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WO2009098850A1 - Composition liquide comprenant un complexe histidine-argent, composition d'un agent germicide et procédé de stabilisation d'un complexe histidine-argent - Google Patents

Composition liquide comprenant un complexe histidine-argent, composition d'un agent germicide et procédé de stabilisation d'un complexe histidine-argent Download PDF

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Publication number
WO2009098850A1
WO2009098850A1 PCT/JP2009/000337 JP2009000337W WO2009098850A1 WO 2009098850 A1 WO2009098850 A1 WO 2009098850A1 JP 2009000337 W JP2009000337 W JP 2009000337W WO 2009098850 A1 WO2009098850 A1 WO 2009098850A1
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WO
WIPO (PCT)
Prior art keywords
histidine
acid
silver
liquid composition
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2009/000337
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English (en)
Japanese (ja)
Inventor
Shigebumi Arai
Tetsuo Kubota
Motoaki Yabe
Kenji Nomiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanagawa University
Nippon Soda Co Ltd
Original Assignee
Kanagawa University
Nippon Soda Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanagawa University, Nippon Soda Co Ltd filed Critical Kanagawa University
Priority to JP2009552399A priority Critical patent/JP5435475B2/ja
Priority to CN2009801040963A priority patent/CN101938900A/zh
Publication of WO2009098850A1 publication Critical patent/WO2009098850A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40—Additives
    • C09D7/60—Additives non-macromolecular
    • C09D7/61—Additives non-macromolecular inorganic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/02—Elements
    • C08K3/08—Metals

Definitions

  • the present invention relates to a liquid composition containing a long-term stable histidine silver complex, and particularly to a liquid composition containing a long-term stable histidine silver complex used as an industrial disinfectant.
  • the liquid composition of the present invention is suitable as a coating composition.
  • this histidine silver complex is also stable to heat and light at room temperature in a powder state, and the powder is water-soluble, but cannot be stably present for a long period of time when dissolved in water.
  • the problem remains that silver is deposited and causes severe discoloration.
  • the discoloration of the histidine silver complex itself also caused discoloration of the object to be added, and the applicable object had to be extremely limited.
  • histidine which is an expensive amino acid, is used in a large amount, it is disadvantageous in terms of production cost as compared with other fungicides.
  • the present invention has been made in view of the above circumstances, and is to provide a liquid composition containing a histidine silver complex that can maintain disinfecting activity for a long period of time without causing discoloration or precipitation.
  • the inventors have obtained an aqueous solution of a histidine silver complex as an active ingredient, one or more selected from the group consisting of hydroxycarboxylic acids, polyvalent carboxylic acids and salts thereof, Preferably, the inventors have found that the above problem can be solved by containing one or more selected from the group consisting of glucuronic acid, citric acid and salts thereof, and have completed the present invention.
  • the present invention [1] A liquid composition comprising a silver histidine complex and at least one selected from the group consisting of hydroxycarboxylic acids, polyvalent carboxylic acids and salts thereof, [2] One or more types selected from the group consisting of hydroxycarboxylic acids, polyvalent carboxylic acids and salts thereof are one or more types selected from the group consisting of glucuronic acid, citric acid and salts thereof. 1] liquid composition, [3] The present invention relates to a fungicidal composition comprising the liquid composition of [1] or [2].
  • the present invention also provides: [4] The liquid composition according to [1] or [2], wherein the liquid composition is a coating composition, [5] The fungicide composition according to [3], wherein the fungicide composition is a bactericidal paint composition.
  • a histidine comprising a mixture of (a) a silver compound, (b) histidine, and (c) one or more selected from the group consisting of a hydroxycarboxylic acid, a polyvalent carboxylic acid, and a salt thereof.
  • a method for stabilizing a silver complex in a liquid composition [7] A silver histidine complex characterized by mixing (i) a histidine silver complex and (ii) one or more selected from the group consisting of hydroxycarboxylic acid, polyvalent carboxylic acid and salts thereof.
