[go: up one dir, main page]

WO2008120754A1 - ピコリン酸アミド化合物 - Google Patents

ピコリン酸アミド化合物 Download PDF

Info

Publication number
WO2008120754A1
WO2008120754A1 PCT/JP2008/056197 JP2008056197W WO2008120754A1 WO 2008120754 A1 WO2008120754 A1 WO 2008120754A1 JP 2008056197 W JP2008056197 W JP 2008056197W WO 2008120754 A1 WO2008120754 A1 WO 2008120754A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
picolinamide compound
bond
formula
picolinamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/056197
Other languages
English (en)
French (fr)
Inventor
Hiroki Umemiya
Kengo Watatani
Takanori Kawaguchi
Daisuke Wakasugi
Kenichi Kawabe
Takumi Okada
Shigetada Sasako
Noriko Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Taisho Pharmaceutical Co Ltd
Original Assignee
Nissan Chemical Corp
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Taisho Pharmaceutical Co Ltd filed Critical Nissan Chemical Corp
Publication of WO2008120754A1 publication Critical patent/WO2008120754A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

　下記式（１） （式（１）中、 　Ｒ１はＣ１－８アルキル基、Ｃ１－９ヘテロアリール基、Ｃ２－９ヘテロシクリル基等を示し、Ｒ２は水素原子、Ｃ１－８アルキル基、フェニル基、Ｃ７－１４アリールアルキル基等を示し、Ａｒは、Ｃ＝Ｎ結合を有し、かつ式（１）中でＡｒと隣接するアミド基の窒素原子と該ＡｒのＣ＝Ｎ結合を形成する炭素原子とが結合するＣ１－９ヘテロアリール基で表されるピコリン酸アミド化合物は、ＧＫ活性化作用を有し医薬品として有用な化合物である。
PCT/JP2008/056197 2007-03-30 2008-03-28 ピコリン酸アミド化合物 Ceased WO2008120754A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-094877 2007-03-30
JP2007094877A JP2010138073A (ja) 2007-03-30 2007-03-30 ピコリン酸アミド化合物

Publications (1)

Publication Number Publication Date
WO2008120754A1 true WO2008120754A1 (ja) 2008-10-09

Family

ID=39808334

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056197 Ceased WO2008120754A1 (ja) 2007-03-30 2008-03-28 ピコリン酸アミド化合物

Country Status (2)

