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WO2009048081A1 - Method, apparatus and program for diagnosis of fatty liver disease, and method for screening of therapeutic agent for fatty liver disease - Google Patents

Method, apparatus and program for diagnosis of fatty liver disease, and method for screening of therapeutic agent for fatty liver disease Download PDF

Info

Publication number
WO2009048081A1
WO2009048081A1 PCT/JP2008/068308 JP2008068308W WO2009048081A1 WO 2009048081 A1 WO2009048081 A1 WO 2009048081A1 JP 2008068308 W JP2008068308 W JP 2008068308W WO 2009048081 A1 WO2009048081 A1 WO 2009048081A1
Authority
WO
WIPO (PCT)
Prior art keywords
fatty liver
liver disease
disease
diagnosis
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/068308
Other languages
French (fr)
Japanese (ja)
Inventor
Atsushi Nakajima
Masato Yoneda
Koji Fujita
Takushi Nakajima
Hiroki Sasaki
Junichiro Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SKYLIGHT BIOTECH Inc
Yokohama City University
Original Assignee
SKYLIGHT BIOTECH Inc
Yokohama City University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SKYLIGHT BIOTECH Inc, Yokohama City University filed Critical SKYLIGHT BIOTECH Inc
Priority to JP2009537013A priority Critical patent/JPWO2009048081A1/en
Publication of WO2009048081A1 publication Critical patent/WO2009048081A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The object is to diagnose the presence or absence of the occurrence of a fatty liver disease, the degree of progression of a fatty liver disease or the like in a simpler manner compared with conventional liver biopsies. Disclosed is a method for diagnosing a fatty liver disease, which comprises the steps of: analyzing at least one component selected from the group consisting of a chylomicron, a very-low-density lipoprotein, a chylomicron remnant and a very-low-density lipoprotein remnant contained in a sample derived from the blood collected from a subject; and determining the presence or absence of the occurrence of the fatty liver disease, the severity of the disease, or the therapeutic effect against the disease in the subject based on the results of the analysis.
PCT/JP2008/068308 2007-10-12 2008-10-08 Method, apparatus and program for diagnosis of fatty liver disease, and method for screening of therapeutic agent for fatty liver disease Ceased WO2009048081A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009537013A JPWO2009048081A1 (en) 2007-10-12 2008-10-08 Method for diagnosing fatty liver disease, diagnostic device, diagnostic program, and screening method for therapeutic agent for fatty liver disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-266431 2007-10-12
JP2007266431 2007-10-12

Publications (1)

Publication Number Publication Date
WO2009048081A1 true WO2009048081A1 (en) 2009-04-16

Family

ID=40549225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068308 Ceased WO2009048081A1 (en) 2007-10-12 2008-10-08 Method, apparatus and program for diagnosis of fatty liver disease, and method for screening of therapeutic agent for fatty liver disease

Country Status (2)

Country Link
JP (1) JPWO2009048081A1 (en)
WO (1) WO2009048081A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013164755A (en) * 2012-02-10 2013-08-22 Crust Inc Diagnosis support system, diagnosis support program and diagnosis support method
CN111971710A (en) * 2018-03-26 2020-11-20 皇家飞利浦有限公司 Generating spectral inflammation maps from spectral imaging data
CN118425487A (en) * 2024-04-24 2024-08-02 复旦大学附属中山医院 A metabolic-related fatty hepatitis and liver disease death prediction model based on metabolomics and its application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0915225A (en) * 1995-04-28 1997-01-17 Tosoh Corp Method for analyzing serum lipoprotein
JP2002139501A (en) * 2000-10-30 2002-05-17 Mass Medical Kk Method for analyzing and diagnosing lipoprotein subclass
JP2004264051A (en) * 2003-02-07 2004-09-24 Shinichi Usui Analytical method and analytical program for lipoprotein
JP2006349457A (en) * 2005-06-15 2006-12-28 Tokyo Medical & Dental Univ Screening method for non-alcoholic fatty liver treatment
JP2007192746A (en) * 2006-01-20 2007-08-02 Keio Gijuku Determination method of oxidative stress

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0915225A (en) * 1995-04-28 1997-01-17 Tosoh Corp Method for analyzing serum lipoprotein
JP2002139501A (en) * 2000-10-30 2002-05-17 Mass Medical Kk Method for analyzing and diagnosing lipoprotein subclass
JP2004264051A (en) * 2003-02-07 2004-09-24 Shinichi Usui Analytical method and analytical program for lipoprotein
JP2006349457A (en) * 2005-06-15 2006-12-28 Tokyo Medical & Dental Univ Screening method for non-alcoholic fatty liver treatment
JP2007192746A (en) * 2006-01-20 2007-08-02 Keio Gijuku Determination method of oxidative stress

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAURIZIO CASSADER ET AL.: "Postprandial Triglyceride-Rich Lipoprotein Metabolism and Insulin Sensitivity in Nonalcoholic Steatohepatitis Patients", LIPIDS, vol. 36, no. 10, 2001, pages 1117 - 1124 *
MITSUYO OKAZAKI: "Atarashii Kessei Lipo Tanpakushitsu no Bunseki Hoho: Gel Roka HPLC", JOURNAL OF ELECTROPHORESIS, vol. 49, no. 4, 15 December 2005 (2005-12-15), pages 111 - 118 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013164755A (en) * 2012-02-10 2013-08-22 Crust Inc Diagnosis support system, diagnosis support program and diagnosis support method
CN111971710A (en) * 2018-03-26 2020-11-20 皇家飞利浦有限公司 Generating spectral inflammation maps from spectral imaging data
CN118425487A (en) * 2024-04-24 2024-08-02 复旦大学附属中山医院 A metabolic-related fatty hepatitis and liver disease death prediction model based on metabolomics and its application

Also Published As

Publication number Publication date
JPWO2009048081A1 (en) 2011-02-24

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