  • a method of stabilizing in a liquid composition [8]
  • One or more types selected from the group consisting of hydroxycarboxylic acids, polyvalent carboxylic acids and salts thereof are one or more types selected from the group consisting of glucuronic acid, citric acid and salts thereof.
  • 6] or [7] a method for stabilizing a silver histidine complex in a liquid composition
  • the present invention relates to the method for stabilizing a histidine silver complex in [6] to [8], wherein the liquid composition is a coating composition.
  • the histidine silver complex is stabilized in a solution by adding the carboxylic acid of the present invention to a histidine silver complex in which histidine is coordinated to a silver ion. It is presumed that the carboxylic acids of the present invention contribute to stabilization or inactivation of the histidine silver complex in an aqueous solution.
  • the liquid composition of the present invention is characterized by containing a histidine silver complex formed by coordination of histidine to silver ions and carboxylic acids. Histidine has optical isomers of L- and D-, but may be used alone or in a mixture of two. More preferred is L-histidine.
  • a silver compound of oxidation number 1 is preferable, for example, a silver nitrate, a silver oxide, and a silver chloride are mentioned. Silver oxide is preferred for the formation of a complex with histidine.
  • the compound which is a supply source of silver ions may be used alone or in combination of two or more.
  • the ratio of the histidine content to silver is preferably 1 mol or more of histidine to 1 mol of silver, more preferably 1.4 mol or more of histidine to 1 mol of silver, and still more preferably Is 1 mol or more of histidine per mol of silver.
  • the content of the histidine silver complex in the liquid composition is 0.0005% by mass to 20% by mass, more preferably 0.05% by mass to 10% by mass, and further preferably 0.25% by mass to 5% by mass.
  • the carboxylic acids used in the present invention are at least one selected from the group consisting of hydroxycarboxylic acids, polyvalent carboxylic acids, and salts thereof.
  • hydroxycarboxylic acid used in the present invention include aliphatic hydroxycarboxylic acid, uronic acid and aromatic hydroxycarboxylic acid.
  • Aliphatic hydroxycarboxylic acids include glycolic acid, lactic acid, tartronic acid, glyceric acid, malic acid, tartaric acid, citramalic acid, citric acid, isocitric acid, leucine acid, mevalonic acid, pantoic acid, ricinoleic acid, ricinaleic acid, cerebranic acid , Quinic acid, shikimic acid and the like, uronic acid includes glucuronic acid, galacturonic acid and mannuronic acid, and aromatic hydroxycarboxylic acid includes salicylic acid, creosote acid, vanillic acid, pyrocatechuic acid, resorcylic acid , Gallic acid, mandelic acid and the like.
  • polyvalent carboxylic acid examples include oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, glutaric acid, and adipic acid. Preferably, it is a divalent or trivalent carboxylic acid.
  • the polyvalent carboxylic acid having a hydroxy group is classified as a hydroxycarboxylic acid.
  • these salts can also be used, for example, lithium salt, sodium salt, potassium salt, magnesium salt, calcium salt, ammonium salt etc. are mentioned.
  • Specific examples of the salt of hydroxycarboxylic acid include sodium glycolate, lithium lactate, calcium lactate, trisodium citrate, potassium tartrate, and sodium potassium tartrate.
  • Examples of the salt of polyvalent carboxylic acid include sodium oxalate, potassium oxalate, ammonium oxalate, sodium succinate, lithium succinate, potassium fumarate, sodium maleate, calcium adipate, magnesium adipate, potassium adipate, etc.
  • glucuronic acid, citric acid and salts thereof can be mentioned.
  • Examples of the citric acid salt include lithium citrate, sodium citrate, potassium citrate, magnesium citrate, calcium citrate, citric acid. Ammonium etc. are mentioned.
  • the liquid composition of the present invention may contain only one kind of these carboxylic acids and salts, or may contain two or more kinds.
  • the content of carboxylic acids varies depending on the type of carboxylic acid used, but is preferably 0.01% by mass or more, more preferably 0.1% by mass or more.
  • the pH of the liquid composition of the present invention is not particularly limited, but is preferably 5 or more, more preferably 6.5 or more and 8.5 or less in terms of stability and safety of the composition.
  • liquid composition of the present invention a plurality of types of amino acids other than histidine and / or their salts, and a plurality of types of carboxylic acids other than hydroxycarboxylic acids and polyvalent carboxylic acids and / or their salts coexist. There is no problem. Furthermore, other components can be blended in the liquid composition of the present invention in any proportion within a range not impairing the effects of the invention.
  • Examples of other components include a surfactant, a solvent, a thickener, an antioxidant, a light stabilizer, a pH adjuster, a fragrance, and an antifoaming agent.
  • a surfactant include cationic surfactants such as alkyltrimethylammonium salt, dialkyldimethylammonium salt, alkylbenzyldimethylammonium salt, alkylpyridinium salt, and polyhexamethylenebiguanide; alkylbenzene sulfonate and alkylsulfuric acid.
  • the solvent examples include lower alcohols such as ethanol and isopropanol; glycol solvents such as ethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, and glycerin; ketone solvents such as acetone, methyl ethyl ketone, and propylene carbonate; dimethyl Examples include polar solvents such as formamide, dimethyl sulfoxide, acetonitrile, and N-methylpyrrolidone.
  • glycol solvents such as ethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, and glycerin
  • ketone solvents such as acetone, methyl ethyl ketone, and propylene carbonate
  • dimethyl examples include polar solvents such as formamide, dimethyl sulfoxide, acetonitrile, and N-methylpyrrolidone.
  • the thickener include carboxymethyl cellulose and xanthan gum.
  • Specific examples of the antioxidant include 2,6-di-t-butyl-4-methylphenol, 2,2′- Specific examples of light stabilizers such as methylene bis [4-methyl-6-t-butylphenol] and alkyldiphenylamine include pH adjusters such as bis (2,2,6,6-tetramethyl-4-sebacate) Examples thereof include sulfuric acid, nitric acid, sodium hydroxide, potassium hydroxide, ammonia, and phosphate. In addition, a fragrance
  • the liquid composition of the present invention is suitable as a coating composition.
  • the coating composition is obtained by blending the above liquid composition into another coating composition.
  • the other coating composition include a coating composition containing an aqueous resin and a coating containing an organic solvent-dispersible resin.
  • examples thereof include a composition and a coating composition containing a wax.
  • the coating composition may be a conventional coating composition or a coating composition obtained by a conventional method without particular limitation.
  • the water-based resin is added to improve the durability, water resistance, adhesion strength to the substrate, heat resistance, blocking resistance, flexibility, etc. of the coating film, and can be dissolved or emulsified and dispersed in water. It is. Specific examples thereof can be roughly classified into rubbery polymers and resinous polymers.
  • Examples of rubbery polymers include natural rubber, ethylene-propylene-diene rubber (EPDM), styrene-butadiene rubber (SBR), Examples of resinous polymers such as chloroprene rubber (CR) and acrylonitrile-butadiene rubber (NBR) include natural resins such as pine resin, polyethylene, styrene-butadiene resins, vinyl resins (eg, polyvinyl acetate, ethylene-acetic acid). (Vinyl copolymer, polyvinyl chloride), polyvinyl butyral, polystyrene, styrene-butadiene resin, urethane resin, silicon resin, acrylic resin, and the like.
  • EPDM ethylene-propylene-diene rubber
  • SBR styrene-butadiene rubber
  • resinous polymers such as chloroprene rubber (CR) and acrylonitrile-butadiene rubber (NBR)
  • natural resins such as pine resin
  • the liquid composition and coating composition of the present invention can be used as a bactericidal composition and a bactericidal coating composition for harmful microorganism propagation control and bactericidal applications due to the effect of silver ions of a histidine silver complex.
  • the “bactericidal agent” is not only an agent having a function of killing microorganisms such as bacteria, molds, and algae, but also a function of removing or preventing contamination of these microorganisms (antibacterial), and It also contains an agent having a function of suppressing growth (bacteriostatic).
  • the disinfectant composition of the present invention has a broad antibacterial and antifungal spectrum, does not affect the quality of the material, and the effect lasts for a long period of time, and further, acute oral toxicity, skin irritation, It can be applied to various materials because of its low mucosal irritation.
