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WO2009086740A1 - Granulé d'indoxacarb hydrosoluble et préparation associée - Google Patents

Granulé d'indoxacarb hydrosoluble et préparation associée Download PDF

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Publication number
WO2009086740A1
WO2009086740A1 PCT/CN2008/070062 CN2008070062W WO2009086740A1 WO 2009086740 A1 WO2009086740 A1 WO 2009086740A1 CN 2008070062 W CN2008070062 W CN 2008070062W WO 2009086740 A1 WO2009086740 A1 WO 2009086740A1
Authority
WO
WIPO (PCT)
Prior art keywords
indoxacarb
water
soluble granule
group
granule according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2008/070062
Other languages
English (en)
Chinese (zh)
Inventor
Guishu Luan
Zhixiang Wang
Yunying Chi
Haixu Li
Changchun Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/CN2008/070062 priority Critical patent/WO2009086740A1/fr
Publication of WO2009086740A1 publication Critical patent/WO2009086740A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof

Definitions

  • the present invention relates to a novel dosage form of the insecticide, and more particularly to a water-soluble granule containing indoxacarb and a process for the preparation thereof. Background technique
  • Indoxacarb is an insecticide recently developed by E. I. du Pont de Nemours and Company. It can effectively control a variety of pests on crops such as grain, cotton, fruit and vegetables.
  • the mechanism of action is to disable the nerve cells by blocking the sodium ion channels in the insect nerve cells. It has contact and stomach toxicity and is effective for larvae of all ages.
  • the agent enters the insect body through contact and feeding. The insect stops eating after 0 ⁇ 4 hours, and then the parasite is paralyzed. The coordination ability of the insect will decrease (can cause the larva to fall from the crop), generally within 24 to 60 hours after the medicine. death.
  • Water emulsion (EW), microemulsion (ME), aqueous suspension (SC), water-soluble liquid (SL), etc. are representative new forms of water-based preparations.
  • the common feature is that water replaces a large amount of organic solvents and reduces solvents. Waste and pollution, reduce the toxicity of the preparation, improve safety, is a new dosage form to replace emulsifiable concentrate. 2.
  • the solid preparation is granulated.
  • the powder preparation is granulated to avoid dust pollution, and packaging is also the direction of dosage form research.
  • Water dispersible granules (WDG) are representative granules.
  • the dosage form has a granular appearance and is rapidly disintegrated and dispersed in water when used, thereby forming a highly suspended dispersion system for use in spray application.
  • the preparation content and suspension rate are much higher than wettable powder, good fluidity, no dust pollution, convenient packaging, storage and transportation. It is a new dosage form integrating the advantages of wettable powder, suspoemulsion and granules. However, these dosage forms do not combine the advantages of both, but also manifest. Summary of the invention
  • the object of the present invention is to overcome the disadvantages of the prior art described above and to provide a substitute for a large amount of organic solvent with water. It reduces solvent waste and pollution, reduces the toxicity of the preparation, improves safety, and has a granular appearance.
  • the water-soluble granules (WSG) containing indoxacarb and its preparation method are rapidly disintegrated and dispersed in water.
  • a mites water soluble granule mainly made of the following weight percentage substances:
  • Indoxacarb 1 ⁇ 50%
  • Emulsifier 1 ⁇ 30%
  • Dispersing agent 1 ⁇ 10%
  • wetting agent 1 ⁇ 5 %
  • Binder 1 ⁇ 4% ;
  • Stabilizer 1 ⁇ 3 %
  • the balance is a filler.
  • the indoxacarb water-soluble granule of the present invention wherein the emulsifier is selected from the group consisting of alkylphenol ethoxylates, benzylphenol ethoxylates and the like, or a fatty alcohol ethoxylate and the like Or two mixtures.
  • the indoxacarb water-soluble granule of the present invention wherein the dispersing agent is selected from the group consisting of alkylnaphthalenesulfonate, bisnaphthalenesulfonate formaldehyde condensate or sodium lignosulfonate.
  • the alkylnaphthalenesulfonate may be a pull-off powder BX, a pull-up powder AC or the like; and the bisnaphthalenesulfonate formaldehyde condensate may be a dispersant N, a dispersant NN0 or the like.
  • the indoxacarb water-soluble granule of the present invention wherein the wetting agent is one selected from the group consisting of alkylbenzenesulfonate, fatty acid amide N-methylsulfonate, alkylaryl polyoxyethylene ether sulfate or Two mixtures.
  • the indoxacarb water-soluble granule of the present invention wherein the binder is one or a mixture of two selected from the group consisting of ⁇ -cyclodextrin, polyvinyl alcohol, and methyl cellulose.
  • the indoxacarb water-soluble granule of the present invention wherein the stabilizer is selected from the group consisting of borax and sodium benzoate.
  • the indoxacarb water-soluble granule of the present invention wherein the filler is selected from one or a mixture of two or more of hydrogencarbonate, anhydrous citric acid, maltose, and anhydrous sodium sulfate.
  • the preparation method of the indoxacarb water-soluble granule of the invention is as follows: the material is homogenized, kneaded and extruded granulated according to the ratio, dried under vacuum at 65 to 75 ° C for 1 to 2 hours, sieved, sieved The product is packaged after testing; the product that cannot pass through the sieve repeats the above steps.
  • the specific preparation method comprises the following steps:
  • the water-soluble granules of the invention meet the requirements of the current development trend of pesticides by replacing the organic solvents such as xylene, methanol and toluene with the aqueous solvent, the solid granulation or tableting of the drug form, the high content of the pesticide and the functionalization.
  • the adhesive is embedded in the original drug and the stability and anti-oxidation effect of the stabilizer, so that the anti-radiation and illumination ability of the original drug is improved, and the shelf life of the drug is prolonged; the bicarbonate and citric acid in the filler can effervescent The role of the agent to promote the dissolution of the granules.
  • the water-soluble granule of the invention can be quickly dissolved in water, has high dispersing rate, has no floating and sinking phenomenon, has a large amount of organic solvent replaced by water, reduces solvent waste and pollution, reduces preparation toxicity, improves safety, and has appearance as granules. It has the characteristics of rapid disintegration and dispersion in water, convenient transportation and storage, and long shelf life.
  • the preparation method is simple, easy to operate and control.
  • the invention contains no or only a small amount of toxic and flammable aromatic hydrocarbon solvents, thereby avoiding flammable and explosive phenomena during production, storage and transportation.
  • This dosage form has no unpleasant toxic odor, is less irritating to the eyes, reduces environmental pollution, and greatly improves the safety of production, storage, transportation and users. Therefore, after industrialization, not only the economic benefits are obvious, but also the development of high-tech green pesticide technology is promoted. It has obvious social benefits for promoting environmental protection and is the research direction of sustainable development. detailed description
  • Indoxacarb 1%
  • Nonylphenol ethoxylate 6%
  • Anhydrous citric acid 35%
  • the columnar particles are vacuum dried at 70 ° C for 1 hour, and then sieved.
  • the sieved product is packaged after testing; the product that cannot pass through the sieve is repeated after the above process is tested and qualified.
  • the preparation process is the same as in Example 1.
  • the raw material formula used is:
  • Indoxacarb 20%;
  • Alkyl aryl polyoxyethylene ether sulfate 7%; Polyvinyl alcohol: 1.5%;
  • Anhydrous citric acid 25%.
  • the preparation process is the same as in Example 1.
  • the raw material formula used is:
  • Indoxacarb 40%;
  • Dispersant N 1.2%;
  • Methyl cellulose 2%;
  • the invention contains no or only a small amount of toxic and flammable aromatic hydrocarbon solvents, thereby avoiding flammable and explosive phenomena during production, storage and transportation.
  • This dosage form has no unpleasant toxic odor, is less irritating to the eyes, reduces environmental pollution, and greatly improves the safety of production, storage, transportation and users. Therefore, after industrialization, not only the economic benefits are obvious, but also the development of high-tech green pesticide technology is promoted. It has obvious social benefits for promoting environmental protection and is the research direction of sustainable development. Notes on the application documents: Unless otherwise stated, the percentages referred to in this application are percentages by weight.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne un granulé d'indoxacarb hydrosoluble, qui est constitué de 1-50% (en poids) d'indoxacarb, de 1-30% d'un émulsifiant, de 1-10% d'un agent dispersant, de 1.5% d'un agent mouillant, de 1-4% d'un liant, de 1-3% d'un stabilisant, le reste étant du matériau de remplissage. Il n'y a aucun solvant hydrocarbure aromatique inflammable et toxique, ou peu, ce qui permet de réduire le risque de brûlure et d'explosion lors de la fabrication, du stockage et du transport. Ses avantages sont notamment l'absence de poison et de pollution, aucune odeur désagréable, une irritation des yeux réduite, une plus grande sécurité pour les producteurs, les transporteurs et les utilisateurs.
PCT/CN2008/070062 2008-01-09 2008-01-09 Granulé d'indoxacarb hydrosoluble et préparation associée Ceased WO2009086740A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2008/070062 WO2009086740A1 (fr) 2008-01-09 2008-01-09 Granulé d'indoxacarb hydrosoluble et préparation associée

