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WO2008126905A1 - 自然免疫機構を活性化／抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化／抑制するための薬剤、食品及びそれらの製造方法 - Google Patents

自然免疫機構を活性化／抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化／抑制するための薬剤、食品及びそれらの製造方法 Download PDF

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Publication number
WO2008126905A1
WO2008126905A1 PCT/JP2008/057105 JP2008057105W WO2008126905A1 WO 2008126905 A1 WO2008126905 A1 WO 2008126905A1 JP 2008057105 W JP2008057105 W JP 2008057105W WO 2008126905 A1 WO2008126905 A1 WO 2008126905A1
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WO
WIPO (PCT)
Prior art keywords
activating
suppressing
action
substance
immune mechanism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/057105
Other languages
English (en)
French (fr)
Inventor
Kazuhisa Sekimizu
Hiroshi Hamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tokyo NUC
Imagine Global Care Corp
Genome Pharmaceuticals Institute Co Ltd
Original Assignee
University of Tokyo NUC
Imagine Global Care Corp
Genome Pharmaceuticals Institute Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tokyo NUC, Imagine Global Care Corp, Genome Pharmaceuticals Institute Co Ltd filed Critical University of Tokyo NUC
Priority to EP08740206.1A priority Critical patent/EP2133693B1/en
Priority to US12/595,245 priority patent/US8313779B2/en
Priority to JP2009509376A priority patent/JP5394233B2/ja
Publication of WO2008126905A1 publication Critical patent/WO2008126905A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)

Abstract

　個体の体内動態に問題のある物質を排除することができ、探索時に混入し得る細菌由来のＬＰＳの影響を受けず、かつ簡便に自然免疫機構を活性化／抑制する作用を有する物質を探索することができる評価方法及びスクリーニング方法、並びに自然免疫機構を活性化／抑制するための薬剤、食品及びそれらの製造方法を提供することを課題とし、自然免疫機構を有する生物の筋肉の収縮を指標として、自然免疫機構を活性化／抑制する作用を有する物質を評価乃至スクリーニングする方法、及び自然免疫機構を活性化／抑制するための薬剤、食品を製造する方法である。また、自然免疫機構を有する生物の筋肉を収縮させる作用を有する物質を含有する自然免疫活性化剤や自然免疫活性化作用を有する食品、及び自然免疫機構を有する生物の筋肉の収縮を抑制する作用を有する物質を含有する自然免疫抑制剤や自然免疫抑制作用を有する食品を提供するものである。
PCT/JP2008/057105 2007-04-10 2008-04-10 自然免疫機構を活性化／抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化／抑制するための薬剤、食品及びそれらの製造方法 Ceased WO2008126905A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08740206.1A EP2133693B1 (en) 2007-04-10 2008-04-10 Screening method for substance having action of activating/suppressing innate immunity.
US12/595,245 US8313779B2 (en) 2007-04-10 2008-04-10 Evaluation method and screening method for substance having action of activating/suppressing innate immunity, agent and food product for activating/suppressing innate immune mechanism and method for producing the same
JP2009509376A JP5394233B2 (ja) 2007-04-10 2008-04-10 自然免疫機構を活性化／抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化／抑制するための薬剤、食品及びそれらの製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-102918 2007-04-10
JP2007102918 2007-04-10

Publications (1)

Publication Number Publication Date
WO2008126905A1 true WO2008126905A1 (ja) 2008-10-23

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PCT/JP2008/057105 Ceased WO2008126905A1 (ja) 2007-04-10 2008-04-10 自然免疫機構を活性化／抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化／抑制するための薬剤、食品及びそれらの製造方法

Country Status (4)

