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WO2009043014A3 - Devices for studying cancer invasion and migration - Google Patents

Devices for studying cancer invasion and migration Download PDF

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Publication number
WO2009043014A3
WO2009043014A3 PCT/US2008/078140 US2008078140W WO2009043014A3 WO 2009043014 A3 WO2009043014 A3 WO 2009043014A3 US 2008078140 W US2008078140 W US 2008078140W WO 2009043014 A3 WO2009043014 A3 WO 2009043014A3
Authority
WO
WIPO (PCT)
Prior art keywords
chip
migration
devices
well
studying cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/078140
Other languages
French (fr)
Other versions
WO2009043014A2 (en
Inventor
Wei Li
Biaoyang Lin
Hai Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Publication of WO2009043014A2 publication Critical patent/WO2009043014A2/en
Publication of WO2009043014A3 publication Critical patent/WO2009043014A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A medical testing device is formed from a polymeric chip. The device comprises a first well in the chip; a second well in the chip; and a microcellular porous foam in the chip, wherein the first well is connected to the second well through the microcellular porous foam and the microcellular porous foam is formed from the material of the polymeric chip. The device is useful for studying cancer cell migration and invasion. Methods for using the device for cell migration, invasion assays, and methods for making the device are also disclosed.
PCT/US2008/078140 2007-09-27 2008-09-29 Devices for studying cancer invasion and migration Ceased WO2009043014A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97574607P 2007-09-27 2007-09-27
US60/975,746 2007-09-27

Publications (2)

Publication Number Publication Date
WO2009043014A2 WO2009043014A2 (en) 2009-04-02
WO2009043014A3 true WO2009043014A3 (en) 2009-05-14

Family

ID=40512127

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/078140 Ceased WO2009043014A2 (en) 2007-09-27 2008-09-29 Devices for studying cancer invasion and migration

Country Status (1)

Country Link
WO (1) WO2009043014A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102507938B (en) * 2011-10-08 2014-12-24 复旦大学附属中山医院 Liver cancer metastasis prognosis quantitative antibody chip and reagent kit
CN112646713A (en) * 2020-12-25 2021-04-13 中国科学院广州生物医药与健康研究院 Chip for integrated tumor cell behavior experiment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921660B2 (en) * 2000-11-08 2005-07-26 Surface Logix, Inc. Cell motility and chemotaxis test device and methods of using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921660B2 (en) * 2000-11-08 2005-07-26 Surface Logix, Inc. Cell motility and chemotaxis test device and methods of using same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HAI WANG ET AL.: "A novel 3D porous micromixer fabricated using selective ultrasonic foaming.", JOURNAL OF MICROMECHANICS AND MICROENGINEERING., vol. 17, no. 9, 10 August 2007 (2007-08-10), pages 1835 - 1842 *
J. M. GODDARD ET AL.: "Polymer surface modification for the attachment of bioactive compounds.", PROGRESS IN POLYMER SCIENCE., vol. 32, no. 7, July 2007 (2007-07-01), pages 698 - 725 *
K. C. CHAQ ET AL.: "Matrigel coated polydimethylsiloxane based microfluidic devices for studying metastatic and non-metastatic cancer cell invasion migration.", BIOMEDICAL MICRODEVICES., vol. 9, no. 4, August 2007 (2007-08-01), pages 597 - 602 *

Also Published As

Publication number Publication date
WO2009043014A2 (en) 2009-04-02

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