[go: up one dir, main page]

WO2009017082A1 - Genetically modified non-human mammal displaying abnormal behavior, and method for production thereof - Google Patents

Genetically modified non-human mammal displaying abnormal behavior, and method for production thereof Download PDF

Info

Publication number
WO2009017082A1
WO2009017082A1 PCT/JP2008/063497 JP2008063497W WO2009017082A1 WO 2009017082 A1 WO2009017082 A1 WO 2009017082A1 JP 2008063497 W JP2008063497 W JP 2008063497W WO 2009017082 A1 WO2009017082 A1 WO 2009017082A1
Authority
WO
WIPO (PCT)
Prior art keywords
human mammal
production
abnormal behavior
genetically modified
modified non
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/063497
Other languages
French (fr)
Japanese (ja)
Inventor
Junji Takeda
Kyoji Horie
Kojiro Yae
Kiyofumi Yamada
Kazuhiro Takuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanazawa University NUC
Osaka Industrial Promotion Organization
University of Osaka NUC
Original Assignee
Kanazawa University NUC
Osaka University NUC
Osaka Industrial Promotion Organization
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanazawa University NUC, Osaka University NUC, Osaka Industrial Promotion Organization filed Critical Kanazawa University NUC
Priority to JP2009525388A priority Critical patent/JPWO2009017082A1/en
Publication of WO2009017082A1 publication Critical patent/WO2009017082A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed is a non-human mammal which displays abnormal behavior and has modified Spsb4 gene in the genome.
PCT/JP2008/063497 2007-07-30 2008-07-28 Genetically modified non-human mammal displaying abnormal behavior, and method for production thereof Ceased WO2009017082A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009525388A JPWO2009017082A1 (en) 2007-07-30 2008-07-28 Genetically modified non-human mammal exhibiting abnormal behavior and method for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-197123 2007-07-30
JP2007197123 2007-07-30

Publications (1)

Publication Number Publication Date
WO2009017082A1 true WO2009017082A1 (en) 2009-02-05

Family

ID=40304312

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/063497 Ceased WO2009017082A1 (en) 2007-07-30 2008-07-28 Genetically modified non-human mammal displaying abnormal behavior, and method for production thereof

Country Status (2)

Country Link
JP (1) JPWO2009017082A1 (en)
WO (1) WO2009017082A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011007859A1 (en) * 2009-07-16 2011-01-20 株式会社免疫生物研究所 Dna fragment and pharmaceutical composition

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001186828A (en) * 1999-12-28 2001-07-10 Japan Science & Technology Corp Hyperactivity disorder model rat
WO2002013602A1 (en) * 2000-08-16 2002-02-21 Kansai Technology Licensing Organization Co., Ltd. Transgenic non-human mammal and method of constructing the same, animal disease model and method of clarifying gene function
WO2005043992A1 (en) * 2003-11-06 2005-05-19 Riken Attention-deficient hyperactivity disorder (adhd) model mouse

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001186828A (en) * 1999-12-28 2001-07-10 Japan Science & Technology Corp Hyperactivity disorder model rat
WO2002013602A1 (en) * 2000-08-16 2002-02-21 Kansai Technology Licensing Organization Co., Ltd. Transgenic non-human mammal and method of constructing the same, animal disease model and method of clarifying gene function
WO2005043992A1 (en) * 2003-11-06 2005-05-19 Riken Attention-deficient hyperactivity disorder (adhd) model mouse

