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WO2009004822A1 - 抗Muc17抗体 - Google Patents

抗Muc17抗体 Download PDF

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Publication number
WO2009004822A1
WO2009004822A1 PCT/JP2008/001777 JP2008001777W WO2009004822A1 WO 2009004822 A1 WO2009004822 A1 WO 2009004822A1 JP 2008001777 W JP2008001777 W JP 2008001777W WO 2009004822 A1 WO2009004822 A1 WO 2009004822A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
muc17
seq
bind
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/001777
Other languages
English (en)
French (fr)
Inventor
Kiyotaka Nakano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forerunner Pharma Research Co Ltd
Original Assignee
Forerunner Pharma Research Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forerunner Pharma Research Co Ltd filed Critical Forerunner Pharma Research Co Ltd
Priority to CN200880023060A priority Critical patent/CN101687924A/zh
Priority to US12/667,595 priority patent/US8546546B2/en
Priority to JP2009521537A priority patent/JP5938816B2/ja
Priority to AU2008272330A priority patent/AU2008272330A1/en
Priority to CA002691734A priority patent/CA2691734A1/en
Priority to EP08790149A priority patent/EP2172483A4/en
Publication of WO2009004822A1 publication Critical patent/WO2009004822A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G01N33/57525—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • G01N33/5753—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4725—Mucins, e.g. human intestinal mucin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　Mucin　17（Muc17）に結合する抗体が開示される。好ましくは、本発明の抗体は、配列番号３のペプチドに結合し、かつ配列番号４のペプチドおよび配列番号５のペプチドには結合しない。本発明の抗体を含む抗癌剤、好ましくは膵臓癌に対する抗癌剤、ならびに本発明の抗体、好ましくは、分泌型Muc17に結合しない抗体を用いることを特徴とする癌の診断方法も開示される。
PCT/JP2008/001777 2007-07-04 2008-07-03 抗Muc17抗体 Ceased WO2009004822A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN200880023060A CN101687924A (zh) 2007-07-04 2008-07-03 抗Muc17抗体
US12/667,595 US8546546B2 (en) 2007-07-04 2008-07-03 Anti-Muc 17 antibody
JP2009521537A JP5938816B2 (ja) 2007-07-04 2008-07-03 抗Ｍｕｃ１７抗体
AU2008272330A AU2008272330A1 (en) 2007-07-04 2008-07-03 Anti-Muc17 antibody
CA002691734A CA2691734A1 (en) 2007-07-04 2008-07-03 Anti-muc17 antibody
EP08790149A EP2172483A4 (en) 2007-07-04 2008-07-03 ANTI-MUC17 ANTIBODY

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-176319 2007-07-04
JP2007176319 2007-07-04

Publications (1)

Publication Number Publication Date
WO2009004822A1 true WO2009004822A1 (ja) 2009-01-08

Family

ID=40225887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001777 Ceased WO2009004822A1 (ja) 2007-07-04 2008-07-03 抗Muc17抗体

Country Status (7)

Country Link
US (1) US8546546B2 (ja)
EP (1) EP2172483A4 (ja)
JP (1) JP5938816B2 (ja)
CN (1) CN101687924A (ja)
AU (1) AU2008272330A1 (ja)
CA (1) CA2691734A1 (ja)
WO (1) WO2009004822A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010119691A1 (ja) * 2009-04-16 2010-10-21 国立大学法人東京大学 抗tmprss11e抗体を用いた癌の診断と治療
KR20200105493A (ko) * 2017-12-29 2020-09-07 암젠 인크 Muc17 및 cd3에 대한 이중특이적 항체 구축물
WO2023066336A1 (zh) * 2021-10-21 2023-04-27 江苏先声药业有限公司 抗muc17纳米抗体及其应用
JP2023518225A (ja) * 2020-03-19 2023-04-28 アムジエン・インコーポレーテツド ムチン１７に対する抗体及びその使用

