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WO2009031564A1 - L-amino acid-producing bacterium and method of producing l-amino acid - Google Patents

L-amino acid-producing bacterium and method of producing l-amino acid Download PDF

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Publication number
WO2009031564A1
WO2009031564A1 PCT/JP2008/065833 JP2008065833W WO2009031564A1 WO 2009031564 A1 WO2009031564 A1 WO 2009031564A1 JP 2008065833 W JP2008065833 W JP 2008065833W WO 2009031564 A1 WO2009031564 A1 WO 2009031564A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
producing
medium
bacterium
producing bacterium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065833
Other languages
French (fr)
Japanese (ja)
Inventor
Yoko Asakura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of WO2009031564A1 publication Critical patent/WO2009031564A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

An L-amino acid is produced by culturing a bacterium belonging to the Enterobacter family, which is capable of producing the L-amino acid and has been modified to repress the expression of one or more genes selected from among ydcU, yfeK, smpA, htrG, adiC, htrA, ydhK, bacA, yaiW and yidQ, in a medium, thus accumulating the L-amino acid in the medium and then harvesting the L-amino acid from the medium.
PCT/JP2008/065833 2007-09-04 2008-09-03 L-amino acid-producing bacterium and method of producing l-amino acid Ceased WO2009031564A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007228728A JP2010263789A (en) 2007-09-04 2007-09-04 L-amino acid-producing microorganism and method for producing l-amino acid
JP2007-228728 2007-09-04

Publications (1)

Publication Number Publication Date
WO2009031564A1 true WO2009031564A1 (en) 2009-03-12

Family

ID=40428878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065833 Ceased WO2009031564A1 (en) 2007-09-04 2008-09-03 L-amino acid-producing bacterium and method of producing l-amino acid

Country Status (2)

Country Link
JP (1) JP2010263789A (en)
WO (1) WO2009031564A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015503353A (en) * 2012-01-06 2015-02-02 シージェイ チェイルジェダン コーポレーション Microorganism producing L-amino acid and method for producing L-amino acid using the same
WO2015060314A1 (en) * 2013-10-21 2015-04-30 味の素株式会社 Method for producing l-amino acid
CN112725254A (en) * 2017-10-13 2021-04-30 四川利尔生物科技有限公司 L-homoserine production strain and construction method and application thereof
EP3904521A4 (en) * 2018-12-26 2022-03-23 Daesang Corporation E COLI VARIANT STRAIN OR L-AMINO ACID PRODUCING CORYNEBACTERIUM GLUTAMICUM VARIANT STRAIN, AND METHOD FOR PRODUCING L-AMINO ACIDS USING THE SAME

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383372B2 (en) * 2008-03-06 2013-02-26 Ajinomoto Co., Inc. L-cysteine producing bacterium and a method for producing L-cysteine
RU2013118637A (en) * 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE yjjK GENE IS ADJUSTABLE

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BABA T. ET AL.: "Construction of Eschirichia coli K-12 in-frame,single-gene knockout mutants:the Keio collection", MOLECULAR SYSTEMS BIOLOGY, 2006, pages 1 - 11, Retrieved from the Internet <URL:http://www.nature.com/msb/journal/v2/n1/pdf/msb4100050.pdf> *
DATABASE GENOBASE [online] Database accession no. ECK0160 *
DATABASE GENOBASE [online] Database accession no. ECK0373 *
DATABASE GENOBASE [online] Database accession no. ECK1436 *
DATABASE GENOBASE [online] Database accession no. ECK1641 *
DATABASE GENOBASE [online] Database accession no. ECK2414 *
DATABASE GENOBASE [online] Database accession no. ECK2613 *
DATABASE GENOBASE [online] Database accession no. ECK3045 *
DATABASE GENOBASE [online] Database accession no. ECK3047 *
DATABASE GENOBASE [online] Database accession no. ECK3680 *
IYER R. ET AL: "Arginine-agmatine antiporter in extreme acid resistance in escherichia coli", J.BACTERIOL., vol. 185, no. 22, 2003, pages 6556 - 6561 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015503353A (en) * 2012-01-06 2015-02-02 シージェイ チェイルジェダン コーポレーション Microorganism producing L-amino acid and method for producing L-amino acid using the same
JP2017042167A (en) * 2012-01-06 2017-03-02 シージェイ チェイルジェダン コーポレーション Microorganism able to produce l-amino acid, and method for producing l-amino acid by using the same
WO2015060314A1 (en) * 2013-10-21 2015-04-30 味の素株式会社 Method for producing l-amino acid
JPWO2015060314A1 (en) * 2013-10-21 2017-03-09 味の素株式会社 Method for producing L-amino acid
CN112725254A (en) * 2017-10-13 2021-04-30 四川利尔生物科技有限公司 L-homoserine production strain and construction method and application thereof
CN112725254B (en) * 2017-10-13 2023-07-11 湖南利尔生物科技有限公司 L-homoserine production strain and construction method and application thereof
EP3904521A4 (en) * 2018-12-26 2022-03-23 Daesang Corporation E COLI VARIANT STRAIN OR L-AMINO ACID PRODUCING CORYNEBACTERIUM GLUTAMICUM VARIANT STRAIN, AND METHOD FOR PRODUCING L-AMINO ACIDS USING THE SAME
EP4159865A1 (en) * 2018-12-26 2023-04-05 Daesang Corporation E. coli variant strain producing l-amino acids, and method for producing amino acids using same
EP4159866A1 (en) * 2018-12-26 2023-04-05 Daesang Corporation E. coli variant strain or corynebacterium glutamicum variant strain producing l-amino acids, and method for producing l-amino acids using same

Also Published As

Publication number Publication date
JP2010263789A (en) 2010-11-25

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