPWO2013008706A1 (ja) * 2011-07-13 2015-02-23 エム・テクニック株式会社 結晶子径を制御された微粒子の製造方法
WO2013137469A1 (ja) * 2012-03-16 2013-09-19 エム・テクニック株式会社 固体金ニッケル合金ナノ粒子及びその製造方法
CN107001810A (zh) * 2014-12-15 2017-08-01 M技术株式会社 有机物微粒的制造方法及有机物微粒的改性方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07144102A (ja) 1993-11-24 1995-06-06 Fuji Photo Film Co Ltd 有機薬品の晶析方法
JP2002097281A (ja) 2000-09-20 2002-04-02 Stanley Electric Co Ltd 有機材料微粒子の製造方法およびこれを用いたツイストボールディスプレイ
JP2004049957A (ja) 2002-07-16 2004-02-19 M Technique Co Ltd 分散乳化装置及び分散乳化方法
JP2004534649A (ja) * 2001-07-20 2004-11-18 プロテンシブ リミティッド 粒子の製造方法
JP2005313102A (ja) * 2004-04-30 2005-11-10 M Technique Co Ltd 微粒子及びその製造方法
JP2007008924A (ja) 2005-05-31 2007-01-18 Kao Corp 有機化合物微粒子の製造方法及びそれにより製造された有機化合物微粒子、並びに、その粒径制御方法

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GB9903474D0 (en) 1999-02-17 1999-04-07 Univ Newcastle Process for the conversion of a fluid phase substrate by dynamic heterogenous contact with an agent
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ATE337085T1 (de) 2002-07-16 2006-09-15 M Tech Co Ltd Verfahren und verarbeitungsgerät for flüssigkeiten
CA2566075A1 (en) * 2004-05-12 2005-12-01 Baxter Healthcare S.A. Microspheres comprising protein and showing injectability at high concentrations of said agent
EP2180021B1 (en) 2007-07-06 2017-11-08 M Technique Co., Ltd. Pigment nano-fine particle manufacturing method using a forced ultra-thin film rotating reaction method, its pigment nano particles, and ink-jet ink using the particles
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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07144102A (ja) 1993-11-24 1995-06-06 Fuji Photo Film Co Ltd 有機薬品の晶析方法
JP2002097281A (ja) 2000-09-20 2002-04-02 Stanley Electric Co Ltd 有機材料微粒子の製造方法およびこれを用いたツイストボールディスプレイ
JP2004534649A (ja) * 2001-07-20 2004-11-18 プロテンシブ リミティッド 粒子の製造方法
JP2004049957A (ja) 2002-07-16 2004-02-19 M Technique Co Ltd 分散乳化装置及び分散乳化方法
JP2005313102A (ja) * 2004-04-30 2005-11-10 M Technique Co Ltd 微粒子及びその製造方法
JP2007008924A (ja) 2005-05-31 2007-01-18 Kao Corp 有機化合物微粒子の製造方法及びそれにより製造された有機化合物微粒子、並びに、その粒径制御方法

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See also references of EP2191890A4 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102510883B (zh) * 2010-02-03 2014-12-24 M技术株式会社 纳米微粒的制造方法
JP4840835B2 (ja) * 2010-02-03 2011-12-21 エム・テクニック株式会社 ナノ微粒子の製造方法
CN102510883A (zh) * 2010-02-03 2012-06-20 M技术株式会社 纳米微粒的制造方法
KR101848716B1 (ko) 2010-02-03 2018-04-13 엠. 테크닉 가부시키가이샤 나노 미립자의 제조 방법
US9481796B2 (en) 2010-02-03 2016-11-01 M. Technique Co., Ltd. Method for producing nanoparticles
WO2011096401A1 (ja) * 2010-02-03 2011-08-11 エム・テクニック株式会社 ナノ微粒子の製造方法
US8889885B2 (en) 2010-02-03 2014-11-18 M. Technique Co., Ltd. Method for producing nanoparticles
CN102905783B (zh) * 2010-05-25 2016-04-27 M技术株式会社 控制了掺杂元素量的析出物质的制造方法
US9346685B2 (en) 2010-05-25 2016-05-24 M. Technique Co., Ltd. Method for producing substances to be separated having controlled amounts of dopant element
CN102905783A (zh) * 2010-05-25 2013-01-30 M技术株式会社 控制了掺杂元素量的析出物质的制造方法
US9242922B2 (en) 2011-04-01 2016-01-26 M. Technique Co., Ltd. Method for producing barium titanyl salt and barium titanate
JPWO2012137628A1 (ja) * 2011-04-01 2014-07-28 エム・テクニック株式会社 バリウムチタニル塩及びチタン酸バリウムの製造方法
WO2012137628A1 (ja) * 2011-04-01 2012-10-11 エム・テクニック株式会社 バリウムチタニル塩及びチタン酸バリウムの製造方法

Also Published As

Publication number Publication date
EP2191890A1 (en) 2010-06-02
EP2191890A4 (en) 2011-09-14
JPWO2009038008A1 (ja) 2011-01-06
US20100215958A1 (en) 2010-08-26
US8992981B2 (en) 2015-03-31
CN101801520A (zh) 2010-08-11
EP2191890B1 (en) 2014-03-19
CN101801520B (zh) 2013-08-28

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