[go: up one dir, main page]

WO2009057733A1 - Novel indole derivative having anti-angiogenic activity - Google Patents

Novel indole derivative having anti-angiogenic activity Download PDF

Info

Publication number
WO2009057733A1
WO2009057733A1 PCT/JP2008/069841 JP2008069841W WO2009057733A1 WO 2009057733 A1 WO2009057733 A1 WO 2009057733A1 JP 2008069841 W JP2008069841 W JP 2008069841W WO 2009057733 A1 WO2009057733 A1 WO 2009057733A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
novel indole
angiogenic activity
indole derivative
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/069841
Other languages
French (fr)
Japanese (ja)
Inventor
Takahiro Honda
Hiroyuki Mogi
Hiroyuki Aono
Masakazu Ban
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of WO2009057733A1 publication Critical patent/WO2009057733A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to the study on the synthesis of novel indole derivatives and also relates to the application of the compounds for medical purposes. Thus, disclosed is a compound represented by the formula (I) or a salt thereof [in the formula, X represents O, S or N-R4; R1 represents an aryl group, an aromatic heterocyclic group or the like; R2 represents an aryl group, an aromatic heterocyclic group or the like; R3 represents a hydrogen atom, an alkyl group, an alkylcarbonyl group or the like; and R4 represents a hydrogen atom, an alkyl group or the like. (I)
PCT/JP2008/069841 2007-10-31 2008-10-31 Novel indole derivative having anti-angiogenic activity Ceased WO2009057733A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007282727 2007-10-31
JP2007-282727 2007-10-31
JP2008054482 2008-03-05
JP2008-054482 2008-03-05

Publications (1)

Publication Number Publication Date
WO2009057733A1 true WO2009057733A1 (en) 2009-05-07

Family

ID=40591113

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069841 Ceased WO2009057733A1 (en) 2007-10-31 2008-10-31 Novel indole derivative having anti-angiogenic activity

Country Status (2)

Country Link
JP (1) JP2009235057A (en)
WO (1) WO2009057733A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015022926A1 (en) * 2013-08-12 2015-02-19 大鵬薬品工業株式会社 Novel fused pyrimidine compound or salt thereof
WO2016121953A1 (en) * 2015-01-30 2016-08-04 大鵬薬品工業株式会社 Prophylactic and/or therapeutic agent for immune diseases
CN110938027A (en) * 2019-11-20 2020-03-31 天津大学 Synthetic method of indole derivatives
EP4076444A4 (en) * 2019-12-18 2024-01-10 Merck Sharp & Dohme LLC INDAZOLE DERIVATIVES AND THEIR METHODS OF USE IN THE TREATMENT OF HERPES VIRUS

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011043429A1 (en) 2009-10-09 2011-04-14 日本電気株式会社 Information management device, data processing method thereof, and computer program

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001502292A (en) * 1995-06-30 2001-02-20 ザイモジェネティクス，インコーポレイティド 4- [2- (N-2-carboxamidoindole) aminoethyl] benzenesulfonamide or sulfonylurea as PDGF antagonist
JP2002167376A (en) * 2000-11-30 2002-06-11 Mercian Corp Indole derivatives having vascular endothelial cell growth factor expression inhibitory action and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001502292A (en) * 1995-06-30 2001-02-20 ザイモジェネティクス，インコーポレイティド 4- [2- (N-2-carboxamidoindole) aminoethyl] benzenesulfonamide or sulfonylurea as PDGF antagonist
JP2002167376A (en) * 2000-11-30 2002-06-11 Mercian Corp Indole derivatives having vascular endothelial cell growth factor expression inhibitory action and uses thereof