  • Examples of materials that can be used for the disinfectant composition of the present invention include, for example, textiles, sanitary products, medical molded products, foods, fruits and vegetables, seeds, crops, livestock, clean films, packaging materials, bactericidal materials, paints, Emulsion resin, metal processing oil such as cutting oil, plywood, wood, casein, starch paste, glue, coated paper, paper coating liquid, surface sizing agent, adhesive, synthetic rubber latex, printing ink, polyvinyl alcohol film, In addition to vinyl chloride films, plastic products, cement admixtures, sealing agents, and joint agents, it is also effective for various industrial water used in paper pulp mills and cooling water circulation processes.
  • the fungicide composition of the present invention can be used in combination with other active ingredients such as known fungicides, antiseptics, and algaeicides, depending on the purpose and application.
  • active ingredients include quaternary ammonium salt compounds such as didecyldimethylammonium chloride (DDAC) and didecyldimethylammonium adipate (DDAA), biguanides such as polyhexamethylene biguanide (PHMB) and chlorhexidine gluconate.
  • DDAC didecyldimethylammonium chloride
  • DDAA didecyldimethylammonium adipate
  • biguanides such as polyhexamethylene biguanide (PHMB) and chlorhexidine gluconate.
  • pyridinium compounds such as cetylpyridinium chloride, dodecylpyridinium chloride, 1,2-benzisothiazolin-3-one, 5-chloro-2-methyl-4-isothiazoline-3-one, 2-methyl-4-isothiazoline Isothiazoline compounds such as -3-one, 2-n-octyl-4-isothiazolin-3-one, Nn-butyl-1,2-benzisothiazolin-3-one, 3-iodo-2-propynyl-butyl Organic iodine such as carbamate
  • pyridine compounds such as 2,3,5,6-tetrachloro-4- (methylsulfonyl) pyridine
  • pyrithione compounds such as zinc pyrithione and sodium pyrithione
  • 2- (4-thiocyanomethylthio) benzothiazole and the like Benzothiazole compounds, imidazole compounds such as methyl-2-benzimidazo
  • Examples include phenylurea compounds and triazine compounds such as 2-methylthio-4-t-butylamino-6-cyclopropylamino-S-triazine. These active ingredients may be used alone or in admixture of two or more. Moreover, these compounding ratios can be arbitrarily determined according to a use.
  • the disinfectant composition of the present invention can be used by being formulated into powders, granules, pastes, microcapsules and the like according to the purpose and application. At this time, it can be prepared by adsorbing to clay, talc, silica, alumina, montmorillonite or the like.
  • the liquid composition of the present invention comprises, for example, a silver compound such as silver nitrate that is a water-soluble silver compound that is a silver ion source or silver oxide that is a poorly soluble silver compound, histidine, carboxylic acids, and water. It is possible to mix and prepare a histidine silver complex in an aqueous solvent.
  • the raw materials are as described above.
  • it can be obtained by mixing a powdery histidine silver complex, the above carboxylic acid, and water.
  • the powdery histidine silver complex can be produced, for example, by the method described in Patent Document 5.
  • the water used in the liquid composition of the present invention can be tap water, purified water (ion exchange water), distilled water, etc., but purified water (ion exchange water) is preferred from the viewpoint of stability and economy. .
  • the liquid composition of the present invention can be produced using known conditions and equipment. For example, when a powdery histidine silver complex, carboxylic acids, and water are mixed to obtain the liquid composition of the present invention, these three components are put into an apparatus having a stirrer, and 10-120 at 10-30 ° C. It can be produced by stirring for a minute. As the stirring device, a known device can be used, and if necessary, filtration can be performed after stirring. As another method, when a liquid composition of the present invention is obtained by mixing a silver compound, histidine, carboxylic acids, and water, these four components are put into an apparatus having a stirrer, and 10 to 15 to 30 ° C. It can be produced by stirring for ⁇ 120 minutes.
