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WO2009030268A1 - Procédé et dispositif permettant de séparer une phase - Google Patents

Procédé et dispositif permettant de séparer une phase Download PDF

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Publication number
WO2009030268A1
WO2009030268A1 PCT/EP2007/059113 EP2007059113W WO2009030268A1 WO 2009030268 A1 WO2009030268 A1 WO 2009030268A1 EP 2007059113 W EP2007059113 W EP 2007059113W WO 2009030268 A1 WO2009030268 A1 WO 2009030268A1
Authority
WO
WIPO (PCT)
Prior art keywords
phase
image
container
phase boundary
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/059113
Other languages
German (de)
English (en)
Inventor
Ernst Freydl
Rene Haenni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Buechi Labortechnik AG
Original Assignee
Buechi Labortechnik AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buechi Labortechnik AG filed Critical Buechi Labortechnik AG
Priority to PCT/EP2007/059113 priority Critical patent/WO2009030268A1/fr
Publication of WO2009030268A1 publication Critical patent/WO2009030268A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G01N2015/045—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates by optical analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing

Definitions

  • the invention relates to a method and a device for separating at least one phase from a fluid, in particular from a liquid, in particular a method and a device for automatic liquid-liquid extraction, as well as an image processing program according to the preambles of the independent claims.
  • the liquid-liquid extraction is one of the usual separation methods in the chemical laboratory, in which a dissolved in a first liquid component by means of a liquid solvent, the so-called extractant is separated.
  • the extractant is chosen to be substantially non-chemically compatible with the first liquid.
  • the first liquid is intimately mixed with the extractant.
  • the mixture is introduced into a separating funnel, whereupon, due to the chemical incompatibility, gradually two vertically spaced phases form.
  • One of the phases is formed by the extraction agent in which the component to be separated is dissolved.
  • the two phases are separated by an emulsion layer in which the liquid components are still mixed together. It is now waited until the emulsion layer is sufficiently thin or virtually undetectable. This process can take a few seconds to minutes or even hours.
  • shut-off valve located at the lower end of the separating funnel is opened manually and kept in an open position until the lower phase has partially or completely left the separating funnel.
  • a synthesis robot which among other things allows an automated liquid-liquid extraction, in which the detection of a phase boundary by means of an image processing method is performed.
  • a CCD camera is aimed at a sample vessel in which the liquid or liquids are located. From the recorded images, the positions of both the phase boundary and the surface of the uppermost liquid layer are determined. From these coordinates and the geometry of a known sample vessel, the volume to be extracted is calculated. This requirement of volume calculation is very disadvantageous. Furthermore, the dependence on the geometry and the dimensions requires that a new calibration must be carried out for each sample vessel or a new calculation rule must be defined.
  • a further disadvantage of the method described in the cited document lies in the way in which one of the two phases is removed, which is realized by means of a needle whose positioning must be driven separately and carried out with a complicated control. Furthermore, the drive and the controller require space. Moreover, the cited document does not provide a method for automatically extracting a phase that is below another phase. It is therefore the object of the present invention to avoid the disadvantages of the known and in particular to provide a method and a device with which an automated separation of a phase from a fluid, in particular a liquid-liquid extraction can be carried out requires only a small mechanical effort, is flexible and in particular allows the automated removal of a lower phase.
  • a first aspect of the invention relates to a method for separating at least one phase from a fluid in which at least one phase boundary between two phases of the fluid is or will be formed.
  • a method is, for example, the liquid-liquid extraction, in which an extractant is separated with a substance dissolved therein.
  • the inventive method first comprises the automatic determination of the position of a phase boundary between a first phase and a second phase of the fluid in a container, in particular in a separating funnel.
  • the automatic determination is performed with a monitoring system comprising an image pickup device and an image processing unit.
  • the image pickup device may be, for example, a camera and / or a plurality of photodiodes.
  • the removal of the first phase from the container is started.
  • the position of the phase boundary is continuously determined by means of the monitoring system.
  • the removal of the first phase is terminated as soon as the position of the phase boundary fulfills a defined termination criterion.
