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WO2009028650A1 - 乳化型外用剤およびその製造方法 - Google Patents

乳化型外用剤およびその製造方法 Download PDF

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Publication number
WO2009028650A1
WO2009028650A1 PCT/JP2008/065501 JP2008065501W WO2009028650A1 WO 2009028650 A1 WO2009028650 A1 WO 2009028650A1 JP 2008065501 W JP2008065501 W JP 2008065501W WO 2009028650 A1 WO2009028650 A1 WO 2009028650A1
Authority
WO
WIPO (PCT)
Prior art keywords
emulsion
external preparation
type external
metal salt
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065501
Other languages
English (en)
French (fr)
Inventor
Yasuhisa Tanoue
Shigeo Doi
Tetsuro Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yutoku Pharmaceutical Industries Co Ltd
Original Assignee
Yutoku Pharmaceutical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yutoku Pharmaceutical Industries Co Ltd filed Critical Yutoku Pharmaceutical Industries Co Ltd
Priority to JP2009530196A priority Critical patent/JP4526598B2/ja
Publication of WO2009028650A1 publication Critical patent/WO2009028650A1/ja
Anticipated expiration legal-status Critical
Priority to US12/714,989 priority patent/US20100256238A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

　カルボン酸系医薬品有効成分化合物のアルカリ金属またはアルカリ土類金属の塩あるいはその水和物において、結晶の析出を有効に抑制することができ、低刺激性であって、かつ有効成分の含有量の低下が抑制された乳化型外用剤およびその製造方法を提供することを目的とし、次の成分（ａ）および（ｂ）　（ａ）カルボン酸基を含有し、アルカリ金属塩またはアルカリ土類金属塩の形態である医薬有効成分化合物および水性溶媒を含有する水相　（ｂ）脂肪酸エステル、炭化水素、動植物油およびその硬化油並びに天然由来のロウよりなる群から選ばれる１種または２種以上の油性成分を含有する油相　を乳化して得られた乳化物と、 酸性水溶性高分子の全部または一部を水性溶媒中で塩基性物質により処理して得られる処理酸性水溶性高分子溶液とを混合して得られる乳化型外用剤およびその製造方法並びにカルボン酸基を含有し、アルカリ金属塩またはアルカリ土類金属塩の形態である医薬有効成分化合物を含む乳化組成物に、塩基性物質によって処理された酸性水溶性高分子を含有する溶液を混合してなる乳化型外用剤およびその製造方法を提供する。  
PCT/JP2008/065501 2007-08-29 2008-08-29 乳化型外用剤およびその製造方法 Ceased WO2009028650A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009530196A JP4526598B2 (ja) 2007-08-29 2008-08-29 乳化型外用剤およびその製造方法
US12/714,989 US20100256238A1 (en) 2007-08-29 2010-03-01 Emulsion-type external preparation, and method for production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-222437 2007-08-29
JP2007222437 2007-08-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/714,989 Continuation-In-Part US20100256238A1 (en) 2007-08-29 2010-03-01 Emulsion-type external preparation, and method for production thereof

Publications (1)

Publication Number Publication Date
WO2009028650A1 true WO2009028650A1 (ja) 2009-03-05

Family

ID=40387361

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065501 Ceased WO2009028650A1 (ja) 2007-08-29 2008-08-29 乳化型外用剤およびその製造方法

Country Status (3)

Country Link
US (1) US20100256238A1 (ja)
JP (1) JP4526598B2 (ja)
WO (1) WO2009028650A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010103845A1 (ja) * 2009-03-11 2010-09-16 興和株式会社 鎮痛・抗炎症剤含有外用剤
WO2010103844A1 (ja) * 2009-03-11 2010-09-16 興和株式会社 鎮痛・抗炎症剤含有外用剤
CN103910750A (zh) * 2014-04-18 2014-07-09 悦康药业集团有限公司 一种头孢唑肟钠化合物
CN104490785A (zh) * 2014-12-20 2015-04-08 福安药业（集团）股份有限公司 一种注射用头孢唑肟钠脂质体组合物及其制备方法
JP2015193620A (ja) * 2014-03-27 2015-11-05 株式会社ポーラファルマ 物性で特定される皮膚外用剤
JP2016079180A (ja) * 2014-10-15 2016-05-16 第一三共ヘルスケア株式会社 ロキソプロフェン含有外用剤組成物
JPWO2015147296A1 (ja) * 2014-03-27 2017-04-13 株式会社ポーラファルマ 乳化剤形の組成物の製造方法
JP2021503001A (ja) * 2017-11-14 2021-02-04 プロフェム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＰｒｏＦｅｍ ＧｍｂＨ 粘膜感染症治療用エマルション
JP2023018864A (ja) * 2021-07-28 2023-02-09 第一三共ヘルスケア株式会社 ロキソプロフェン含有外用塗布剤
JP7809464B2 (ja) 2021-07-28 2026-02-02 第一三共ヘルスケア株式会社 ロキソプロフェン含有外用塗布剤

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013084995A1 (ja) * 2011-12-07 2013-06-13 久光製薬株式会社 貼付剤
CN103284942A (zh) * 2012-03-02 2013-09-11 中国药科大学 一种高渗透性消炎镇痛乳膏
WO2014138802A1 (en) * 2013-03-14 2014-09-18 Coats Andrew J S Canrenoate compositions for treating cancer
EP3124049A4 (en) * 2014-03-27 2017-12-13 Pola Pharma Inc. Process for producing composition of emulsion preparation type