  • stirring device for example, a known device such as a magnetic stirrer or a stirring blade stirrer (for example, Three-One Motor (trade name), manufactured by Shinto Kagaku Co., Ltd.) can be used, and if necessary, filtration is performed after stirring. You can also
  • the coating composition of the present invention can be produced in the same manner as the above liquid composition production method.
  • silver nitrate which is a water-soluble silver compound that becomes a silver ion source
  • silver oxide which is a poorly soluble silver compound
  • the silver compound, histidine, carboxylic acid, and water can be mixed to prepare a histidine silver complex in an aqueous solvent, and a solution of the histidine silver complex and a paint can be further mixed to produce.
  • the powdery histidine silver complex can be produced, for example, by the method described in Patent Document 2.
  • Examples of the water used for the production of the coating composition are the same as those for the production of the liquid composition.
  • the conditions and equipment may be the same as those for the production of the liquid composition.
  • paint, powdered histidine silver complex, carboxylic acids and water as required may be charged into an apparatus having a stirrer. It can be produced by stirring and mixing at 30 ° C. for 10 to 120 minutes.
  • the stirring device a known device can be used, and if necessary, filtration can be performed after stirring.
  • Example 1 1.074 g of silver oxide, 2.88 g of L-histidine, 0.2 g of trisodium citrate and 95.846 g of water were placed in a suitable container, stirred at room temperature for 30 minutes or more, 2.44% by weight of histidine silver complex, An aqueous solution containing 0.2% by weight of the carboxylic acids of the present invention was obtained.
  • Example 2 1.074 g of silver oxide, 2.88 g of L-histidine, 0.4 g of trisodium citrate and 95.646 g of water were placed in a suitable container, stirred at room temperature for 30 minutes or more, 2.44% by weight of histidine silver complex, An aqueous solution containing 0.4% by weight of the carboxylic acids of the present invention was obtained.
  • Example 3 1.074 g of silver oxide, 2.88 g of L-histidine, 0.2 g of trisodium citrate, 0.2 g of L-arginine and 95.646 g of water are placed in a suitable container and stirred at room temperature for 30 minutes or more. An aqueous solution containing 2.44% by weight of the complex and 0.4% by weight of the carboxylic acids of the present invention was obtained.
  • ⁇ Appearance uniformity evaluation method> The composition obtained in Examples 1 to 3 and Comparative Example 1 was placed in a glass screw vial with a capacity of 50 ml, sealed, and left to stand at 25 ° C. for 1 day under fluorescent light irradiation (4000 Lux). Visual evaluation was made.
  • the evaluation criteria are as follows. ⁇ : Uniform and transparent ⁇ : Uniform turbidity or discoloration ⁇ : Precipitation or deposit on glass wall
  • the evaluation results of the compositions obtained in Examples 1 to 3 and Comparative Example 1 are shown in Table 2.
  • MIC minimum inhibitory concentration
  • the specific measurement method is as follows. One platinum ear of Pseudomonas aeruginosa was inoculated into a ⁇ 18 mm, 150 mm long test tube containing 10 ml of a nutrient broth (NB) liquid medium, and pre-cultured at 120 rpm, 30 ° C. for 24 hours. 0.5 ml of a 100-fold diluted solution of this culture solution was added to a test tube having a diameter of 18 mm and a length of 150 mm containing 9 ml of NB medium, and 0.5 ml of a test solution prepared to a set concentration was further added.
  • NB nutrient broth
  • ⁇ Paint antiseptic test method> The paint was prepared for the exterior wall with reference to the formulation of the external emulsion paint white of “Toyo Aoyama Polymer Publishing Association (1986)”.
  • the composition obtained in Example 2 and Comparative Example 1 was added and mixed with the prepared paint so as to have a predetermined concentration.
  • a blank without any composition was used as a blank. This was inoculated with the test bacteria and cultured in a 31 ⁇ 1 ° C. incubator. Samples were collected after 1 week and 7 weeks and cultured on a normal agar medium to confirm the number of bacteria in the sample and inoculate the suspension of the test bacteria. The number of bacteria was measured by the agar plate dilution method.