  • the position of the phase boundary is typically determined by utilizing optical properties, in particular the colors and / or brightnesses and / or refractive indices, in which the first phase and the second phase differ from one another.
  • the removal of the first phase from the container may be accomplished by a variety of per se known devices and / or methods, such as a needle or shut-off valve, through which a phase may be withdrawn.
  • a “continuous" determination also means a repeated determination at regular or irregular time intervals.
  • the method according to the invention allows the automatic separation of a phase from a fluid without the need for monitoring by a person or manual intervention. Compared with the methods known from the prior art, it is of particular advantage in the present invention that only one single position - namely, a single phase boundary - has to be determined here.
  • first a first phase is taken from the container, wherein the position of a first phase boundary between the first and the second phase is determined continuously.
  • a second phase boundary between the second phase and a third phase is determined and the second phase is taken out of the container, wherein the position of the second phase boundary is determined continuously.
  • the lowest phase is taken in the process.
  • a shut-off valve which is arranged in particular at a bottom of the container.
  • Such a removal is mechanically particularly simple, since the lowest phase leaves the container due to its own gravity as soon as the shut-off valve is opened.
  • the shut-off valve is a solenoid valve.
  • Such shut-off valves are well known to those skilled in the art.
  • the termination criterion is defined by the fact that the distance of the phase boundary from the bottom of the container or to a shut-off valve arranged at the bottom of the container reaches or falls below a predetermined value.
  • the predetermined value may also be zero;
  • the termination criterion is defined by the phase boundary reaching the bottom of the container or the shut-off valve located at the bottom of the container.
  • the user is not limited in his selection of a suitable container to certain shapes and / or volumes. Rather, the single determination of a predetermined value for the distance of the position of the phase boundary from the bottom of the container or to a arranged at the bottom of the container shut-off valve is sufficient.
  • a positive value for the distance is thereby preferably selected, if a removal of the second phase should be prevented with certainty.
  • first, middle phase approximately by means of a needle and thereby the distance of a first phase boundary between the middle phase and a second, located above the middle phase of a second phase boundary between the first Phase and a third, below the middle phase to monitor.
  • the termination be defined by the fact that said distance of the two phase boundaries from each other reaches or falls below a predetermined value.
  • At least one further measured value can be monitored before and / or during and / or after the removal of the first phase.
  • the said monitoring system can be used for this purpose.
  • the further measured value may be in particular
  • the sequence of the method can be continuously monitored automatically and the removal can be interrupted automatically, at least temporarily, if the presence of an irregular operating condition is detected in the monitoring.
  • the monitoring can be based, for example, on the above-mentioned further measured values.
  • continuous determination is to be understood as above.
  • An irregular operating condition may be present if the thickness of an emulsion layer increases, which may indicate an uncontrolled mixing of the phases.
  • An irregular operating condition may still exist if the image Processing unit and / or the image processing program due to a fault, the position of the phase boundary can no longer or only insufficiently determined.
  • the removal of the first phase is interrupted according to this development.
  • the risk of uncontrolled removal of undefined fluid in irregular operating conditions is thus minimized or completely eliminated.
  • Such a disturbance can be present, for example, if turbulence forms in the fluid and / or the container is subjected to mechanical shocks.
  • a warning signal is output in the event of an interruption, which may be of a visual and / or acoustic nature, for example.
  • the further measured values such as the thickness of an emulsion layer, are continuously monitored by the image processing unit as from the beginning of an interruption. As soon as regular operating conditions are restored during this monitoring, the removal can be continued automatically.
  • the following steps are performed by the monitoring system in automatically determining the position of the phase boundary:
  • the differential image is preferably calculated pixel-by-pixel.
  • separate difference images can first be calculated for the three color components red, green and blue and then the final difference image calculated by forming the sum of the amounts of the three intensity differences.
  • the difference image D Due to its calculation, the difference image D has the greatest intensities for those spatial regions in which the greatest temporal change of the recorded images takes place.
