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WO2008133329A1 - Pomc遺伝子解析による薬物感受性の評価方法 - Google Patents

Pomc遺伝子解析による薬物感受性の評価方法 Download PDF

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Publication number
WO2008133329A1
WO2008133329A1 PCT/JP2008/058083 JP2008058083W WO2008133329A1 WO 2008133329 A1 WO2008133329 A1 WO 2008133329A1 JP 2008058083 W JP2008058083 W JP 2008058083W WO 2008133329 A1 WO2008133329 A1 WO 2008133329A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug sensitivity
evaluation
analysis
pomc gene
pomc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/058083
Other languages
English (en)
French (fr)
Inventor
Kazutaka Ikeda
Shinya Kasai
Masakazu Hayashida
Susumu Higuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo Metropolitan Organization for Medical Research
Original Assignee
Tokyo Metropolitan Organization for Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Metropolitan Organization for Medical Research filed Critical Tokyo Metropolitan Organization for Medical Research
Priority to US12/597,028 priority Critical patent/US20100240552A1/en
Priority to AT08764247T priority patent/ATE555197T1/de
Priority to EP08764247A priority patent/EP2151496B1/en
Priority to JP2009511918A priority patent/JPWO2008133329A1/ja
Publication of WO2008133329A1 publication Critical patent/WO2008133329A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

　本発明は、薬物感受性の個人差を、POMC遺伝子の遺伝子多型を用いて予測する方法、すなわち、POMC遺伝子の遺伝子多型と、個体の薬物感受性とを関連づけることを特徴とする、薬物感受性の評価方法を提供する。
PCT/JP2008/058083 2007-04-25 2008-04-25 Pomc遺伝子解析による薬物感受性の評価方法 Ceased WO2008133329A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/597,028 US20100240552A1 (en) 2007-04-25 2008-04-25 Method for evaluation of drug sensitivity by analysis of pomc gene
AT08764247T ATE555197T1 (de) 2007-04-25 2008-04-25 Verfahren zur evaluierung der wirkstoffsensitivität mittels analyse des pomc- gens
EP08764247A EP2151496B1 (en) 2007-04-25 2008-04-25 Method for evaluation of drug sensitivity by analysis of pomc gene
JP2009511918A JPWO2008133329A1 (ja) 2007-04-25 2008-04-25 Ｐｏｍｃ遺伝子解析による薬物感受性の評価方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007114968 2007-04-25
JP2007-114968 2007-04-25

Publications (1)

Publication Number Publication Date
WO2008133329A1 true WO2008133329A1 (ja) 2008-11-06

Family

ID=39925775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/058083 Ceased WO2008133329A1 (ja) 2007-04-25 2008-04-25 Pomc遺伝子解析による薬物感受性の評価方法

Country Status (5)

Country Link
US (1) US20100240552A1 (ja)
EP (1) EP2151496B1 (ja)
JP (1) JPWO2008133329A1 (ja)
AT (1) ATE555197T1 (ja)
WO (1) WO2008133329A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102549171A (zh) * 2009-10-07 2012-07-04 学校法人武库川学院 基因型的判断方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3483288B1 (en) 2011-11-30 2022-03-16 Children's Hospital Medical Center Personalized pain management and anesthesia: preemptive risk identification
CA2940422A1 (en) 2014-02-24 2015-08-27 Children's Hospital Medical Center Methods and compositions for personalized pain management
US11618924B2 (en) 2017-01-20 2023-04-04 Children's Hospital Medical Center Methods and compositions relating to OPRM1 DNA methylation for personalized pain management

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007114968A (ja) 2005-10-19 2007-05-10 Junji Mizuma バッテリの充電システムおよび充電方法
WO2007070252A2 (en) * 2005-11-30 2007-06-21 The University Of North Carolina At Chapel Hill Identification of genetic polymorphic variants associated with somatosensory disorders and methods of using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007114968A (ja) 2005-10-19 2007-05-10 Junji Mizuma バッテリの充電システムおよび充電方法
WO2007070252A2 (en) * 2005-11-30 2007-06-21 The University Of North Carolina At Chapel Hill Identification of genetic polymorphic variants associated with somatosensory disorders and methods of using the same

Non-Patent Citations (20)