  • the strains used in the test were Bacillus Subtilis, Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, Pseudomonas fluorescens, Proteus mirabilis, Proteus mirabilis, Proteus mirabilis, Proteus miratus, Proteus mirabilis, Proteus mirabilis, Proteus mirabilis, Proteus mirabilis, Proteus mirabilis, Proteus mirabilis, Proteus mirabilis, and Proteus mirabilis.
  • the composition of the paint is shown in Table 5, and the results of the antiseptic test are shown in Table 6-1 and Table 6-2.
  • Example 4 A coating composition was obtained by adding the silver histidine complex aqueous solution of Example 1 to a coating composition at a weight ratio of 1%.
  • Comparative Example 2 Obtained by dispersing 1 g of 1,2-benzisothiazolin-3-one (common name BIT) in 1 liter of distilled water and allowing to stand at room temperature for 24 hours, and filtering the supernatant with a membrane filter (pore size 0.45 ⁇ m).
  • the BIT aqueous solution was used as a BIT saturated solution, and a paint composition was obtained by adding 10% by weight to the paint.
  • the coating film was prepared by the following method. Thick filter paper (model 26, manufactured by ADVANTEC) cut into 10 cm square is wrapped in aluminum foil and sterilized by autoclave. Then, 1.0 g each of the above paints is applied to the front and back of the cut filter paper. Cut. As a pretreatment, each filter paper coating film was immersed in about 50 ml of hot water (40 ° C.), treated for 3 days, and then subjected to an antibacterial test. Antibacterial test is JIS Z 2801 method was followed. The results are shown in Table 7.
  • liquid composition containing a silver histidine complex that maintains a very strong antibacterial property and is stable for a long period of time without causing discoloration or aggregation precipitation.
  • the liquid composition of the present invention is suitable as a coating composition.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paints Or Removers (AREA)

Abstract

L'invention concerne une composition liquide qui comprend un complexe histidine-argent, lequel ne cause pas de décoloration ou de précipitation et lequel peut garder son activité germicide pour une longue période. L'invention concerne également une composition de revêtement. Plus particulièrement, l'invention concerne une composition liquide qui comprend : un complexe histidine-argent dans lequel l'histidine est coordonnée par un ion argent ; et au moins un élément choisi dans le groupe constitué d'un acide hydroxycarboxylique, un acide polycarboxylique, un sel de l'acide hydroxycarboxylique et un sel de l'acide polycarboxylique. Le complexe histidine-argent (qui est un principe actif de la composition) peut être stabilisé pour une longue période même dans une solution aqueuse en mélangeant le complexe histidine-argent avec au moins un élément choisi dans le groupe constitué d'un acide hydroxycarboxylique, d'un acide polycarboxylique, d'un sel de l'acide hydroxycarboxylique et d'un sel de l'acide polycarboxylique (particulièrement de préférence au moins un élément choisi dans le groupe constitué de l'acide glucuronique, de l'acide citrique, d'un sel de l'acide glucuronique et d'un sel de l'acide citrique). La composition peut être utilisée pour l'inhibition de la croissance de microorganismes nocifs ou la stérilisation par l'action d'un ion argent.