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9119869B2 (en) * 2010-04-29 2015-09-01 Ronald J. Shebuski Mucin derived polypeptides
EP2589609A1 (en) * 2011-11-03 2013-05-08 Pierre Fabre Medicament Antigen binding protein and its use as addressing product for the treatment of cancer
HK1201045A1 (en) * 2012-05-14 2015-08-21 霍夫曼-拉罗奇有限公司 Compositions and methods for the diagnosis and treatment of tumor
EP2888283B1 (en) 2012-08-24 2018-09-19 The Regents of The University of California Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
US9907593B2 (en) 2014-08-05 2018-03-06 Woven Orthopedic Technologies, Llc Woven retention devices, systems and methods
US10555758B2 (en) 2015-08-05 2020-02-11 Woven Orthopedic Technologies, Llc Tapping devices, systems and methods for use in bone tissue
US10654934B2 (en) 2016-04-01 2020-05-19 Innovative Cellular Therapeutics CO., LTD. Use of chimeric antigen receptor modified cells to treat cancer
CN109219445B (zh) 2016-04-01 2022-08-26 上海煦顼技术有限公司 嵌合抗原受体修饰细胞治疗癌症的应用
WO2018005519A2 (en) 2016-06-27 2018-01-04 The Regents Of The University Of California Cancer treatment combinations
WO2018027203A1 (en) * 2016-08-05 2018-02-08 Allakos, Inc. Anti-siglec-7 antibodies for the treatment of cancer
EP3551105A4 (en) 2016-12-09 2020-07-29 Woven Orthopedic Technologies, LLC RESTRAINT DEVICES, GRIDS AND RELATED SYSTEMS AND METHODS
EP3737410A4 (en) 2018-01-11 2022-04-20 Allakos, Inc. Anti-siglec-7 antibodies having reduced effector function
JP2023542257A (ja) 2020-09-16 2023-10-05 アムジェン インコーポレイテッド 癌の治療のために二重特異性ｔ細胞誘導分子の治療用量を投与する方法
CN120603853A (zh) * 2023-02-03 2025-09-05 山东先声生物制药有限公司 针对muc17和cd3的双特异性抗体及其应用
CN118667026A (zh) * 2023-03-15 2024-09-20 三生国健药业（上海）股份有限公司 抗muc17*cd3*cd28三特异性抗体
CN117534750B (zh) * 2023-10-16 2024-06-11 遵义医科大学珠海校区 一种抗新型冠状病毒核衣壳蛋白的抗体或其抗原结合片段及其应用
WO2025180469A1 (zh) * 2024-02-28 2025-09-04 杭州中美华东制药有限公司 抗Mucin 17抗体、其偶联物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061739A1 (fr) * 1999-04-09 2000-10-19 Kyowa Hakko Kogyo Co., Ltd. Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle
US20050100925A1 (en) * 2003-11-10 2005-05-12 Surinder Batra MUC17 encoding nucleic acid sequences, polypeptides, antibodies and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061739A1 (fr) * 1999-04-09 2000-10-19 Kyowa Hakko Kogyo Co., Ltd. Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle
US20050100925A1 (en) * 2003-11-10 2005-05-12 Surinder Batra MUC17 encoding nucleic acid sequences, polypeptides, antibodies and methods of use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS Database accession no. 2003:421452 *
HO JENNY J L ET AL.: "N-glycosylation is required for the surface localization of MUC17 mucin", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 23, no. 3, 2003, pages 585 - 592, XP009134842 *
J R GUM ET AL.: "MUC17, a Novel membrane- tethered mucin", BIOCHEM BIOPHYS RES COMMUN, vol. 291, 2002, pages 466 - 475, XP002443029 *
N MONIAUX ET AL.: "Characterizatopn of Human Mucin MUC17", J BIOL CHEM, vol. 281, no. 33, 2006, pages 23676 - 23685, XP008129451 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010119691A1 (ja) * 2009-04-16 2010-10-21 国立大学法人東京大学 抗tmprss11e抗体を用いた癌の診断と治療
JP5746018B2 (ja) * 2009-04-16 2015-07-08 国立大学法人 東京大学 抗ｔｍｐｒｓｓ１１ｅ抗体を用いた癌の診断と治療
US9079957B2 (en) 2009-04-16 2015-07-14 The University Of Tokyo Diagnosis and treatment of cancer using anti-TMPRSS11E antibody
KR20200105493A (ko) * 2017-12-29 2020-09-07 암젠 인크 Muc17 및 cd3에 대한 이중특이적 항체 구축물
JP2021508465A (ja) * 2017-12-29 2021-03-11 アムジェン インコーポレイテッド Ｍｕｃ１７及びｃｄ３に向けられる二重特異性抗体コンストラクト
JP2023134497A (ja) * 2017-12-29 2023-09-27 アムジェン インコーポレイテッド Ｍｕｃ１７及びｃｄ３に向けられる二重特異性抗体コンストラクト
JP7605913B2 (ja) 2017-12-29 2024-12-24 アムジェン インコーポレイテッド Ｍｕｃ１７及びｃｄ３に向けられる二重特異性抗体コンストラクト
KR102910479B1 (ko) 2017-12-29 2026-01-09 암젠 인크 Muc17 및 cd3에 대한 이중특이적 항체 구축물
JP2023518225A (ja) * 2020-03-19 2023-04-28 アムジエン・インコーポレーテツド ムチン１７に対する抗体及びその使用
JP7750852B2 (ja) 2020-03-19 2025-10-07 アムジエン・インコーポレーテツド ムチン１７に対する抗体及びその使用
WO2023066336A1 (zh) * 2021-10-21 2023-04-27 江苏先声药业有限公司 抗muc17纳米抗体及其应用

Also Published As

Publication number Publication date
EP2172483A4 (en) 2010-08-04
CA2691734A1 (en) 2009-01-08
EP2172483A1 (en) 2010-04-07
AU2008272330A1 (en) 2009-01-08
US20100240872A1 (en) 2010-09-23
JPWO2009004822A1 (ja) 2010-08-26
CN101687924A (zh) 2010-03-31
US8546546B2 (en) 2013-10-01
JP5938816B2 (ja) 2016-06-22

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