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WO2009062036A3 - Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof - Google Patents

Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof Download PDF

Info

Publication number
WO2009062036A3
WO2009062036A3 PCT/US2008/082802 US2008082802W WO2009062036A3 WO 2009062036 A3 WO2009062036 A3 WO 2009062036A3 US 2008082802 W US2008082802 W US 2008082802W WO 2009062036 A3 WO2009062036 A3 WO 2009062036A3
Authority
WO
WIPO (PCT)
Prior art keywords
processes
pharmaceutically acceptable
acceptable salts
preparing
levocetirizine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/082802
Other languages
French (fr)
Other versions
WO2009062036A2 (en
Inventor
Srinivasan Thirumalai Rajan
Uppala Venkata Bhaskara Rao
Akundi Surya Prabhakar
Joga Rajender
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Original Assignee
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd, Dr Reddys Laboratories Inc filed Critical Dr Reddys Laboratories Ltd
Publication of WO2009062036A2 publication Critical patent/WO2009062036A2/en
Publication of WO2009062036A3 publication Critical patent/WO2009062036A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Processes for preparing levocetirizine dihydrochloride.
PCT/US2008/082802 2007-11-09 2008-11-07 Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof Ceased WO2009062036A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2575CH2007 2007-11-09
IN2575/CHE/2007 2007-11-09
US5749608P 2008-05-30 2008-05-30
US61/057,496 2008-05-30

Publications (2)

Publication Number Publication Date
WO2009062036A2 WO2009062036A2 (en) 2009-05-14
WO2009062036A3 true WO2009062036A3 (en) 2009-07-16

Family

ID=40626447

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/082802 Ceased WO2009062036A2 (en) 2007-11-09 2008-11-07 Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof

Country Status (1)

Country Link
WO (1) WO2009062036A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106187920A (en) * 2016-07-15 2016-12-07 苏州东瑞制药有限公司 A kind of levo-cetirizine hydrochloride tablets have related substance and analyzing detecting method thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012101648A1 (en) * 2011-01-24 2012-08-02 Havaldar Freddy H Novel process for the synthesis of enantiomerically pure 2-methoxy-5-[(2r)-2-(4-alkylpiperazin-l-yl)propyl]-benzenesulfonamide
CN104045607B (en) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 A kind of purification process of cetrizine hcl
CN105954419B (en) * 2016-06-01 2018-02-06 重庆华邦胜凯制药有限公司 The method of HPLC method separation determination levo-cetirizine hydrochlorides and its enantiomter
CN111205247B (en) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 Preparation method of levocetirizine
CN117209453A (en) * 2023-08-24 2023-12-12 迪嘉药业集团股份有限公司 Preparation and application of levocetirizine hydrochloride intermediate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0058146A1 (en) * 1981-02-06 1982-08-18 U C B, S.A. 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions
GB2225321A (en) * 1988-11-23 1990-05-30 Ucb Sa Process for preparation of a 1-piperazine-ethoxyacetic acid
WO1999052553A1 (en) * 1998-04-14 1999-10-21 Sepracor Inc. Methods and compositions using cetirizine in combination with leukotriene inhibitors for treating conditions responsive to leukotriene inhibition
US6046332A (en) * 1996-07-11 2000-04-04 Tao; Yong Methods for the manufacture of cetirizine
WO2000052000A1 (en) * 1999-03-04 2000-09-08 A/S Gea Farmaceutisk Fabrik A process for the preparation of 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}acetic acid compounds or salts thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0058146A1 (en) * 1981-02-06 1982-08-18 U C B, S.A. 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions
GB2225321A (en) * 1988-11-23 1990-05-30 Ucb Sa Process for preparation of a 1-piperazine-ethoxyacetic acid
US6046332A (en) * 1996-07-11 2000-04-04 Tao; Yong Methods for the manufacture of cetirizine
WO1999052553A1 (en) * 1998-04-14 1999-10-21 Sepracor Inc. Methods and compositions using cetirizine in combination with leukotriene inhibitors for treating conditions responsive to leukotriene inhibition
US6790849B2 (en) * 1998-04-14 2004-09-14 Sepracor Inc. Methods and compositions using optically pure (-) cetirizine in combination with leukotriene inhibitors or decongestants
WO2000052000A1 (en) * 1999-03-04 2000-09-08 A/S Gea Farmaceutisk Fabrik A process for the preparation of 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}acetic acid compounds or salts thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106187920A (en) * 2016-07-15 2016-12-07 苏州东瑞制药有限公司 A kind of levo-cetirizine hydrochloride tablets have related substance and analyzing detecting method thereof

Also Published As

Publication number Publication date
WO2009062036A2 (en) 2009-05-14

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