PCT/JP2009/000337 2008-02-08 2009-01-29 Composition liquide comprenant un complexe histidine-argent, composition d'un agent germicide et procédé de stabilisation d'un complexe histidine-argent Ceased WO2009098850A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009552399A JP5435475B2 (ja) 2008-02-08 2009-01-29 ヒスチジン銀錯体を含有する液状組成物、殺菌剤組成物及びヒスチジン銀錯体の安定化方法
CN2009801040963A CN101938900A (zh) 2008-02-08 2009-01-29 含有组氨酸银配合物的液态组合物、杀菌剂组合物及组氨酸银配合物的稳定化方法

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JP2008-029298 2008-02-08
JP2008029298 2008-02-08
JP2008-203124 2008-08-06
JP2008203124 2008-08-06

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011195582A (ja) * 2010-02-25 2011-10-06 Nippon Soda Co Ltd 抗菌、殺菌若しくは抗ウイルス性組成物
JP2012031118A (ja) * 2010-08-02 2012-02-16 J-Chemical:Kk 抗菌性組成物及びその用途
JP2012041287A (ja) * 2010-08-17 2012-03-01 Nippon Soda Co Ltd 水性殺菌・抗菌剤組成物
JP2012144438A (ja) * 2011-01-06 2012-08-02 Nippon Soda Co Ltd 頭皮頭髪用化粧料
WO2012144476A1 (fr) * 2011-04-19 2012-10-26 株式会社ネオス Procédé de développement du pouvoir bactéricide d'un complexe histidine-argent dans une solution comprenant des ions chlore, composition d'additif liquide, et composition antibactérienne liquide
WO2012144475A1 (fr) * 2011-04-18 2012-10-26 株式会社ネオス Procédé de conservation du pouvoir bactéricide d'un complexe histidine-argent dans une solution comprenant des ions chlore, et composition antibactérienne liquide
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WO2019021143A1 (fr) * 2017-07-22 2019-01-31 Rangasamy Naidu Educational Trust Hydrogel à base de molécules de l-histidine
CN109731464A (zh) * 2019-01-15 2019-05-10 一汽轿车股份有限公司 一种新型多功能空调滤芯
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JP2023108470A (ja) * 2022-01-25 2023-08-04 メディサイエンス・エスポア株式会社 アレルゲン不活化組成物およびこれを含む機能性物品
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JP2012144438A (ja) * 2011-01-06 2012-08-02 Nippon Soda Co Ltd 頭皮頭髪用化粧料
WO2012144475A1 (fr) * 2011-04-18 2012-10-26 株式会社ネオス Procédé de conservation du pouvoir bactéricide d'un complexe histidine-argent dans une solution comprenant des ions chlore, et composition antibactérienne liquide
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WO2012144476A1 (fr) * 2011-04-19 2012-10-26 株式会社ネオス Procédé de développement du pouvoir bactéricide d'un complexe histidine-argent dans une solution comprenant des ions chlore, composition d'additif liquide, et composition antibactérienne liquide
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WO2012153760A1 (fr) 2011-05-11 2012-11-15 日本曹達株式会社 Conservateur pour matériaux de construction
AU2012254464B2 (en) * 2011-05-11 2014-08-21 Nippon Soda Co., Ltd. Construction material preservative
JP5714101B2 (ja) * 2011-05-11 2015-05-07 日本曹達株式会社 建築材料保存剤
US9433216B2 (en) 2011-05-11 2016-09-06 Nippon Soda Co., Ltd. Construction material preservative
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JP2013001665A (ja) * 2011-06-14 2013-01-07 Zenshin:Kk 抗菌組成物
JP2013035796A (ja) * 2011-08-09 2013-02-21 Nippon Soda Co Ltd 固体材料
WO2019021144A1 (fr) * 2017-07-22 2019-01-31 Rangasamy Naidu Educational Trust Procédé de préparation d'hydrogel à base de molécule de l-histidine par gélification de l'eau
WO2019021143A1 (fr) * 2017-07-22 2019-01-31 Rangasamy Naidu Educational Trust Hydrogel à base de molécules de l-histidine
CN109731464A (zh) * 2019-01-15 2019-05-10 一汽轿车股份有限公司 一种新型多功能空调滤芯
KR20200088781A (ko) * 2019-01-15 2020-07-23 주식회사 엘지화학 항균 조성물
KR102568722B1 (ko) 2019-01-15 2023-08-22 주식회사 엘지화학 항균 조성물
WO2023007994A1 (fr) * 2021-07-28 2023-02-02 メディサイエンス・エスポア株式会社 Composition de lavement à l'oxygène, outil de lavement et procédé de production d'une composition de lavement à l'oxygène
JP2023108470A (ja) * 2022-01-25 2023-08-04 メディサイエンス・エスポア株式会社 アレルゲン不活化組成物およびこれを含む機能性物品
WO2024005163A1 (fr) * 2022-06-30 2024-01-04 株式会社キャスティングイン Composition antibactérienne

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