* Cited by examiner, † Cited by third party
Title
BAKER, M. ET AL.: "Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study", DIABETES, vol. 54, 2005, pages 2492 - 6
BIENERTOVA-VASKU, J. A. ET AL.: "Proopiomelanocortin gene: a new susceptibility gene for cutaneous T-cell lymphoma", PROC. EUR. SOC. DERMATOL. RES., 2006, pages 33
BLOMQVIST O. ET AL.: "Pro-opiomelanocortin (POMC) gene polymorphism and association with alcohol and/or drug dependence", ALCOHOLISM CLINICAL AND EXPERIMENTAL RESEARCH, vol. 24, no. 5, SUPPL., 2000, pages 25A, XP008123073 *
CHEN Y. ET AL.: "Pro-opiomelanocortin gene variants are associated with serum leptin and body fat in a normal femal population", EUR. J. HUM. GENET., vol. 13, 2005, pages 772 - 780, XP008123069 *
CHEN, Y. ET AL., EUR. J. HUM. GENET., vol. 13, 2005, pages 772 - 80
CHEN, Y. ET AL.: "Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population", EUR. J. HUM. GENET., vol. 13, 2005, pages 772 - 80
FEDER J. ET AL.: "DNA restriction fragment analysis of the pro-opiomelanocortin gene in schizophrenia and bipolar disorders", AM. J. HUM. GENET., vol. 37, no. 2, 1985, pages 286 - 294, XP008123098 *
GRISEL J.E. ET AL.: "Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression", BRAIN RES., vol. 835, no. 1, 1999, pages 62 - 67, XP008123071 *
HIXSON, J. E. ET AL.: "Normal variation in leptin levels is associated with polymorphisms in the proopiomelanocortin gene, POMC", J. CLIN. ENDOCRINOL. METAB., vol. 84, 1999, pages 3187 - 91
IKEDA K. ET AL.: "How individual sensitivity to opiates can be predicted by gene analyses", TRENDS PHARMACOL. SCI., vol. 26, no. 6, 2005, pages 311 - 317, XP004912366 *
IKEDA, K. ET AL.: "How individual sensitivity to opiates can be predicted by gene analyses", TRENDS PHARMACOL. SCI., vol. 26, 2005, pages 311 - 7
LAFORGE K.S. ET AL.: "Opioid receptor and peptide gene polymorphisms: potential implications for addictions", EUR. J. PHARMACOL., vol. 410, 2000, pages 249 - 268, XP008123072 *
LEE T.H. ET AL.: "In vivo electroporation of pro-opiomelanocortin induces analgesia in a formalin-injection pain model in rats", PAIN, vol. 104, 2003, pages 159 - 167, XP008123068 *
LEE, T. H. ET AL.: "In vivo electroporation of proopiomelanocortin induces analgesia in a formalin-injection pain model in rats", PAIN, vol. 104, 2003, pages 159 - 67
RUBINSTEIN M. ET AL.: "Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis", PROC. NATL. ACAD. SCI. USA, vol. 93, no. 9, 1996, pages 3995 - 4000, XP000602049 *
RUBINSTEIN, M. ET AL.: "Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis", PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 3995 - 4000
SUDO Y. ET AL.: "Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene (POMC) with low bone mineral density in adult women", J. HUM. GENET., vol. 50, 2005, pages 235 - 240, XP019374298 *
SUDO, Y. ET AL.: "Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene (POMC) with low bone mineral density in adult women", J. HUM. GENET., vol. 50, 2005, pages 235 - 40
SUVIOLAHTI, E. ET AL.: "Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals", INT. J. OBES. RELAT. METAB. DISORD., vol. 27, 2003, pages 1204 - 11
WITHDRAWAL. J., PHARMACOL. EXP. THER., vol. 315, 2005, pages 949 - 58

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102549171A (zh) * 2009-10-07 2012-07-04 学校法人武库川学院 基因型的判断方法

Also Published As

Publication number Publication date
US20100240552A1 (en) 2010-09-23
JPWO2008133329A1 (ja) 2010-07-29
EP2151496A1 (en) 2010-02-10
ATE555197T1 (de) 2012-05-15
EP2151496B1 (en) 2012-04-25
EP2151496A4 (en) 2010-10-13

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