  • the position of a moving phase boundary can be determined in particular from the difference image D.
  • Static influences, such as reflections, inscriptions or scratches on, for example, the container or the background are effectively filtered out by the subtraction, so that the position of the phase boundary can be easily determined.
  • the inventive device is thus much more flexible than those known from the prior art.
  • the determination of the position of the phase boundary from the difference image D in the above step iv) comprises the following steps:
  • iv.b for each image object, determine the position of the phase limit as the vertical position of the computational center of gravity and the distribution of the image object.
  • image object is actually a moving phase boundary
  • further physical conditions may be used. For example, it can be checked whether the image object extends substantially horizontally. An image object that extends approximately substantially vertically can thus be filtered out. Furthermore, it can be checked whether the image object moves downward during the deflation. This can for example be used to distinguish a downward moving phase boundary of rising air bubbles.
  • At least one separation parameter is determined continuously before starting to remove the first phase. This determination can be carried out in particular with the monitoring system.
  • the separation parameter is chosen such that it is determined by the progression of the formation of a phase boundary between a first phase and a second phase.
  • the separation parameter is continuously compared with a defined separation criterion. This is preferably done with the aid of the image processing unit. As soon as the separation criterion is met, the removal of the first phase is started according to the method according to the invention.
  • the separation criterion comprises The achievement or falling below a defined maximum thickness of an emulsion layer between the first phase and the second phase and / or the temporal and spatial constancy of the phase boundary.
  • step ii) at least as many images are taken and stored in the data memory, as required by the implementation of the subsequent steps.
  • step iii) the formation of difference images takes place relative to a defined image B k , wherein the difference images can be formed as explained above. In this case, a previously predetermined number m of difference images is formed. If additional images are required in this step iii) which have not yet been recorded and stored in the data memory, further images are added to the data memory in accordance with step ii).
  • the decision according to step iv) is carried out, for example, by first checking, pixel by pixel, the achievement or exceeding of a predetermined threshold value.
  • step v) causes the separation to be considered complete if the images remain substantially constant in time in a time interval defined over the number m of images considered. If one of the difference images fulfills the threshold criterion and thus no static situation has yet been reached, then further difference images are generated again and starting from the first substantially different image.
  • step a) is executed only after a predetermined time interval after the provision of the fluid. In particular, with a high number of successive separations, a suitable predetermined time interval can be set, after which a phase boundary has formed.
  • Another aspect of the invention relates to a device for separating at least one phase from a fluid in which at least one phase boundary between two phases of the fluid is formed or can be formed.
  • the device is suitable for carrying out the method according to the invention.
  • the apparatus comprises at least one image recording device for recording image data from a container containing the fluid and at least one image processing unit for processing the image data.
  • the image processing unit is designed such that the position of a moving phase boundary between a first phase and a second phase of the fluid contained in the container is continuously determinable.
  • the algorithm encompasses the steps already mentioned above and serves, in particular, to detect blockages and / or to make temporal forecasts of the phase separation process.
  • the device has a holder for the container.
  • the holder may be a per se known and only has to allow the recording of image data from the container, so in particular does not include the container in such a way that the container from the perspective of the image pickup device is not visible.
  • the device comprises at least one container, which is designed in particular as a separating funnel.
  • the container is at least partially translucent.
  • the Separating funnels can have isolated labels or imprints, which however do not fill its entire surface. As explained above, such labels are not detrimental to use. They can be filtered out by using templates or patterns.
  • the device preferably has removal means for removing at least parts of the fluid from a container.
  • the removal means comprise a stop valve arranged on a container, in particular a controllable solenoid valve.
  • the removal means are controllable on the basis of information of the image processing unit.