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012821A1 (fr) * 1990-03-02 1991-09-05 Shiseido Company, Ltd. Composition d'emulsion aqueuse contenant un analgesique anti-inflammatoire steroidien
JPH04300831A (ja) * 1991-03-28 1992-10-23 Tokyo Tanabe Co Ltd ９−メチル−３−（１Ｈ−テトラゾール−５−イル）−４Ｈ−ピリド〔１，２−ａ〕ピリミジン−４−オン又はその塩のクリーム剤
JPH10182450A (ja) * 1996-12-27 1998-07-07 Ss Pharmaceut Co Ltd 外用組成物
JP2001081024A (ja) * 2000-04-10 2001-03-27 Kokyu Alcohol Kogyo Co Ltd 乳白状水中油型乳化組成物及びその製造方法
JP2001199883A (ja) * 1999-11-10 2001-07-24 Toko Yakuhin Kogyo Kk 消炎鎮痛外用剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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US3965156A (en) * 1974-02-04 1976-06-22 General Electric Company Process for preparing vinyl esters of carboxylic acids
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
JPH07116026B2 (ja) * 1987-07-07 1995-12-13 株式会社資生堂 ジクロフェナックナトリウム含有乳化外用剤
US5462744A (en) * 1989-12-01 1995-10-31 Boehringer Ingelheim Kg Transdermal system for the administration of pharmacological compounds under pH-controlled conditions
JPH06219940A (ja) * 1993-01-27 1994-08-09 Shiseido Co Ltd 貼付剤
JP3526887B2 (ja) * 1993-04-23 2004-05-17 帝國製薬株式会社 消炎鎮痛外用貼付剤
US5795916A (en) * 1994-08-09 1998-08-18 Tsumura & Co. Composition of external preparation
JPH10128450A (ja) * 1996-10-30 1998-05-19 Amada Co Ltd 下降式プレスブレーキ
US20040077604A1 (en) * 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
US7820145B2 (en) * 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7132452B2 (en) * 2003-03-10 2006-11-07 Fang-Yu Lee Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012821A1 (fr) * 1990-03-02 1991-09-05 Shiseido Company, Ltd. Composition d'emulsion aqueuse contenant un analgesique anti-inflammatoire steroidien
JPH04300831A (ja) * 1991-03-28 1992-10-23 Tokyo Tanabe Co Ltd ９−メチル−３−（１Ｈ−テトラゾール−５−イル）−４Ｈ−ピリド〔１，２−ａ〕ピリミジン−４−オン又はその塩のクリーム剤
JPH10182450A (ja) * 1996-12-27 1998-07-07 Ss Pharmaceut Co Ltd 外用組成物
JP2001199883A (ja) * 1999-11-10 2001-07-24 Toko Yakuhin Kogyo Kk 消炎鎮痛外用剤
JP2001081024A (ja) * 2000-04-10 2001-03-27 Kokyu Alcohol Kogyo Co Ltd 乳白状水中油型乳化組成物及びその製造方法

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010103845A1 (ja) * 2009-03-11 2010-09-16 興和株式会社 鎮痛・抗炎症剤含有外用剤
WO2010103844A1 (ja) * 2009-03-11 2010-09-16 興和株式会社 鎮痛・抗炎症剤含有外用剤
CN102341124A (zh) * 2009-03-11 2012-02-01 兴和株式会社 含有镇痛-抗炎症剂的外用剂
JPWO2010103845A1 (ja) * 2009-03-11 2012-09-13 興和株式会社 鎮痛・抗炎症剤含有外用剤
JPWO2010103844A1 (ja) * 2009-03-11 2012-09-13 興和株式会社 鎮痛・抗炎症剤含有外用剤
JPWO2015147296A1 (ja) * 2014-03-27 2017-04-13 株式会社ポーラファルマ 乳化剤形の組成物の製造方法
JP2015193620A (ja) * 2014-03-27 2015-11-05 株式会社ポーラファルマ 物性で特定される皮膚外用剤
CN103910750A (zh) * 2014-04-18 2014-07-09 悦康药业集团有限公司 一种头孢唑肟钠化合物
JP2016079180A (ja) * 2014-10-15 2016-05-16 第一三共ヘルスケア株式会社 ロキソプロフェン含有外用剤組成物
CN104490785A (zh) * 2014-12-20 2015-04-08 福安药业（集团）股份有限公司 一种注射用头孢唑肟钠脂质体组合物及其制备方法
JP2021503001A (ja) * 2017-11-14 2021-02-04 プロフェム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＰｒｏＦｅｍ ＧｍｂＨ 粘膜感染症治療用エマルション
JP7419241B2 (ja) 2017-11-14 2024-01-22 プロフェム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 粘膜感染症治療用エマルション
JP2023018864A (ja) * 2021-07-28 2023-02-09 第一三共ヘルスケア株式会社 ロキソプロフェン含有外用塗布剤
JP7809464B2 (ja) 2021-07-28 2026-02-02 第一三共ヘルスケア株式会社 ロキソプロフェン含有外用塗布剤

Also Published As

Publication number Publication date
JP4526598B2 (ja) 2010-08-18
JPWO2009028650A1 (ja) 2010-12-02
US20100256238A1 (en) 2010-10-07

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