Country Link
JP (1) JP2010138073A (ja)
WO (1) WO2008120754A1 (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US8389552B2 (en) 2008-09-11 2013-03-05 Pfizer Inc. (S)-6-(2-(4-(cyclobutylsulfonyl)-1H-imidazol-1-yl)-3-cyclopentylpropanamido)nicotinic acid useful as a glucokinase activator
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8455496B2 (en) 2009-03-11 2013-06-04 Pfizer Inc. Benzofuranyl derivatives
JP2018505166A (ja) * 2015-02-06 2018-02-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｉｒａｋ阻害剤としてのピリダジノン大環状化合物及びその使用
WO2019229250A1 (en) * 2018-05-31 2019-12-05 Universiteit Leiden Inhibitors of n-acylphosphatidylethanolamine phospholipase d (nape-pld)
WO2023134708A1 (en) * 2022-01-12 2023-07-20 Beigene , Ltd. Thiazolopyridyl amide derivatives as dna polymerase theta inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2020232A1 (en) * 2007-08-03 2009-02-04 Zeltia, S.A. N-(1-thiazolyl)-amide derivatives for the treatment of obesity, diabetes and cardiovascular diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795984A (en) * 1980-12-05 1982-06-15 Tanabe Seiyaku Co Ltd Pyridinecarboxamide derivative and its preparation
WO2003082838A1 (en) * 2002-04-02 2003-10-09 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences New methionine aminopeptidase inhibitor
WO2004076420A1 (ja) * 2003-02-26 2004-09-10 Banyu Pharmaceutical Co., Ltd. ヘテロアリールカルバモイルベンゼン誘導体
WO2004081001A1 (ja) * 2003-02-13 2004-09-23 Banyu Pharmaceutical Co., Ltd. 新規２－ピリジンカルボキサミド誘導体
JP2005500312A (ja) * 2001-06-26 2005-01-06 アストラゼネカ アクチボラグ グルコキナーゼ（ｇｌｋ）モジュレーターとしてのアミノニコチネート誘導体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795984A (en) * 1980-12-05 1982-06-15 Tanabe Seiyaku Co Ltd Pyridinecarboxamide derivative and its preparation
JP2005500312A (ja) * 2001-06-26 2005-01-06 アストラゼネカ アクチボラグ グルコキナーゼ（ｇｌｋ）モジュレーターとしてのアミノニコチネート誘導体
WO2003082838A1 (en) * 2002-04-02 2003-10-09 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences New methionine aminopeptidase inhibitor
WO2004081001A1 (ja) * 2003-02-13 2004-09-23 Banyu Pharmaceutical Co., Ltd. 新規２－ピリジンカルボキサミド誘導体
WO2004076420A1 (ja) * 2003-02-26 2004-09-10 Banyu Pharmaceutical Co., Ltd. ヘテロアリールカルバモイルベンゼン誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAN S.A. ET AL.: "Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, no. 18, 15 September 2005 (2005-09-15), pages 4085 - 4090, XP005021103 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8389552B2 (en) 2008-09-11 2013-03-05 Pfizer Inc. (S)-6-(2-(4-(cyclobutylsulfonyl)-1H-imidazol-1-yl)-3-cyclopentylpropanamido)nicotinic acid useful as a glucokinase activator
US8455496B2 (en) 2009-03-11 2013-06-04 Pfizer Inc. Benzofuranyl derivatives
US8735396B2 (en) 2009-03-11 2014-05-27 Pfizer Inc. Benzofuranyl derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP2018505166A (ja) * 2015-02-06 2018-02-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｉｒａｋ阻害剤としてのピリダジノン大環状化合物及びその使用
WO2019229250A1 (en) * 2018-05-31 2019-12-05 Universiteit Leiden Inhibitors of n-acylphosphatidylethanolamine phospholipase d (nape-pld)
WO2023134708A1 (en) * 2022-01-12 2023-07-20 Beigene , Ltd. Thiazolopyridyl amide derivatives as dna polymerase theta inhibitors

Also Published As

Publication number Publication date
JP2010138073A (ja) 2010-06-24

Similar Documents

Publication Publication Date Title
WO2008120754A1 (ja) ピコリン酸アミド化合物
WO2008108378A3 (en) Bicyclic oxomorpholine derivative
WO2009041453A1 (ja) 二環性γ－アミノ酸誘導体
WO2008156174A1 (ja) ピラジンアミド化合物
WO2009028543A1 (ja) 置換ピラゾール誘導体
TW200510381A (en) Novel 2-pyridinecarboxamide derivatives
WO2008108380A3 (en) Pyrrole compounds
WO2008126933A3 (en) Process for producing pesticidal benzamide compounds
TW200744659A (en) Preparation for preventing and ameliorating wrinkle
TW200745034A (en) New compounds
MX2009003073A (es) Derivado de 2-piridincarboxamida que tiene efecto activador de gk.
UA95972C2 (ru) Аминопиридиновые производные с селективной ингибирующей активностью в отношении авроры а
WO2008146871A1 (ja) グルココルチコイド受容体結合活性を有する、スルホン酸エステル又はスルホン酸アミド構造を導入したフェニル基を置換基として有する新規１，２，３，４－テトラヒドロキノキサリン誘導体
WO2008126890A1 (ja) ヒドラジド化合物およびそれを含有する有害節足動物防除剤
EA017861B9 (ru) Способ получения 4-оксохинолинового соединения
WO2009022687A1 (ja) フェニル酢酸化合物
SG170049A1 (en) Novel 11 beta - hydroxyandrosta-4-ene-3-ones
MY151072A (en) Heteroaryl derivative
WO2008136512A1 (ja) 光学異性体用分離剤
WO2008139845A1 (ja) 新規アミド誘導体
WO2006024741A3 (fr) Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
TW200745153A (en) Trehalose compound and pharmaceutical comprising the compound
WO2008117871A1 (ja) 含窒素レドックス触媒
WO2007147847A3 (en) Reversibly thermochromic compositions
MY161992A (en) Novel tetrahydroisoquinoline derivative

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08739315

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08739315

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP