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WO2009021083A8 - Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases - Google Patents

Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases Download PDF

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Publication number
WO2009021083A8
WO2009021083A8 PCT/US2008/072401 US2008072401W WO2009021083A8 WO 2009021083 A8 WO2009021083 A8 WO 2009021083A8 US 2008072401 W US2008072401 W US 2008072401W WO 2009021083 A8 WO2009021083 A8 WO 2009021083A8
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WIPO (PCT)
Prior art keywords
quinoxaline derivatives
diseases
kinase inhibitors
invented
pancreatitis
Prior art date
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Ceased
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PCT/US2008/072401
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English (en)
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WO2009021083A1 (fr
Inventor
Steven David Knight
Cynthia A Parrish
Lance H Ridgers
Martha A Sarpong
Amita M Chaudhari
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SmithKline Beecham Corp
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SmithKline Beecham Corp
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Publication date
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Priority to EP08797323A priority Critical patent/EP2173354A4/fr
Priority to JP2010520295A priority patent/JP2010535804A/ja
Publication of WO2009021083A1 publication Critical patent/WO2009021083A1/fr
Publication of WO2009021083A8 publication Critical patent/WO2009021083A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Cette invention se rapporte à un procédé d'inhibition de l'activité/de la fonction des PI3-kinases utilisant des dérivés des quinoxalines. L'invention concerne également un procédé permettant de traiter une ou plusieurs des affections pathologiques suivantes : les maladies auto-immunes, les maladies inflammatoires, les maladies cardiovasculaires, les maladies neurodégénératives, l'allergie, l'asthme, la pancréatite, la défaillance multiviscérale, les maladies rénales, l'agrégation plaquettaire, le cancer, la motilité de sperme, le rejet de greffe, le rejet du greffon et les lésions pulmonaires, en administrant des dérivés des quinoxalines.
PCT/US2008/072401 2007-08-09 2008-08-07 Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases Ceased WO2009021083A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08797323A EP2173354A4 (fr) 2007-08-09 2008-08-07 Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases
JP2010520295A JP2010535804A (ja) 2007-08-09 2008-08-07 Ｐｉ３キナーゼ阻害薬としてのキノキサリン誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95484507P 2007-08-09 2007-08-09
US60/954,845 2007-08-09

Publications (2)

Publication Number Publication Date
WO2009021083A1 WO2009021083A1 (fr) 2009-02-12
WO2009021083A8 true WO2009021083A8 (fr) 2009-04-09

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PCT/US2008/072401 Ceased WO2009021083A1 (fr) 2007-08-09 2008-08-07 Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases

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EP (1) EP2173354A4 (fr)
JP (1) JP2010535804A (fr)
WO (1) WO2009021083A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
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US8895601B2 (en) 2010-04-30 2014-11-25 Astex Therapeutics Ltd Pyrazolyl quinoxaline kinase inhibitors
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

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GB0908905D0 (en) 2009-05-26 2009-07-01 Sentinel Oncology Ltd Pharmaceutical compounds
CN102596932A (zh) * 2009-09-04 2012-07-18 拜耳医药股份有限公司 作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
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GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
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GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
CN104284896B (zh) 2012-03-14 2016-06-01 拜耳知识产权有限责任公司 取代的咪唑并哒嗪
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
NZ702747A (en) 2012-06-13 2017-03-31 Incyte Holdings Corp Substituted tricyclic compounds as fgfr inhibitors
WO2014026125A1 (fr) 2012-08-10 2014-02-13 Incyte Corporation Dérivés de pyrazine en tant qu'inhibiteurs de fgfr
US9487526B2 (en) 2012-08-13 2016-11-08 Takeda Pharmaceutical Company Limited Quinoxaline derivatives as GPR6 modulators
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
CA2900303A1 (fr) 2013-02-07 2014-08-14 Merck Patent Gmbh Derives de quinoxaline substitues et leur utilisation a titre de modulateurs allosteriques positifs du mglur4
LT2986610T (lt) 2013-04-19 2018-04-10 Incyte Holdings Corporation Bicikliniai heterociklai, kaip fgfr inhibitoriai
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
AP2015008898A0 (en) 2013-06-11 2015-12-31 Bayer Pharma AG Prodrug derivatives of substituted triazolopyridines
US9936700B2 (en) 2013-10-23 2018-04-10 Bayer Cropscience Aktiengesellschaft Substituted quinoxaline derivatives as pest control agent
US10179783B2 (en) 2014-02-14 2019-01-15 Taketa Pharmaceutical Company Limited Tetrahydropyridopyrazines as modulators of GPR6
AU2015238305B2 (en) 2014-03-26 2020-06-18 Astex Therapeutics Ltd Combinations of an FGFR inhibitor and an IGF1R inhibitor
SMT202100115T1 (it) 2014-03-26 2021-05-07 Astex Therapeutics Ltd Combinazioni di inibitori di fgfr e cmet per il trattamento del cancro
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
SG10201913036RA (en) 2015-02-20 2020-02-27 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
JP2018525371A (ja) * 2015-07-30 2018-09-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アリール置換された二環式ヘテロアリール化合物
EP3353164B1 (fr) 2015-09-23 2021-11-03 Janssen Pharmaceutica, N.V. 1,4-benzodiazepines bi-heteroaryl substituees et leurs utilisations pour le traitement du cancer
WO2017050864A1 (fr) 2015-09-23 2017-03-30 Janssen Pharmaceutica Nv Nouveaux composés
WO2017060406A1 (fr) * 2015-10-09 2017-04-13 Janssen Pharmaceutica Nv Dérivés de quinoxaline et de pyridopyrazine à titre d'inhibiteurs de pi3kβ
WO2017216293A1 (fr) 2016-06-16 2017-12-21 Janssen Pharmaceutica Nv Dérivés d'azabenzimidazole utilisés comme inhibiteurs de pi3k bêta
LT3472160T (lt) 2016-06-16 2021-04-26 Janssen Pharmaceutica Nv Biciklinio piridino, pirazino ir pirimidino dariniai kaip pi3k beta inhibitoriai
AU2018246321B2 (en) * 2017-03-29 2021-07-29 Janssen Pharmaceutica Nv Quinoxaline and pyridopyrazine derivatives as PI3K-beta inhibitors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
EP3788046B1 (fr) 2018-05-04 2025-12-10 Incyte Corporation Sels d'un inhibiteur de fgfr
EP4309737A3 (fr) 2018-05-04 2024-03-27 Incyte Corporation Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021067374A1 (fr) 2019-10-01 2021-04-08 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
CR20220169A (es) 2019-10-14 2022-10-27 Incyte Corp Heterociclos bicíclicos como inhibidores de fgfr
CA3163875A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
KR20220131900A (ko) 2019-12-04 2022-09-29 인사이트 코포레이션 Fgfr 억제제의 유도체
CN112979613B (zh) * 2019-12-16 2022-04-26 四川大学华西医院 2-(1h-吡唑-3-基)吡啶衍生物及其制备方法和用途
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