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WO2009012039A3 - Crystalline polymorphs - Google Patents

Crystalline polymorphs Download PDF

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Publication number
WO2009012039A3
WO2009012039A3 PCT/US2008/068558 US2008068558W WO2009012039A3 WO 2009012039 A3 WO2009012039 A3 WO 2009012039A3 US 2008068558 W US2008068558 W US 2008068558W WO 2009012039 A3 WO2009012039 A3 WO 2009012039A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystalline polymorphs
present
compositions
provides
ethoxycarbonylprop
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/068558
Other languages
French (fr)
Other versions
WO2009012039A2 (en
Inventor
Joseph J Kopcho
Scott J Hecker
Patricia Frech
Mike Deason
Qun Dang
Karen Gushurst
Donglai Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabasis Therapeutics Inc
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of WO2009012039A2 publication Critical patent/WO2009012039A2/en
Publication of WO2009012039A3 publication Critical patent/WO2009012039A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides for crystalline forms of 2-amino-5-(2,2- dimethylpropionyl)-4-{[5-(N,N'-(2-ethoxycarbonylprop-2-yl)phosphonamido] furan-2-yl}thiazole and compositions thereof including pharmaceutical compositions. The present invention further provides for methods of using and processes for making the same.
PCT/US2008/068558 2007-07-13 2008-06-27 Crystalline polymorphs Ceased WO2009012039A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94968107P 2007-07-13 2007-07-13
US60/949,681 2007-07-13

Publications (2)

Publication Number Publication Date
WO2009012039A2 WO2009012039A2 (en) 2009-01-22
WO2009012039A3 true WO2009012039A3 (en) 2009-03-19

Family

ID=40260294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/068558 Ceased WO2009012039A2 (en) 2007-07-13 2008-06-27 Crystalline polymorphs

Country Status (1)

Country Link
WO (1) WO2009012039A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
MX2018003453A (en) * 2015-09-22 2019-07-04 Viking Therapeutics Inc Conjoint therapies with inhibitors of glucose production.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756360B1 (en) * 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
WO2006023515A2 (en) * 2004-08-18 2006-03-02 Metabasis Therapeutics, Inc. Novel thiazole inhibitors of fructose 1,6-bisphosphatase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756360B1 (en) * 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
WO2006023515A2 (en) * 2004-08-18 2006-03-02 Metabasis Therapeutics, Inc. Novel thiazole inhibitors of fructose 1,6-bisphosphatase

Also Published As

Publication number Publication date
WO2009012039A2 (en) 2009-01-22

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