  • the device contains a lighting unit for illuminating the container.
  • the lighting unit is designed and arranged such that the illumination of the container by reflected light and / or rear light takes place.
  • the lighting unit may also contain a plurality of lights, which in particular have different colors and / or intensities.
  • the individual luminaires can in particular be spatially separated and / or movable relative to the container.
  • the device contains an image background with a defined, structured marking, in particular in the form of a chess board or an arrangement of lines.
  • the image background is positioned and / or positionable such that the container is positioned or positionable in the light path between the image capture device and the image background.
  • Such an image background leads to a stronger and well-defined contrast, which facilitates the image processing.
  • the device preferably has a mirror system, which comprises at least one deflecting mirror. With such a mirror system, the light path between the container and the image pickup device and / or between the container and the image background can be redirected. This leads to a reduced size of the entire devices, which is an advantage, especially in view of the frequent lack of space in the laboratory.
  • the device may have further optical elements which deflect or focus the light path approximately and thus possibly lead to a reduction in the size, such as lenses, prisms, collimators or filters.
  • the device may have recognition means for detecting the optical properties of the fluid, such as transmission, absorption, emission (eg, color), reflection, brightness, refraction (in combination with a suitable, e.g. B. checkered background), polarization, scattering, luminescence and / or gloss.
  • optical properties of the fluid such as transmission, absorption, emission (eg, color), reflection, brightness, refraction (in combination with a suitable, e.g. B. checkered background), polarization, scattering, luminescence and / or gloss.
  • Such agents are known in the art, such as polarizing filters or color filters.
  • some or more of the mentioned optical properties can be recorded directly via the image recording device and determined by means of the image processing unit. On the basis of the optical properties mentioned, it is possible to draw conclusions about further physical and / or chemical properties of the phases, for example, before and / or during the separation.
  • the device can have display means, in particular a monitor, which are connected to the image processing unit for data exchange.
  • the display means may be used for displaying the data recorded by the image acquisition device and / or the image processing unit used by the image acquisition device. be processed data suitable.
  • the device may include input means, in particular a keyboard and / or a touch screen, which are connectable or connected for data exchange with the image processing unit. Parameters may be input via these input means, such as predetermined distances for defining a termination criterion or predetermined time intervals during which a phase boundary may form in a fluid.
  • the device can have at least one data memory in which the data recorded by the image processing unit and / or the data processed by the image processing unit can be stored.
  • the image recording device is movable relative to the container, in particular height-adjustable.
  • the area of the container from which the image pickup device can acquire image data can be increased.
  • a small opening angle of the image pickup device and / or a small distance between the image pickup device and the container so much larger containers can be used.
  • the device preferably has an arrangement of a plurality of containers and a monitoring system, which are arranged and configured such that a separation can be carried out simultaneously in each of the containers and the removal means can be controlled independently of one another by the image processing unit.
  • the term "simultaneously” also means that the positions of the phase boundaries in the containers can be determined cyclically or in another defined sequence by the image processing unit be controllable.
  • Another aspect of the invention relates to an image processing program which executes a method of the invention when executed by a computer.
  • the image processing program can be executed by an image processing unit of a device according to the invention.
  • the image processing program performs the following steps:
  • the difference image D of two directly successive images B k and B k _ x is determined. Further preferably, the difference image D is calculated directly from the images B n and B n _ x as soon as the image B n has been recorded. Further preferably, the difference image is calculated pixel by pixel.
  • the determination of the position of the phase boundary from the difference image D in step iv) comprises the following steps: iv.a) connecting pixels of the image to image objects, each image object falling below a predetermined, maximum vertical extent;
  • Fig. 1 is a perspective, schematic representation of an inventive device
  • FIG. 2 shows a further schematic illustration of the device according to the invention
