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WO2009084028A3 - Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate - Google Patents

Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate Download PDF

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Publication number
WO2009084028A3
WO2009084028A3 PCT/IN2008/000803 IN2008000803W WO2009084028A3 WO 2009084028 A3 WO2009084028 A3 WO 2009084028A3 IN 2008000803 W IN2008000803 W IN 2008000803W WO 2009084028 A3 WO2009084028 A3 WO 2009084028A3
Authority
WO
WIPO (PCT)
Prior art keywords
carboxyphenyl
thiophen
ylmethyl
prop
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000803
Other languages
French (fr)
Other versions
WO2009084028A2 (en
Inventor
Arul Ramakrishnan
Umesh Upadhyay
Sanjay Bhawsar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuland Laboratories Ltd
Original Assignee
Neuland Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuland Laboratories Ltd filed Critical Neuland Laboratories Ltd
Publication of WO2009084028A2 publication Critical patent/WO2009084028A2/en
Anticipated expiration legal-status Critical
Publication of WO2009084028A3 publication Critical patent/WO2009084028A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to a simple efficient and cost effective process for commercial manufacture of (E)-3-[2-Butyl-1-{(4-carboxyphenyl) methyl}-1H-imidazole-5-yl]- 2-(thiophen-2-ylmethyl)prop-2-enoic acid and its conversion to substantially pure anhydrous mesylate salt as shown in Formula (I), with a purity level of 99.85% and single individual impurity of less than 0.10 %.
PCT/IN2008/000803 2007-12-03 2008-12-02 Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate Ceased WO2009084028A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2861CH2007 2007-12-03
IN2861/CHE/2007 2007-12-03

Publications (2)

Publication Number Publication Date
WO2009084028A2 WO2009084028A2 (en) 2009-07-09
WO2009084028A3 true WO2009084028A3 (en) 2010-12-02

Family

ID=40824843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000803 Ceased WO2009084028A2 (en) 2007-12-03 2008-12-02 Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate

Country Status (1)

Country Link
WO (1) WO2009084028A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101333216A (en) * 2008-08-03 2008-12-31 浙江华海药业股份有限公司 Novel saltforming process of eprosartan mesylate
WO2011051975A1 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of pure eprosartanand its pharmaceutical acceptable salts
CN102584709B (en) * 2011-12-19 2016-08-17 浙江华海药业股份有限公司 A kind of preparation technology of the Eprosartan intermediate aryl imidazole aldehyde of improvement
CN104788382A (en) * 2015-04-21 2015-07-22 浙江华海药业股份有限公司 Method for preparing eprosartan midbody impurity EP2A
CN106916139A (en) * 2017-05-09 2017-07-04 浙江华海致诚药业有限公司 A kind of preparation method of improved Eprosartan intermediate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
WO1997036874A1 (en) * 1996-03-29 1997-10-09 Smithkline Beecham Corporation Eprosartan dihydrate and a process for its production and formulation
WO1998035963A1 (en) * 1997-02-14 1998-08-20 Smithkline Beecham Corporation Process for preparing eprosartan
WO2008078330A1 (en) * 2006-12-27 2008-07-03 Hetero Drugs Limited Improved process for eprosartan

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
WO1997036874A1 (en) * 1996-03-29 1997-10-09 Smithkline Beecham Corporation Eprosartan dihydrate and a process for its production and formulation
WO1998035963A1 (en) * 1997-02-14 1998-08-20 Smithkline Beecham Corporation Process for preparing eprosartan
WO2008078330A1 (en) * 2006-12-27 2008-07-03 Hetero Drugs Limited Improved process for eprosartan

Also Published As

Publication number Publication date
WO2009084028A2 (en) 2009-07-09

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