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
HORIE K. ET AL.: "Characterization of Sleeping Beauty transposon and its application to genetic screening in mice", MOL CELL BIOL, vol. 23, no. 24, 2003, pages 9189 - 9207, XP009029401 *
KENG V.W. ET AL.: "Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system", NAT METHODS, vol. 2, no. 10, 2005, pages 763 - 769 *
KITADA K. ET AL.: "Transposon-tagged mutagenesis in the rat", NAT METHODS, vol. 4, no. 2, 2007, pages 131 - 133 *
KOKUBU C. ET AL.: "Mapping by Hopping: A Transposon-Based Chromosomal Engineering Strategy to Survey a Large Cis-Regulatory Landscape in the Mouse Genome", JAPAN SOCIETY OF DEVELOPMENT BIOLOGISTS TAIKAI HAPPYO YOSHISHU, vol. 40TH, 15 May 2007 (2007-05-15), pages 74 *
KOKUBU C. ET AL.: "Mouse Kotai no Okeru Ryoiki Tokuiteki Genome Kino Kaisekiho no Kaihatsu", SLEEPING BEAUTY TRANSPOSON NO LOCAL HOPPING TOKUSEI NO KATSUYO, ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, vol. 28TH, 25 November 2005 (2005-11-25), pages 103 *
NANKO S. ET AL.: "Ten'i Inshi to Seinhin Shikkan -Togo Shiccosho o Chushin ni-", NO TO SEINHIN NO IGAKU, vol. 16, no. 2, 2005 *
TAKEDA J. ET AL.: "Shikkan Model Dobutsu no Sosei", 2. SLEEPING BEAUTY(SB) TRANSPOSON SYSTEM NI YORU MOUSE IDENSHI NO DAIKIBO SCREENING SENYAKU, PROCEEDING OF THE JAPANESE SOCIETY OF ANIMAL MODELS FOR HUMAN DISEASES, vol. 20, 5 July 2004 (2004-07-05), pages 15 - 20 *
UENO M. ET AL.: "Ryoiki Tokuiteki Alu Takei to Togo Shicchosho tono Kanren Kenkyu", ANNUAL REPORT OF PHARMACOPSYCHIATRY RESEARCH. DAI 38 SHU, 2006, pages 109 - 114 *
XING Y. ET AL.: "Murine homologues of the Drosophila gustavus gene are expressed in ovarian granulosa cells", REPRODUCTION, vol. 131, no. 5, 2006, pages 905 - 915 *
YAE K. ET AL.: "Sleeping beauty transposon-based phenotypic analysis of mice:lack of Arpc3 results in defective trophoblast outgrowth", MOL CELL BIOL, vol. 26, no. 16, 2006, pages 6185 - 6196 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011007859A1 (en) * 2009-07-16 2011-01-20 株式会社免疫生物研究所 Dna fragment and pharmaceutical composition

Also Published As

Publication number Publication date
JPWO2009017082A1 (en) 2010-10-21

Similar Documents

Publication Publication Date Title
WO2012050710A3 (en) Ebook advertising, including cost-sharing techniques
WO2011053144A3 (en) Methods and compositions for dysferlin exon-skipping
EP2251395B8 (en) Methods for increase gas production and load recovery
EP2380995A4 (en) Smelting vessel, steel making plant and steel production method
AP3018A (en) Compositions and methods for inhibiting expressionof a gene from the ebola
EP2245173A4 (en) Thermophilic and thermoacidophilic glycosylation genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
IL199213A0 (en) Fuel cell stack and seal for a fuel cell stack, as well as a production method for it
EP2000765A4 (en) Strain gauge manufacturing method
WO2006075254A3 (en) Methods and products for in vitro genotyping
EP2299452A4 (en) Microstructure, and method for production thereof
AU2008296967A8 (en) Automated retail kiosk with changeable presentation formats
EP2245143A4 (en) Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
PL2162251T3 (en) A thin cast strip product with microalloy additions, and method for making the same
WO2008005267A3 (en) Sugar-free storage-stable antihistaminic syrups
IL220359A (en) C.histolyticum recombinant collagenases and method for the manufacture thereof
ZA201108873B (en) Method for producing a cooling element for pyrometallurgical reactor and the cooling element
EP2351496A4 (en) Briefs for men and a method for the production thereof
SG10201400530XA (en) Branched conjugated diene-aromatic vinyl copolymer and production method for the same
WO2010124803A3 (en) High-bay warehouse as well as support for a high-bay warehouse and method for producing the support
WO2009097666A3 (en) Toy building block
WO2010039613A3 (en) A lolium multiflorum line inducing genome loss
WO2009017082A1 (en) Genetically modified non-human mammal displaying abnormal behavior, and method for production thereof
GB2451384B (en) 2-cyanophenylboronic acid or ester thereof in which impurities are decreased, and production method thereof
EP2370603A4 (en) Method for producing a cooling element for pyrometallurgical reactor and the cooling element
WO2006116261A3 (en) Nanomaterials manufacturing methods and products thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08791732

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2009525388

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08791732

Country of ref document: EP

Kind code of ref document: A1