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WO2009007112A3 - Thrombomodulin for increasing reperfusion and preventing blood vessels obstruction - Google Patents

Thrombomodulin for increasing reperfusion and preventing blood vessels obstruction Download PDF

Info

Publication number
WO2009007112A3
WO2009007112A3 PCT/EP2008/005623 EP2008005623W WO2009007112A3 WO 2009007112 A3 WO2009007112 A3 WO 2009007112A3 EP 2008005623 W EP2008005623 W EP 2008005623W WO 2009007112 A3 WO2009007112 A3 WO 2009007112A3
Authority
WO
WIPO (PCT)
Prior art keywords
thrombomodulin
blood vessels
preventing blood
reperfusion
increasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/005623
Other languages
French (fr)
Other versions
WO2009007112A4 (en
WO2009007112A2 (en
Inventor
Karl-Uwe Petersen
Henning Brohman
Daniel A Lawrence
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paion Deutschland GmbH
Original Assignee
Paion Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40229136&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009007112(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP07013480A external-priority patent/EP2014296A1/en
Application filed by Paion Deutschland GmbH filed Critical Paion Deutschland GmbH
Priority to EP08784685A priority Critical patent/EP2175872A2/en
Priority to JP2010515412A priority patent/JP2010532776A/en
Publication of WO2009007112A2 publication Critical patent/WO2009007112A2/en
Publication of WO2009007112A3 publication Critical patent/WO2009007112A3/en
Publication of WO2009007112A4 publication Critical patent/WO2009007112A4/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/366—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Use of thrombomodulin for the manufacture of a medicament for stimulating the reperfusion of an ischemic tissue or organ within a patient in the need thereof, in particular a stroke patient.
PCT/EP2008/005623 2007-07-10 2008-07-10 Thrombomodulin for increasing reperfusion and preventing blood vessels obstruction Ceased WO2009007112A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08784685A EP2175872A2 (en) 2007-07-10 2008-07-10 Thrombomodulin for increasing reperfusion and preventing blood vessels obstruction
JP2010515412A JP2010532776A (en) 2007-07-10 2008-07-10 Thrombomodulin to increase reperfusion and prevent vascular occlusion

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP07013480.4 2007-07-10
EP07013480A EP2014296A1 (en) 2007-07-10 2007-07-10 Novel strategies for increasing the reperfusion in obstructed blood vessel
EP08009096 2008-05-16
EP08009096.2 2008-05-16
EP08010333 2008-06-06
EP08010333.6 2008-06-06

Publications (3)

Publication Number Publication Date
WO2009007112A2 WO2009007112A2 (en) 2009-01-15
WO2009007112A3 true WO2009007112A3 (en) 2009-04-16
WO2009007112A4 WO2009007112A4 (en) 2009-06-11

Family

ID=40229136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/005623 Ceased WO2009007112A2 (en) 2007-07-10 2008-07-10 Thrombomodulin for increasing reperfusion and preventing blood vessels obstruction

Country Status (5)

Country Link
EP (1) EP2175872A2 (en)
JP (1) JP2010532776A (en)
AR (1) AR067345A1 (en)
CL (1) CL2008001977A1 (en)
WO (1) WO2009007112A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2781221B9 (en) 2011-11-15 2020-09-02 Asahi Kasei Pharma Corporation Medicine for treatment and/or improvement of sepsis
WO2020084853A1 (en) 2018-10-22 2020-04-30 旭化成ファーマ株式会社 Drug for treating and/or improving septicemia associated with coagulation abnormality

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023279A1 (en) * 1996-11-27 1998-06-04 Rhone-Poulenc Rorer Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACTIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND
US20010041686A1 (en) * 2000-01-06 2001-11-15 Veronique Mary Novel therapeutic application of enoxaparin
WO2002017953A2 (en) * 2000-08-31 2002-03-07 Schering Aktiengesellschaft Thrombomodulin analogs for use in recovery of signal cord injury
WO2002096947A2 (en) * 2001-05-25 2002-12-05 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw The lectin-like domain of thrombomodulin and its therapeutic use
WO2002100445A1 (en) * 2001-06-13 2002-12-19 The University Of Sydney Treatment and composition for wound healing
EP1449849A2 (en) * 1992-02-05 2004-08-25 Paion GmbH Protease-resistant thrombomodulin analog
WO2004096267A1 (en) * 2003-05-02 2004-11-11 Paion Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1449849A2 (en) * 1992-02-05 2004-08-25 Paion GmbH Protease-resistant thrombomodulin analog
WO1998023279A1 (en) * 1996-11-27 1998-06-04 Rhone-Poulenc Rorer Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACTIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND
US20010041686A1 (en) * 2000-01-06 2001-11-15 Veronique Mary Novel therapeutic application of enoxaparin
WO2002017953A2 (en) * 2000-08-31 2002-03-07 Schering Aktiengesellschaft Thrombomodulin analogs for use in recovery of signal cord injury
WO2002096947A2 (en) * 2001-05-25 2002-12-05 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw The lectin-like domain of thrombomodulin and its therapeutic use
WO2002100445A1 (en) * 2001-06-13 2002-12-19 The University Of Sydney Treatment and composition for wound healing
WO2004096267A1 (en) * 2003-05-02 2004-11-11 Paion Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YSHAI Y. YAVIN: "New antithrombotics in the prevention of thromboembolic disease", EUROPEAN JOURNAL OF INTERNAL MEDICINE, vol. 16, 2005, pages 257 - 266, XP005006131 *

Also Published As

Publication number Publication date
JP2010532776A (en) 2010-10-14
WO2009007112A4 (en) 2009-06-11
CL2008001977A1 (en) 2009-03-06
WO2009007112A2 (en) 2009-01-15
EP2175872A2 (en) 2010-04-21
AR067345A1 (en) 2009-10-07

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