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WO2009098451A3 - Biomarkers of aminopeptidase inhibition - Google Patents

Biomarkers of aminopeptidase inhibition Download PDF

Info

Publication number
WO2009098451A3
WO2009098451A3 PCT/GB2009/000304 GB2009000304W WO2009098451A3 WO 2009098451 A3 WO2009098451 A3 WO 2009098451A3 GB 2009000304 W GB2009000304 W GB 2009000304W WO 2009098451 A3 WO2009098451 A3 WO 2009098451A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomarkers
aminopeptidase
inhibition
aminopeptidase inhibition
bestatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2009/000304
Other languages
French (fr)
Other versions
WO2009098451A2 (en
Inventor
David Krige
Alan Hastings Drummond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chroma Therapeutics Ltd
Original Assignee
Chroma Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chroma Therapeutics Ltd filed Critical Chroma Therapeutics Ltd
Publication of WO2009098451A2 publication Critical patent/WO2009098451A2/en
Publication of WO2009098451A3 publication Critical patent/WO2009098451A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G01N33/5758—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to biomarkers for aminopeptidase inhibition. These biomarkers may be useful, for example, in assessing the extent of aminopeptidase inhibition in vivo or in monitoring cancer treatments using aminopeptidase inhibitors, such as bestatin or CHR-2797.
PCT/GB2009/000304 2008-02-04 2009-02-04 Biomarkers of aminopeptidase inhibition Ceased WO2009098451A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0802009.1 2008-02-04
GBGB0802009.1A GB0802009D0 (en) 2008-02-04 2008-02-04 Biomarkers of aminopeptidase inhibition

Publications (2)

Publication Number Publication Date
WO2009098451A2 WO2009098451A2 (en) 2009-08-13
WO2009098451A3 true WO2009098451A3 (en) 2009-12-10

Family

ID=39204188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/000304 Ceased WO2009098451A2 (en) 2008-02-04 2009-02-04 Biomarkers of aminopeptidase inhibition

Country Status (2)

Country Link
GB (1) GB0802009D0 (en)
WO (1) WO2009098451A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2788902C (en) * 2010-02-08 2019-09-03 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
CN114807374A (en) * 2022-06-01 2022-07-29 北京大学第三医院（北京大学第三临床医学院） Ovarian cancer prognosis risk model based on polyunsaturated fatty acid related genes and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008322A (en) * 1996-04-02 1999-12-28 Zymogenetics, Inc. Stanniocalcin-2
WO2001008697A2 (en) * 1999-07-30 2001-02-08 Zymogenetics, Inc. Use of stanniocalcin 2 in the treatment of type ii diabetes and complications thereof
US20030130180A1 (en) * 2000-01-24 2003-07-10 Walter Schubert Utilization of an aminopeptidase inhibitor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008322A (en) * 1996-04-02 1999-12-28 Zymogenetics, Inc. Stanniocalcin-2
WO2001008697A2 (en) * 1999-07-30 2001-02-08 Zymogenetics, Inc. Use of stanniocalcin 2 in the treatment of type ii diabetes and complications thereof
US20030130180A1 (en) * 2000-01-24 2003-07-10 Walter Schubert Utilization of an aminopeptidase inhibitor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DAVIES FAITH E ET AL: "Aminopeptidase inhibition as a targeted treatment strategy in myeloma", BLOOD, vol. 110, no. 11, Part 1, November 2007 (2007-11-01), & 49TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ATLANTA, GA, USA; DECEMBER 08 -11, 2007, pages 738A - 739A, XP002537076, ISSN: 0006-4971 *
DRUMMOND ALAN H ET AL: "Anti-proliferative aminopeptidase inhibitors inhibit mTOR and alter expression of Noxa and Mlc-1 in leukemic cells via amino acid deprivation.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 48, April 2007 (2007-04-01), & 98TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH; LOS ANGELES, CA, USA; APRIL 14 -18, 2007, pages 963 - 964, XP001537169, ISSN: 0197-016X *
GRÜNEBACH FRANK ET AL: "Molecular and functional characterization of human Dectin-1.", EXPERIMENTAL HEMATOLOGY NOV 2002, vol. 30, no. 11, November 2002 (2002-11-01), pages 1309 - 1315, XP002537146, ISSN: 0301-472X, Retrieved from the Internet <URL:http://www.ebi.ac.uk/~sp/intern/projects/pdf_archive/pdfpumped/4/12423684.pdf> [retrieved on 20090715] *
KANAYAMA N ET AL: "Inactivation of interleukin-8 by aminopeptidase N (CD13).", JOURNAL OF LEUKOCYTE BIOLOGY JAN 1995, vol. 57, no. 1, January 1995 (1995-01-01), pages 129 - 134, XP002537078, ISSN: 0741-5400, Retrieved from the Internet <URL:http://www.jleukbio.org/cgi/reprint/57/1/129> [retrieved on 20090714] *
KRIGE DAVID ET AL: "CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.", CANCER RESEARCH 15 AUG 2008, vol. 68, no. 16, 15 August 2008 (2008-08-15), pages 6669 - 6679, XP002537080, ISSN: 1538-7445 *
TSUNOGAKE S ET AL: "Effect of aminopeptidase inhibitors on the production of various cytokines by peripheral blood mononuclear cells and stromal cells and on stem cell factor gene expression in stromal cells: comparison of ubenimex with its stereoisomers", INTERNATIONAL JOURNAL OF IMMUNOTHERAPY, vol. 10, no. 2, 1994, pages 41 - 47, XP002537079, ISSN: 0255-9625 *

Also Published As

Publication number Publication date
WO2009098451A2 (en) 2009-08-13
GB0802009D0 (en) 2008-03-12

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