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WO2008130381A3 - Compositions d'acide polyglutamique et leur utilisation comme immunogènes - Google Patents

Compositions d'acide polyglutamique et leur utilisation comme immunogènes Download PDF

Info

Publication number
WO2008130381A3
WO2008130381A3 PCT/US2007/022567 US2007022567W WO2008130381A3 WO 2008130381 A3 WO2008130381 A3 WO 2008130381A3 US 2007022567 W US2007022567 W US 2007022567W WO 2008130381 A3 WO2008130381 A3 WO 2008130381A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunogens
polyglutamic acid
acid compositions
pga
staphylococcus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/022567
Other languages
English (en)
Other versions
WO2008130381A2 (fr
Inventor
Bret Richard Sellman
Viliam Pavliak
Thushari Bombuwala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of WO2008130381A2 publication Critical patent/WO2008130381A2/fr
Publication of WO2008130381A3 publication Critical patent/WO2008130381A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/07—Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur des composés et des compositions contenant des fractions d'acide poly-γ-D,L-glutamique (PGA) et sur leur utilisation dans la prévention ou le traitement d'infections nosocomiales provoquées par Staphylococcus et Bacillus.
PCT/US2007/022567 2006-10-24 2007-10-24 Compositions d'acide polyglutamique et leur utilisation comme immunogènes Ceased WO2008130381A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85376206P 2006-10-24 2006-10-24
US60/853,762 2006-10-24

Publications (2)

Publication Number Publication Date
WO2008130381A2 WO2008130381A2 (fr) 2008-10-30
WO2008130381A3 true WO2008130381A3 (fr) 2009-02-05

Family

ID=39876095

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/022567 Ceased WO2008130381A2 (fr) 2006-10-24 2007-10-24 Compositions d'acide polyglutamique et leur utilisation comme immunogènes

Country Status (1)

Country Link
WO (1) WO2008130381A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118240201B (zh) * 2024-05-22 2024-08-20 成都金开生物工程有限公司 利用γ-聚谷氨酸发酵液提取纯化γ-聚谷氨酸的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000884A1 (fr) * 2003-06-05 2005-01-06 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Conjugues d'acide poly-gamma-glutamique pour solliciter des reponses immunitaires dirigees contre des bacilles
WO2005007804A2 (fr) * 2003-04-10 2005-01-27 President And Fellows Of Harvard College Vaccin conjugue contre l'anthrax et anticorps diriges contre des bacilles et des toxines de l'anthrax
WO2007008904A2 (fr) * 2005-07-08 2007-01-18 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Ciblage de l'acide poly-gamma-glutamique en vue de traiter les infections provoquees par le staphylococcus epidermidis et les infections apparentees

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007804A2 (fr) * 2003-04-10 2005-01-27 President And Fellows Of Harvard College Vaccin conjugue contre l'anthrax et anticorps diriges contre des bacilles et des toxines de l'anthrax
WO2005000884A1 (fr) * 2003-06-05 2005-01-06 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Conjugues d'acide poly-gamma-glutamique pour solliciter des reponses immunitaires dirigees contre des bacilles
WO2007008904A2 (fr) * 2005-07-08 2007-01-18 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Ciblage de l'acide poly-gamma-glutamique en vue de traiter les infections provoquees par le staphylococcus epidermidis et les infections apparentees

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KOCIANOVA STANISLAVA ET AL: "KEY ROLE OF POLY-GAMMA-DL-GLUTAMIC ACID IN IMMUNE EVASION AND VIRULENCE OF STAPHYLOCOCCUS EPIDERMIDIS", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, vol. 115, no. 3, 1 March 2005 (2005-03-01), pages 688 - 694, XP009077809, ISSN: 0021-9738 *
KUBLER-KIELB JOANNA ET AL: "Additional conjugation methods and immunogenicity of Bacillus anthracis poly-gamma-D-glutamic acid-protein conjugates.", INFECTION AND IMMUNITY, vol. 74, no. 8, August 2006 (2006-08-01), pages 4744 - 4749, XP002475519, ISSN: 0019-9567 *
SCHNEERSON RACHEL ET AL: "Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: A potential addition to the anthrax vaccine", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 100, no. 15, 22 July 2003 (2003-07-22), pages 8945 - 8950, XP002306072, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2008130381A2 (fr) 2008-10-30

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