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WO2008131364A3 - Methods of diagnosing alzheimer's disease and associated markers - Google Patents

Methods of diagnosing alzheimer's disease and associated markers Download PDF

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Publication number
WO2008131364A3
WO2008131364A3 PCT/US2008/061068 US2008061068W WO2008131364A3 WO 2008131364 A3 WO2008131364 A3 WO 2008131364A3 US 2008061068 W US2008061068 W US 2008061068W WO 2008131364 A3 WO2008131364 A3 WO 2008131364A3
Authority
WO
WIPO (PCT)
Prior art keywords
load
methods
disease
gab2
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/061068
Other languages
French (fr)
Other versions
WO2008131364A2 (en
Inventor
Dietrich A Stephan
Eric M Reiman
Jennifer Webster
Christopher B Heward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Translational Genomics Research Institute TGen
Kronos Science Laboratory
Original Assignee
Translational Genomics Research Institute TGen
Kronos Science Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Translational Genomics Research Institute TGen, Kronos Science Laboratory filed Critical Translational Genomics Research Institute TGen
Publication of WO2008131364A2 publication Critical patent/WO2008131364A2/en
Publication of WO2008131364A3 publication Critical patent/WO2008131364A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.
PCT/US2008/061068 2007-04-20 2008-04-21 Methods of diagnosing alzheimer's disease and associated markers Ceased WO2008131364A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92563807P 2007-04-20 2007-04-20
US60/925,638 2007-04-20
US93358207P 2007-06-06 2007-06-06
US60/933,582 2007-06-06

Publications (2)

Publication Number Publication Date
WO2008131364A2 WO2008131364A2 (en) 2008-10-30
WO2008131364A3 true WO2008131364A3 (en) 2009-02-12

Family

ID=39876185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/061068 Ceased WO2008131364A2 (en) 2007-04-20 2008-04-21 Methods of diagnosing alzheimer's disease and associated markers

Country Status (1)

Country Link
WO (1) WO2008131364A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067512A1 (en) * 2001-11-09 2004-04-08 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
US20040116682A1 (en) * 1998-03-06 2004-06-17 Nordine Cheikh Nucleic acid molecules and other molecules associated with the carbon assimilation pathway
US20050170399A1 (en) * 1996-05-23 2005-08-04 Stefan Somlo Polycystic kidney disease PKD2 gene and uses thereof
US20070054278A1 (en) * 2003-11-18 2007-03-08 Applera Corporation Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050170399A1 (en) * 1996-05-23 2005-08-04 Stefan Somlo Polycystic kidney disease PKD2 gene and uses thereof
US20040116682A1 (en) * 1998-03-06 2004-06-17 Nordine Cheikh Nucleic acid molecules and other molecules associated with the carbon assimilation pathway
US20040067512A1 (en) * 2001-11-09 2004-04-08 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
US20070054278A1 (en) * 2003-11-18 2007-03-08 Applera Corporation Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAO ET AL.: "A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation", JOURNAL OF CELL BIOLOGY, vol. 170, 2005, pages 305 - 316 *
MISRA ET AL.: "Binding of receptor-recognized forms of alpha 2-macroglobulin to the alpha 2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase", JOURNAL BIOLOGICAL CHEMISTRY, vol. 273, 1998, pages 13399 - 13402 *

Also Published As

Publication number Publication date
WO2008131364A2 (en) 2008-10-30

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