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105452257B (en) * 2013-08-12 2017-09-05 大鹏药品工业株式会社 Novel fused pyrimidine compound or its salt
CN105452257A (en) * 2013-08-12 2016-03-30 大鹏药品工业株式会社 Novel fused pyrimidine compound or salt thereof
RU2666349C2 (en) * 2013-08-12 2018-09-07 Тайхо Фармасьютикал Ко., Лтд. Novel fused pyrimidine compound or salt thereof
US9580432B2 (en) 2013-08-12 2017-02-28 Taiho Pharmaceutical Co., Ltd. Fused pyrimidine compound or salt thereof
JPWO2015022926A1 (en) * 2013-08-12 2017-03-02 大鵬薬品工業株式会社 Novel condensed pyrimidine compound or salt thereof
WO2015022926A1 (en) * 2013-08-12 2015-02-19 大鵬薬品工業株式会社 Novel fused pyrimidine compound or salt thereof
US9782412B2 (en) 2015-01-30 2017-10-10 Taiho Pharmaceutical Co., Ltd. Preventive and/or therapeutic agent of immune disease
JPWO2016121953A1 (en) * 2015-01-30 2017-04-27 大鵬薬品工業株式会社 Preventive and / or therapeutic agent for immune disease
RU2705154C2 (en) * 2015-01-30 2019-11-05 Тайхо Фармасьютикал Ко., Лтд. Agent for preventing and/or treating immune disease
WO2016121953A1 (en) * 2015-01-30 2016-08-04 大鵬薬品工業株式会社 Prophylactic and/or therapeutic agent for immune diseases
CN113768935A (en) * 2015-01-30 2021-12-10 大鹏药品工业株式会社 Prophylactic and/or therapeutic agents for immune diseases
CN113768935B (en) * 2015-01-30 2024-10-01 大鹏药品工业株式会社 Preventive and/or therapeutic agent for immune diseases
CN110938027A (en) * 2019-11-20 2020-03-31 天津大学 Synthetic method of indole derivatives
CN110938027B (en) * 2019-11-20 2022-11-25 河北凯诺中星科技有限公司 Synthetic method of indole derivatives
EP4076444A4 (en) * 2019-12-18 2024-01-10 Merck Sharp & Dohme LLC INDAZOLE DERIVATIVES AND THEIR METHODS OF USE IN THE TREATMENT OF HERPES VIRUS

Also Published As

Publication number Publication date
JP2009235057A (en) 2009-10-15

Similar Documents

Publication Publication Date Title
WO2008108378A3 (en) Bicyclic oxomorpholine derivative
WO2008114817A1 (en) Novel adenine compound
NO20084350L (en) Heterocyclic amides for use as pharmaceuticals
UA105185C2 (en) Pyrrols
WO2008087933A1 (en) NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON IϰB KINASE β
JO3259B1 (en) Fused heterocyclic derivative and use thereof
WO2008126901A1 (en) Nitrogen-containing heterocyclic compound and pharmaceutical composition containing the same
WO2008108380A3 (en) Pyrrole compounds
EP1724262A4 (en) DERIVATIVE OF 1- (2H) -ISOQUINOLONE
MY177250A (en) Novel nicotinamide derivative or salt thereof
WO2011004162A3 (en) 1, 2, 4-thiazolidin-3-one derivatives and their use in the treatment of cancer
WO2008108386A1 (en) Pharmaceutical composition
WO2008146871A1 (en) Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein and has glucocorticoid receptor-binding activity
WO2009069736A1 (en) Nitrogenated compound
WO2008114812A1 (en) Jak inhibitor
TW200745034A (en) New compounds
WO2008136444A1 (en) Fused heterocyclic derivative
WO2009154754A3 (en) Synthesis of deuterated morpholine derivatives
MX2010001566A (en) Aminopyrazole amide derivative.
WO2009057733A1 (en) Novel indole derivative having anti-angiogenic activity
WO2008153042A1 (en) Anti-tumor agent
TW200726470A (en) 6,7-unsaturated-7-carbamoylmorphinan derivatives
WO2008136378A1 (en) Novel sulfonamide derivative and salt thereof
MY161992A (en) Novel tetrahydroisoquinoline derivative
TNSN08161A1 (en) 6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08843901

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08843901

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP