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WO2008139484A3 - New process for the synthesis of loferpramine maleate: a stable salt of loferpramine - Google Patents

New process for the synthesis of loferpramine maleate: a stable salt of loferpramine Download PDF

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Publication number
WO2008139484A3
WO2008139484A3 PCT/IN2007/000195 IN2007000195W WO2008139484A3 WO 2008139484 A3 WO2008139484 A3 WO 2008139484A3 IN 2007000195 W IN2007000195 W IN 2007000195W WO 2008139484 A3 WO2008139484 A3 WO 2008139484A3
Authority
WO
WIPO (PCT)
Prior art keywords
loferpramine
maleate
lofepramine
synthesis
stable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2007/000195
Other languages
French (fr)
Other versions
WO2008139484A2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R L FINE CHEM
Ramesha A R
Roy A K
Original Assignee
R L FINE CHEM
Ramesha A R
Roy A K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R L FINE CHEM, Ramesha A R, Roy A K filed Critical R L FINE CHEM
Priority to PCT/IN2007/000195 priority Critical patent/WO2008139484A2/en
Publication of WO2008139484A2 publication Critical patent/WO2008139484A2/en
Publication of WO2008139484A3 publication Critical patent/WO2008139484A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention relates to a stable salt of Lofepramine and A process for the synthesis of stable Lofepramine maleate comprising; dissolving maleic acid in ethyl acetate by warming and the solution is then filtered hot; adding purified Lofepramine base to the said clear solution of maleic acid and heated upto about 40-60°C; filtering the precipitates of Lofepramine maleate; drying the said precipitates at 45 to 55°C to obtain Lofepramine maleate.
PCT/IN2007/000195 2007-05-16 2007-05-16 New process for the synthesis of loferpramine maleate: a stable salt of loferpramine Ceased WO2008139484A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IN2007/000195 WO2008139484A2 (en) 2007-05-16 2007-05-16 New process for the synthesis of loferpramine maleate: a stable salt of loferpramine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2007/000195 WO2008139484A2 (en) 2007-05-16 2007-05-16 New process for the synthesis of loferpramine maleate: a stable salt of loferpramine

Publications (2)

Publication Number Publication Date
WO2008139484A2 WO2008139484A2 (en) 2008-11-20
WO2008139484A3 true WO2008139484A3 (en) 2009-09-24

Family

ID=40002736

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000195 Ceased WO2008139484A2 (en) 2007-05-16 2007-05-16 New process for the synthesis of loferpramine maleate: a stable salt of loferpramine

Country Status (1)

Country Link
WO (1) WO2008139484A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110446495B (en) 2017-02-17 2023-09-05 特维娜有限公司 Delta opioid receptor modulating compounds containing 7-membered aza heterocycles and methods of use and preparation thereof
EP4295864A3 (en) 2018-09-28 2024-03-13 Research Institute at Nationwide Children's Hospital Phenylpropionic acid derivatives for modulating pathogen activity
WO2022093904A1 (en) * 2020-10-27 2022-05-05 Trevena, Inc. Crystalline and amorphous forms of a delta-opioid modulator

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0575370B1 (en) * 1991-03-13 1996-04-24 SCHULER, Wilhelm Process for the purification of lofepramine by crystallisation
WO2003015699A2 (en) * 2001-08-17 2003-02-27 Epicept Corporation Topical compositions and methods for treating pain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0575370B1 (en) * 1991-03-13 1996-04-24 SCHULER, Wilhelm Process for the purification of lofepramine by crystallisation
WO2003015699A2 (en) * 2001-08-17 2003-02-27 Epicept Corporation Topical compositions and methods for treating pain

Also Published As

Publication number Publication date
WO2008139484A2 (en) 2008-11-20

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