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WO2009048072A1 - 破骨細胞関連蛋白質Ｓｉｇｌｅｃ－１５を標的とした抗体 - Google Patents

破骨細胞関連蛋白質Ｓｉｇｌｅｃ－１５を標的とした抗体 Download PDF

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Publication number
WO2009048072A1
WO2009048072A1 PCT/JP2008/068287 JP2008068287W WO2009048072A1 WO 2009048072 A1 WO2009048072 A1 WO 2009048072A1 JP 2008068287 W JP2008068287 W JP 2008068287W WO 2009048072 A1 WO2009048072 A1 WO 2009048072A1
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WO
WIPO (PCT)
Prior art keywords
abnormality
related protein
bone metabolism
antibody targeting
protein siglec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/068287
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English (en)
French (fr)
Inventor
Yoshiharu Hiruma
Eisuke Tsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40549216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009048072(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DK08838427.6T priority Critical patent/DK2206727T3/en
Priority to EP08838427.6A priority patent/EP2206727B1/en
Priority to RU2010106639/10A priority patent/RU2475499C2/ru
Priority to SI200831433T priority patent/SI2206727T1/sl
Priority to NZ583397A priority patent/NZ583397A/en
Priority to AU2008311698A priority patent/AU2008311698C1/en
Priority to US12/677,621 priority patent/US8546540B2/en
Priority to ES08838427.6T priority patent/ES2540733T3/es
Priority to JP2009537006A priority patent/JPWO2009048072A1/ja
Priority to BRPI0818437A priority patent/BRPI0818437B8/pt
Priority to KR1020107005095A priority patent/KR101534884B1/ko
Priority to CA2698326A priority patent/CA2698326C/en
Priority to KR1020157004726A priority patent/KR101577935B1/ko
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Priority to PL08838427T priority patent/PL2206727T3/pl
Priority to HRP20150485TT priority patent/HRP20150485T1/hr
Priority to HK11100127.3A priority patent/HK1145847B/en
Priority to MX2010003884A priority patent/MX2010003884A/es
Priority to CN200880110441.XA priority patent/CN101896501B/zh
Publication of WO2009048072A1 publication Critical patent/WO2009048072A1/ja
Priority to IL204607A priority patent/IL204607A/en
Anticipated expiration legal-status Critical
Priority to AU2012201263A priority patent/AU2012201263B9/en
Priority to US13/457,967 priority patent/US9090692B2/en
Priority to US13/481,016 priority patent/US10723800B2/en
Priority to IL234078A priority patent/IL234078B/en
Priority to US14/826,515 priority patent/US9815899B2/en
Priority to US15/729,947 priority patent/US10308715B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
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Abstract

破骨細胞で強く発現する遺伝子を用いた骨代謝異常の検出方法、骨代謝異常治療及び／又は予防効果を有する化合物のスクリーニング法、及び骨代謝異常治療及び／又は予防用医薬組成物を提供すること。ヒトＳｉｇｌｅｃ－１５遺伝子の発現を指標とした骨代謝異常の検出方法、及びヒトＳｉｇｌｅｃ－１５を特異的に認識し、破骨細胞の形成を抑制する活性を有する抗体を含む医薬組成物の提供等。
PCT/JP2008/068287 2007-10-11 2008-10-08 破骨細胞関連蛋白質Ｓｉｇｌｅｃ－１５を標的とした抗体 Ceased WO2009048072A1 (ja)

Priority Applications (25)

Application Number Priority Date Filing Date Title
CA2698326A CA2698326C (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein siglec-15
PL08838427T PL2206727T3 (pl) 2007-10-11 2008-10-08 Przeciwciało skierowane na białko Siglec-15 związane z osteoklastami
RU2010106639/10A RU2475499C2 (ru) 2007-10-11 2008-10-08 Антитело, направленное на белок siglec-15, связанный с остеокластами
SI200831433T SI2206727T1 (sl) 2007-10-11 2008-10-08 Protitelo, ki cilja osteoklast - soroden protein Siglec-15
NZ583397A NZ583397A (en) 2007-10-11 2008-10-08 ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15
AU2008311698A AU2008311698C1 (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein Siglec-15
US12/677,621 US8546540B2 (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein Siglec-15
ES08838427.6T ES2540733T3 (es) 2007-10-11 2008-10-08 Anticuerpo que se dirige a la proteína Siglec-15 relacionada con osteoclastos
JP2009537006A JPWO2009048072A1 (ja) 2007-10-11 2008-10-08 破骨細胞関連蛋白質Ｓｉｇｌｅｃ−１５を標的とした抗体
BRPI0818437A BRPI0818437B8 (pt) 2007-10-11 2008-10-08 anticorpo ou fragmento funcional do anticorpo, composição farmacêutica, uso de pelo menos um dos anticorpos ou fragmentos funcionais dos anticorpos, e, hibridoma
KR1020107005095A KR101534884B1 (ko) 2007-10-11 2008-10-08 파골 세포 관련 단백질 Ｓｉｇｌｅｃ-15 를 표적으로 한 항체
EP08838427.6A EP2206727B1 (en) 2007-10-11 2008-10-08 ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15
KR1020157004726A KR101577935B1 (ko) 2007-10-11 2008-10-08 파골 세포 관련 단백질 Ｓｉｇｌｅｃ-15 를 표적으로 한 항체
DK08838427.6T DK2206727T3 (en) 2007-10-11 2008-10-08 ANTIBODY SPECIFIC TO OSTEOKLASTRELATERET PROTEIN Siglec-15
HK11100127.3A HK1145847B (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein siglec-15
CN200880110441.XA CN101896501B (zh) 2007-10-11 2008-10-08 靶向破骨细胞相关蛋白Siglec‑15的抗体
HRP20150485TT HRP20150485T1 (xx) 2007-10-11 2008-10-08 ANTITIJELA ZA PROTEIN U KORELACIJI SA OSTEOPLASTOM Siglec
MX2010003884A MX2010003884A (es) 2007-10-11 2008-10-08 Anticuerpo dirigido a la proteina lecitina similar a inmunoglobulina de union a acido sialico-15 relacionado con osteoclastos.
IL204607A IL204607A (en) 2007-10-11 2010-03-18 Anti-protein 15 siglec antagonists - osteoclast-related preparations containing them and their uses
AU2012201263A AU2012201263B9 (en) 2007-10-11 2012-02-27 Antibody targeting osteoclast-related protein Siglec-15
US13/457,967 US9090692B2 (en) 2007-10-11 2012-04-27 Antibody targeting osteoclast-related protein Siglec-15
US13/481,016 US10723800B2 (en) 2007-10-11 2012-05-25 Antibody targeting osteoclast-related protein siglec-15
IL234078A IL234078B (en) 2007-10-11 2014-08-12 Polynucleotides encoding antibodies against osteoclast-associated protein Siglec-15
US14/826,515 US9815899B2 (en) 2007-10-11 2015-08-14 Antibody targeting osteoclast-related protein siglec-15
US15/729,947 US10308715B2 (en) 2007-10-11 2017-10-11 Antibody targeting osteoclast-related protein Siglec-15

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-265420 2007-10-11
JP2007265420 2007-10-11

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US12/677,621 A-371-Of-International US8546540B2 (en) 2007-10-11 2008-10-08 Antibody targeting osteoclast-related protein Siglec-15
US13/457,967 Continuation US9090692B2 (en) 2007-10-11 2012-04-27 Antibody targeting osteoclast-related protein Siglec-15
US13/481,016 Continuation US10723800B2 (en) 2007-10-11 2012-05-25 Antibody targeting osteoclast-related protein siglec-15

Publications (1)

Publication Number Publication Date
WO2009048072A1 true WO2009048072A1 (ja) 2009-04-16

Family

ID=40549216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068287 Ceased WO2009048072A1 (ja) 2007-10-11 2008-10-08 破骨細胞関連蛋白質Ｓｉｇｌｅｃ－１５を標的とした抗体

Country Status (24)

Country Link
US (5) US8546540B2 (ja)
EP (2) EP2907826B1 (ja)
JP (4) JPWO2009048072A1 (ja)
KR (2) KR101577935B1 (ja)
CN (2) CN108130327A (ja)
AU (2) AU2008311698C1 (ja)
BR (1) BRPI0818437B8 (ja)
CA (2) CA2698326C (ja)
CY (1) CY1116432T1 (ja)
DK (1) DK2206727T3 (ja)
ES (2) ES2677246T3 (ja)
HR (1) HRP20150485T1 (ja)
HU (1) HUE025262T2 (ja)
IL (2) IL204607A (ja)
MX (1) MX2010003884A (ja)
NZ (1) NZ583397A (ja)
PL (1) PL2206727T3 (ja)
PT (1) PT2206727E (ja)
RU (2) RU2475499C2 (ja)
SG (2) SG187523A1 (ja)
SI (1) SI2206727T1 (ja)
TW (1) TWI511740B (ja)
WO (1) WO2009048072A1 (ja)
ZA (1) ZA201001339B (ja)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010117011A1 (ja) 2009-04-09 2010-10-14 第一三共株式会社 抗Ｓｉｇｌｅｃ－１５抗体
US7989160B2 (en) 2006-02-13 2011-08-02 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
WO2012045481A2 (en) 2010-10-05 2012-04-12 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein siglec-15
WO2012050154A1 (ja) * 2010-10-13 2012-04-19 学校法人 東京女子医科大学 抗vdac抗体を含有する破骨細胞形成抑制剤
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
WO2013147212A1 (ja) 2012-03-30 2013-10-03 第一三共株式会社 新規抗Ｓｉｇｌｅｃ－１５抗体
WO2013147213A1 (ja) 2012-03-30 2013-10-03 第一三共株式会社 ＣＤＲ改変抗Ｓｉｇｌｅｃ－１５抗体
JP2014527804A (ja) * 2011-09-09 2014-10-23 メディミューン リミテッド 抗Ｓｉｇｌｅｃ−１５抗体およびその使用
US8980272B2 (en) 2004-02-12 2015-03-17 Sankyo Company, Limited Antibody targeting osteoclast-associated protein
WO2015046505A1 (ja) 2013-09-30 2015-04-02 第一三共株式会社 抗ｌｐｓ ｏ１１抗体
US9493562B2 (en) 2012-07-19 2016-11-15 Alethia Biotherapeutics Inc. Anti-Siglec-15 antibodies
US9815899B2 (en) 2007-10-11 2017-11-14 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein siglec-15
WO2018147245A1 (ja) 2017-02-07 2018-08-16 第一三共株式会社 抗ｇｐｒｃ５ｄ抗体及び該抗体を含む分子
WO2018181656A1 (ja) 2017-03-30 2018-10-04 第一三共株式会社 抗ｇｐｒ２０抗体
WO2019004487A1 (ja) 2017-06-30 2019-01-03 国立大学法人北海道大学 成長障害を生じない小児骨粗鬆症治療薬
WO2019022187A1 (ja) 2017-07-27 2019-01-31 第一三共株式会社 抗ｃｄ１４７抗体
WO2019230869A1 (ja) 2018-05-31 2019-12-05 第一三共株式会社 抗ヒトｔｌｒ７抗体
WO2020022475A1 (ja) 2018-07-27 2020-01-30 第一三共株式会社 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質
CN112625132A (zh) * 2021-01-15 2021-04-09 沈阳荣欣生物制药科技有限公司 纳米抗体及其编码基因、表达载体、宿主细胞和应用
EP4180455A1 (en) 2015-06-29 2023-05-17 Daiichi Sankyo Company, Limited Method for selectively manufacturing antibody-drug conjugate

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015150326A1 (en) * 2014-03-31 2015-10-08 Universiteit Gent A method of treating bone disease
EP3373962A4 (en) * 2015-11-10 2020-02-19 Yale University COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES AND CANCER DISEASES
EP4360714A3 (en) * 2016-09-21 2024-07-24 Nextcure, Inc. Antibodies for siglec-15 and methods of use thereof
US11390675B2 (en) 2016-09-21 2022-07-19 Nextcure, Inc. Antibodies for Siglec-15 and methods of use thereof
US12172108B2 (en) 2018-08-16 2024-12-24 Emd Millipore Corporation Closed bioprocessing device
CN111378043B (zh) * 2020-02-19 2021-02-09 南京医科大学 一种具有中和作用的人鼠嵌合抗Siglec-15全分子IgG及其制备方法和应用
CN112159475B (zh) * 2020-10-10 2021-04-30 南京凯地生物科技有限公司 Siglec-15单克隆抗体及其应用
CN114957468A (zh) * 2021-02-25 2022-08-30 石药集团巨石生物制药有限公司 一种抗Siglec15抗体及其用途
CN112979761B (zh) * 2021-03-19 2021-12-10 江苏元本生物科技有限公司 一种靶向Siglec-15的噬菌体多肽
CN112961214B (zh) * 2021-03-19 2022-08-02 江苏元本生物科技有限公司 一种靶向Siglec-15的噬菌体多肽
CN113577283A (zh) * 2021-07-19 2021-11-02 河北医科大学第三医院 Siglec-15抑制剂在制备防治骨巨细胞瘤药物中的应用
CN114807052A (zh) * 2022-06-07 2022-07-29 江苏亲科生物研究中心有限公司 Siglec15单克隆抗体及其制备方法和用途
WO2024022008A1 (zh) * 2022-07-26 2024-02-01 北京东方百泰生物科技股份有限公司 一种抗Siglec-15单克隆抗体、其抗原结合片段及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064771A1 (fr) * 2001-02-15 2002-08-22 Mochida Pharmaceutical Co., Ltd. Nouvelle molecule d'adhesion cellulaire specifique de leucocyte active
WO2003048305A2 (en) * 2001-11-13 2003-06-12 Incyte Genomics, Inc. Receptors and membrane-associated proteins
JP2007020403A (ja) * 2005-07-12 2007-02-01 National Institute Of Advanced Industrial & Technology 新規糖鎖認識蛋白質及びその遺伝子
WO2007093042A1 (en) * 2006-02-13 2007-08-23 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5116828A (en) * 1989-10-26 1992-05-26 Nippon Zoki Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of osteoporosis
AU665190B2 (en) 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE181571T1 (de) 1991-09-23 1999-07-15 Medical Res Council Methoden zur herstellung humanisierter antikörper
US5885793A (en) 1991-12-02 1999-03-23 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
US5660827A (en) * 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
JP3507073B2 (ja) 1992-03-24 2004-03-15 ケンブリッジ アンティボディー テクノロジー リミティド 特異的結合対の成員の製造方法
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
EP0731842A1 (en) 1993-12-03 1996-09-18 Medical Research Council Recombinant binding proteins and peptides
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
DE19653646A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
NZ332995A (en) 1997-04-15 2000-07-28 Snow Brand Milk Products Co Ltd A protein which binds to osteoclastogenesis inhibitory factor (OCIF)
CA2331998A1 (en) 1998-05-08 1999-11-18 Toyama Chemical Co., Ltd. Novel spiro compounds or salts thereof and preventives/remedies for autoimmune diseases and ap-1 inhibitors containing the same
AU2002224546A1 (en) * 2000-07-21 2002-02-05 Bristol-Myers Squibb Company Siglec (sialic acid-binding IG-related lectin) polypeptides and uses thereof
US7608704B2 (en) * 2000-11-08 2009-10-27 Incyte Corporation Secreted proteins
WO2002038602A2 (en) 2000-11-08 2002-05-16 Incyte Genomics, Inc. Secreted proteins
EP3492100B1 (en) 2001-06-26 2021-12-08 Amgen Inc. Antibodies to opgl
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
CA2481074A1 (en) 2002-04-05 2003-10-23 Amgen Inc. Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors
MXPA05006724A (es) 2003-01-07 2005-09-08 Symphogen As Metodo para producir proteinas policlonales recombinantes.
JP4633491B2 (ja) * 2004-02-12 2011-02-16 第一三共株式会社 破骨細胞関連タンパク質を標的とした抗体
TWI359026B (en) 2004-02-12 2012-03-01 Sankyo Co Pharmaceutical composition for the osteoclast rela
US7405037B2 (en) 2004-05-07 2008-07-29 Lonza Walkersville, Inc. Methods and tools for detecting collagen degradation
CN101035807A (zh) * 2004-06-09 2007-09-12 泰勒公司 Siglec－6相关疾病的诊断和治疗
GB0521991D0 (en) * 2005-10-28 2005-12-07 Univ Dundee Siglec-9 binding agents
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
RU2475499C2 (ru) 2007-10-11 2013-02-20 Дайити Санкио Компани, Лимитед Антитело, направленное на белок siglec-15, связанный с остеокластами
BRPI1006134A2 (pt) 2009-04-09 2016-02-23 Daiichi Sankyo Co Ltd anticorpo ou um fragmento funcional do anticorpo, composição farmacêutica, uso de um anticorpo ou um fragmento funcional do mesmo, polinucleotídeo, vetor, e, célula hospedeira transformada.
EP2585349B1 (fr) 2010-06-23 2014-12-31 Creissels Technologies Installation a cables aeriens et a vehicule asservi, sans suspente
TW201219568A (en) 2010-10-05 2012-05-16 Daiichi Sankyo Co Ltd Antibody targeting osteoclast-related protein Siglec-15
NZ631509A (en) 2012-03-30 2016-09-30 Daiichi Sankyo Co Ltd Cdr-modified anti-siglec-15 antibody
JPWO2013147212A1 (ja) 2012-03-30 2015-12-14 第一三共株式会社 新規抗Ｓｉｇｌｅｃ−１５抗体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064771A1 (fr) * 2001-02-15 2002-08-22 Mochida Pharmaceutical Co., Ltd. Nouvelle molecule d'adhesion cellulaire specifique de leucocyte active
WO2003048305A2 (en) * 2001-11-13 2003-06-12 Incyte Genomics, Inc. Receptors and membrane-associated proteins
JP2007020403A (ja) * 2005-07-12 2007-02-01 National Institute Of Advanced Industrial & Technology 新規糖鎖認識蛋白質及びその遺伝子
WO2007093042A1 (en) * 2006-02-13 2007-08-23 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANGATA, T. ET AL.: "Siglec-15: an immune system Siglec conserved throughtout vertebrate evolution", GLYCOBIOLOGY, vol. 17, no. 8, August 2007 (2007-08-01), pages 838 - 846, XP002617540 *
EISUKE TSUDA: "Hone Kyushu Yokuseiyaku Koho to shite no Hakotsu Saibo Keisei Yokusei Inshi OCIF/OPG, Ko-RANKL Kotai, Oyobi sono Hoka no RANKL/RANK System Modulator", J.JPN.ORTHOP. ASSOC., vol. 79, no. 8, 2005, XP008141150 *
See also references of EP2206727A1 *

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980272B2 (en) 2004-02-12 2015-03-17 Sankyo Company, Limited Antibody targeting osteoclast-associated protein
US7989160B2 (en) 2006-02-13 2011-08-02 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
US9695419B2 (en) 2006-02-13 2017-07-04 Daiichi Sankyo Company, Limited Polynucleotides and polypeptide sequences involved in the process of bone remodeling
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
US9067984B2 (en) 2006-02-13 2015-06-30 Alethia Biotherapeutics Inc. Methods of impairing osteoclast differentiation using antibodies that bind Siglec-15
US9040246B2 (en) 2006-02-13 2015-05-26 Alethia Biotherapeutics Inc. Methods of making antibodies that bind polypeptides involved in the process of bone remodeling
US8431126B2 (en) 2006-02-13 2013-04-30 Alethia Biotherapeutics Inc. Antibodies that bind polypeptides involved in the process of bone remodeling
US8540988B2 (en) 2006-02-13 2013-09-24 Alethia Biotherapeutics Inc. Antibodies that bind polypeptides involved in the process of bone remodeling
US10308715B2 (en) 2007-10-11 2019-06-04 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein Siglec-15
US9815899B2 (en) 2007-10-11 2017-11-14 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein siglec-15
US9079959B2 (en) 2009-04-09 2015-07-14 Daiichi Sankyo Company, Limited Methods of administering anti-Siglec-15 antibody
EP3699277A1 (en) 2009-04-09 2020-08-26 Daiichi Sankyo Company, Limited Anti-siglec-15 antibody
US8575316B2 (en) 2009-04-09 2013-11-05 Daiichi Sankyo Company, Limited Anti-Siglec-15 antibody
WO2010117011A1 (ja) 2009-04-09 2010-10-14 第一三共株式会社 抗Ｓｉｇｌｅｃ－１５抗体
EP2377932A4 (en) * 2009-04-09 2013-04-24 Daiichi Sankyo Co Ltd ANTI-Siglec-15 ANTIBODY
AU2010235453B2 (en) * 2009-04-09 2013-10-03 Daiichi Sankyo Company,Limited Anti-Siglec-15 antibody
US9751944B2 (en) 2009-04-09 2017-09-05 Daiichi Sankyo Company, Limited Anti-Siglec-15 antibody
USRE47672E1 (en) 2009-10-06 2019-10-29 Daiichi Sankyo Company, Limited Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
JP2016040324A (ja) * 2009-10-06 2016-03-24 アレシア・バイオセラピューティクス・インコーポレーテッド 破骨細胞特異的抗原の生物学的活性を特異的にブロックする抗体
US8900579B2 (en) 2009-10-06 2014-12-02 Alethia Biotherapuetics Inc. Siglec-15 antibodies in treating bone loss-related disease
AU2010305281B2 (en) * 2009-10-06 2014-06-12 Alethia Biotherapeutics Inc. Siglec 15 antibodies in treating bone loss-related disease
US9617337B2 (en) 2009-10-06 2017-04-11 Daiichi Sankyo Company, Limited Siglec-15 antibodies in treating bone loss-related disease
US8741289B2 (en) 2009-10-06 2014-06-03 Alethia Biotherapeutics Inc. Siglec 15 antibodies in treating bone loss-related disease
JP2013506428A (ja) * 2009-10-06 2013-02-28 アレシア・バイオセラピューティクス・インコーポレーテッド 破骨細胞特異的抗原の生物学的活性を特異的にブロックする抗体
AU2010305281C1 (en) * 2009-10-06 2014-12-04 Alethia Biotherapeutics Inc. Siglec 15 antibodies in treating bone loss-related disease
RU2596392C2 (ru) * 2009-10-06 2016-09-10 Алетиа Байотерапьютикс Инк. Антитела против сиглека-15 для лечения заболевания, связанного с потерей костной массы
US9388242B2 (en) 2009-10-06 2016-07-12 Alethia Biotherapeutics Inc. Nucleic acids encoding anti-Siglec-15 antibodies
WO2012045481A2 (en) 2010-10-05 2012-04-12 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein siglec-15
JP2013543382A (ja) * 2010-10-05 2013-12-05 第一三共株式会社 破骨細胞関連蛋白質Ｓｉｇｌｅｃ−１５を標的とした抗体
US9114131B2 (en) 2010-10-05 2015-08-25 Daiichi Sankyo Company, Limited Antibody targeting osteoclast-related protein Siglec-15
WO2012050154A1 (ja) * 2010-10-13 2012-04-19 学校法人 東京女子医科大学 抗vdac抗体を含有する破骨細胞形成抑制剤
JP2014527804A (ja) * 2011-09-09 2014-10-23 メディミューン リミテッド 抗Ｓｉｇｌｅｃ−１５抗体およびその使用
JP2017101032A (ja) * 2011-09-09 2017-06-08 メディミューン リミテッド 抗Ｓｉｇｌｅｃ−１５抗体およびその使用
US9994636B2 (en) 2011-09-09 2018-06-12 Medimmune Limited Anti-Siglec-15 antibodies and uses thereof
JPWO2013147212A1 (ja) * 2012-03-30 2015-12-14 第一三共株式会社 新規抗Ｓｉｇｌｅｃ−１５抗体
WO2013147212A1 (ja) 2012-03-30 2013-10-03 第一三共株式会社 新規抗Ｓｉｇｌｅｃ－１５抗体
US9464133B2 (en) 2012-03-30 2016-10-11 Daiichi Sankyo Company, Limited CDR-modified anti-Siglec-15 antibody
JPWO2013147213A1 (ja) * 2012-03-30 2015-12-14 第一三共株式会社 ＣＤＲ改変抗Ｓｉｇｌｅｃ−１５抗体
WO2013147213A1 (ja) 2012-03-30 2013-10-03 第一三共株式会社 ＣＤＲ改変抗Ｓｉｇｌｅｃ－１５抗体
CN104321430A (zh) * 2012-03-30 2015-01-28 第一三共株式会社 新颖的抗-siglec-15抗体
US9493562B2 (en) 2012-07-19 2016-11-15 Alethia Biotherapeutics Inc. Anti-Siglec-15 antibodies
WO2015046505A1 (ja) 2013-09-30 2015-04-02 第一三共株式会社 抗ｌｐｓ ｏ１１抗体
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WO2018147245A1 (ja) 2017-02-07 2018-08-16 第一三共株式会社 抗ｇｐｒｃ５ｄ抗体及び該抗体を含む分子
WO2018181656A1 (ja) 2017-03-30 2018-10-04 第一三共株式会社 抗ｇｐｒ２０抗体
WO2019004487A1 (ja) 2017-06-30 2019-01-03 国立大学法人北海道大学 成長障害を生じない小児骨粗鬆症治療薬
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