  • FIG. 3 is a schematic representation of a device according to the invention with a mirror system
  • Fig. 4 is an illustration for illustrating the algorithm for determining the position of a phase boundary.
  • the device according to the invention shown in FIG. 1 has a monitoring system 18, which contains an image recording device 3 in the form of a camera and an image processing unit 8, not shown here. Furthermore, the device has a container 1 in the form of a separating funnel. The camera 3 is positioned so that it can take pictures of the separating funnel 1. Moreover, the device has an image background 11 in the form of a checkerboard pattern and a lighting unit comprising a plurality of luminaires 22. The container 1 is positioned in the light path between the image pickup device 3 and the image background 11. The separating funnel 1 is held in a holder 23 and contains a fluid 4. The fluid 4 comprises a first phase 6 and a second phase 7 arranged vertically above it, the two phases 6, 7 being spatially separated from each other by a phase boundary 5.
  • the separation funnel 1 typically has a volume in the range of about 100 to 1000 ml. Its height is usually between 150 and 330 mm, its diameter between 55 and 130 mm.
  • the separating funnel may have isolated labels or imprints, which however do not fill its entire surface. Such markings as well as time-invariable light reflections are not detrimental to use.
  • the camera 3 used preferably has a resolution of at least 640 by 480 pixels, the pixel sizes being approximately 7 ⁇ m. Depending on the optics and the light conditions, however, other resolutions and / or pixel sizes are also conceivable.
  • a conventional CMOS sensor is provided. It can be used both a monochrome and a color camera. When using a monochrome camera, a lighting unit of lights 22 may be provided in several different colors, which can be activated alternately or in different intensity combinations.
  • the focal length of the camera 3 is about 10 mm.
  • the distance between camera 3 and container 1 is at least about 600 mm. To prevent reflections on the separating funnel 1 and a polarizing filter can be brought into the light path.
  • the image processing unit 8 used is based on an embedded system, a ColdFire system. 240 MHz Freescale microprocessor, 30 kB internal RAM and 16 MB external RAM. The code is implemented in ANSI-C.
  • the image processing unit 8 is designed in such a way that the position of a moving phase boundary 5 between a first phase 6 and a second phase 7 of the fluid 4 contained in the container 4 can be determined continuously.
  • sampling means designed as a shut-off valve 2 can be seen.
  • the shut-off valve 2 is arranged on the bottom 19 of the separating funnel 1. Between the first phase 6 and the second phase 7, an emulsion layer 21 is formed here; the phase separation is therefore not complete at this time.
  • the thickness of the emulsion layer 21 is first determined continuously by means of the monitoring system 18 and compared with a defined maximum thickness. If the thickness coincides with the defined maximum thickness or falls below this or no change in the layer thickness is detected, the removal is started. Alternatively, the removal is started after a predetermined time interval.
  • the image processing unit 8 controls the shut-off valve 2 via a control line 14 in an open position, so that the first phase 6 can run out of the container.
  • the thickness of the emulsion layer 21 between the first phase 6 and the second phase 7 is determined during the removal as a further measured value. If the thickness of the emulsion layer 21 increases excessively, in particular exceeds a predetermined value, the removal of the first phase 6 is interrupted. broken by the image processing unit 8 controls the shut-off valve 2 via the control line 14 in a closed position.
  • the alternative arrangement sketched in FIG. 3 has a mirror system 13 by means of which the light path can be deflected.
  • a space-saving structure can be achieved, which has a depth of 40 cm and a width in the range of 20 to 30 cm.
  • FIG. 4 shows the algorithm for determining the positions of two moving phase boundaries.
  • the photographically reproduced container 1 contains a fluid 4. This photographic reproduction is superposed on an image taken by an image pickup device and processed by an image processing unit.
  • the pixels determined in the formation of a difference image from two temporally successive images, in which the intensity difference exceeds a predetermined threshold value, are shown here in white.
  • the image processing unit connects the not individually recognizable pixels to image objects 24, which are enclosed in the figure for clarification of rectangles.
  • the pixels are connected by the image processing unit to image objects 24 such that they have vertical extensions d1, d2 and d3, each of which falls below a predetermined maximum vertical extent d of typically 1-10 mm.
  • the image processing unit calculates the vertical position of the center of gravity 25, which is assumed to be the position of a phase boundary. Due to the selection of the extent d of the image objects 24, the resolution of two moving phase boundaries 5 within the fluid 4 and the moving surface of the fluid 4, d. H. the interface between the fluid 4 and the air above it.

