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WO2008134289A3 - High relaxivity coordinatively unsaturated lanthanide complexes - Google Patents

High relaxivity coordinatively unsaturated lanthanide complexes Download PDF

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Publication number
WO2008134289A3
WO2008134289A3 PCT/US2008/061078 US2008061078W WO2008134289A3 WO 2008134289 A3 WO2008134289 A3 WO 2008134289A3 US 2008061078 W US2008061078 W US 2008061078W WO 2008134289 A3 WO2008134289 A3 WO 2008134289A3
Authority
WO
WIPO (PCT)
Prior art keywords
lanthanide complexes
coordinatively unsaturated
high relaxivity
unsaturated lanthanide
relaxivity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/061078
Other languages
French (fr)
Other versions
WO2008134289A2 (en
Inventor
Dennis A Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of WO2008134289A2 publication Critical patent/WO2008134289A2/en
Publication of WO2008134289A3 publication Critical patent/WO2008134289A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention is directed to tetraazamacrocyclic compounds and lanthanide complexes thereof useful as MRI contrast agents having enhanced relaxivity.
PCT/US2008/061078 2007-04-26 2008-04-22 High relaxivity coordinatively unsaturated lanthanide complexes Ceased WO2008134289A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91405407P 2007-04-26 2007-04-26
US60/914,054 2007-04-26

Publications (2)

Publication Number Publication Date
WO2008134289A2 WO2008134289A2 (en) 2008-11-06
WO2008134289A3 true WO2008134289A3 (en) 2008-12-11

Family

ID=39760993

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/061078 Ceased WO2008134289A2 (en) 2007-04-26 2008-04-22 High relaxivity coordinatively unsaturated lanthanide complexes

Country Status (1)

Country Link
WO (1) WO2008134289A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11191854B2 (en) 2017-05-05 2021-12-07 Centre For Probe Development And Commercialization Pharmacokinetic enhancements of bifunctional chelates and uses thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012151539A2 (en) * 2011-05-05 2012-11-08 New York University Lanthanoid complex capsule and particle contrast agents, methods of making and using thereof
WO2015142583A1 (en) 2014-03-17 2015-09-24 The Board Of Regents Of The University Of Texas System New gadolinium-based contrast agents for sensitive detection of zn2+ with mri
WO2018204872A2 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
CN114573609B (en) * 2022-03-07 2024-02-06 桂林理工大学 Single-molecule magnet based on asymmetric binuclear dysprosium complex and preparation method thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
CA2055093A1 (en) * 1990-11-08 1992-05-09 Johannes Platzek Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivatives
WO1995024221A1 (en) * 1986-08-18 1995-09-14 The Dow Chemical Company Bioactive and/or targeted dendrimer conjugates
WO1995028392A1 (en) * 1994-04-14 1995-10-26 Nycomed Salutar Inc. Chelant compounds
WO1996011023A1 (en) * 1994-10-10 1996-04-18 Nycomed Salutar Inc. Liposomal agents
WO1996028433A1 (en) * 1995-03-10 1996-09-19 Nycomed Imaging A.S Polyazacycloalkane compounds
WO2005062828A2 (en) * 2003-12-23 2005-07-14 Bracco Imaging S.P.A. New compounds useful as metal chelators
WO2008073828A2 (en) * 2006-12-08 2008-06-19 Northwestern University Compositions and methods for magnetic resonance imaging contrast agents
WO2008098056A2 (en) * 2007-02-06 2008-08-14 Epix Pharmaceuticals, Inc. High relaxivity chelates

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024221A1 (en) * 1986-08-18 1995-09-14 The Dow Chemical Company Bioactive and/or targeted dendrimer conjugates
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
CA2055093A1 (en) * 1990-11-08 1992-05-09 Johannes Platzek Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivatives
WO1995028392A1 (en) * 1994-04-14 1995-10-26 Nycomed Salutar Inc. Chelant compounds
WO1996011023A1 (en) * 1994-10-10 1996-04-18 Nycomed Salutar Inc. Liposomal agents
WO1996028433A1 (en) * 1995-03-10 1996-09-19 Nycomed Imaging A.S Polyazacycloalkane compounds
WO2005062828A2 (en) * 2003-12-23 2005-07-14 Bracco Imaging S.P.A. New compounds useful as metal chelators
WO2008073828A2 (en) * 2006-12-08 2008-06-19 Northwestern University Compositions and methods for magnetic resonance imaging contrast agents
WO2008098056A2 (en) * 2007-02-06 2008-08-14 Epix Pharmaceuticals, Inc. High relaxivity chelates

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DESSOLIN J ET AL: "Tri-N-Boc-tetraazamacrocycle-nucleoside conjugates: synthesis and anti-HI activities", NUCLEOSIDES & NUCLEOTIDES, vol. 17, no. 5, 13 April 1998 (1998-04-13), pages 957 - 968, XP002094374, ISSN: 0732-8311 *
KARFELD L S ET AL: "Use of a genetically engineered protein for the design of a multivalent MRI contrast agent", BIOCONJUGATE CHEMISTRY, vol. 18, no. 6, November 2007 (2007-11-01), pages 1697 - 1700, XP009106214, ISSN: 1043-1802 *
ZECH S G ET AL: "Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopy", CHEMPHYSCHEM - A EUROPEAN JOURNAL OF CHEMICAL PHYSICS & PHYSICALCHEMISTRY, vol. 6, no. 12, December 2005 (2005-12-01), pages 2570 - 2577, XP009105424, ISSN: 1439-4235 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11191854B2 (en) 2017-05-05 2021-12-07 Centre For Probe Development And Commercialization Pharmacokinetic enhancements of bifunctional chelates and uses thereof

Also Published As

Publication number Publication date
WO2008134289A2 (en) 2008-11-06

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