Country Link
US (1) US8313779B2 (ja)
EP (1) EP2133693B1 (ja)
JP (3) JP5394233B2 (ja)
WO (1) WO2008126905A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009157409A1 (ja) * 2008-06-24 2009-12-30 株式会社ゲノム創薬研究所 植物体由来の自然免疫活性化作用が増強された自然免疫活性化組成物
WO2012108347A1 (ja) * 2011-02-07 2012-08-16 森川健康堂株式会社 自然免疫促進作用が増強された自然免疫活性化剤の製造方法及びその製造方法で製造されたローヤルゼリー由来の自然免疫活性化剤
JP2013502559A (ja) * 2009-08-12 2013-01-24 エントモファーム アーペーエス 化合物の腸内吸収を測定するために昆虫モデルを利用する方法
WO2015056770A1 (ja) * 2013-10-17 2015-04-23 株式会社ゲノム創薬研究所 新規乳酸菌、新規乳酸菌を有効成分とする自然免疫活性化剤、及び新規乳酸菌を含有する飲食品
KR20170110076A (ko) 2015-02-06 2017-10-10 가부시키가이샤 게놈소야쿠겡큐쇼 유산균, 그 유산균 유래의 자연 면역 활성화제, 감염증 예방 치료제 및 음식품
JP2018024737A (ja) * 2016-08-09 2018-02-15 株式会社ゲノム創薬研究所 自然免疫活性化作用を有する多糖類及び該多糖類を含有する自然免疫活性化剤又は飲食品
WO2018034203A1 (ja) * 2016-08-16 2018-02-22 株式会社ゲノム創薬研究所 新規乳酸菌、新規乳酸菌を有効成分として含有する自然免疫活性化剤、及び新規乳酸菌を含有する飲食品
JP2021059505A (ja) * 2019-10-04 2021-04-15 株式会社ゲノム創薬研究所 自然免疫活性化剤の製造方法及び自然免疫活性化剤
JP2021175946A (ja) * 2020-05-01 2021-11-04 株式会社ゲノム創薬研究所 免疫抑制剤のスクリーニング方法
JP2022091709A (ja) * 2020-12-09 2022-06-21 株式会社ゲノム創薬研究所 サイトカインストーム治療・予防剤のスクリーニング方法及びサイトカインストーム治療・予防剤
WO2024090415A1 (ja) * 2022-10-25 2024-05-02 株式会社ゲノム創薬研究所 乳酸菌、該乳酸菌由来の自然免疫活性化剤及び該乳酸菌を含有する食品

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WO2009111486A2 (en) * 2008-03-04 2009-09-11 The Regents Of The University Of California Reversing the immune decline of aging by a nutraceutical antioxidant in mice
KR102121810B1 (ko) * 2018-05-16 2020-06-12 대한민국 누에의 면역반응 유도방법

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009157409A1 (ja) * 2008-06-24 2009-12-30 株式会社ゲノム創薬研究所 植物体由来の自然免疫活性化作用が増強された自然免疫活性化組成物
JP2013502559A (ja) * 2009-08-12 2013-01-24 エントモファーム アーペーエス 化合物の腸内吸収を測定するために昆虫モデルを利用する方法
WO2012108347A1 (ja) * 2011-02-07 2012-08-16 森川健康堂株式会社 自然免疫促進作用が増強された自然免疫活性化剤の製造方法及びその製造方法で製造されたローヤルゼリー由来の自然免疫活性化剤
JP2012162488A (ja) * 2011-02-07 2012-08-30 Genome Soyaku Kenkyusho:Kk 自然免疫促進作用が増強された自然免疫活性化剤の製造方法及びその製造方法で製造されたローヤルゼリー由来の自然免疫活性化剤
WO2015056770A1 (ja) * 2013-10-17 2015-04-23 株式会社ゲノム創薬研究所 新規乳酸菌、新規乳酸菌を有効成分とする自然免疫活性化剤、及び新規乳酸菌を含有する飲食品
JPWO2015056770A1 (ja) * 2013-10-17 2017-03-09 株式会社ゲノム創薬研究所 新規乳酸菌、新規乳酸菌を有効成分とする自然免疫活性化剤、及び新規乳酸菌を含有する飲食品
KR20170110076A (ko) 2015-02-06 2017-10-10 가부시키가이샤 게놈소야쿠겡큐쇼 유산균, 그 유산균 유래의 자연 면역 활성화제, 감염증 예방 치료제 및 음식품
US10265352B2 (en) 2015-02-06 2019-04-23 Genome Pharmaceuticals Institute Co., Ltd. Lactic acid bacteria, natural immunoactivator and infection preventative/therapeutic derived from said lactic acid bacteria, and food/beverage
KR20190008931A (ko) 2016-08-09 2019-01-25 이매진 글로벌 케어 코퍼레이션 자연 면역 활성화 작용을 가지는 다당류 및 그 다당류를 함유하는 자연 면역 활성화제 또는 음식물
US11213058B2 (en) 2016-08-09 2022-01-04 Imagine Global Care Corporation Polysaccharide having innate immunity stimulating activity
WO2018030542A1 (ja) 2016-08-09 2018-02-15 イマジン・グローバル・ケア株式会社 自然免疫活性化作用を有する多糖類及び該多糖類を含有する自然免疫活性化剤又は飲食品
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JP7475586B2 (ja) 2020-05-01 2024-04-30 株式会社ゲノム創薬研究所 免疫抑制剤のスクリーニング方法
JP2022091709A (ja) * 2020-12-09 2022-06-21 株式会社ゲノム創薬研究所 サイトカインストーム治療・予防剤のスクリーニング方法及びサイトカインストーム治療・予防剤
WO2024090415A1 (ja) * 2022-10-25 2024-05-02 株式会社ゲノム創薬研究所 乳酸菌、該乳酸菌由来の自然免疫活性化剤及び該乳酸菌を含有する食品

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US8313779B2 (en) 2012-11-20
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