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Abstract

La présente invention concerne un procédé permettant de séparer au moins une phase d'un fluide (4) dans lequel au moins une limite de phase (5) est définie entre deux phases (6, 7) du fluide (4), notamment des procédés d'extraction liquide-liquide. Le procédé consiste d'abord à déterminer automatiquement la position d'une limite de phase (5) entre une première phase (6) et une seconde phase (7) du fluide (4) dans un récipient (1), notamment dans un entonnoir à séparation, au moyen d'un système de contrôle (18) qui comprend un dispositif de prise de vue (3) et une unité de traitement d'image (8), puis à commencer à prélever la première phase (6) du récipient (1), opération au cours de laquelle la position de la limite de phase (5) est déterminée en continu au moyen du système de contrôle (18), puis à arrêter de prélever la première phase (6) dès que la limite de phase (5) satisfait un critère d'achèvement défini. L'invention concerne également un dispositif permettant de mettre en oeuvre le procédé, ainsi qu'un programme de traitement d'image permettant de mettre en oeuvre le procédé lorsqu'il est réalisé par l'unité de traitement d'image (8).
PCT/EP2007/059113 2007-08-31 2007-08-31 Procédé et dispositif permettant de séparer une phase Ceased WO2009030268A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2007/059113 WO2009030268A1 (fr) 2007-08-31 2007-08-31 Procédé et dispositif permettant de séparer une phase

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Application Number Priority Date Filing Date Title
PCT/EP2007/059113 WO2009030268A1 (fr) 2007-08-31 2007-08-31 Procédé et dispositif permettant de séparer une phase

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WO2009030268A1 true WO2009030268A1 (fr) 2009-03-12

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220082484A1 (en) * 2020-09-17 2022-03-17 Evonik Operations Gmbh Characterization of a phase separation of a coating composition

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1258747A (fr) * 1968-10-15 1971-12-30
US5463228A (en) * 1992-12-19 1995-10-31 Boehringer Mannheim Gmbh Apparatus for the detection of a fluid phase boundary in a transparent measuring tube and for the automatic exact metering of an amount of liquid
JPH09145453A (ja) * 1995-11-20 1997-06-06 Mitsubishi Heavy Ind Ltd 光学的境界面計測装置
US6673316B1 (en) * 1996-10-30 2004-01-06 Sumitomo Chemical Co., Ltd. Synthesis experiment automating system, liquid separating treating apparatus and reaction vessel
EP1712263A1 (fr) * 2005-02-22 2006-10-18 Büchi Labortechnik AG Dispositif et méthode pour extraction liquide-liquide automatique, méthode pour le transfert d'une phase et module additif pour un appareil à synthèse

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1258747A (fr) * 1968-10-15 1971-12-30
US5463228A (en) * 1992-12-19 1995-10-31 Boehringer Mannheim Gmbh Apparatus for the detection of a fluid phase boundary in a transparent measuring tube and for the automatic exact metering of an amount of liquid
JPH09145453A (ja) * 1995-11-20 1997-06-06 Mitsubishi Heavy Ind Ltd 光学的境界面計測装置
US6673316B1 (en) * 1996-10-30 2004-01-06 Sumitomo Chemical Co., Ltd. Synthesis experiment automating system, liquid separating treating apparatus and reaction vessel
EP1712263A1 (fr) * 2005-02-22 2006-10-18 Büchi Labortechnik AG Dispositif et méthode pour extraction liquide-liquide automatique, méthode pour le transfert d'une phase et module additif pour un appareil à synthèse

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220082484A1 (en) * 2020-09-17 2022-03-17 Evonik Operations Gmbh Characterization of a phase separation of a coating composition
US11988643B2 (en) * 2020-09-17 2024-05-21 Evonik Operations Gmbh Characterization of a phase separation of a coating composition

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