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2008/070062 WO2009086740A1 (fr) 2008-01-09 2008-01-09 Granulé d'indoxacarb hydrosoluble et préparation associée

Publications (1)

Publication Number Publication Date
WO2009086740A1 true WO2009086740A1 (fr) 2009-07-16

Family

ID=40852799

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2008/070062 Ceased WO2009086740A1 (fr) 2008-01-09 2008-01-09 Granulé d'indoxacarb hydrosoluble et préparation associée

Country Status (1)

Country Link
WO (1) WO2009086740A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593144A (zh) * 2004-07-13 2005-03-16 江苏长青农化股份有限公司 一种杀虫剂
CN1736200A (zh) * 2001-07-25 2006-02-22 辛甄塔有限公司 含γ－氯氟氰菊酯的杀虫混合物
CN1775027A (zh) * 2005-11-21 2006-05-24 河北威远生物化工股份有限公司 含有甲氨基阿维菌素苯甲酸盐的杀虫可溶性颗粒剂
CN1903036A (zh) * 2006-07-19 2007-01-31 湖南化工研究院 一种杀虫剂组合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1736200A (zh) * 2001-07-25 2006-02-22 辛甄塔有限公司 含γ－氯氟氰菊酯的杀虫混合物
CN1593144A (zh) * 2004-07-13 2005-03-16 江苏长青农化股份有限公司 一种杀虫剂
CN1775027A (zh) * 2005-11-21 2006-05-24 河北威远生物化工股份有限公司 含有甲氨基阿维菌素苯甲酸盐的杀虫可溶性颗粒剂
CN1903036A (zh) * 2006-07-19 2007-01-31 湖南化工研究院 一种杀虫剂组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIU, CHANGLING: "Novel Insecticide Indoxacarb", PESTICIDES, vol. 42, no. 2, February 2003 (2003-02-01), pages 42 - 43 *

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