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WO2009035534A3 - Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif) - Google Patents

Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif) Download PDF

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Publication number
WO2009035534A3
WO2009035534A3 PCT/US2008/010413 US2008010413W WO2009035534A3 WO 2009035534 A3 WO2009035534 A3 WO 2009035534A3 US 2008010413 W US2008010413 W US 2008010413W WO 2009035534 A3 WO2009035534 A3 WO 2009035534A3
Authority
WO
WIPO (PCT)
Prior art keywords
hif
eye disease
systematic
treatment
inducible factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/010413
Other languages
French (fr)
Other versions
WO2009035534A2 (en
Inventor
Jonathan E Sears
George B Hoppe
Quteba Ebrahem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cleveland Clinic Foundation
Original Assignee
Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation filed Critical Cleveland Clinic Foundation
Publication of WO2009035534A2 publication Critical patent/WO2009035534A2/en
Publication of WO2009035534A3 publication Critical patent/WO2009035534A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention consists of a method of treating a subject with an ischemic eye disease associated with the down-regulation of HIF comprising administering to the subject an effective amount of a compound that induces HIF activity and/or induces EPO activity to induce and maintain growth or normal retinal blood vessels in the early stage of the disease.
PCT/US2008/010413 2007-09-07 2008-09-05 Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif) Ceased WO2009035534A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96790107P 2007-09-07 2007-09-07
US60/967,901 2007-09-07

Publications (2)

Publication Number Publication Date
WO2009035534A2 WO2009035534A2 (en) 2009-03-19
WO2009035534A3 true WO2009035534A3 (en) 2009-05-07

Family

ID=40134829

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/010413 Ceased WO2009035534A2 (en) 2007-09-07 2008-09-05 Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif)

Country Status (1)

Country Link
WO (1) WO2009035534A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012013879A (en) 2010-06-01 2013-04-03 Biotheryx Inc Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases.
WO2012128689A1 (en) * 2011-03-21 2012-09-27 Vivolux Ab Treatment of solid tumours
NO2686520T3 (en) 2011-06-06 2018-03-17
ES2734479T3 (en) 2012-09-21 2019-12-10 Vivolux Ab Means and methods to treat solid tumors
ES2974273T3 (en) 2013-06-13 2024-06-26 Akebia Therapeutics Inc Compositions and methods for treating anemia
WO2015112831A1 (en) * 2014-01-23 2015-07-30 Akebia Therapeutics, Inc. Compositions and methods for treating ocular diseases
US10150734B2 (en) 2015-01-23 2018-12-11 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
MX374909B (en) 2015-04-01 2025-03-06 Akebia Therapeutics Inc THE USE OF HYPOXIA INDUCIBLE FACTOR (HIF) PROPYL HYDROLASE INHIBITOR FOR THE TREATMENT OR PREVENTION OF ANEMIA.
US10668056B2 (en) * 2015-12-18 2020-06-02 Vivolux Ab Pharmaceutical composition comprising indole derivatives, process for preparation and use thereof
GB201720320D0 (en) 2017-12-06 2018-01-17 Univ Of Sussex Tissue repair
WO2019136466A1 (en) 2018-01-08 2019-07-11 Yale University Compounds and methods for treating or preventing anterior segment ocular disorders and/or retinal degenerations
KR20210006967A (en) 2018-05-09 2021-01-19 아케비아 테라퓨틱스 인코포레이티드 Method for Producing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US20230301984A1 (en) * 2020-07-02 2023-09-28 The Usa, As Represented By The Secretary, Department Of Health And Human Services Cyclic compounds for use in treating retinal degeneration

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002089809A1 (en) * 2001-05-04 2002-11-14 The Procter & Gamble Company Medicinal uses of hydrazones and hydrazines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002089809A1 (en) * 2001-05-04 2002-11-14 The Procter & Gamble Company Medicinal uses of hydrazones and hydrazines
US20030092716A1 (en) * 2001-05-04 2003-05-15 The Procter & Gamble Company Medicinal uses of hydrazones

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JUNK A K ET AL: "Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 99, no. 16, 1 January 2002 (2002-01-01), pages 10659 - 10664, XP008090830, ISSN: 0027-8424 *
NAGLE DALE G ET AL: "Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1).", CURRENT PHARMACEUTICAL DESIGN 2006, vol. 12, no. 21, 2006, pages 2673 - 2688, XP002509125, ISSN: 1381-6128 *
WHITLOCK N ANDREW ET AL: "Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE MAR 2005, vol. 46, no. 3, March 2005 (2005-03-01), pages 1092 - 1098, XP002509127, ISSN: 0146-0404 *
ZHU Y ET AL: "DESFERROXAMINE PRETREATMENT PROMOTES PROLONGED RETINAL ISCHEMIC TOLERANCE IN MICE: A NEW MODEL OF CHEMICAL PRECONDITIONING IN RETINA", ARVO ANNUAL MEETING ABSTRACT SEARCH AND PROGRAM PLANNER, vol. 2003, 2003, & ANNUAL MEETING OF THE ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY; FORT LAUDERDALE, FL, USA; MAY 04-08, 2003, pages Abstract No. 2925, XP002509126 *

Also Published As

Publication number Publication date
WO2009035534A2 (en) 2009-03-19

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