[go: up one dir, main page]

WO2008130319A3 - Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain - Google Patents

Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain Download PDF

Info

Publication number
WO2008130319A3
WO2008130319A3 PCT/SE2008/050458 SE2008050458W WO2008130319A3 WO 2008130319 A3 WO2008130319 A3 WO 2008130319A3 SE 2008050458 W SE2008050458 W SE 2008050458W WO 2008130319 A3 WO2008130319 A3 WO 2008130319A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetrahydronaphtalene
chromane
pain
novel
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE2008/050458
Other languages
French (fr)
Other versions
WO2008130319A2 (en
Inventor
Yevgeni Besidski
Alf Claesson
Gabor Csjernyik
Ylva Gravenfors
Inger Kers
Karin Skogholm
Daniel Sohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of WO2008130319A2 publication Critical patent/WO2008130319A2/en
Publication of WO2008130319A3 publication Critical patent/WO2008130319A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to new compounds and to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof.
PCT/SE2008/050458 2007-04-23 2008-04-22 Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain Ceased WO2008130319A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91330907P 2007-04-23 2007-04-23
US60/913,309 2007-04-23

Publications (2)

Publication Number Publication Date
WO2008130319A2 WO2008130319A2 (en) 2008-10-30
WO2008130319A3 true WO2008130319A3 (en) 2008-12-18

Family

ID=39876086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2008/050458 Ceased WO2008130319A2 (en) 2007-04-23 2008-04-22 Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain

Country Status (1)

Country Link
WO (1) WO2008130319A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103347860A (en) * 2010-11-15 2013-10-09 Abbvie公司 Nampt inhibitor
SG190819A1 (en) 2010-11-15 2013-07-31 Abbvie Inc Nampt and rock inhibitors
AU2014287471C1 (en) 2013-07-10 2019-11-28 Vertex Pharmaceuticals Incorporated Fused piperidine amides as modulators of ion channels
KR102812440B1 (en) 2018-09-10 2025-05-26 가껭세이야꾸가부시기가이샤 Novel heteroaromatic amide derivatives and pharmaceutical agents containing the same
CN112062688B (en) * 2020-09-28 2023-02-03 绍兴兴欣新材料股份有限公司 Preparation method of N, N-diethyl acetamide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034883A1 (en) * 1996-03-22 1997-09-25 Astra Aktiebolag Substituted 1,2,3,4-tetrahydronaphthalene derivatives
WO1999005134A1 (en) * 1997-07-25 1999-02-04 Astra Aktiebolag Substituted 1,2,3,4-tetrahydronaphthalene derivatives
WO1999014213A1 (en) * 1997-09-18 1999-03-25 Astrazeneca Ab Substituted chroman derivatives
WO1999014212A1 (en) * 1997-09-18 1999-03-25 Astrazeneca Ab Substituted chroman derivatives
WO2005013914A2 (en) * 2003-08-08 2005-02-17 Vertex Pharmaceuticals Incorporated Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain
US20060025415A1 (en) * 2003-08-08 2006-02-02 Gonzalez Jesus E Iii Compositions useful as inhibitors of voltage-gated sodium channels

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034883A1 (en) * 1996-03-22 1997-09-25 Astra Aktiebolag Substituted 1,2,3,4-tetrahydronaphthalene derivatives
WO1999005134A1 (en) * 1997-07-25 1999-02-04 Astra Aktiebolag Substituted 1,2,3,4-tetrahydronaphthalene derivatives
WO1999014213A1 (en) * 1997-09-18 1999-03-25 Astrazeneca Ab Substituted chroman derivatives
WO1999014212A1 (en) * 1997-09-18 1999-03-25 Astrazeneca Ab Substituted chroman derivatives
WO2005013914A2 (en) * 2003-08-08 2005-02-17 Vertex Pharmaceuticals Incorporated Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain
US20050137190A1 (en) * 2003-08-08 2005-06-23 Gonzalez Jesus E.Iii Compositions useful as inhibitors of voltage-gated sodium channels
US20060025415A1 (en) * 2003-08-08 2006-02-02 Gonzalez Jesus E Iii Compositions useful as inhibitors of voltage-gated sodium channels

Also Published As

Publication number Publication date
WO2008130319A2 (en) 2008-10-30

Similar Documents

Publication Publication Date Title
WO2008130320A3 (en) Novel n- (8-heteroaryltetrahydronaphtalene-2yl) or n- (5- heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain
MX2009006704A (en) New compounds.
MY179527A (en) Catecholamine derivatives useful for the treatment of parkinson's disease
GB0522311D0 (en) Pharmaceutical compositions for the treatment of pain
MY161991A (en) Proteasome inhibitors
WO2009153496A3 (en) Ppar agonist compounds and preparation and uses thereof for treating diabetes and/or dyslipidemia
TW200800976A (en) New compounds for the treatment of neurological, psychiatric or pain disorders
TW200606162A (en) Pyrazolopyridine derivatives
WO2007038459A3 (en) Carboxyamine compounds and their use in the treatment of hdac dependent diseases
IL201189A (en) Fluorinated derivatives of deferiprone for use as iron chelators in the treatment of neurodegenerative diseases, process for their preparation and pharmaceutical compositions comprising them
WO2008076954A3 (en) Heterocycle compounds and methods of use thereof
UA104988C2 (en) Novel pyrone-indole derivatives and process for their preparation
WO2009062576A3 (en) Benzimidazoledihydrothiadiazinone derivatives as fructose-1,6-bisphosphatase inhibitors, and pharmaceutical compositions comprising same
IL192415A0 (en) Pharmaceutical composition for the treatment of nail diseases
WO2009099553A3 (en) Use of kinase inhibitor in treatment of atherosclerosis
MX2013002118A (en) Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators.
TW200745122A (en) New compounds I
CL2008000982A1 (en) COMPOUNDS DERIVED FROM 5-OXO-ISOXAZOL-CARBOXAMIDA; PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION; PROCEDURE OF PRODUCTION OF THE PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT AND / OR PREVENTION OF ATEROSCLEROTIC DISORDERS, OF METABOLISM OF
IL195632A0 (en) Substituted carboxamides
WO2008130319A3 (en) Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain
WO2007139833A3 (en) Imidazoazephinone compounds
WO2008130321A3 (en) Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain
IL206464A0 (en) Pharmaceutical composition, use of 2-imminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases
TW200745133A (en) New compounds II
MX2013002295A (en) Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08779259

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08779259

Country of ref document: EP

Kind code of ref document: A2